IL296693A - A method for treating neurological disorders using synaptic pathway training - Google Patents
A method for treating neurological disorders using synaptic pathway trainingInfo
- Publication number
- IL296693A IL296693A IL296693A IL29669322A IL296693A IL 296693 A IL296693 A IL 296693A IL 296693 A IL296693 A IL 296693A IL 29669322 A IL29669322 A IL 29669322A IL 296693 A IL296693 A IL 296693A
- Authority
- IL
- Israel
- Prior art keywords
- synaptic
- patient
- pathways
- pathway
- treatment
- Prior art date
Links
- 230000000946 synaptic effect Effects 0.000 title claims description 115
- 230000037361 pathway Effects 0.000 title claims description 96
- 238000000034 method Methods 0.000 title claims description 49
- 238000012549 training Methods 0.000 title claims description 32
- 238000011282 treatment Methods 0.000 title description 46
- 208000012902 Nervous system disease Diseases 0.000 title description 3
- 208000025966 Neurological disease Diseases 0.000 title description 3
- 239000002831 pharmacologic agent Substances 0.000 claims description 41
- 230000004936 stimulating effect Effects 0.000 claims description 32
- 210000004556 brain Anatomy 0.000 claims description 28
- 230000001149 cognitive effect Effects 0.000 claims description 22
- 208000007848 Alcoholism Diseases 0.000 claims description 21
- 230000003213 activating effect Effects 0.000 claims description 20
- 201000007930 alcohol dependence Diseases 0.000 claims description 19
- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 15
- 208000020925 Bipolar disease Diseases 0.000 claims description 13
- 230000000926 neurological effect Effects 0.000 claims description 10
- 230000001965 increasing effect Effects 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000003400 hallucinatory effect Effects 0.000 claims description 2
- 238000011457 non-pharmacological treatment Methods 0.000 claims 5
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 38
- 229960003299 ketamine Drugs 0.000 description 38
- 230000000638 stimulation Effects 0.000 description 29
- 230000000694 effects Effects 0.000 description 24
- 208000024891 symptom Diseases 0.000 description 24
- 229940079593 drug Drugs 0.000 description 15
- 239000003814 drug Substances 0.000 description 15
- 206010026749 Mania Diseases 0.000 description 12
- 238000001990 intravenous administration Methods 0.000 description 12
- 210000001320 hippocampus Anatomy 0.000 description 11
- 230000004913 activation Effects 0.000 description 9
- 238000002483 medication Methods 0.000 description 9
- 238000002560 therapeutic procedure Methods 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 238000009225 cognitive behavioral therapy Methods 0.000 description 8
- 238000002635 electroconvulsive therapy Methods 0.000 description 8
- 210000002569 neuron Anatomy 0.000 description 8
- 238000001802 infusion Methods 0.000 description 7
- 230000001537 neural effect Effects 0.000 description 7
- 230000000144 pharmacologic effect Effects 0.000 description 7
- 230000001953 sensory effect Effects 0.000 description 7
- 230000000971 hippocampal effect Effects 0.000 description 6
- 210000000225 synapse Anatomy 0.000 description 6
- 208000030886 Traumatic Brain injury Diseases 0.000 description 5
- 230000001476 alcoholic effect Effects 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000001430 anti-depressive effect Effects 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 238000011458 pharmacological treatment Methods 0.000 description 4
- 230000001242 postsynaptic effect Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 230000009529 traumatic brain injury Effects 0.000 description 4
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 3
- 230000003444 anaesthetic effect Effects 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 238000002651 drug therapy Methods 0.000 description 3
- 238000011221 initial treatment Methods 0.000 description 3
- 210000005215 presynaptic neuron Anatomy 0.000 description 3
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 206010010219 Compulsions Diseases 0.000 description 2
- 208000020401 Depressive disease Diseases 0.000 description 2
- 206010054089 Depressive symptom Diseases 0.000 description 2
- 206010013470 Dissociative states Diseases 0.000 description 2
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 2
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 2
- 229940099433 NMDA receptor antagonist Drugs 0.000 description 2
- QVDSEJDULKLHCG-UHFFFAOYSA-N Psilocybine Natural products C1=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CNC2=C1 QVDSEJDULKLHCG-UHFFFAOYSA-N 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 206010001584 alcohol abuse Diseases 0.000 description 2
- 208000025746 alcohol use disease Diseases 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 229940005513 antidepressants Drugs 0.000 description 2
- 235000013405 beer Nutrition 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 208000029028 brain injury Diseases 0.000 description 2
- 210000005013 brain tissue Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 208000024732 dysthymic disease Diseases 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 210000003715 limbic system Anatomy 0.000 description 2
