IL264544A - Fluidic microelectromechanical sensors/devices and fabrication methods thereof - Google Patents
Fluidic microelectromechanical sensors/devices and fabrication methods thereofInfo
- Publication number
- IL264544A IL264544A IL264544A IL26454419A IL264544A IL 264544 A IL264544 A IL 264544A IL 264544 A IL264544 A IL 264544A IL 26454419 A IL26454419 A IL 26454419A IL 264544 A IL264544 A IL 264544A
- Authority
- IL
- Israel
- Prior art keywords
- fluid
- sealing element
- opening
- elements
- cavity
- Prior art date
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16804—Flow controllers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16877—Adjusting flow; Devices for setting a flow rate
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L1/00—Measuring force or stress, in general
- G01L1/20—Measuring force or stress, in general by measuring variations in ohmic resistance of solid materials or of electrically-conductive fluids; by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress
- G01L1/22—Measuring force or stress, in general by measuring variations in ohmic resistance of solid materials or of electrically-conductive fluids; by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress using resistance strain gauges
- G01L1/225—Measuring circuits therefor
- G01L1/2262—Measuring circuits therefor involving simple electrical bridges
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
- B01L2200/147—Employing temperature sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/023—Sending and receiving of information, e.g. using bluetooth
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/082—Active control of flow resistance, e.g. flow controllers
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Description
FLUIDIC MICROELECTROMECHANICAL SENSORS/DEVICES AND
FABRICATION METHODS THEREOF
TECHNOLOGICAL FIELD
The present invention is generally in the field of fluidic microelectromechanical
(MEM) sensor systems/devices.
BACKGROUND
MEM systems/devices (e.g., for medical usage) usually employ sensor elements
implemented by semiconductor structures, where the fluid flow paths of these devices
and their connections to external systems/devices, their packaging, and their
mechanical/electrical interfaces are typically implemented by means of plastic elements.
In addition, electrical connectivity of such MEM systems/devices with external systems
is not implemented directly on the semiconductor die, and requires, inter alia, additional
electrical interface involving wiring and electrical contacts, plastic structures, and
printed circuit boards (PCB).
These manufacturing techniques require accurate and complex attachments of
the semiconductor die to its carrier to achieve electrical and mechanical connectivity to
guarantee that pressure forces are correctly transmitted to the sensing elements, and
obtain proper alignment between the fluid flow structures formed in the plastic
packaging with the sensors and/or actuators implemented in the semiconductor die. This
combination of manufacturing techniques typically results in a costly, and considerably
complex, fabrication and integration of the fluidic MEM sensor (e.g., Silicon) into the
fluidic MEM.
Fluidic MEM devices fabrication techniques known from the patent literature
are described in the following patent publications.
U.S. Patent No. 7,311,693 describes a drug delivery device with a pressurized
reservoir in communication with a flow path to an outlet. The flow path includes two
normally-closed valves and a flow restriction. A pressure measurement arrangement
measures a differential fluid pressure between two points along the flow path which
span at least part of the flow restriction, one of the points being between the valves. A
controller selectively opens the valves to deliver a defined quantity of the liquid
medicament to the outlet.- 2 -
US Patent No. 6,782,755 describes surface-micromachined high-pressure sensor,
formed by forming a cavity using a sacrificial layer. The sacrificial layer can be
reflowed to make the edges of the cavity more rounded. The material that is used for the
diaphragm can be silicon nitride, or multiple layers including silicon nitride and other
materials. The pressure sensor is intended to be used in high pressure applications, e.g.
pressure is higher than 6000, 10,000 or 30,000 P.S.I.
US Patent Publication No. 2007/028683 describes a pressure sensing device and
method for sensing pressure that utilizes a deformable cavity containing a conductive
medium. Pressure changes induce deformations of the cavity, resulting in changes of
conductivity, as measured by electrodes. The device may either sense pressure directly
or may be used to sense the pressure in a separate cavity that is in close proximity.
Since the measurements do not require electrodes in the sensing region, the device is
simple to fabricate. The device also has high sensitivity, making it suitable for
microfluidic or biomedical applications where a low profile and disposable device is
required.
GENERAL DESCRIPTION
Fabrication of the fluidic MEMSs used nowadays, for example, in medical
devices, is a complex and expensive process requiring expertise, inter alia, in
semiconductors fabrication technologies, plastic packaging techniques, and electronic
circuit board design and manufacture. The sensor elements of the MEMSs are usually
fabricated in semiconductor wafers, which are then diced, separately packaged,
electrically/electronically equipped and wired. The packaged semiconductors then
separately fluidly interfaced by adding fluid connectors/ports, and separately calibrated.
The present application provides MEMSs structures and fabrication techniques
that significantly simplify the MEMSs production process, and substantially reduces the
production costs and times. In a broad aspect the MEMSs disclosed herein are
comprised of a main body structure having a fluid passage therealong and at least one
opening in one of its walls in fluid communication with the fluid passage (i.e., the at
least one opening opens into the fluid passage), and a sealing element attached on a
surface area of the main body structure comprising the at least one opening to sealably
close it and place thereover one or more electrical and/or sensor components patterned
or attached thereon.- 3 -
The one or more electrical and/or sensor components patterned/attached on the
sealing element are configured to measure one or more properties and/or conditions of a
fluid substance (such as a liquid and/or gaseous material) introduced into the fluid
passage and interacting with the portion of the sealing element positioned over the at
least one opening. In some embodiments the one or more electrical and/or sensor
components are patterned/attached on the sealing element after it is attached to the main
body structure.
The main body structure comprises in some embodiments at least one cavity
along its fluid passage, the at least one cavity being in direct fluid communication with
the at least one opening, and configured to receive thereinto fluid substance from the
fluid passage and have it interact with the sealing element attached over the opening.
The fluid passage can comprise at least one fluid restrictor/constriction and/or flow
manipulating element associated with the cavity, for causing changes in the fluid flow
rate and/or direction, and/or pressure therein.
