IL28896A - Disinfectant composition comprising formaldehyde benzalkonium or benzethonium halide and a cresol derrivative - Google Patents
Disinfectant composition comprising formaldehyde benzalkonium or benzethonium halide and a cresol derrivativeInfo
- Publication number
- IL28896A IL28896A IL2889667A IL2889667A IL28896A IL 28896 A IL28896 A IL 28896A IL 2889667 A IL2889667 A IL 2889667A IL 2889667 A IL2889667 A IL 2889667A IL 28896 A IL28896 A IL 28896A
- Authority
- IL
- Israel
- Prior art keywords
- composition
- benzalkonium
- ingredients
- parts
- formaldehyde
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 39
- 239000000645 desinfectant Substances 0.000 title claims description 23
- -1 benzethonium halide Chemical class 0.000 title claims description 14
- 229960001716 benzalkonium Drugs 0.000 title claims description 7
- 229960003872 benzethonium Drugs 0.000 title claims description 6
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 title claims description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 title description 28
- 229930003836 cresol Natural products 0.000 title description 6
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 title description 5
- 239000004615 ingredient Substances 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 239000001488 sodium phosphate Substances 0.000 claims description 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 3
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 3
- 235000019801 trisodium phosphate Nutrition 0.000 claims description 3
- 239000004215 Carbon black (E152) Substances 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 229930195733 hydrocarbon Natural products 0.000 claims description 2
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 2
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 claims description 2
- 229910000342 sodium bisulfate Inorganic materials 0.000 claims description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 2
- 150000002894 organic compounds Chemical class 0.000 claims 1
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 11
- 230000000249 desinfective effect Effects 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 230000002401 inhibitory effect Effects 0.000 description 7
- 231100000518 lethal Toxicity 0.000 description 7
- 230000001665 lethal effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 229960000686 benzalkonium chloride Drugs 0.000 description 6
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 239000012265 solid product Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 244000144977 poultry Species 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 239000012263 liquid product Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 229930040373 Paraformaldehyde Natural products 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229920002866 paraformaldehyde Polymers 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 241001225321 Aspergillus fumigatus Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 2
- 229940091771 aspergillus fumigatus Drugs 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 210000003250 oocyst Anatomy 0.000 description 2
- 150000003242 quaternary ammonium salts Chemical group 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 241000204725 Ascaridia galli Species 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 241000711404 Avian avulavirus 1 Species 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 241000589562 Brucella Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000186810 Erysipelothrix rhusiopathiae Species 0.000 description 1
- 208000000666 Fowlpox Diseases 0.000 description 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 description 1
- 241000606860 Pasteurella Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- RBSBTRALZZSVBA-FXBHKIKWSA-N Solamin Natural products O=C1C(CCCCCCCCCCCC[C@@H](O)[C@@H]2O[C@H]([C@H](O)CCCCCCCCCCCC)CC2)=C[C@H](C)O1 RBSBTRALZZSVBA-FXBHKIKWSA-N 0.000 description 1
- QUMHDXJIDPCZCB-UHFFFAOYSA-N Solamine Natural products CN(C)CCCCNCCCCN(C)C QUMHDXJIDPCZCB-UHFFFAOYSA-N 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 125000006182 dimethyl benzyl group Chemical group 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 201000009837 laryngotracheitis Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
PA T B B I S L AW S P E C I F I C A T I OM DISINFECTANT COMPOSITION COMPRISING FORMALDEHYDE BENZAL O IUH OR BEN2ETH0NI0M HALIDE AND A CRESOL DERRIVATIVE This invention relates to e disinfectant composition having particular utility and value when used in poultry and animal husbandry, but also having broader applications as well.
The use of disinfectants in poultry and animal husbandry is virtually essential for carrying on profitable operations. In this industry there are several important yardsticks by which the value of any particular disinfectant is generally assessed. One of these is the range of virulent microorganisms against which the disinfectant is effective. This is important because the greater the range of effectiveness, the more versatile and reliable is the disinfectant for destroying the multitude of harmful microorganism species which are commonly encountered in poultry and animal husbandry. Another important consideration is the capability of the disinfectant to remain effective as its use level concentration is decreased. This is largely an economic consideration but nevertheless highly important, since the less of the disinfectant that can be effectively used, the lower will be the cost of carrying out the disinfecting process.
