IL287477A - נוגדני anti-cd38 ופורמולציות - Google Patents
נוגדני anti-cd38 ופורמולציותInfo
- Publication number
- IL287477A IL287477A IL287477A IL28747721A IL287477A IL 287477 A IL287477 A IL 287477A IL 287477 A IL287477 A IL 287477A IL 28747721 A IL28747721 A IL 28747721A IL 287477 A IL287477 A IL 287477A
- Authority
- IL
- Israel
- Prior art keywords
- antibodies
- formulations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962837518P | 2019-04-23 | 2019-04-23 | |
| US201962859699P | 2019-06-10 | 2019-06-10 | |
| EP20305146 | 2020-02-17 | ||
| EP20305145 | 2020-02-17 | ||
| PCT/US2020/029531 WO2020219681A1 (en) | 2019-04-23 | 2020-04-23 | Anti-cd38 antibodies and formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL287477A true IL287477A (he) | 2021-12-01 |
Family
ID=70739160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL287477A IL287477A (he) | 2019-04-23 | 2021-10-21 | נוגדני anti-cd38 ופורמולציות |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP3958898A1 (he) |
| JP (1) | JP7602485B2 (he) |
| KR (1) | KR20220003562A (he) |
| CN (2) | CN114269375A (he) |
| AU (1) | AU2020261039A1 (he) |
| BR (1) | BR112021021060A2 (he) |
| CA (1) | CA3137365A1 (he) |
| CO (1) | CO2021015462A2 (he) |
| IL (1) | IL287477A (he) |
| MA (1) | MA55761A (he) |
| MX (1) | MX2021012967A (he) |
| MY (1) | MY206426A (he) |
| SG (1) | SG11202111602YA (he) |
| TW (1) | TWI878289B (he) |
| WO (1) | WO2020219681A1 (he) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023109928A1 (zh) * | 2021-12-16 | 2023-06-22 | 上海宝济药业有限公司 | 抗免疫球蛋白降解酶酶切的Fc变体 |
| WO2024023843A1 (en) * | 2022-07-26 | 2024-02-01 | Dr. Reddy’S Laboratories Limited | A pharmaceutical formulation of a therapeuticantibody and preparations thereof |
| WO2025245526A1 (en) * | 2024-05-24 | 2025-11-27 | Research Institute At Nationwide Children's Hospital | Cd-38 protein binding compositions and methods related thereto |
| CN120535629B (zh) * | 2025-04-22 | 2026-01-23 | 西安市中心血站(陕西省血液中心) | 一种用于抑制cd38单抗对输血相容性检测干扰的抗体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005016683D1 (de) | 2004-07-10 | 2009-10-29 | Fox Chase Cancer Ct | Genetisch modifizierte, menschliche, natürliche killerzellenlinien: |
| CN103172731A (zh) * | 2004-07-15 | 2013-06-26 | 赞科股份有限公司 | 优化的Fc变体 |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| SG10201603411WA (en) * | 2011-10-28 | 2016-07-28 | Teva Pharmaceuticals Australia Pty Ltd | Polypeptide constructs and uses thereof |
| US10617757B2 (en) * | 2014-08-08 | 2020-04-14 | The Regents Of The University Of California | Methods for treating multiple myeloma |
| DK3827845T3 (da) * | 2015-11-03 | 2022-05-23 | Janssen Biotech Inc | Subkutane formuleringer af anti-cd38-antistoffer og anvendelser deraf |
| GEP20217249B (en) * | 2016-06-30 | 2021-04-26 | Inc Celltrion | Stable liquid pharmaceutical preparation |
| SG11201910134SA (en) * | 2017-05-02 | 2019-11-28 | Merck Sharp & Dohme | Stable formulations of anti-ctla4 antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| WO2019064263A1 (en) * | 2017-09-29 | 2019-04-04 | Janssen Biotech, Inc. | NOVEL FORMULATIONS FOR STABILIZING LOW DOSE ANTIBODY COMPOSITIONS |
| CN108752475B (zh) * | 2018-06-14 | 2021-07-30 | 北京智仁美博生物科技有限公司 | 抗人cd38抗体及其用途 |