Optionally, and in some embodiment preferably, the sealing element is made
from a thin film or foil made of polymeric material (e.g., polyimide, polycarbonate,
peek, ultem, polyurethane, etc.), and having thickness of about 10 to 1000 microns, and
its one or more electrical and/or sensor components can be patterned by sputtering,
evaporation, lamination, electroplating, elecroless plating, electroforming, printing,
and/or attached by means of printed circuit board surface mounting technology.
The one or more electrical and/or sensor components can be made from metals,
semiconductor, polymers having specific electrical conductivity properties,
piezoresistive materials, piezoelectric materials, or combinations thereof, according to
the application and type sensing elements to be implemented (e.g., Gold, NiCr alloys,
platinum, titanium). The thickness of the one or more electrical and/or sensor
components can be between 50 angstrom to 50 microns, that can be applied using
electrically conductive ink, by deposition, lamination, evaporation, sputtering, printing,
electroless plating and/or electroplating, to assume any suitable shape (e.g., zig zag,
serpentine, rosettes, etc).
The one or more electrical and/or sensor components can be configured to
measure tension changes in portion of the sealing element on which they are patterned
caused by deformation of the sealing element portion responsive to interaction with the- 4 -
fluid substance inside the fluid passage, for determining the one or more properties
and/or conditions of the fluid substance (e.g., fluid pressure, flow rate, and suchlike).
Alternatively, or additionally, the one or more electrical and/or sensor
components patterned on the sealing element can be configured to measure one more
properties of the fluid induced through the sealing element (e.g., temperature). In some
embodiments the one or more electrical and/or sensor components patterned on the
sealing element are configured to physically contact the fluid substance inside the
passage of the main body structure and thereby measure the one or more properties
and/or conditions of the fluid substance (e.g., pH, reduction potential, electrical
conductivity, and suchlike). Thus, in some embodiments, the sealing element comprises
electrical and/or sensor components patterned/attached on both its upper and under
sides, which can be electrically coupled by one or more vias.
Optionally, and in some embodiments preferably, the main body structure is
assembled from two or more body elements having preformed channels and/or cavities,
and configured to form the fluid passage by attaching the two or more elements one to
the other, and/or the at least one cavity, and/or the at least one fluid
restrictor/constriction and/or flow manipulating element. At least some of the two or
more body elements can comprise structural patterns configured to form fluid ports
and/or connectors in fluid communication with the fluid passage of the main body
structure. The two or more body elements can be configured to be assembled in a layer
by layer form, so as to form a multilayered structure comprising the different elements
of the main body structure i.e., the fluid passage, and the at least one cavity and/or the at
least one fluid restrictor/constriction and/or the at least one flow manipulating element
and/or the fluid ports/connectors.
The layered assemble approach of the main body structures of the MEMSs is
utilized in some embodiment for fabrication of a layered wafer comprising an array of
main body structures of the MEMSs. Particularly, each of the two or more body
elements can be fabricated in an array of integrally formed such body elements, and the
layers of integrally comprised body elements can be attached one to the other to form
the array of main body structures the MEMSs.
A sealing sheet comprising a respective array of the sealing elements, each
having its at least one electrical and/or senor components patterned/attached thereon, is
then attached over the wafer such that each one of its sealing elements is attached on a- 5 -
respective main body structure to sealably close the at least one opening of the main
body structure and accurately locate the at least one electrical and/or senor component
over its respective opening. This way a wafer comprising an array of MEMSs is
constructed in a layered fashion that can be advantageously used to calibrate all of
MEMSs in a single calibration step, as described herein in US Provisional Patent
application No. 62,470/407, of the same applicant hereof, the disclosure of which is
incorporated herein by reference.
Advantageously, each one of the different body elements of the MEMS is
configured such that it can be easily fabricated by any conventional 3D object
production technique without presenting undercuts and/or need to form partially or fully
closed cavities. With this design the layers comprising the arrays of the body elements
can be similarly fabricated by any conventional 3D object production technique without
presenting undercuts and/or need to form partially or fully closed cavities.
Optionally, and in some embodiments preferably, the electrical and/or sensor
components are patterned/attached on the sealing element/sheet before it is attached to
the main body structure/wafer comprising the array of main body structures. In some
embodiments the electrical and/or sensor components are patterned/attached on the
sealing element/sheet after it is attached to the main body structure/wafer comprising
the array of main body structures.
The wafer of MEMSs can be diced, before or after the calibration of the
MEMSs, using any suitable wafer dicing technique to cut out each of the MEMSs
therefrom.
One inventive aspect of the subject matter disclosed herein relates to a fluidic
sensor device comprising a base body structure comprising a fluid channel passing
along the base body structure and at least one opening in an external face of the base
body structure and being in fluid communication with the fluid channel, and a sealing
element comprising one or more sensing elements a priori patterned or mounted
thereon, the sealing element sealably attached over the external face of the base body
structure comprising the at least one opening such that its one or more sensing elements
become located over the at least one opening. The one or more sensing elements
configured to measure at least one property or condition of a fluid substance when the
fluid substance is introduced into the fluid channel and interact with a portion of the
sealing element located over the at least one opening. Optionally, the base body- 6 -
structure comprises at least one open cavity in fluid communication with the fluid
channel.
Optionally, and in some embodiments preferably, the base body structure is
assembled from two or more separate body elements configured to attach one to the
other and thereby form the fluid channel passing along the base body structure. At least
one of the two or more separate body structures can comprise the at least one opening
configured to form the at least one opening in the external face of the base body
structure and being in fluid communication with the fluid channel when the two or more
separate body elements are attached one to the other to assemble the base body
structure.
The base body structure can comprise at least one fluid port adapted to
connect to a fluid source. The at least one fluid port can be assembled by the attachment
of the two one or more body elements, and being in fluid communication with the fluid
channel.
Optionally, and in some embodiments preferably, the fluid channel comprises at
least one fluid restrictor. The at least one fluid restrictor can be assembled from at least
two restrictor portions elements by the attachment of the two or more body elements.
