IL302476A - Engineered ipsc and immune effector cells for heterogenous tumor control - Google Patents

Engineered ipsc and immune effector cells for heterogenous tumor control

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Publication number
IL302476A
IL302476A IL302476A IL30247623A IL302476A IL 302476 A IL302476 A IL 302476A IL 302476 A IL302476 A IL 302476A IL 30247623 A IL30247623 A IL 30247623A IL 302476 A IL302476 A IL 302476A
Authority
IL
Israel
Prior art keywords
cell
car
receptor
cells
antigen
Prior art date
Application number
IL302476A
Other languages
English (en)
Hebrew (he)
Inventor
Bahram Valamehr
Martin Hoskong
Tom Tong Lee
John Charles Goulding
Original Assignee
Fate Therapeutics Inc
Bahram Valamehr
Martin Hoskong
Tom Tong Lee
John Charles Goulding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fate Therapeutics Inc, Bahram Valamehr, Martin Hoskong, Tom Tong Lee, John Charles Goulding filed Critical Fate Therapeutics Inc
Publication of IL302476A publication Critical patent/IL302476A/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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IL302476A 2020-11-04 2021-11-04 Engineered ipsc and immune effector cells for heterogenous tumor control IL302476A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063109829P 2020-11-04 2020-11-04
US202163172891P 2021-04-09 2021-04-09
PCT/US2021/058138 WO2022098925A1 (en) 2020-11-04 2021-11-04 Engineered ipsc and immune effector cells for heterogenous tumor control

Publications (1)

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IL302476A true IL302476A (en) 2023-06-01

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IL302476A IL302476A (en) 2020-11-04 2021-11-04 Engineered ipsc and immune effector cells for heterogenous tumor control

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US (1) US20230405121A1 (https=)
EP (1) EP4240832A4 (https=)
JP (1) JP2023548829A (https=)
KR (1) KR20230098637A (https=)
AU (1) AU2021376358A1 (https=)
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