IL28926A - Process for the manufacture of 5-phenyl-1h-1,4-benzodiazepines and novel benzodiazepine-3-carbonitrile derivatives - Google Patents
Process for the manufacture of 5-phenyl-1h-1,4-benzodiazepines and novel benzodiazepine-3-carbonitrile derivativesInfo
- Publication number
- IL28926A IL28926A IL28926A IL2892667A IL28926A IL 28926 A IL28926 A IL 28926A IL 28926 A IL28926 A IL 28926A IL 2892667 A IL2892667 A IL 2892667A IL 28926 A IL28926 A IL 28926A
- Authority
- IL
- Israel
- Prior art keywords
- benzodiazepine
- phenyl
- general formula
- chloro
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 16
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- NMDQXMUDOUHGFB-UHFFFAOYSA-N 1h-1,2-benzodiazepine-3-carbonitrile Chemical class C1=CC(C#N)=NNC2=CC=CC=C21 NMDQXMUDOUHGFB-UHFFFAOYSA-N 0.000 title description 2
- YNHGHPCGMBEGEU-UHFFFAOYSA-N 5-phenyl-1h-1,4-benzodiazepine Chemical class C12=CC=CC=C2NC=CN=C1C1=CC=CC=C1 YNHGHPCGMBEGEU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 12
- 229940049706 benzodiazepine Drugs 0.000 claims description 10
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 239000003513 alkali Substances 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
- 230000001131 transforming effect Effects 0.000 claims description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 4
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 150000001557 benzodiazepines Chemical class 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000000543 intermediate Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Natural products N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- IEGKHNXXLDCDTE-UHFFFAOYSA-N 1,2-benzodiazepin-2-amine Chemical class NN1C=CC=C2C=CC=CC2=N1 IEGKHNXXLDCDTE-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- -1 alkali metal cyanide Chemical class 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 description 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Natural products C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 description 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 1
- SLYYPFDRASAEIX-UHFFFAOYSA-N [N+]=1(NC=CC=C2C=1C=CC=C2)[O-] Chemical class [N+]=1(NC=CC=C2C=1C=CC=C2)[O-] SLYYPFDRASAEIX-UHFFFAOYSA-N 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 230000002152 alkylating effect Effects 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 description 1
- 229960004782 chlordiazepoxide Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60183866A | 1966-12-15 | 1966-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL28926A true IL28926A (en) | 1971-10-20 |
Family
ID=24408968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL28926A IL28926A (en) | 1966-12-15 | 1967-11-13 | Process for the manufacture of 5-phenyl-1h-1,4-benzodiazepines and novel benzodiazepine-3-carbonitrile derivatives |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3492290A (sv) |
| BE (1) | BE707846A (sv) |
| CH (1) | CH491938A (sv) |
| DE (1) | DE1695213A1 (sv) |
| DK (2) | DK122080B (sv) |
| ES (1) | ES348275A1 (sv) |
| FI (1) | FI48191C (sv) |
| FR (1) | FR1549718A (sv) |
| GB (1) | GB1153809A (sv) |
| GR (1) | GR37783B (sv) |
| IL (1) | IL28926A (sv) |
| MY (1) | MY7000056A (sv) |
| NL (1) | NL6716112A (sv) |
| SE (2) | SE356517B (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4244868A (en) * | 1979-05-29 | 1981-01-13 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
| US4244867A (en) * | 1980-02-21 | 1981-01-13 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2893992A (en) * | 1959-07-07 | I ii i i |
-
1966
- 1966-12-15 US US601838A patent/US3492290A/en not_active Expired - Lifetime
-
1967
- 1967-11-10 CH CH1575067A patent/CH491938A/de not_active IP Right Cessation
- 1967-11-13 IL IL28926A patent/IL28926A/en unknown
- 1967-11-14 DE DE19671695213 patent/DE1695213A1/de active Pending
- 1967-11-27 NL NL6716112A patent/NL6716112A/xx unknown
- 1967-12-05 GB GB55297/67A patent/GB1153809A/en not_active Expired
- 1967-12-12 DK DK621967AA patent/DK122080B/da unknown
- 1967-12-12 BE BE707846D patent/BE707846A/xx unknown
- 1967-12-12 FI FI673312A patent/FI48191C/sv active
- 1967-12-13 SE SE13671/70A patent/SE356517B/xx unknown
- 1967-12-13 SE SE17113/67A patent/SE335735B/xx unknown
- 1967-12-14 FR FR1549718D patent/FR1549718A/fr not_active Expired
- 1967-12-14 GR GR670137783A patent/GR37783B/el unknown
- 1967-12-14 ES ES348275A patent/ES348275A1/es not_active Expired
-
1969
- 1969-08-15 DK DK439769AA patent/DK125093B/da unknown
-
1970
- 1970-12-31 MY MY197056A patent/MY7000056A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1153809A (en) | 1969-05-29 |
| US3492290A (en) | 1970-01-27 |
| FI48191B (sv) | 1974-04-01 |
| CH491938A (de) | 1970-06-15 |
| NL6716112A (sv) | 1968-06-17 |
| DK125093B (da) | 1972-12-27 |
| FR1549718A (sv) | 1968-12-13 |
| GR37783B (el) | 1969-07-14 |
| SE335735B (sv) | 1971-06-07 |
| MY7000056A (en) | 1970-12-31 |
| FI48191C (sv) | 1974-07-10 |
| SE356517B (sv) | 1973-05-28 |
| DK122080B (da) | 1972-01-17 |
| BE707846A (sv) | 1968-06-12 |
| DE1695213A1 (de) | 1972-01-27 |
| ES348275A1 (es) | 1969-03-01 |
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