In some embodiments the at least two body elements comprise two channel
forming body elements, each of the two channel forming body elements comprises a
base portion and at least one open channel extending along a length of the base portion.
The at least one open channel of the two body elements can be configured to form at
least a portion of the fluid channel being in fluid communication with the at least one
opening when attached one to the other. Optionally, and in some embodiments
preferably, each of the two channel forming body elements comprises a respective at
least one connector portion extending from its base portion and configured to form a
connector structure when the two channel forming body elements are attached one to
the other. Each of the two channel forming body elements can comprise a respective at
least one partition portion configured to form a partition inside the fluid channel when
the two channels forming the body elements are attached one to the other. Optionally,
the at least two body elements comprise two casing body elements configured to attach
one to the other and thereby form an enclosure fixedly encasing all other body elements
therein.- 7 -
In some embodiments the base portion of one of the two channels forming the
body elements comprises first and second cavities with respective first and second
openings formed in a wall thereof, where each opening opens into its respective cavity
and sealably covered by a portion of the sealing element comprising a respective
sensing element. The base portion of the other one of the two channel forming body
elements can comprise a slender channel having first and second ends configured to
respectively fluidly communicate with the first and second cavities when the body
element are attached one to the other. Alternatively, the base portion of one of the two
channel forming body elements comprises first and second cavities with respective first
and second openings formed in a wall thereof, each opening opens into its respective
cavity and sealably covered by a portion of the sealing element comprising a respective
sensing element, and a slender channel having first and second ends configured to
respectively fluidly communicate with the first and second cavities, where the slender
channel is sealably closed by the sealing element.
The sealing element can comprise a pass through bore configured to be located
over the first opening and fluidly communicate therewith to thereby form a fluid
transmission passage, and the second opening can be sealably covered by a portion of
the sealing element comprising the at least one sensing element. A flow transmission
body element comprising an elongated open channel can be used to sealably attach over
a portion of the sealing element and fluidly communicate between the fluid transmission
passage and the portion of the sealing element sealably covering the second opening.
Optionally, and in some embodiments preferably, at least a portion of the sealing
element is a multilayered element, such as a laminated layered structure, having at least
one sealing layer configured to attach to the base body structure and seal the at least one
opening, and at least one sensing layer located above said at least one sealing layer and
comprising the one or more sensing elements. In some embodiments the multilayered
sealing element comprises an inner layer comprising the sensing element sealably
sandwiched between two protective layers. Optionally, at least one of the layers of the
sealing element configured to allow bonding (e.g., by laser, ultrasonic, gluing) to the
base body structure. The two protective layers are made in some embodiments from one
or more biocompatible materials.
The sealing element can be a multilayered element constructed as described and
illustrated in US Provisional application No. 62/523,315, and/or in US Provisional- 8 -
application No. 62/423,219, both of the same applicant hereof, the disclosures of which
is incorporated herein by reference. Optionally, and in some embodiments preferably,
the sealing element in the various embodiments disclosed herein comprises additional
circuitries and electronic element configured to communicate measurement and/or
control data with external machinery/systems, as described and illustrated in US
Provisional application No. 62/470,407, of the same applicant hereof, the disclosure of
which is incorporated herein by reference.
Optionally, the one or more sensing elements are patterned or mounted on the
sealing element after it is attached to the base body structure
Optionally, the flow transmission body element comprises an opening formed in
a wall thereof covered by a gas discharge component, where the gas discharge
component configured to eject gasses trapped inside the elongated channel of the flow
reversing body element.
Optionally, and in some embodiments preferably, at least a portion of the sealing
element attached over the at least one opening is deformable, and the one or more
sensing elements are configured to measure the at least one property or condition of the
fluid responsive to deformations of the portion of the sealing element. The one or more
sensing elements can comprise a temperature sensor being configured for measurement
of temperature of the fluid substance contacting the sealing element. The one or more
sensing elements can comprise at least one electrode positioned on an underside of the
sealing element and configured to become in physical contact with the fluid substance
when streamed through the fluid channel. Accordingly, the sealing element comprises in
some embodiments at least one via for electrically coupling to the at least one electrode
by means of contacts pads on the upper side of the sealing element.
The base body structure comprises in some embodiments a shielding element
attached over a portion of the sealing element comprising the at least one sensing
element and configured to prevent deformations of the portion of the sealing element.
The shielding element can be configured to thermally isolate the portion of the sealing
element from external environment and to prevent at least one of physical user contact
with the at least one sensing element and detachment of the sealing element.
In some embodiments the base body structure comprises a shielding element
attached over a portion of the sealing element comprising the at least one sensing
element, where the shielding element comprises an open cavity configured to be placed- 9 -
over a portion of the sealing element covering one of the at least one opening and
thereby enable deformation of the portion of the sealing element while thermally and/or
physically isolating it from the external environment. Optionally, the open cavity
comprises one or more openings configured to allow entry of air from the external
environment into the cavity. Alternatively, the open cavity can be configured to
maintain a predetermined pressure level over a portion of the sealing elements covering
one of the at least one opening. The shielding element can comprise one or more
fastening pins configured to fasten the shielding element to the base body structure.
Optionally, and in some embodiments preferably, the body elements of the base
body structure are fabricated by three-dimensional object production techniques without
presenting undercuts or closed cavities.
Another inventive aspect of the subject matter disclosed herein relates to a wafer
comprising an array of fluidic sensor devices according to any one of the embodiments
described hereinabove and hereinbelow integrally assembled therein by attaching two or
more layers one to the other. The wafer comprises in some embodiments a sealing sheet
comprising a respective array of the sealing elements sealably attached to a respective
array of base body structures for covering their openings and placing the a priori
patterned or mounted sensing elements thereover.
In some embodiments the array of base body structures is assembled from two
or more arrays of body elements configured to form elements of said fluidic sensor
devices when attached one to the other.
