IL297882A - Microscopy system and method using liquid - Google Patents
Microscopy system and method using liquidInfo
- Publication number
- IL297882A IL297882A IL297882A IL29788222A IL297882A IL 297882 A IL297882 A IL 297882A IL 297882 A IL297882 A IL 297882A IL 29788222 A IL29788222 A IL 29788222A IL 297882 A IL297882 A IL 297882A
- Authority
- IL
- Israel
- Prior art keywords
- liquid
- objective lens
- oil
- immersion objective
- liquid immersion
- Prior art date
Links
- 238000007654 immersion Methods 0.000 title claims description 142
- 239000007788 liquid Substances 0.000 title claims description 102
- 238000000034 method Methods 0.000 title claims description 60
- 238000000386 microscopy Methods 0.000 title claims description 33
- 239000003921 oil Substances 0.000 claims description 315
- 230000007246 mechanism Effects 0.000 claims description 22
- 238000012545 processing Methods 0.000 claims description 16
- 238000003860 storage Methods 0.000 claims description 8
- 238000003384 imaging method Methods 0.000 claims description 7
- 239000004215 Carbon black (E152) Substances 0.000 claims description 4
- 229930195733 hydrocarbon Natural products 0.000 claims description 4
- 150000002430 hydrocarbons Chemical class 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 67
- 230000003287 optical effect Effects 0.000 description 34
- 230000033001 locomotion Effects 0.000 description 22
- 230000008878 coupling Effects 0.000 description 19
- 238000010168 coupling process Methods 0.000 description 19
- 238000005859 coupling reaction Methods 0.000 description 19
- 230000008569 process Effects 0.000 description 18
- 238000005286 illumination Methods 0.000 description 16
- 239000012530 fluid Substances 0.000 description 15
- 239000012472 biological sample Substances 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 238000005303 weighing Methods 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 10
- 238000007373 indentation Methods 0.000 description 9
- 238000004891 communication Methods 0.000 description 8
- 230000008859 change Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000007850 fluorescent dye Substances 0.000 description 6
- 239000011888 foil Substances 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 5
- 230000007480 spreading Effects 0.000 description 5
- 238000003892 spreading Methods 0.000 description 5
- 230000007423 decrease Effects 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 230000005291 magnetic effect Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000002093 peripheral effect Effects 0.000 description 4
- 238000005476 soldering Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 230000005670 electromagnetic radiation Effects 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 230000005294 ferromagnetic effect Effects 0.000 description 3
- 230000000284 resting effect Effects 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003302 ferromagnetic material Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000002952 image-based readout Methods 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 102000034287 fluorescent proteins Human genes 0.000 description 1
- 108091006047 fluorescent proteins Proteins 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000003129 oil well Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/33—Immersion oils, or microscope systems or objectives for use with immersion fluids
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Microscoopes, Condenser (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163180694P | 2021-04-28 | 2021-04-28 | |
| US202163180693P | 2021-04-28 | 2021-04-28 | |
| PCT/IB2022/053972 WO2022229906A1 (fr) | 2021-04-28 | 2022-04-28 | Système et procédé de microscopie faisant appel à un liquide d'immersion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL297882A true IL297882A (en) | 2023-01-01 |
Family
ID=82115765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL297882A IL297882A (en) | 2021-04-28 | 2022-04-28 | Microscopy system and method using liquid |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP4330753A1 (fr) |
| JP (1) | JP2024516261A (fr) |
| CA (1) | CA3218518A1 (fr) |
| IL (1) | IL297882A (fr) |
| WO (1) | WO2022229906A1 (fr) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4328359B2 (ja) * | 2007-01-15 | 2009-09-09 | オリンパス株式会社 | 液浸対物レンズを備えた観察装置 |
-
2022
- 2022-04-28 IL IL297882A patent/IL297882A/en unknown
- 2022-04-28 WO PCT/IB2022/053972 patent/WO2022229906A1/fr active Application Filing
- 2022-04-28 CA CA3218518A patent/CA3218518A1/fr active Pending
- 2022-04-28 EP EP22731787.2A patent/EP4330753A1/fr active Pending
- 2022-04-28 JP JP2023566966A patent/JP2024516261A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4330753A1 (fr) | 2024-03-06 |
| JP2024516261A (ja) | 2024-04-12 |
| CA3218518A1 (fr) | 2022-11-03 |
| WO2022229906A1 (fr) | 2022-11-03 |
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