IL298192A - A modular and generalizable biosensor platform based on redesigned protein switches - Google Patents
A modular and generalizable biosensor platform based on redesigned protein switchesInfo
- Publication number
- IL298192A IL298192A IL298192A IL29819222A IL298192A IL 298192 A IL298192 A IL 298192A IL 298192 A IL298192 A IL 298192A IL 29819222 A IL29819222 A IL 29819222A IL 298192 A IL298192 A IL 298192A
- Authority
- IL
- Israel
- Prior art keywords
- amino acid
- seq
- acid sequence
- protein
- cage
- Prior art date
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Classifications
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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- G—PHYSICS
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- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5761—Hepatitis B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
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- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
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| US202063030836P | 2020-05-27 | 2020-05-27 | |
| US202063051549P | 2020-07-14 | 2020-07-14 | |
| US202063067643P | 2020-08-19 | 2020-08-19 | |
| PCT/US2021/034104 WO2021242780A2 (en) | 2020-05-27 | 2021-05-25 | Modular and generalizable biosensor platform based on de novo designed protein switches |
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| EP (1) | EP4157854A2 (https=) |
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| CN (1) | CN116368156A (https=) |
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| CA (1) | CA3178016A1 (https=) |
| IL (1) | IL298192A (https=) |
| MX (1) | MX2022014917A (https=) |
| WO (1) | WO2021242780A2 (https=) |
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| US20240309059A1 (en) * | 2021-07-07 | 2024-09-19 | National University Corporation Tokyo Medical And Dental University | Peptide having anti-viral activity, anti-viral agent comprising said peptide, and method for producing said anti-viral agent |
| TW202419461A (zh) * | 2022-11-01 | 2024-05-16 | 華盛頓大學 | 全新設計的螢光素酶 |
| WO2024102823A2 (en) * | 2022-11-09 | 2024-05-16 | The Regents Of The University Of California | Systems and methods for detecting and/or screening protein aggregation and/or disaggregation |
| IT202200025416A1 (it) * | 2022-12-13 | 2024-06-13 | Univ Pisa | Biosensore per la rilevazione di particelle virali |
| WO2025101453A1 (en) * | 2023-11-07 | 2025-05-15 | University Of Washington | De novo design of potent minibinder antagonists of il-6r, gp130, and il1-r1 |
| CN121049494B (zh) * | 2025-08-27 | 2026-02-27 | 南昌大学 | 用于检测伏马毒素B1的dlucCage生物传感器及其制备方法和应用 |
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| WO2019241438A2 (en) * | 2018-06-12 | 2019-12-19 | Promega Corporation | Multipartite luciferase |
| CA3106279A1 (en) | 2018-07-19 | 2020-01-23 | University Of Washington | De novo design of protein switches |
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Also Published As
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| JP2023527786A (ja) | 2023-06-30 |
| US20230279056A1 (en) | 2023-09-07 |
| CA3178016A1 (en) | 2021-12-02 |
| AU2021282172A1 (en) | 2022-12-15 |
| WO2021242780A3 (en) | 2022-02-17 |
| MX2022014917A (es) | 2023-02-22 |
| KR20230017215A (ko) | 2023-02-03 |
| EP4157854A2 (en) | 2023-04-05 |
| CN116368156A (zh) | 2023-06-30 |
| WO2021242780A2 (en) | 2021-12-02 |
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