IL272045B1 - Improved dual specificity polypeptide molecule - Google Patents

Improved dual specificity polypeptide molecule

Info

Publication number
IL272045B1
IL272045B1 IL272045A IL27204520A IL272045B1 IL 272045 B1 IL272045 B1 IL 272045B1 IL 272045 A IL272045 A IL 272045A IL 27204520 A IL27204520 A IL 27204520A IL 272045 B1 IL272045 B1 IL 272045B1
Authority
IL
Israel
Prior art keywords
seq
tcr
polypeptide
cell
domain
Prior art date
Application number
IL272045A
Other languages
English (en)
Hebrew (he)
Other versions
IL272045A (en
Inventor
Maurer Dominik
Bunk Sebastian
Unverdorben Felix
Hofmann Martin
Original Assignee
Immatics Biotechnologies Gmbh
Maurer Dominik
Bunk Sebastian
Unverdorben Felix
Hofmann Martin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102017115966.5A external-priority patent/DE102017115966A1/de
Application filed by Immatics Biotechnologies Gmbh, Maurer Dominik, Bunk Sebastian, Unverdorben Felix, Hofmann Martin filed Critical Immatics Biotechnologies Gmbh
Priority claimed from PCT/EP2018/069151 external-priority patent/WO2019012138A1/en
Publication of IL272045A publication Critical patent/IL272045A/en
Publication of IL272045B1 publication Critical patent/IL272045B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL272045A 2017-07-14 2018-07-13 Improved dual specificity polypeptide molecule IL272045B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762532713P 2017-07-14 2017-07-14
DE102017115966.5A DE102017115966A1 (de) 2017-07-14 2017-07-14 Polypeptidmolekül mit verbesserter zweifacher Spezifität
DE102017119866 2017-08-30
US201862658318P 2018-04-16 2018-04-16
DE102018108995 2018-04-16
PCT/EP2018/069151 WO2019012138A1 (en) 2017-07-14 2018-07-13 POLYPEPTIDE MOLECULE WITH IMPROVED DOUBLE-SPECIFICITY

Publications (2)

Publication Number Publication Date
IL272045A IL272045A (en) 2020-03-31
IL272045B1 true IL272045B1 (en) 2025-06-01

Family

ID=70848164

Family Applications (2)

Application Number Title Priority Date Filing Date
IL272045A IL272045B1 (en) 2017-07-14 2018-07-13 Improved dual specificity polypeptide molecule
IL272046A IL272046A (en) 2017-07-14 2020-01-14 Improved dual specificity polypeptide molecule

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL272046A IL272046A (en) 2017-07-14 2020-01-14 Improved dual specificity polypeptide molecule

Country Status (6)

Country Link
JP (1) JP2021019626A (enrdf_load_stackoverflow)
CL (2) CL2020000097A1 (enrdf_load_stackoverflow)
HR (1) HRP20210759T1 (enrdf_load_stackoverflow)
IL (2) IL272045B1 (enrdf_load_stackoverflow)
PH (2) PH12020500098A1 (enrdf_load_stackoverflow)
ZA (1) ZA202000636B (enrdf_load_stackoverflow)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX383596B (es) * 2013-03-14 2025-03-14 Macrogenics Inc Moleculas biespecificas que son inmunorreactivas con celulas efectoras inmunes que expresan un receptor activador y un antigeno expresado por una celula infectada por un virus y usos de las mismas.

Also Published As

Publication number Publication date
CL2020000097A1 (es) 2020-05-29
CL2020000098A1 (es) 2020-05-29
HRP20210759T1 (hr) 2021-06-11
PH12020500098A1 (en) 2020-12-07
PH12020500095A1 (en) 2020-12-07
ZA202000636B (en) 2021-07-28
IL272046A (en) 2020-03-31
JP2021019626A (ja) 2021-02-18
IL272045A (en) 2020-03-31

Similar Documents

Publication Publication Date Title
US20230348598A1 (en) Improved dual specificity polypeptide molecule
DE102017115966A1 (de) Polypeptidmolekül mit verbesserter zweifacher Spezifität
HK40071054A (en) Improved dual specificity polypeptide molecule
IL272045B1 (en) Improved dual specificity polypeptide molecule
HK40003407A (en) Improved dual specificity polypeptide molecule
HK40003407B (en) Improved dual specificity polypeptide molecule
HK40029654A (en) Improved dual specificity polypeptide molecule
HK40029654B (en) Improved dual specificity polypeptide molecule
EA043129B1 (ru) Усовершенствованная молекула полипептида с двойной специфичностью
EA043319B1 (ru) Усовершенствованная молекула полипептида с двойной специфичностью