IL289423B2 - Compounds and methods for treating neurological and cardiovascular conditions - Google Patents

Compounds and methods for treating neurological and cardiovascular conditions

Info

Publication number
IL289423B2
IL289423B2 IL289423A IL28942321A IL289423B2 IL 289423 B2 IL289423 B2 IL 289423B2 IL 289423 A IL289423 A IL 289423A IL 28942321 A IL28942321 A IL 28942321A IL 289423 B2 IL289423 B2 IL 289423B2
Authority
IL
Israel
Prior art keywords
compounds
methods
treating neurological
cardiovascular conditions
cardiovascular
Prior art date
Application number
IL289423A
Other languages
English (en)
Hebrew (he)
Other versions
IL289423B1 (en
IL289423A (en
Original Assignee
Univ Texas
Us Health
Astrocyte Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Us Health, Astrocyte Pharmaceuticals Inc filed Critical Univ Texas
Publication of IL289423A publication Critical patent/IL289423A/en
Publication of IL289423B1 publication Critical patent/IL289423B1/en
Publication of IL289423B2 publication Critical patent/IL289423B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL289423A 2016-04-21 2017-04-21 Compounds and methods for treating neurological and cardiovascular conditions IL289423B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662325860P 2016-04-21 2016-04-21
PCT/US2017/028996 WO2017185061A1 (en) 2016-04-21 2017-04-21 Compounds and methods for treating neurological and cardiovascular conditions

Publications (3)

Publication Number Publication Date
IL289423A IL289423A (en) 2022-02-01
IL289423B1 IL289423B1 (en) 2025-11-01
IL289423B2 true IL289423B2 (en) 2026-03-01

Family

ID=60022855

Family Applications (2)

Application Number Title Priority Date Filing Date
IL289423A IL289423B2 (en) 2016-04-21 2017-04-21 Compounds and methods for treating neurological and cardiovascular conditions
IL262487A IL262487B (en) 2016-04-21 2018-10-21 Compounds and methods for treating neurological and cardiovascular conditions

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL262487A IL262487B (en) 2016-04-21 2018-10-21 Compounds and methods for treating neurological and cardiovascular conditions

Country Status (12)

Country Link
US (7) US12239654B2 (enExample)
EP (2) EP3445368B1 (enExample)
JP (3) JP7109005B2 (enExample)
KR (2) KR20220132042A (enExample)
CN (2) CN109310695B (enExample)
AU (2) AU2017254720B2 (enExample)
CA (1) CA3020490A1 (enExample)
EA (1) EA201892008A1 (enExample)
ES (1) ES2989621T3 (enExample)
IL (2) IL289423B2 (enExample)
MX (1) MX391725B (enExample)
WO (1) WO2017185061A1 (enExample)

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UA120628C2 (uk) 2014-11-07 2020-01-10 Басф Се Пестицидні суміші
US11241012B2 (en) 2016-03-16 2022-02-08 Basf Se Use of tetrazolinones for combating resistant phytopathogenic fungi on soybean
CA3015456C (en) 2016-03-16 2024-09-17 Basf Se USE OF TETRAZOLINONES TO CONTROL RESISTANT PLANT PATHOGENIC FUNGI ON FRUIT
ES3056157T3 (en) 2016-03-16 2026-02-18 Basf Se Use of a specific tetrazolinone for combating resistant phytopathogenic fungi on cereals
EP3445368B1 (en) 2016-04-21 2024-07-17 Astrocyte Pharmaceuticals, Inc. Compounds and methods for treating neurological and cardiovascular conditions
CN112218638A (zh) * 2018-02-09 2021-01-12 阿斯特罗赛特制药公司 用于治疗成瘾和相关病症的化合物和方法
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KR20240122782A (ko) * 2021-11-22 2024-08-13 아스트로사이트 파마슈티컬스, 인코포레이티드 신경학적 및 심혈관 상태를 치료하는 방법
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WO2024097387A1 (en) * 2022-11-03 2024-05-10 Astrocyte Pharmaceuticals, Inc. Compositions for intravenous administration
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Also Published As

Publication number Publication date
JP7109005B2 (ja) 2022-07-29
KR20190006501A (ko) 2019-01-18
EP4414027A2 (en) 2024-08-14
US20220000899A1 (en) 2022-01-06
IL289423B1 (en) 2025-11-01
IL262487B (en) 2022-02-01
MX2018012655A (es) 2019-09-06
EP3445368A4 (en) 2019-12-18
ES2989621T3 (es) 2024-11-27
AU2017254720A1 (en) 2018-11-01
BR112018071560A2 (pt) 2019-02-12
WO2017185061A1 (en) 2017-10-26
MX391725B (es) 2025-03-21
KR20220132042A (ko) 2022-09-29
IL289423A (en) 2022-02-01
US20180021363A1 (en) 2018-01-25
JP2022088642A (ja) 2022-06-14
US20250345353A1 (en) 2025-11-13
US10953031B2 (en) 2021-03-23
AU2023202694B2 (en) 2025-07-10
EP4414027A3 (en) 2024-11-13
US12239654B2 (en) 2025-03-04
EP3445368B1 (en) 2024-07-17
JP2025084908A (ja) 2025-06-03
EP3445368A1 (en) 2019-02-27
AU2017254720B2 (en) 2023-02-02
CN109310695B (zh) 2022-04-01
JP7709141B2 (ja) 2025-07-16
EP3445368C0 (en) 2024-07-17
US20200046751A1 (en) 2020-02-13
US11484545B2 (en) 2022-11-01
CN109310695A (zh) 2019-02-05
CA3020490A1 (en) 2017-10-26
CN114903903A (zh) 2022-08-16
US20230165887A1 (en) 2023-06-01
NZ747047A (en) 2025-02-28
US10265338B2 (en) 2019-04-23
IL262487A (en) 2018-12-31
KR102445887B1 (ko) 2022-09-21
JP2019515920A (ja) 2019-06-13
US20220305044A1 (en) 2022-09-29
US12390483B2 (en) 2025-08-19
EA201892008A1 (ru) 2019-06-28
US9789131B1 (en) 2017-10-17
AU2023202694A1 (en) 2023-05-18

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