IL277775B2 - Disseminated system and method for light biomodulated healing - Google Patents

Disseminated system and method for light biomodulated healing

Info

Publication number
IL277775B2
IL277775B2 IL277775A IL27777520A IL277775B2 IL 277775 B2 IL277775 B2 IL 277775B2 IL 277775 A IL277775 A IL 277775A IL 27777520 A IL27777520 A IL 27777520A IL 277775 B2 IL277775 B2 IL 277775B2
Authority
IL
Israel
Prior art keywords
led
pbt
pad
waveform
controller
Prior art date
Application number
IL277775A
Other languages
Hebrew (he)
Other versions
IL277775B1 (en
IL277775A (en
Original Assignee
Williams Richard K
Applied Biophotonics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Williams Richard K, Applied Biophotonics Ltd filed Critical Williams Richard K
Publication of IL277775A publication Critical patent/IL277775A/en
Publication of IL277775B1 publication Critical patent/IL277775B1/en
Publication of IL277775B2 publication Critical patent/IL277775B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0625—Warming the body, e.g. hyperthermia treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/40—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0606—Mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0644—Handheld applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Business, Economics & Management (AREA)
  • General Business, Economics & Management (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Radiation-Therapy Devices (AREA)
  • Confectionery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (33)

1. / 1 CLAIMS 1. A distributed photobiomodulation therapy (PBT) system comprising: a PBT controller, said PBT controller comprising a main microcontroller, a communication interface, and a digital clock; a light-emitting diode (LED) pad, said LED pad comprising a pad microcontroller, a memory, and an array of LEDs, said array of LEDs comprising one or more LED strings, the LEDs in each of said LED strings being connected in series, and an LED driver for controlling a current in each LED string; and a communication link for carrying digital data between said PBT controller and said LED pad for controlling the current in and illumination of said one or more LED strings; wherein the LED driver for controlling the current in each LED string comprises a MOSFET and a current sense and control element, each of said MOSFET and said current sense and control unit being connected in series with the LEDs in said LED string, said current sense and control unit being connected to a source of enable pulses for turning said MOSFET on and off and to a source of a reference current for controlling a level of said current in said MOSFET when said MOSFET is turned on.
2. The distributed PBT system of Claim 1 wherein each LED driver is linked to said pad microcontroller such that said pad microcontroller is capable of controlling a current in each LED string.
3. The distributed PBT system of Claim 2 wherein said LED array comprises at least two LED strings and wherein the LEDs in a first LED string are capable of emitting light of a first wavelength and the LEDs in a second LED string are capable of emitting light of a second wavelength, said second wavelength being different from said first wavelength.
4. The distributed PBT system of Claim 2 wherein a source of a reference current for a first LED string comprises a first reference MOSFET and a source of a reference current for a second LED string comprises a second reference MOSFET, each of said first and second reference MOSFETs being connected in a current mirror arrangement with a third threshold-connected MOSFET. 277775/ 1
5. The distributed PBT system of Claim 4 further comprising a trim network connected to said third threshold-connected MOSFET.
6. The distributed PBT system of Claim 4 further comprising a digital-to-analog (D/A) converter, an output of said D/A converter controlling the magnitude of a current in said third threshold-connected MOSFET.
7. The distributed PBT system of Claim 1 wherein the communication link comprises a USB cable or other wired communication medium.
8. The distributed PBT system of Claim 7 wherein the communication link comprises a conductor for supplying power to the LED pad.
9. The distributed PBT system of Claim 1 wherein the PBT controller comprises a first clock and the LED pad comprises a second clock, said second clock not being synchronized to said first clock.
10. The distributed PBT system of Claim 1 wherein the LED comprises a device ID register, said device ID register being stored in a non-volatile memory and comprising data for use by the PBT controller for authenticating the identity of the LED pad.
11. The distributed PBT system of Claim 1 wherein the LED pad comprises a memory, the memory holding data for controlling the LED drivers in accordance with a selected PBT treatment.
12. A method of performing photobiomodulation therapy (PBT) using the PBT system of Claim 1, the method comprising transmitting software defining a PBT treatment session from said PBT controller to said LED pad, the PBT treatment session defining the times at which LEDs in said LED array are to be turned on and turned off, the software being transmitted in segments such that said PBT controller transmits a treatment segment to said LED pad and said LED pad then executes said treatment segment.
13. The method of Claim 12 wherein said memory comprises a serial shift register and said LED pad comprises a decoder, the method comprising transmitting a data stream defining said PBT treatment session from said PBT controller to said decoder, loading an output of said decoder into a serial shift register, said output of said 277775/ 1 decoder specifying said times at which said LEDs are to be turned on and turned, and using said serial shift register to control said LED driver.
14. The method of Claim 13 wherein said transmitting said data stream from said PBT controller to said decoder does not occur contemporaneously with said loading said output of said decoder into said serial shift register.
15. A method of performing photobiomodulation therapy (PBT) using the PBT system of Claim 1, the method comprising transferring a file containing executable code from said PBT controller to said LED pad, said executable code comprising instructions for said pad microcontroller to execute and complete a PBT treatment without further instruction from said PBT controller.
16. The method of Claim 15 wherein said file containing executable code transferred from said PCT controller to said LED pad is compressed and/or encrypted, the method further comprising decompressing and/or decrypting said file in said LED pad.
17. The method of Claim 16 comprising decrypting said file in its entirety in said LED pad and then executing said PBT treatment.
18. The method of Claim 16 comprising: decrypting a first portion of said file in said LED pad and executing a first portion of said treatment; and decrypting a second portion of said file in said LED pad and executing a second portion of said treatment.
19. A method of performing photobiomodulation therapy (PBT) using the PBT system of Claim 1, the method comprising transferring an LED player and an LED driver from said PBT controller to said LED pad.
20. The method of Claim 19 wherein said file comprising said LED player is encrypted and/or compressed, the method further comprising decrypting and/or decompressing said file in said LED pad and then storing said file in volatile memory in said LED pad.
21. The method of Claim 19 wherein said LED player comprises a waveform synthesizer and a pulse width modulation (PWM) player.
22. The method of Claim 21 comprising delivering waveform primitives and waveform parametrics of a waveform to said waveform synthesizer, said waveform 277775/ 1 synthesizer processing said waveform primitives and said waveform parametrics to generate a PWM function representative of said waveform.
23. The method of Claim 22 wherein said waveform primitives identify said waveform as a sine wave and said waveform parametrics specify a frequency and amplitude of said sine wave.
24. The method of Claim 21 comprising delivering a mathematical function expressing said waveform to said waveform synthesizer, said waveform synthesizer processing said mathematical function to generate a PWM function representative of said waveform.
25. The method of Claim 21 wherein said PWM player receives an output signal of said waveform synthesizer and generates a pulse train, each pulse in said pulse train comprising at least a portion of said PWM function representative of said waveform, the pulses in said pulse train having a frequency less than pulses in said PWM function.
26. The method of Claim 25 wherein said LED driver receives an output signal of said PWM player and generates an analog signal representative of said waveform, said LED driver determining a maximum value of said analog signal by controlling a maximum value of a current in each of said one or more LED strings.
27. The method of Claim 19 comprising transferring an LED playback file to a volatile memory in said LED pad, said playback file defining a sequence of a PBT treatment.
28. A method of performing photobiomodulation therapy (PBT) using the PBT system of Claim 1, software stored in said memory comprising a blink timer, the method comprising: causing said blink timer to begin counting; causing said blink timer to generate a blink timeout signal when a first predetermined time period has elapsed since said blink timer began operating, said blink timeout signal causing said program software to execute an interrupt service routine (ISR); and causing said program software to interrupt a PBT treatment and to conduct a safety check of said LED pad during said ISR. 277775/ 1
29. The method of Claim 28 wherein said safety check comprises reading a temperature sensor and/or checking an electrical connection in said LED pad.
30. The method of Claim 28 wherein software stored in said memory comprises a watchdog timer, the method comprising: resetting and starting said watchdog time at the conclusion of an ISR; causing said watchdog timer to generate an interrupt flag when a second predetermined time period has elapsed since said watchdog timer began operating, said second predetermined time period being longer than said first predetermined time period; and causing said program software to interrupt a PBT treatment when said interrupt flag is generated.
31. The method of Claim 28 wherein said LED pad comprises a temperature sensor, the method comprising causing said software to interrupt a PBT treatment if said temperature sensor detects an over temperature condition.
32. The method of Claim 28 wherein said communication link comprises a WiFi or other wireless communication path.
33. The method of Claim 32 wherein said LED pad comprises a safety system, said safety system comprising at least one of a blink timer, a watchdog timer and a temperature sensor, wherein said safety system continues to operate even if communication via said communication link is interrupted. For the Applicant, Naschitz, Brandes, Amir & Co. P-16472-IL
IL277775A 2018-04-06 2019-04-06 Disseminated system and method for light biomodulated healing IL277775B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862653846P 2018-04-06 2018-04-06
PCT/US2019/026222 WO2019195816A1 (en) 2018-04-06 2019-04-06 Distributed photobiomodulation therapy system and method