The present invention provides a new disinfectant composition which ha8 unprecedented value in poultry and animal husbandry hen measured by the yardsticks described above. First of all, the composition has an exceptionally broad range of effectiveness against many different species of virulent microorganisms, including bacteria, fungi, viruses, worm eggs and coccidial oocysts. More specifically, the disinfectant composition of the invention has been demonstrated to effectively destroy Salmonella group, Pasteurella group, Brucella group, Staphylococci, Streptococci, Erysipelothrix rhusiopathiae, oocysts, Ascaridia galli eggs, Newcastle disease virus, Infectious bronchitis, Fowl pox, Laryngotracheitis, Avian encephalitis and Leukosis. Thus, the versatility of the new disinfectant composition is very great, whereby the composition may be used as a single substitute for two or more conventional disinfectants that have been heretofore necessary to combat more than one of the above-specified microorganisms . ■ In addition to its broad range of effectiveness, the new disinfectant composition has greater destructive power than does any one of its components or the sum of the separate effects of its components. In other words, the components of the composition interact synergistically, in some unexplainable manner, to give a disinfecting effec beyond what would be expected by measuring the separate effect of each component and adding the results up. This attribute of the composition has been demonstrated by laboratory testi with several of the microorganism species named above and was entirely surprising and unexpected. Furthermore, the synergis ically superior disinfecting capability of the composition means that it may be effectively used at very high dilutions, or conversely low levels of concentration, to provide substantial cost-of-material savings to the user. This advantage combined with its versatility makes the composition extremely valuable as an all-around, general purpose disinfectant for use in poultry and animal husbandry. However, the composition may also be used to advantage in other applications, such as in hospitals, kitchens, comfort stations, laboratories, and other locations which have hygienic requirements. disinfectant composition of the quaternary ammonium salt which may be a benzalkonium or benzethonium halide, a cresol or an aliphatic hydrocarbon derivative thereof and formaldehyde. As to the first ingredient, benzalkonium and benzethonium halides comprise quaternary ammonium halide salts of substituted dimethyl benzyl amines. Benzalkonium halide is alky.ydimethyf^benzyl ammonium halide in which the alkyl group varies from eight to eighteen carbon atoms, and benzethonium halide is diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium halide. Both of these materials are available commercially, usually as the chloride, under various tradenames such as Zephirol, BTC, Roccal, Fhemeride, Quatrachlor, Solamine and others. Any of these commercially available benzalkonium or benzethonium chloride salts, as well as the bromide and iodide salts, may be used as one of the essential ingredients of the disinfectant composition of the invention.
As to the second ingredient of the composition, this may be a cresol or an aliphatic hydrocarbon derivative thereof having from one to seven carbon atoms. Thus, the second ingredient of the composition is defined by in which R is hydrogen atom or a branched or straight chain aliphatic hydrocarbon radical having from one to seven carbon atoms. Of the various compounds defined by the above formula, best results.have been achieved with 2-isopropyl-5-methyl-phenol in combination with benzalkonium halide and para-eresol in combination with benzethonium halide. Accordingly, the use of these particular compounds is recommended for the maximum benefits i terms of range and power Αβ to the third ingredient of the composition, which is formaldehyde, this may be used in the form of the commercially available aqueous solutions (Formalin) or in the solid form, paraformaldehyde, depending on whether the composition is made as a liquid or solid product.
In preparing the novel disinfecting composition of the invention, the best results have been achieved when the three essential ingredients are controlled within the relative proportions expressed in parts by weight of about 1 to about 20 parts of the quaternary ammonium salt, about 1 to about 20 parts of the cresol or hydrocarbon derivative thereof and about 10 to about 150 parts of formaldehyde. In particular, the synergistic quality of the disinfectant composition will invariably be achieved when the proportions of the three essential ingredients are maintained within the stated ranges. Therefore, for best results, it is again recommended that the composition be made according to these relative proportions.