Each of the layers can comprise an array of one of the body elements configured
to form elements of the fluidic sensor devices when attached to at least one other layer.
A sealing sheet comprising a respective array of the sealing elements is sealably
attached to one of the layers for covering the opening of its body element and placing
the sensing elements thereover. Optionally, each body element in at least one of the
layers comprises at least one support element configured to connect the body element to
at least one other adjacent body element in the layer.
Yet another inventive aspect of the subject matter disclosed herein relates to a
wafer for construction of an array of fluidic sensor devices according to any one of the
embodiments disclosed hereinabove and hereinbelow, the wafer comprising a holder
assembly comprising a plurality of sockets each configured to snugly receive a base
body structure of one of the fluidic sensor devices and firmly hold it therein to thereby- 10 -
facilitate placement of a sealing sheet comprising a respective array of the sealing
elements thereover. The wafer can comprise a support frame having a respective
plurality of sockets each configured to snugly attach over one of the base body
structures of fluidic sensor devices in the holder and firmly hold it in place, where the
support frame comprising one or more elongated windows configured to facilitate
attachment of sealing sheets comprising the sealing elements over one or more rows of
said base body structures.
Optionally, the holder arrangement and it support frame are configured to
sealably communicate between two or more adjacently located fluidic sensor devices.
The support frame can comprise one or more connectors, each sealably connected to the
two or more adjacently located fluidic sensor devices sealably communicated by the
holder arrangement and it support to enable concurrently calibrating them in a same
calibration process.
A yet further inventive aspect of the subject matter disclosed herein relates to a
method of constructing fluidic sensor device by forming a base body structure having a
fluid channel passing along the base body structure and being in fluid communication
with at least one opening in an external face of the base body structure, and attaching a
sealing element comprising one or more sensing elements a priori patterned or mounted
thereon over the external face of the base body structure comprising the at least one
opening such that its one or more sensing elements become located over the at least one
opening. In some embodiments the base body structure is constructed by attaching two
or more separate body elements to thereby form the fluid channel in fluid
communication with the at least one opening.
The one or more sensing elements can be configured to measure at least one
property or condition of a fluid substance when the fluid substance is introduced into
the fluid channel and interact with a portion of the sealing element located over the at
least one opening. Optionally, the assembling comprises forming at least one fluid port
by the attachment of the two one or more body elements, and the at least one fluid port
being in fluid communication with the fluid channel. The assembling can also comprise
forming at least one fluid restrictor in the fluid channel by the attachment of the two or
more body elements. Optionally, the assembling comprises attaching two casing body
elements one to the other to form an enclosure fixedly encasing all other body elements
therein.- 11 -
A yet additional inventive aspect of the subject matter disclosed herein relates to
a method of constructing a wafer integrally comprising an array of the fluidic sensor
device according to any one of the embodiments described hereinabove and
hereinbelow. The method can comprise preparing an array of body base structures,
patterning or mounting on a sealing sheet an array of one or more sensing elements, and
attaching the sealing sheet over said array of the base body structures so as to seal the
respective at least one openings of the base body structures and place respective one or
more sensing elements thereover.
In some possible embodiments the wafer is constructed by preparing a plurality
of layers, each layer comprising an array of one the body elements, attaching the
plurality of layers one to the other to form a respective array of the base body structures,
preparing a sealing sheet comprising a respective array of the sealing elements,
patterning or mounting in each sealing element one or more sensing elements, and
attaching the sealing sheet over the array of the base body structures to thereby seal the
respective at least one openings of the base body structures and place respective one or
more sensing elements thereover.
BRIEF DESCRIPTION OF THE DRAWINGS
In order to understand the invention and to see how it may be carried out in
practice, embodiments will now be described, by way of non-limiting example only,
with reference to the accompanying drawings. Features shown in the drawings are
meant to be illustrative of only some embodiments of the invention, unless otherwise
implicitly indicated. In the drawings like reference numerals are used to indicate
corresponding parts, and in which:
Figs. 1A and 1B schematically illustrate fluidic MEMS according to some
possible embodiments comprised of a fluid flow structure and a sealing
membrane/deformable element attached thereto and comprising sensing and electrical
structures thereon, wherein Fig. 1A shows a sectional view of the fluidic MEMS and
Fig. 1B shows fabrication of a plurality of the fluidic MEMS in a wafer;
Figs. 2A to 2C schematically illustrate fluidic MEMSs array comprising in some
possible embodiments a layered fluid flow structure, wherein Figs. 2A and 2B
respectively show top and bottom perspective views of the fluid flow structure, and Fig.- 12 -
2C shows attachment of a sealing deformable element/membrane to the layered fluid
flow structure;
Fig. 3A to 3F schematically illustrate fluidic MEMS of some possible
embodiments comprising a multilayered fluid flow structure, wherein Fig. 3A shows an
exploded perspective view of the multilayered fluid flow structure, Fig. 3B shows a
sectional exploded perspective view of the multilayered fluid flow structure, Fig. 3C
shows a perspective view of the multilayered fluid flow structure; Fig. 3D shows a
sectional perspective view of the multilayered fluid flow structure; and Figs. 3E and 3F
show construction of a wafer comprising an array of MEMSs with multilayered fluid
flow structures and a sealing membrane/deformable element;
Figs. 4A and 4B schematically illustrate fluidic MEMS of some possible
embodiments configured for temperature measurements, wherein Fig. 4A shows a
perspective view of the MEMS and Fig. 4B shows construction of a wafer comprising
an array of the MEMSs;
Figs. 5A to 5H schematically illustrate fluidic MEMS of some possible
embodiments comprising male and female connector elements, wherein Fig. 5A shows
an exploded perspective view of a preassembled fluid flow structure of the MEMS, Fig.