Publications (3)

Publication Number Publication Date
IL277775A IL277775A (en) 2020-11-30
IL277775B1 IL277775B1 (en) 2024-03-01
IL277775B2 true IL277775B2 (en) 2024-07-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
IL277775A IL277775B2 (en) 2018-04-06 2019-04-06 Disseminated system and method for light biomodulated healing

Country Status (12)

Country Link
JP (1) JP7740878B2 (en)
KR (1) KR102768767B1 (en)
CN (1) CN112996559B (en)
CL (1) CL2020002581A1 (en)
ES (1) ES2788140B2 (en)
IL (1) IL277775B2 (en)
MX (1) MX2020010553A (en)
PE (1) PE20210544A1 (en)
SG (1) SG11202009869RA (en)
TW (1) TWI787493B (en)
WO (1) WO2019195816A1 (en)
ZA (1) ZA202006175B (en)

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Publication number Publication date
KR102768767B1 (en) 2025-02-14
IL277775B1 (en) 2024-03-01
WO2019195816A1 (en) 2019-10-10
KR20210005616A (en) 2021-01-14
CN112996559B (en) 2023-11-21
MX2020010553A (en) 2021-03-25
ZA202006175B (en) 2022-02-23
ES2788140B2 (en) 2023-03-24
JP7740878B2 (en) 2025-09-17
ES2788140R1 (en) 2021-09-14
SG11202009869RA (en) 2020-11-27
CL2020002581A1 (en) 2021-05-14
CN112996559A (en) 2021-06-18
TW201944430A (en) 2019-11-16
TWI787493B (en) 2022-12-21
ES2788140A2 (en) 2020-10-20
IL277775A (en) 2020-11-30
JP2021520867A (en) 2021-08-26
PE20210544A1 (en) 2021-03-17

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