Where the composition is to be made as a liquid product, the three essential ingredients may be conveniently dissolved in water or in water with admixed low molecular weight alcohols such as methanol and ethanol. It is also convenient to make the liquid product in the form of a concentrated solution in which the total amount of the three essential ingredients constitutes from about 6% to about 50% of the weight of the solution. This concentrated solution may be packaged and shipped at relatively low cost and then diluted by the addition of water by the user to whatever lower concentration is necessary to carry out the desired disinfecting process.
The disinfecting composition may also be made in the form of a compounds which are solid at ambient temperature, e.g., para-cresol. In preparing a solid product it is highly desirable to include inorganic salts which will help to solubilize the paraformaldehyde and solid cresol compound when the solid product is combined with water for actual use. In this connection, excellent results have been achieved with trisodium phosphate as an added inorganic salt which assists solubilization. However, other salts may also be used including mono and dihydrogen sodium phosphates, sodium bisulfate, sodium bicarbonate, sodium carbonate and sodium pyrophosphate.
In preparing a solid product, the total amount of the three essential ingredients may constitute from about 6% to about 65% of the weight of the total product, the balance being one or more of the inorganic salts mentioned above. The solid product may be dissolved in water or water plus the previously-mentioned organic alcohols at whatever concentration is necessary for carrying out the desired disinfecting process. In both the liquid and solid product, the relative proportions of the three essential ingredients should be controlled for best results within the ranges previously specified, in both the prepared form and in the diluted form of actual use. Of course, if the prepared product is controlled within the specified relative proportions, then those same proportions will be maintained no matter how much the prepared product is diluted for actual use.
Further details of the invention will be readily understood in connection with the following examples which constitute specific embodiments thereof and in which all proportions are expressed on he basis of wei ht nless otherwise indicated proportions of 2 parts benzalkonium chloride, 2.5 parts of 2-isopropyl 5-methyl-phenol and 25 parts of formaldehyde. The composition was dissolved in a mixture of water, methanol and ethanol so as to give a concentrated solution which when diluted with water in the ratio of 1:100 gave a solution having 200 ppm of the benzalkonium chloride, 250 ppm of the 2-isopropyl-5-methyl-phenol and 2500 ppm of the formaldehyde. The efficacy of the composition at this dilution level and at further dilutions in the ratios of 1:1000, 1:2000, 1:4000, 1:8000 and 1:16000, to inhibit the growth of and to kill Staphylococcus aureus was measured according to the standard laboratory test described by Kolmer and Boerner in Approved Laboratory Technic, Fourth Edition, published by D. Appleton-Century Company, Incorporated.
Likewise, each of the separate components of the composition, at the same dilutions and by the same test, was separately tested to measure the efficacy of each component alone to arrest the growth of and to kill the same specie of bacteria.
The results of these tests are given in the table below, the column labeled Inhibitory giving the maximum dilution at which the material under test could arrest the growth of the bacteria and the column labeled Lethal giving the maximum dilution at which the material under test could kill the bacteria.
Staphylococcus aureus Material Tested Inhibitory Lethal Benzalkonium chloride alone 1:2000 1:1000 2-isopropyl-5-methyl-phenol alone 1:100 1:100 Formaldehyde alone 1:4000 1:4000 1 16000 As will be noted from the foregoing results, the combination of the three essential ingredients in accordance with the present invention was more inhibitory and more lethal to the bacteria than was any one of the components alone or the sum of the separate effects of each component. Thus, normally one would expect that the combination of the three ingredients would give an effect approx* imately equal to the algebraic sum of the separate effects measured in the test. However, this was not the case and the effect of the combination of the ingredients exceeded the best performance given by the best component alone. Thus, the disinfectant composition of three essential ingredients made according to the invention was surprisingly and unexpectedly superior, and this result could not be explained except for synergism.