- 230000004630 mental health Effects 0.000 description 2
- 230000036651 mood Effects 0.000 description 2
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 description 2
- 230000006611 pharmacological activation Effects 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 210000002442 prefrontal cortex Anatomy 0.000 description 2
- 230000003518 presynaptic effect Effects 0.000 description 2
- QKTAAWLCLHMUTJ-UHFFFAOYSA-N psilocybin Chemical group C1C=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CN=C21 QKTAAWLCLHMUTJ-UHFFFAOYSA-N 0.000 description 2
- 229940044551 receptor antagonist Drugs 0.000 description 2
- 239000002464 receptor antagonist Substances 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 2
- 229960002646 scopolamine Drugs 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010002942 Apathy Diseases 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 1
- PAFZNILMFXTMIY-UHFFFAOYSA-N Cyclohexylamine Natural products NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 1
- 206010013886 Dysaesthesia Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 206010016374 Feelings of worthlessness Diseases 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- ALFGKMXHOUSVAD-UHFFFAOYSA-N Ketobemidone Chemical compound C=1C=CC(O)=CC=1C1(C(=O)CC)CCN(C)CC1 ALFGKMXHOUSVAD-UHFFFAOYSA-N 0.000 description 1
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 description 1
- VAYOSLLFUXYJDT-RDTXWAMCSA-N Lysergic acid diethylamide Chemical group C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N(CC)CC)C2)=C3C2=CNC3=C1 VAYOSLLFUXYJDT-RDTXWAMCSA-N 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- 229940121743 Muscarinic receptor agonist Drugs 0.000 description 1
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 description 1
- 102000003840 Opioid Receptors Human genes 0.000 description 1
- 108090000137 Opioid Receptors Proteins 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
- 229960003805 amantadine Drugs 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- -1 aryl cyclohexylamine Chemical compound 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000003376 axonal effect Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229940088623 biologically active substance Drugs 0.000 description 1
- 208000028683 bipolar I disease Diseases 0.000 description 1
- 208000025307 bipolar depression Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000006931 brain damage Effects 0.000 description 1
- 231100000874 brain damage Toxicity 0.000 description 1
- 230000010336 brain pathway Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 208000022371 chronic pain syndrome Diseases 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 238000013170 computed tomography imaging Methods 0.000 description 1
- 210000001787 dendrite Anatomy 0.000 description 1
- 230000002999 depolarising effect Effects 0.000 description 1
- 230000003001 depressive effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 229960001985 dextromethorphan Drugs 0.000 description 1
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 description 1
- 229960004193 dextropropoxyphene Drugs 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 201000003104 endogenous depression Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000009093 first-line therapy Methods 0.000 description 1
- 238000002599 functional magnetic resonance imaging Methods 0.000 description 1
- 210000000609 ganglia Anatomy 0.000 description 1
- 239000000380 hallucinogen Substances 0.000 description 1
- 208000022119 inability to concentrate Diseases 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 229960003029 ketobemidone Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000012153 long-term therapy Methods 0.000 description 1
- 229950002454 lysergide Drugs 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 208000024714 major depressive disease Diseases 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 description 1
- 230000028161 membrane depolarization Effects 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000472 muscarinic agonist Substances 0.000 description 1
- 229940033872 namenda Drugs 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 238000002610 neuroimaging Methods 0.000 description 1
- 230000008284 neuronal mechanism Effects 0.000 description 1
- 208000021722 neuropathic pain Diseases 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical group C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 1
- 229950010883 phencyclidine Drugs 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001337 psychedelic effect Effects 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 239000003196 psychodysleptic agent Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 239000000952 serotonin receptor agonist Substances 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 230000000192 social effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 201000009032 substance abuse Diseases 0.000 description 1
- 231100000736 substance abuse Toxicity 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 235000013522 vodka Nutrition 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Developmental Disabilities (AREA)