5B shows a perspective view of the assembled fluid flow structure of the MEMS before
dicing, Fig. 5C and 5D respectively show sectional and back perspective views of the
fluid flow structure of the MEMS after dicing, Fig. 5E shows construction of a wafer
comprising an array of the fluidic MEMSs, Figs. 5F and 5G show a possible process for
dicing the array of the fluidic MEMSs, and Fig. 5H shows construction of a wafer
comprising an array of the fluidic MEMSs using a plurality of separate sealing
sheets/foils;
Figs. 6A to 6F schematically illustrate fluidic MEMS of some possible
embodiments comprising two female connector elements, wherein Figs. 6A and 6B
respectively show a perspective-exploded view and a side-sectional view of the fluidic
MEMS, Fig. 6C shows a variant of the fluidic MEMS comprising an upper slender
channel, Fig. 6D shows construction of a wafer comprising an array of the fluidic
MEMSs, Fig. 6E shows a possible process for dicing the array of fluidic MEMSs, and
Fig. 6F shows construction of an array of the fluidic MEMSs using separate sealing
sheets/foils;- 13 -
Figs. 7A to 7E schematically illustrate fluidic MEMS of some possible
embodiments comprising a differential flow sensing element, wherein Figs. 7A and 7B
respectively show an exploded perspective view and an exploded perspective sectional
view of the preassembled fluidic MEMS, Fig. 7C shows a sectional view of the fluid
MEMS, Fig. 7D shows a sectional view of the sealing element, and Fig. 7E shows
construction of a wafer comprising an array of the fluidic MEMSs and a possible
process for dicing the same;
Figs. 8A to 8E schematically illustrate fluidic MEMS of some possible
embodiments comprising a conductivity sensing element, wherein Figs. 8A shows an
exploded perspective view of the preassembled fluidic MEMS, Fig. 8B shows a
perspective sectional view of the fluidic MEMS, Fig. 8C shows a perspective view of a
sealing element of the fluidic MEMS with sensing and electrical elements patterned on
its top and bottom sides, and Figs. 8D and 8E show construction of a wafer comprising
an array of the fluidic MEMS;
Figs. 9A to 9E schematically illustrate fluidic MEMSs of some possible
embodiments comprising several sensing elements, wherein Figs. 9A shows an
exploded perspective view of a preassembled fluidic MEMS, Fig. 9B shows a
perspective sectional view of the MEMS, Figs. 9C and 9D show exploded perspective
views of modifications of the MEMS, and Fig. 9E illustrates possible attachment of a
shielding element to the body of the MEMSs;
Figs. 10A to 10C schematically illustrate arrangements configured for holding
an array of fluidic MEMSs, wherein Fig. 10A shows a perspective view of an
arrangement for holding a single row of MEMSs, and Figs. 10B and 10C show
perspective views of arrangements for holding an array of MEMSs; and
Figs. 11A to 11C schematically illustrate fluidic MEMS of some possible
embodiments implemented without fluidic channel(s), wherein Figs. 11A shows an
application of the fluidic MEMS for a sealing element, Fig.11B shows fabrication of an
array of the fluidic MEMSs; and Fig. 11C demonstrates applications of the fluidic
MEMSs in a syringe hub and/or barrel.
DETAILED DESCRIPTION OF EMBODIMENTS
One or more specific embodiments of the present disclosure will be described
below with reference to the drawings, which are to be considered in all aspects as- 14 -
illustrative only and not restrictive in any manner. In an effort to provide a concise
description of these embodiments, not all features of an actual implementation are
described in the specification. Elements illustrated in the drawings are not necessarily to
scale, or in correct proportional relationships, which are not critical. Emphasis instead
being placed upon clearly illustrating the principles of the invention such that persons
skilled in the art will be able to make and use the fluidic MEMS, once they understand
the principles of the subject matter disclosed herein. This invention may be provided in
other specific forms and embodiments without departing from the essential
characteristics described herein.
The present application provides structures, and fabrication techniques, for
MEMSs comprised of several layers, each of which can be separately manufactured
from same or different material. In some embodiments the MEMSs comprise a main
body structure made of two or more body parts separately prepared using any suitable
three-dimensional (3D) object production techniques, and configured to attach one to
the other is layer by layer fashion. In some embodiments at least some of the body parts
of the MEMSs are manufactured by injection molding, computer numerical control
(CNC) milling, 3D printing. Optionally, and in some embodiments preferably, at least
one, or all, of the body parts of the MEMSs are manufactured from plastic/polymeric
materials using the above-mentioned production techniques, or any other suitable plastic
manufacturing technique.
A thin sealing element (e.g., foil or film) comprising one or more
sensor/electrical elements is attached to the main body structure to seal at least one
opening formed therein and accurately place the one or more sensor/electrical elements
over the one or more openings. The one or more sensor/electrical elements can be
patterned on the sealing element (e.g., by metal deposition/lamination and then
lithography). The sealing element can be manufactured by spinning, roll to roll, or any
other suitable technique.
The fluidic MEMSs of the present application can be advantageously
manufactured in form of arrays of MEMSs assembled by attaching two or more
different and separately fabricated layers to form a wafer comprising a plurality of the
fluidic MEMSs. The fluidic MEMSs are then cut/diced our from the wafer using any
suitable wafer cutting/dicing technique, such as, but not limited to, laser cutting,
mechanical sawing, water jet cutter, and hot wire cutting. Optionally, and in some- 15 -
embodiments preferably, the different layers of the MEMSs array are manufactured
form polymeric materials, which are then assembled to form a polymeric wafer
comprising an array of the fluidic MEMSs.
The multilayered MEMSs (plastic/polymeric) wafer construction techniques
described herein can advantageously overcome the manufacturing limitation commonly
encountered in plastic fabrication techniques. For example:
• injection molding manufacture techniques cannot be used to manufacture undercuts
(recessed surfaces) or empty closed volumes in a single mold;
• in many cases 3D printing cannot be used to create undercuts without a support;
• 3D printing techniques also cannot be used to manufacture objects with empty
closed volumes, as these techniques requires that a drainage opening be formed to
empty the cavity from the uncured material(s).