Example 2 Example 1 was repeated with a specie of fungi, Candida albicans, and the measured results are given in the table below: Candida albicans Material Tested Inhibitory Lethal Benzalkonium chloride alone 1:100 1:100 2-isopropyl-5-methyl-phenol alone 1:100 1:100 Formaldehyde alone 1:100 1:100 Above three combined 1:4000 1:1000 As will be noted, the combination of the three essential ingredients made in accordance with the invention was again more inhibitory and more lethal than was the best of its separate components. Again, this result could not be explained except for Example 3 Example 1 was again repeated with another speciesof fungi, Aspergillus fumigatus, and the measured results are given in the table below: Aspergillus fumigatus Material Tested Inhibitory Lethal Benzalkonium chloride alone - - 2-isopropyl-5-methyl-phenol alone 1:1000 Formaldehyde alone 1:2000 1:2000 Above three combined 1:8000 1:2000 As will be noted, with this specie of fungi, the combination of the three ingredients was more inhibitory and equally as lethal as the best of its separate components alone. Thus, once again the combination of the three ingredients was more effective as a disinfectant because of synergistic interaction between the ingredients in the combination.
Example 4 A solid disinfectant composition was made in accordance with the invention by combining 20 parts of benzethonium chloride, 25 parts of para-eresol and 275 parts of paraformaldehyde as the essential active ingredients, and 180 parts of a trisodium phosphate were included as a solubilization aid.
This 500 gram quantity of the composition, when dissolved in 100 liters of water, provided concentrations of the three essential ingredients equivalent to the concentrations of the 1:100 dilution specified in Examples 1-3 above. The dissolved product was an extreme ly effective disinfectant against many of the microorganism species mentioned at the beginning of this specification, to a degree equivalent to the synergistic superiority exhibited in the tests of Examples 1-3.
It will be understood that it is intended to cover all changes and modifications of the preferred embodiments of the invention, herein chosen for the purpose of illustration, which do not constitute departures from the spirit and scope of the invention.
Havtrig now particularly described and ascertained the nature of our said Invention and In what manner the same is to be performed, we declare that what we claim is :-
Claims (7)
1. A disinfectant composition comprising an admixture of (1) formaldehyde, (2) benzalkonium or benzethonium halide and (3) an organic compound having the formula: wherein R is hyd hydrocarbon radical having from one to seven carbon atoms.
2. A composition as in claim 1 wherein said ingredients are admixed in the relative proportions, expressed as parts by weight, of about 10 to about 150 parts of (1), about 1 to about 20 parts of (2) and about 1 to about 20 parts of (3).
3. A composition as in claim 1 dissolved in water, the total amount of said ingredients (1), (2) and (3) combined being from about 67. to about 50% of the weight of said solution.
4. A composition as in claim 3 wherein said solution includes admixed methanol.
5. A composition as in claim 3 wherein said solution includes admixed ethanol.
6. A composition as in claim 1 in the form of an admixture of solid ingredients (1), (2) and (3), said solid admixture including an inorganic salt comprising mono, di or tri sodium phosphate, sodium bisulfate, sodium bicarbonate, or sodium pyrophosphate, the total amount of said ingredients (1) , (2) and (3) combined being from about 67. to about 657. of the weight of said solid admixture.
7. A composition as in claim 1 wherein (2) is benzalkonium
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66355267A | 1967-08-28 | 1967-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL28896A true IL28896A (en) | 1972-01-27 |
Family
ID=24662320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL2889667A IL28896A (en) | 1967-08-28 | 1967-11-07 | Disinfectant composition comprising formaldehyde benzalkonium or benzethonium halide and a cresol derrivative |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB1162770A (en) |
| IL (1) | IL28896A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2321300A2 (en) * | 1975-08-20 | 1977-03-18 | Anios Lab Sarl | BACTERICIDE COMPOSITION |
| FR2588264B1 (en) * | 1985-10-07 | 1987-11-27 | Sterling Sa Division Phagogene | DISINFECTANT COMPOSITION FOR AIRWAY |
| CN110257468B (en) * | 2019-06-03 | 2022-05-27 | 北京鑫骥金诺医疗器械有限公司 | Composition for quality control of bacterial counting, preparation method and application thereof |
| CN114271760A (en) * | 2021-12-29 | 2022-04-05 | 山东省润荷卫生材料有限公司 | Down jacket cleaning wet tissue and preparation method thereof |
-
1967
- 1967-11-07 IL IL2889667A patent/IL28896A/en unknown
- 1967-11-15 GB GB5191267A patent/GB1162770A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1162770A (en) | 1969-08-27 |
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