IL300816A - Preparations and methods for neurological diseases - Google Patents

Preparations and methods for neurological diseases

Info

Publication number
IL300816A
IL300816A IL300816A IL30081623A IL300816A IL 300816 A IL300816 A IL 300816A IL 300816 A IL300816 A IL 300816A IL 30081623 A IL30081623 A IL 30081623A IL 300816 A IL300816 A IL 300816A
Authority
IL
Israel
Prior art keywords
receptor
engineered
neuron
ligand
engineered receptor
Prior art date
Application number
IL300816A
Other languages
English (en)
Hebrew (he)
Inventor
Anthony Lau Jr
Orion P Keifer Jr
Stefanie Makinson
Alexander Naka
Original Assignee
Trames Bio Inc
Anthony Lau Jr
Orion P Keifer Jr
Stefanie Makinson
Alexander Naka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trames Bio Inc, Anthony Lau Jr, Orion P Keifer Jr, Stefanie Makinson, Alexander Naka filed Critical Trames Bio Inc
Publication of IL300816A publication Critical patent/IL300816A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0085Brain, e.g. brain implants; Spinal cord
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0619Neurons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL300816A 2020-08-21 2021-08-20 Preparations and methods for neurological diseases IL300816A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063068890P 2020-08-21 2020-08-21
PCT/US2021/046915 WO2022040535A2 (en) 2020-08-21 2021-08-20 Compositions and methods for neurological diseases

Publications (1)

Publication Number Publication Date
IL300816A true IL300816A (en) 2023-04-01

Family

ID=80350587

Family Applications (1)

Application Number Title Priority Date Filing Date
IL300816A IL300816A (en) 2020-08-21 2021-08-20 Preparations and methods for neurological diseases

Country Status (11)

Country Link
US (1) US20240317834A1 (https=)
EP (1) EP4200020A4 (https=)
JP (1) JP2023538130A (https=)
KR (1) KR20230061409A (https=)
CN (1) CN116802201A (https=)
AU (1) AU2021329529A1 (https=)
BR (1) BR112023003167A2 (https=)
CA (1) CA3192604A1 (https=)
IL (1) IL300816A (https=)
MX (1) MX2023002161A (https=)
WO (1) WO2022040535A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117487904B (zh) * 2023-12-28 2024-05-31 湖南家辉生物技术有限公司 Gabrb3基因突变体、突变体蛋白、试剂、试剂盒及应用
CN119331917B (zh) * 2024-10-28 2025-10-17 北京爱思益普生物科技股份有限公司 能够表达GlyR α1/β型GlyR的细胞株及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL304040B2 (en) * 2016-07-07 2024-09-01 Hughes Howard Med Inst Modified ligand-gated ion channels and methods of use
US10538571B2 (en) * 2017-11-27 2020-01-21 Coda Biotherapeutics, Inc. Compositions and methods for neurological diseases
AU2020334147A1 (en) * 2019-08-21 2022-03-31 Trames Bio, Inc. Compositions and methods for neurological diseases

Also Published As

Publication number Publication date
WO2022040535A3 (en) 2022-03-31
EP4200020A2 (en) 2023-06-28
BR112023003167A2 (pt) 2023-05-02
US20240317834A1 (en) 2024-09-26
AU2021329529A9 (en) 2025-03-13
EP4200020A4 (en) 2024-11-20
MX2023002161A (es) 2023-05-18
CN116802201A (zh) 2023-09-22
JP2023538130A (ja) 2023-09-06
KR20230061409A (ko) 2023-05-08
WO2022040535A2 (en) 2022-02-24
AU2021329529A1 (en) 2023-04-27
CA3192604A1 (en) 2022-02-24

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