The multilayered MEMSs fabrication techniques disclosed herein can be used to
manufacture arrays of MEMSs having different structures and forms from the examples
provided herein, without departing from the scope and spirit of the present application.
For example, the MEMSs structures described in international patent publication No.
WO 2015/114635, of the same applicant hereof, the disclosure of which is incorporated
herein by reference, can be fabricated as multilayered structures/wafers using any of the
techniques described herein.
Figs. 1A schematically illustrate a fluidic MEMS/device 160 comprising,
according to some possible embodiments, a fluid flow base element/structure 162
having at least one fluid port 162p and at least one cavity or fluid flow path 162f in
fluid communication with the at least one fluid port 162p via at least one fluid passage
162t, and at least one elastically deformable layer 161 (e.g., thin membrane/film/foil,
also referred to herein as encapsulating/sealing layer) attached thereto. The base element
162 is structured and arranged with an opening 165 provided in one of its surface areas,
said opening 165 being in fluid communication with the at least one cavity or fluid flow
path 162f and is sealably closed by the deformable layer 161 attached thereover.
In the specific non-limiting example shown in Fig. 1A, the fluid flow base
element/structure 162 is a unitary element (monolithic i.e., made from one piece
material), the at least one cavity or fluid flow path 162f is formed along a section of the
top side surface of the base element 162, and it is in fluid communication with two
lateral fluid ports 162p via respective two fluid passages 162t having lumens that taper- 16 -
upwardly towards the at least one cavity or fluid flow path 162f. However, lumens of
the fluid passages 162t are not essentially having tapering configurations, and indeed in
some embodiments the lumens in the MEMS/device are not tapering, or only
slightly/partly tapper.
The numeral 166 in Fig. 1A references electrical conducting lines, sensing
elements (e.g., for sensing fluid pressure inside the at least one cavity or fluid flow path
162f), electric circuitries, and/or actuating means for regulating fluid flow through the at
least one cavity or fluid flow path 162f, pattered and/or mounted on a surface area of the
deformable layer 161 located above the at least one cavity or fluid flow path 162f, using
any suitable technique e.g., sputtering, evaporation, lamination, electroplating,
elecroless plating, electroforming, printing, and/or printed circuit board surface
mounting technology. Electrical contacts/pads 161c can be also patterned on the
deformable layer 161, preferably, but not essentially, on a surface area not affected by
its deformations. Accordingly, the MEMS/device 160 is generally constructed from the
two main layers, the base element 160 with its fluid flow structures, and the deformable
layer 161 attached thereover sealing the top opening 165 of the at least one cavity or
fluid flow path 162f.
In some embodiments, the base element 162 and the deformable layer 161 are
made from a same (or different) type of polymeric material, or any other suitable
material (e.g., by lamination, CNC or micro-CNC, 3D printing, micro scale molding,
micro machining, nano and micro imprinting, hot embossing, injection molding,
lithography, laser micromachining, additive manufacturing, and suchlike).
Fig. 1B demonstrates fabrication of a plurality of the fluidic MEMSs/devices
160 according to some possible embodiments. The base elements 162 of the
MEMSs/devices 160 are fabricated in this non-limiting example as dies in the wafer
162' (also referred to herein as MEMSs production wafer) structured and arranged to
form the inner fluid flow structures (not shown) of each MEMSs/device 160, being in
fluid communication with a respective top opening 165 thereof. A common elastically
deformable layer 161' is attached (e.g., by lamination, ultrasonic welding, bonding,
gluing, laser welding) on top of the wafer 161' for sealably closing the top openings 165
of all of the base elements 162 in the wafer 161'. After attaching the deformable layer
161' over the top surface and closing the openings 165, the plurality of MEMSs/devices- 17 -
160 are cut (diced, illustrated by a dashed-line rectangle) out from the obtained layered
structure using any known suitable dicing technique.
The electrical contacts/pads (161c in Fig. 1A), and/or the electrical conducting
lines and/or circuitries, and/or the sensing elements, and/or the actuating means (166 in
Fig. 1B) can be formed or mounted on the deformable layer before or after cutting out
the MEMSs/devices 160, using any of the techniques described hereinabove.
Optionally, additional circuitries (e.g., a controller, data communication means,
memories, passive components, such as, but not limited to, resistors, capacitors and
inductors) are patterned/deposited/mounted on the MEMSs/devices 160 for handling
electrical signals thereby and externally received control signals, and/or for
communicating (via the electrical contacts/pads, or wirelessly) these signals with one or
more external devices. In some possible embodiments the actuating means placed on the
deformable layer are configured to regulate the fluid flow through the at least one cavity
or fluid flow path 162f responsive to mechanical or electromagnetic external control
e.g., applied by an external device.
The wafer 162' comprises a plurality of lateral openings 167, at least some of
which are in fluid communication with its internal fluid flow structures. As seen, in this
specific and non-limiting example, the lateral openings 167 are of rectangular
geometrical shape to allow sealing them easily (e.g., using glue, adhesive tape, sealably
fitting plugs, and suchlike) to prevent contamination of the inner fluid passages,
cavities/flow paths. In possible embodiments the wafer 162' does not include the lateral
openings 167.
Figs. 2A to 2C schematically illustrate another possible technique of fabricating
a plurality of the fluidic MEMSs/devices 160 shown in Fig. 1A. As seen in Figs. 2A
and 2B, in this non-limiting example the wafer 170 (also referred to herein as MEMSs
production wafer) is assembled from two different and separately fabricated layers
configured to form the fluid flow structures of the base elements (162) by sealably
attaching one layer to the other. The bottom layer 170b of the wafer 170 is structured
and arranged with a fluid port portions 174b and cavity/fluid flow channel portions
172b, and the top layer 170a of the wafer 170 is structured and arranged with
complementary fluid port portions 174a and cavity/fluid flow channel portions 172a,
and respective openings 165 in fluid communication with their respective fluid port
portions 174a.- 18 -
The top layer 170a can be attached to the bottom layer 170b of the wafer 170 by
lamination, ultrasonic welding, bonding, gluing, or laser welding. The attachment of the
layers 170a and 170b in alignment of their fluid interaction portions sealably construct
the fluid ports, fluid passages, and cavities/fluid flow paths/lumens of the base elements.
