IL276010B2 - Methods of purifying cannabinoids using liquid:liquid chromatography - Google Patents

Methods of purifying cannabinoids using liquid:liquid chromatography

Info

Publication number
IL276010B2
IL276010B2 IL276010A IL27601020A IL276010B2 IL 276010 B2 IL276010 B2 IL 276010B2 IL 276010 A IL276010 A IL 276010A IL 27601020 A IL27601020 A IL 27601020A IL 276010 B2 IL276010 B2 IL 276010B2
Authority
IL
Israel
Prior art keywords
liquid
methods
purifying cannabinoids
liquid chromatography
chromatography
Prior art date
Application number
IL276010A
Other languages
Hebrew (he)
Other versions
IL276010A (en
IL276010B1 (en
Inventor
Roura Xavier Nadal
Original Assignee
Phytoplant Res S L
Roura Xavier Nadal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65276144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL276010(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US15/882,516 external-priority patent/US10207198B2/en
Application filed by Phytoplant Res S L, Roura Xavier Nadal filed Critical Phytoplant Res S L
Publication of IL276010A publication Critical patent/IL276010A/en
Publication of IL276010B1 publication Critical patent/IL276010B1/en
Publication of IL276010B2 publication Critical patent/IL276010B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/004—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by obtaining phenols from plant material or from animal material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0492—Applications, solvents used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds or centrifugal chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0004—Crystallisation cooling by heat exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring
    • C07C39/19—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
IL276010A 2018-01-29 2020-07-13 Methods of purifying cannabinoids using liquid:liquid chromatography IL276010B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/882,516 US10207198B2 (en) 2015-01-22 2018-01-29 Methods of purifying cannabinoids using liquid:liquid chromatography
PCT/EP2019/052069 WO2019145552A1 (en) 2018-01-29 2019-01-29 Methods of purifying cannabinoids using liquid:liquid chromatography

Publications (3)

Publication Number Publication Date
IL276010A IL276010A (en) 2020-08-31
IL276010B1 IL276010B1 (en) 2025-09-01
IL276010B2 true IL276010B2 (en) 2026-01-01

Family

ID=65276144

Family Applications (1)

Application Number Title Priority Date Filing Date
IL276010A IL276010B2 (en) 2018-01-29 2020-07-13 Methods of purifying cannabinoids using liquid:liquid chromatography

Country Status (9)

Country Link
EP (1) EP3746419A1 (en)
CN (1) CN111788171A (en)
AU (1) AU2019211188A1 (en)
CA (1) CA3089490A1 (en)
CL (1) CL2020001964A1 (en)
CO (1) CO2020009747A2 (en)
IL (1) IL276010B2 (en)
MX (1) MX2020007960A (en)
WO (1) WO2019145552A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020252369A1 (en) * 2019-06-14 2020-12-17 Purisys Llc Crystalline cannabigerol
CN110590511B (en) * 2019-09-11 2021-05-28 上海同田生物技术股份有限公司 Method for simultaneously separating cannabidiol and cannabigerol
CN112279752B (en) * 2020-10-30 2022-11-11 云南芙雅生物科技有限公司 Supercritical carbon dioxide extraction method of cannabinoids for industrial cannabis sativa
CN113135885A (en) * 2021-04-07 2021-07-20 上海同田生物技术有限公司 Method for separating and purifying tetrahydrocannabinol by high-speed counter-current chromatography
KR20240121723A (en) 2021-10-26 2024-08-09 에코파이버 유에스에이 인코포레이티드 How to Treat Endometrial Cancer Using Cannabis Extract
EP4422612A1 (en) 2021-10-26 2024-09-04 The University of Newcastle Methods of treating endometriosis and other non-cancer gynecological disorders with hemp extract
WO2023076931A2 (en) 2021-10-26 2023-05-04 Ecofibre Limited Systems and methods for producing hemp extracts and compositions
CN115385780B (en) * 2022-08-26 2024-02-27 晨光生物科技集团股份有限公司 Secondary cannabidiol crystal polymorph and preparation method and application thereof
AU2023367739A1 (en) 2022-10-26 2025-06-12 Dove Innovation Pty Limited Stabilized compositions comprising cannabidiol
AU2023367737A1 (en) 2022-10-26 2025-06-12 Dove Innovation Pty Limited Methods of treating estrogen sensitive diseases with cannabis extract
FR3146813A1 (en) * 2023-03-24 2024-09-27 Gilson Purification Processes for the separation and purification of an organic compound contained in a material of natural origin
FR3159605A1 (en) * 2024-02-26 2025-08-29 Delled Use of bio-sourced lipid in a biphasic Centrifugal Partition Chromatography system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016135346A1 (en) * 2015-02-27 2016-09-01 Bionorica Ethics Gmbh Cpc distribution chromatography of cannabinoids
WO2016187679A1 (en) * 2015-05-22 2016-12-01 "Pobelch - Gle" Ood Method for preparation of a cannabinoid extract from hemp
US20180000879A1 (en) * 2015-01-22 2018-01-04 Phytoplant Research S.L. Methods of Purifying Cannabinoids, Compositions and Kits Thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (en) 1990-01-23 1999-01-15 . Cyclodextrin derivatives with increased water solubility and uses thereof
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
ATE396984T1 (en) * 2002-02-01 2008-06-15 Resolution Chemicals Ltd OBTAINING DELTA-9 TETRAHYDROCANNABINOL
US20080103193A1 (en) * 2006-10-26 2008-05-01 Trevor Percival Castor Methods for making compositions and compositions for treating pain and cachexia
BR112017015536B1 (en) 2015-01-22 2021-05-18 Phytoplant Research S.L cannabinoid purification methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180000879A1 (en) * 2015-01-22 2018-01-04 Phytoplant Research S.L. Methods of Purifying Cannabinoids, Compositions and Kits Thereof
WO2016135346A1 (en) * 2015-02-27 2016-09-01 Bionorica Ethics Gmbh Cpc distribution chromatography of cannabinoids
WO2016187679A1 (en) * 2015-05-22 2016-12-01 "Pobelch - Gle" Ood Method for preparation of a cannabinoid extract from hemp

Also Published As

Publication number Publication date
CO2020009747A2 (en) 2020-08-21
CA3089490A1 (en) 2019-08-01
CN111788171A (en) 2020-10-16
CL2020001964A1 (en) 2020-12-18
AU2019211188A1 (en) 2020-07-30
WO2019145552A1 (en) 2019-08-01
IL276010A (en) 2020-08-31
MX2020007960A (en) 2020-09-24
IL276010B1 (en) 2025-09-01
EP3746419A1 (en) 2020-12-09

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