-
2020
- 2020-04-23 TW TW109113639A patent/TWI878289B/zh active
- 2020-04-23 MY MYPI2021006312A patent/MY206426A/en unknown
- 2020-04-23 MX MX2021012967A patent/MX2021012967A/es unknown
- 2020-04-23 CA CA3137365A patent/CA3137365A1/en active Pending
- 2020-04-23 MA MA055761A patent/MA55761A/fr unknown
- 2020-04-23 WO PCT/US2020/029531 patent/WO2020219681A1/en not_active Ceased
- 2020-04-23 SG SG11202111602YA patent/SG11202111602YA/en unknown
- 2020-04-23 CN CN202080030148.3A patent/CN114269375A/zh active Pending
- 2020-04-23 EP EP20726267.6A patent/EP3958898A1/en active Pending
- 2020-04-23 JP JP2021562989A patent/JP7602485B2/ja active Active
- 2020-04-23 BR BR112021021060A patent/BR112021021060A2/pt unknown
- 2020-04-23 KR KR1020217037641A patent/KR20220003562A/ko not_active Ceased
- 2020-04-23 CN CN202510964194.5A patent/CN120757645A/zh active Pending
- 2020-04-23 AU AU2020261039A patent/AU2020261039A1/en active Pending
-
2021
- 2021-10-21 IL IL287477A patent/IL287477A/he unknown
- 2021-11-17 CO CONC2021/0015462A patent/CO2021015462A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP7602485B2 (ja) | 2024-12-18 |
| CN120757645A (zh) | 2025-10-10 |
| BR112021021060A2 (pt) | 2021-12-14 |
| WO2020219681A1 (en) | 2020-10-29 |
| MX2021012967A (es) | 2022-01-18 |
| KR20220003562A (ko) | 2022-01-10 |
| EP3958898A1 (en) | 2022-03-02 |
| CO2021015462A2 (es) | 2021-12-10 |
| MA55761A (fr) | 2022-03-02 |
| JP2022529502A (ja) | 2022-06-22 |
| CN114269375A (zh) | 2022-04-01 |
| CA3137365A1 (en) | 2020-10-29 |
| MY206426A (en) | 2024-12-17 |
| SG11202111602YA (en) | 2021-11-29 |
| AU2020261039A1 (en) | 2021-12-09 |
| TW202104269A (zh) | 2021-02-01 |
| TWI878289B (zh) | 2025-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL282968A (he) | נוגדנים ל- Anti - NKG2A והשימוש בהם | |
| IL276950A (he) | נוגדנים אנטי- cd73 ושימושים בהם | |
| IL289354A (he) | נוגדנים אנטי-154cd ושימושים בהם | |
| IL290141A (he) | פורמולציות של נוגדנים אנטי-pvrig ושימושים בהם | |
| EP3740224A4 (en) | ANTI-LILRB ANTIBODIES AND THEIR USES | |
| MA52366A (fr) | Anticorps anti-tl1a optimisés | |
| EP3445407A4 (en) | COMPOSITIONS AND METHODS FOR CELLULAR IMMUNOTHERAPY | |
| IL288153A (he) | פורמולציות מיוצבות המכילות נוגדנים anti-angptl3 | |
| IL275826A (he) | נוגדנים אנטי-mct1 ושימושים שלהם | |
| EP3904382A4 (en) | ANTI-IL-23P19 ANTIBODIES AND ITS USES | |
| EP4071172A4 (en) | ANTI-LILRB1 ANTIBODIES AND ITS USES | |
| IL292716A (he) | תכשירים פרו-בושם | |
| IL278466B1 (he) | נוגדנים אנטי-dll3 ושימושים בהם | |
| IL281297A (he) | נוגדנים אנטי-npr1 ושימושים בהם | |
| IL287477A (he) | נוגדני anti-cd38 ופורמולציות | |
| IL280321A (he) | נוגדנים נגד cxcr2 ושימושים שלהם | |
| IL286100A (he) | פורמולציות של נוגדנים אנטי- il-36r | |
| EP4025609A4 (en) | ANTI-STEAP1 ANTIBODIES AND THEIR USES | |
| IL283875A (he) | נוגדנים אנטי-il-27 ושימושים בהם | |
| IL281202A (he) | נוגדנים אנטי- tnfrsf9ושימושים בהם | |
| IL291131A (he) | פורמולציות של נוגדנים אנטי- il-23p19 | |
| IL277075A (he) | נוגדנים אנטי-phf-טאו ושימושים בהם | |
| IL289656A (he) | נוגדנים אנטי-tigit ויישום שלהם | |
| IL286024A (he) | פורמולציות מיוצבות הכוללות נוגדנים נגד il-33 | |
| IL277330A (he) | נוגדנים אנטי-il-27 ושימושים בהם |