IL301305A - Method for treating cancer with kidney protection - Google Patents
Method for treating cancer with kidney protectionInfo
- Publication number
- IL301305A IL301305A IL301305A IL30130523A IL301305A IL 301305 A IL301305 A IL 301305A IL 301305 A IL301305 A IL 301305A IL 30130523 A IL30130523 A IL 30130523A IL 301305 A IL301305 A IL 301305A
- Authority
- IL
- Israel
- Prior art keywords
- iron
- content
- protoporphyrin
- hepcidin
- amount
- Prior art date
Links
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- 210000003734 kidney Anatomy 0.000 title claims description 40
- 206010028980 Neoplasm Diseases 0.000 title claims description 9
- 201000011510 cancer Diseases 0.000 title claims description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 131
- 102000018511 hepcidin Human genes 0.000 claims description 93
- 108060003558 hepcidin Proteins 0.000 claims description 93
- XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims description 91
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Landscapes
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-
2021
- 2021-09-13 WO PCT/US2021/050064 patent/WO2022056378A1/en not_active Ceased
- 2021-09-13 US US17/472,954 patent/US20220079984A1/en not_active Abandoned
- 2021-09-13 JP JP2023516137A patent/JP2023541606A/ja active Pending
- 2021-09-13 AU AU2021342291A patent/AU2021342291A1/en not_active Abandoned
- 2021-09-13 CA CA3192411A patent/CA3192411A1/en active Pending
- 2021-09-13 CN CN202180070528.4A patent/CN116348107A/zh active Pending
- 2021-09-13 IL IL301305A patent/IL301305A/en unknown
- 2021-09-13 MX MX2023002929A patent/MX2023002929A/es unknown
- 2021-09-13 EP EP21867758.1A patent/EP4210691A4/en not_active Withdrawn
- 2021-09-13 KR KR1020237011800A patent/KR20230112608A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4210691A4 (en) | 2025-02-26 |
| MX2023002929A (es) | 2023-05-22 |
| BR112023004583A2 (pt) | 2023-04-11 |
| WO2022056378A1 (en) | 2022-03-17 |
| AU2021342291A1 (en) | 2023-04-20 |
| JP2023541606A (ja) | 2023-10-03 |
| EP4210691A1 (en) | 2023-07-19 |
| CN116348107A (zh) | 2023-06-27 |
| US20220079984A1 (en) | 2022-03-17 |
| KR20230112608A (ko) | 2023-07-27 |
| CA3192411A1 (en) | 2022-03-17 |
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