ES2989621T3 - Compuestos y métodos para el tratamiento de afecciones neurológicas y cardiovasculares - Google Patents

Compuestos y métodos para el tratamiento de afecciones neurológicas y cardiovasculares Download PDF

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Publication number
ES2989621T3
ES2989621T3 ES17786774T ES17786774T ES2989621T3 ES 2989621 T3 ES2989621 T3 ES 2989621T3 ES 17786774 T ES17786774 T ES 17786774T ES 17786774 T ES17786774 T ES 17786774T ES 2989621 T3 ES2989621 T3 ES 2989621T3
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Spain
Prior art keywords
agonist
disease
brain
mrs4322
injury
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Active
Application number
ES17786774T
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English (en)
Spanish (es)
Inventor
William S Korinek
James D Lechleiter
Theodore E Liston
Kenneth A Jacobson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Astrocyte Pharmaceuticals Inc
US Department of Health and Human Services
Original Assignee
University of Texas System
University of Texas at Austin
Astrocyte Pharmaceuticals Inc
US Department of Health and Human Services
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES17786774T 2016-04-21 2017-04-21 Compuestos y métodos para el tratamiento de afecciones neurológicas y cardiovasculares Active ES2989621T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662325860P 2016-04-21 2016-04-21
PCT/US2017/028996 WO2017185061A1 (en) 2016-04-21 2017-04-21 Compounds and methods for treating neurological and cardiovascular conditions

Publications (1)

Publication Number Publication Date
ES2989621T3 true ES2989621T3 (es) 2024-11-27

Family

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Family Applications (1)

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ES17786774T Active ES2989621T3 (es) 2016-04-21 2017-04-21 Compuestos y métodos para el tratamiento de afecciones neurológicas y cardiovasculares

Country Status (12)

Country Link
US (7) US12239654B2 (enExample)
EP (2) EP3445368B1 (enExample)
JP (3) JP7109005B2 (enExample)
KR (2) KR20220132042A (enExample)
CN (2) CN109310695B (enExample)
AU (2) AU2017254720B2 (enExample)
CA (1) CA3020490A1 (enExample)
EA (1) EA201892008A1 (enExample)
ES (1) ES2989621T3 (enExample)
IL (2) IL289423B2 (enExample)
MX (1) MX391725B (enExample)
WO (1) WO2017185061A1 (enExample)

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CA3015456C (en) 2016-03-16 2024-09-17 Basf Se USE OF TETRAZOLINONES TO CONTROL RESISTANT PLANT PATHOGENIC FUNGI ON FRUIT
ES3056157T3 (en) 2016-03-16 2026-02-18 Basf Se Use of a specific tetrazolinone for combating resistant phytopathogenic fungi on cereals
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JP7109005B2 (ja) 2022-07-29
KR20190006501A (ko) 2019-01-18
EP4414027A2 (en) 2024-08-14
US20220000899A1 (en) 2022-01-06
IL289423B1 (en) 2025-11-01
IL262487B (en) 2022-02-01
MX2018012655A (es) 2019-09-06
EP3445368A4 (en) 2019-12-18
IL289423B2 (en) 2026-03-01
AU2017254720A1 (en) 2018-11-01
BR112018071560A2 (pt) 2019-02-12
WO2017185061A1 (en) 2017-10-26
MX391725B (es) 2025-03-21
KR20220132042A (ko) 2022-09-29
IL289423A (en) 2022-02-01
US20180021363A1 (en) 2018-01-25
JP2022088642A (ja) 2022-06-14
US20250345353A1 (en) 2025-11-13
US10953031B2 (en) 2021-03-23
AU2023202694B2 (en) 2025-07-10
EP4414027A3 (en) 2024-11-13
US12239654B2 (en) 2025-03-04
EP3445368B1 (en) 2024-07-17
JP2025084908A (ja) 2025-06-03
EP3445368A1 (en) 2019-02-27
AU2017254720B2 (en) 2023-02-02
CN109310695B (zh) 2022-04-01
JP7709141B2 (ja) 2025-07-16
EP3445368C0 (en) 2024-07-17
US20200046751A1 (en) 2020-02-13
US11484545B2 (en) 2022-11-01
CN109310695A (zh) 2019-02-05
CA3020490A1 (en) 2017-10-26
CN114903903A (zh) 2022-08-16
US20230165887A1 (en) 2023-06-01
NZ747047A (en) 2025-02-28
US10265338B2 (en) 2019-04-23
IL262487A (en) 2018-12-31
KR102445887B1 (ko) 2022-09-21
JP2019515920A (ja) 2019-06-13
US20220305044A1 (en) 2022-09-29
US12390483B2 (en) 2025-08-19
EA201892008A1 (ru) 2019-06-28
US9789131B1 (en) 2017-10-17
AU2023202694A1 (en) 2023-05-18

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