IL26947A - 5-halobenzoic acid derivatives and their preparation - Google Patents

Description

acid derivatives and their preparation DE la present invention provides acid derivatives of the general in which is a or or amino is hydrogen or lower and I a halogen The acid derivatives of formula I according to the are useful as key intermediates for the preparation which possess useful medical activities such as a anesthetic and present invention also provides a process the preparatio acid ester derivatives of formula I in which is which comprises reacting a acid derivative having the general I in is hydrogen with a compound of the general formula which an is hydrogen and is halogen or hydrogen or and together represent the group of alkoxy group referred to hereto are examples of the group are butanamido and pentanamido of the alkyl are and butyl examples of group propylidene and biitylidene radicals and examples of halogen atom are starting materials formula I in which is in thi are novel and some of acid can be pared by reacting in presence of hydrous carbonate carbon dioxide increased pressure in autoclaveψ and acid can prepared by reacting with the others ma be prepared by the same processes as disclosed She compounds are halides or in which some example mono sulfates are mono some examples of halides are methyl ethyl butyl propy and some examples of are In case where mono sulfates or alkyl halides are used starting it is preferable to carry out the reaction in the presence of a basic agent such as metal alkaline earth metal metal alkaline earth metal carbonate fe reactio may be carried out in the presence or of The reaction may be carried out in a will depend on the kind of o are preferably used in mono sulfates are used as the compounds aromatic dimethyl in the cases using and in the cases where are The reaction generally carried out under and reflux in case of using the mono d sulfates halides9 and generally at room temperature in o using the examples will serve to illustrate the 1 fo a solution of g of acid dissolved in ml of absolute g of potassium carbonate anhydride was added with stirring under and further g of dimethyl ture was refluxed with stirring for 15 hours and then filtrate was treated wit active carbon and the solvent was distilled residu was from aqueous methanol to obtain methyl as white yield AnalysisJ Calculated for C I a solution of g benzoic acid dissolved in 100 ml of absolute of potassium ml of dimethyl sulfate and 10 ml of heating at 16 After the reaction was the reaction mixture was filtrated and further residual cakes washed The washings and the filtrate were incorporated and the solvent was distilled off to obtain g of methyl zoate as colorless scaled Yield was crystals were reerystallized from a mixed solvent of 85 ml of methanol and ml of water using of active carbon to obtain g of the purified crystals as colorless yield Calculated for 4 S Found G insufficientOCRQuality

Claims (1)

1. aeid derivatives of the formula in is a hydroxy or is an nitro or amino is hydrogen or lower and X is halogen A process for the preparation of acid ester derivatives of formula I in Claim in which is an alkyl group and is an group wherein a acid derivative having the general formula in in which is is reacted with a compound havin the general in which is an alkylidene is a hydrogen atom and a halogen atom the where is a hydrogen or an alkyl or and together represen the group insufficientOCRQuality