- Hospice & Palliative Care (AREA)
- Social Psychology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/827,546 US20200222656A1 (en) | 2016-10-18 | 2020-03-23 | Method for treatment of depression using synaptic pathway training |
PCT/US2021/022517 WO2021194796A1 (fr) | 2020-03-23 | 2021-03-16 | Méthode de traitement de troubles neurologiques à l'aide d'un entraînement de voie synaptique |
Publications (1)
Publication Number | Publication Date |
---|---|
IL296693A true IL296693A (en) | 2022-11-01 |
Family
ID=77890584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL296693A IL296693A (en) | 2020-03-23 | 2021-03-16 | A method for treating neurological disorders using synaptic pathway training |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP4126199A4 (fr) |
BR (1) | BR112022019234A2 (fr) |
CA (1) | CA3172981A1 (fr) |
IL (1) | IL296693A (fr) |
MX (1) | MX2022011862A (fr) |
WO (1) | WO2021194796A1 (fr) |
ZA (1) | ZA202210356B (fr) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9064036B2 (en) * | 2008-04-24 | 2015-06-23 | The Invention Science Fund I, Llc | Methods and systems for monitoring bioactive agent use |
WO2016004396A1 (fr) * | 2014-07-02 | 2016-01-07 | Christopher Decharms | Technologies pour entraînement d'exercice cérébral |
WO2016061320A2 (fr) * | 2014-10-15 | 2016-04-21 | Rowan University | Thérapie timber pour le trouble du stress post-traumatique |
CA3020681A1 (fr) * | 2016-04-11 | 2017-10-19 | Clexio Biosciences Ltd. | Derives de ketamine deuteres |
US20200222656A1 (en) * | 2016-10-18 | 2020-07-16 | Joseph Rustick | Method for treatment of depression using synaptic pathway training |
US10596378B2 (en) * | 2016-10-18 | 2020-03-24 | Joseph Rustick | Method for treatment of depression using synaptic pathway training |
CA3099293A1 (fr) * | 2018-05-04 | 2019-11-07 | Perception Neuroscience, Inc. | Methodes de traitement de la toxicomanie |
-
2021
- 2021-03-16 IL IL296693A patent/IL296693A/en unknown
- 2021-03-16 CA CA3172981A patent/CA3172981A1/fr active Pending
- 2021-03-16 EP EP21776197.2A patent/EP4126199A4/fr active Pending
- 2021-03-16 WO PCT/US2021/022517 patent/WO2021194796A1/fr unknown
- 2021-03-16 MX MX2022011862A patent/MX2022011862A/es unknown
- 2021-03-16 BR BR112022019234A patent/BR112022019234A2/pt unknown
-
2022
- 2022-09-19 ZA ZA2022/10356A patent/ZA202210356B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP4126199A1 (fr) | 2023-02-08 |
WO2021194796A1 (fr) | 2021-09-30 |
CA3172981A1 (fr) | 2021-09-30 |
ZA202210356B (en) | 2023-02-22 |
EP4126199A4 (fr) | 2024-04-10 |
BR112022019234A2 (pt) | 2022-11-08 |
MX2022011862A (es) | 2023-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20230347101A1 (en) | Method for treatment of depression using synaptic pathway training | |
US10596378B2 (en) | Method for treatment of depression using synaptic pathway training | |
US10716950B2 (en) | Treatment of thalamocortical dysrhythmia | |
Nichols et al. | The history of psychedelics in psychiatry | |
WO2000056301A2 (fr) | Traitement de l'etat de stress post-traumatique, de troubles obsessifs compulsifs et de troubles neuropsychiatriques associes | |
O’Leary et al. | Self-efficacy and the physiological stress response | |
Jalal et al. | “Fake it till You Make it”! Contaminating Rubber Hands (“Multisensory Stimulation Therapy”) to Treat Obsessive-Compulsive Disorder | |
Matias et al. | “Rescue” of bilateral subthalamic stimulation by bilateral pallidal stimulation: case report | |
IL296693A (en) | A method for treating neurological disorders using synaptic pathway training | |
RU2665629C1 (ru) | Способ лечения алкоголизма | |
CN117396200A (zh) | 辅助性d-环丝氨酸对重度抑郁症的经颅磁刺激(tms)治疗的增效作用 | |
WO2014158059A1 (fr) | Procédé de traitement d'une dépendance | |
Sukhomlinova et al. | Physiology of pain | |
Iengo | Brief Strategic Therapy in Panic Disorder Treatment | |
Kang et al. | Effect of rTMS on fractional anisotropy, radial diffusivity, and axonal volume in select fiber tracts in patients with traumatic brain injury | |
Liegl | Potential benefits and withdrawal effects of Cranial Nerve Non-Invasive Neuromodulation on functional mobility for individuals with traumatic brain injury | |
Sridhar et al. | Impact of Physical therapy on post traumatic stress disorder among post COVID-19 geriatric survivors-a Pilot study | |
Showen et al. | 360 Efficacy of CBT-I and its Components on Health-Related Quality of Life Outcomes in Older Adults | |
Murata | The effect of transcranial direct current stimulation combined with conventional care on gait parameters in individuals with Parkinson's disease: A meta-analysis | |
Meron | Novel treatment approaches for anxiety disorders: Mindfulness-based approaches and Transcranial Direct Current Stimulation | |
Clark et al. | Transcranial Magnetic Stimulation Treatment of Posttraumatic Stress Disorder | |
RU2392910C1 (ru) | Способ лечения хронического офтальмальгического синдрома | |
Krug | Deep brain stimulation and enhancement | |
Arnsten et al. | Pharmacological strategies for neuroprotection and rehabilitation | |
Hamidian et al. | Cognitive Therapy with Pharmacotherapy on Depression and Emotion Regulation of Patients with Dysthymia: A Clinical Study |