For example, and without being limiting, if laser welding is used, the top layer 170a can
be a thermoplastic laser adsorbent layer, the bottom layer 170b can be a thermoplastic
transparent laser layer, and the deformable layer 161' can be a laser transparent layer.
Fig. 2C shows attachment of a common elastically deformable layer 161' on top
of the top layer 170a of the assembled wafer 170, sealing the openings 165 of the base
elements 162 integrated in it. The deformable layer 161' can be attached on the top
layer 170a to sealably close its openings 165, using any of the techniques described
herein, or any other suitable technique. After attaching the deformable layer 161' over
the top surface and closing the openings 165, the plurality of MEMSs/devices 160 are
cut (diced, illustrated by a dashed-line rectangle) out from the obtained layered structure
using any known suitable dicing technique.
In some possible embodiments the top layer 170a is structured and arranged to
integrally include deformable elements i.e., by fabricating the top layer 170a to include
elastic/flexible thin regions instead of the opening 165. In this configuration attachment
of the common deformable layer 161' on top of the top layer 170a is only optional and
it can be omitted.
The top and/or bottom layers 170a and 170b, and/or the deformable layer 161',
can be manufactured from polymeric materials (same or different) by any suitable
technique, such as described herein. The electrical contacts/pads, and/or the electrical
conducting lines, and/or the sensing elements, and/or the actuating means, and/or any
additional circuitries (e.g., a controller, data communication means), can be
patterned/mounted on the deformable layer 161' before or after cutting out the MEMS
device 160, using any of the techniques described herein, or any other suitable
technique.
Figs. 2A to 2C demonstrate aligning the portions of the fluid interacting
structures in the layers 170a and 170b in parallel structures, but of course any other
suitable arrangement can be employed instead per implementation and design
configuration. In the specific and non-limiting example shown in Figs. 1B and 2A-C the
wafer 162' and the deformable layer 161' are of a circular disk shape, and the wafer- 19 -
162' is structured and arranged to include 8 base elements 162. However, the fabrication
technique shown in Fig. 1B and 2A-Cof course can used to manufacture wafers
comprising any number of MEMSs/devices and having any other suitable shape and
dimensions.
Figs. 3A to 3E schematically illustrate structures and construction of fluidic
MEMS 30 according to some possible embodiments comprising a multilayered fluid
flow structure 10 including top and bottom elongated shell elements, 33 and 34
respectively, configured to be attached one to the other and form an enclosure for
packaging top and bottom fluid channel portions, 31 and 32 (also referred to herein as
connector portions), respectively. The top shell element 33 comprises an elongated open
passage formed along its length and extending between the threading portions 33a and
33b formed at the extremities thereof, a top central window 33p that opens into the
elongated open passage, and two lateral central cuts 33r passing through the side walls
of the shell element 33 all the way into the elongated open passage.
The bottom shell element 34 comprises an elongated open passage formed along
its length, extending between threading portion 34a and 34b formed at the extremities
thereof, a bottom central window 34p that opens into the elongated open passage, and
two central lateral cuts 34r passing through the side walls of the shell element 34 all the
way into the elongated open passage.
As seen, except for the threading portions, 33a-33b and 34a-34b, the top and
bottom shell elements 33 and 34 can be substantially symmetric about the plane of their
connection where lateral edges of their elongated open passage reside.
The top fluid channel portion 31 comprises two fluid port portions 31a and 31b
extending from its extremities towards its center. Each of the fluid port portions 31a and
31b comprises a central open channel extending along its length from the extremities
towards the center of the top fluid channel portion 31, wherein a partition portion 31n
(also referred to herein restrictor portion) is formed to partition between the two open
channels. The fluid port portions 31a and 31b are connected to a central hub element
31t configured to snugly fit into the top central window 33p of the top shell element 33.
The central hub element 31t comprises a cavity 31c located above and in fluid
communication with the open channels of the fluid port portions 31a and 31b, a top
opening 31p that opens into cavity 31c, and two lateral shoulders 31s configured to
snugly fit into the lateral cuts 33r formed in the lateral walls of the shell element 33.- 20 -
The bottom fluid channel portion 32 comprises two fluid port portions 32a and
32b extending from its extremities towards its center. Each of the fluid port portions
32a and 32b comprises a central open channel extending along its length from the
extremities towards the center of the bottom fluid channel portion 32, wherein a
partition portion 32n is formed to partition between the two open channels. The fluid
port portions 32a and 32b are connected to a central hub element 32t configured to
snugly fit into the bottom central window 34p of the bottom shell element 34. The
central hub element 32t comprises two lateral shoulders 32s configured to snugly fit
into the lateral cuts 34r formed in the lateral walls of the shell element 34.
Each fluid port portion can be configured as a frusta-conical element halved
along its length, bored along its central axis to form the open channel passing along the
central axis, and that gradually taper from the center of the fluid channel portion
towards the extremity of the fluid port portion. This way, the fluid port portion 31a of
the fluid channel portion 31 and the fluid port portion 32a of the fluid channel portion
32 are substantially symmetric about the plane of their connection, where lateral edges
of their open channels reside. Similarly, the fluid port portion 31b of the fluid channel
portion 31 and the fluid port portion 32b of the fluid channel portion 32 are
substantially symmetric about the plane of their connection, where lateral edges of their
open channels reside.
When the shell elements, 33 and 34, with their respective fluid channel portions
31 and 32, are attached one to the other, an elongated passage is formed by their
elongated open passages that enclose the fluid channel portions 31 and 32 thereinside
immobilized by the central hub elements and lateral shoulders of the fluid channel
portions 31 and 32, that snugly fit into the respective central windows and lateral cuts of
the shell elements 33 and 34. In this assembled state the open channels of the fluid
channel portions 31 and 32 form two respective fluid lumens a and b, each sealed along
its length, and two respective male connectors 31a-32a and 31b-32b are also formed,
each having a frusta-conical shape tapering towards the extremity of the fluid flow
structure 10.
As seen in Fig. 3D, in the assembled state, the partition portions 31n and 32n of
the fluid channel portions 31 and 32 are attached one to the other to form a partition
31n-32n sealably partitioning between the fluid lumens a and b. In this way a
continuous fluid passage 37 is formed along the device 30 extending along the sealed- 21 -
lumen a formed by the fluid port portions 31a and 32a, passing through the cavity 31c
formed inside the central hub 31t, and therefrom extending along the sealed lumen b
formed by the fluid port portions 31b and 32b. As shown in Fig. 3C, after assembling
the fluid flow structure 10 a sealing element 36' is sealably attached over the top surface
of the top shell element 33, to sealably close the top opening 31p of the central hub
element 31t and place thereover sensor and/or circuitry elements 36i formed thereon.
As seen in Figs. 3C and 3D, when all parts of the fluid flow structure 10 are
assembled, the threading portions 33a and 34a are joined to form connector threading
that can be used to secure a fluid connector to the connector 31a-32a, and similarly the
threading portions 33b and 34b are joined to form connector threading that can be used
to secure a fluid connector to the connector 31b-32b. The device 30 can be connected to
a fluid source either by the connector 31a-32a formed at one side thereof, or by the
connector 31b-32b at the other side, for flowing a fluid through the fluid passage 37,
thereby filling the cavity 31c with the streamed fluid and causing it to interact with the
sealing element 36' sealing its top opening 31p. The sensor elements/circuitries 36i
patterned/mounted on the sealing element 36' can be used to measure properties of the
liquid substance introduced into the cavity 31c.
In some embodiments the sealing element comprises sensors elements
configured to contact the fluid introduced into the cavity 31c and measure properties
thereof (e.g., using electrodes), such as, but not limited to pH level, electrical
conductivity, and suchlike. Additionally, or alternatively, the sealing element 36' can
comprise contactless sensor elements (not shown) configure to measure properties of
the liquid in the cavity 31c, such as, but not limited to, temperature of the liquid (e.g.,
using piezoelectric sensing elements). Optionally, and in some embodiments preferably,
the sealing element 36' is a multilayered structure, such as illustrated in Fig. 7D.
Optionally, and in some embodiments preferably, the sealing element 36' is
elastically (or flexible) deformable element (thin foil/film) comprising one or more
piezoelectric elements configured to measure forces applied over the sealing element
36' as it is deformed in response to the fluid streamed through the device 30, that can be
used to determine fluid pressure and/or flow rate. In some embodiments the sealing
element 36' comprises two or more different sensors configured to measure two or more
different properties of the liquid.- 22 -
As seen and described above, the device 30 is assembled from four parts (also
referred to herein as body elements) and a sealing elements attached over the top
opening 31p, and each one of the different parts, 31, 32, 33 and 34, can be easily
fabricated by any conventional 3D object production technique without presenting
undercuts and/or need to form partially or fully closed cavities.
Optionally, and in some embodiments preferably, each of the different parts of the
device 30 is fabricated as an integral part of an array of such parts configured to be
attached to arrays of parts to be attached thereto, such that four different arrays of parts
are formed for attachment one to other to from a layered structure. With reference to
Fig. 3E, in this embodiment each top fluid channel portion 31 is fabricated as an
integral part of an array of top fluid channel portion parts A31, each bottom fluid
channel portion 32 is fabricated as an integral part of an array of bottom fluid channel
portion parts A32, each top shell element 33 is fabricated as an integral part of an array
of top shell elements A33, and each bottom shell element 34 is fabricated as an integral
part of an array of such bottom shell elements A34.
A plurality of fluid flow structures 10 of MEMSs/devices 30 are assembled by
attaching the array of top shell elements A33 to the array of top fluid channel portion
parts A31 to form a top assembly, attaching the array of bottom shell elements A34 to
the array of bottom fluid channel portion parts A32 to from a bottom assembly, and
attaching the top assembly to the bottom assembly. In some embodiments the array of
top shell elements A33 is arranged in an upper support frame 33f having a plurality
fastening pins 33i protruding downwardly therefrom, and the array of bottom shell
elements A34 is arranged in a bottom support frame 34f having a respective plurality of
fastening sockets 34s formed in upper faces thereof. The plurality of fastening sockets
34s of the bottom support frame 34f are configured to snugly receive the plurality of
fastening pins 33i of the upper support frame 33f, to thereby firmly encase the different
layers of the structure attached one to other and form a wafer 39 (in Fig. 3F) comprising
an array of the fluid flow structures 10 of MEMSs/devices 30.
It should be understood that the arrays of parts A33, A31, A32 and A34, can be
attached one to other in any suitable order, and not limited to the above-provided
example. The arrays of parts A33, A31, A32 and A34, can be attached one to the other
as shown in Figs. 3E and 3F using any suitable techniques, such as, but not limited to,
gluing, laser welding, ultrasonic welding, hot welding, and suchlike. The reasons to- 23 -
construct the fluid flow structures 10 of MEMSs/devices 30 in such multilayered
structure is derived from the complexity of the final device, and how it is arrayed. The
motivation in this specific and non-limiting example arises at least in part from the
following:
- in case the wafer 39 is fabricated by injection molding, the wafer 39 cannot be
built from one or two parts because undercuts or closed empty volumes are
inevitably present in such designs; and
- in case the wafer 39 is fabricated by 3D printing (SLA, DLP, SLS, etc..), while
undercuts can be printed, there is an inevitable need to clean uncured material,
as it is impossible to otherwise print closed empty volumes in such techniques.
It is important to note that this specific and non-limiting example the wafer 39 of
fluid flow structures 10 of MEMSs/devices 30 cannot be built as one integral
(monolithic) part by 3D printing, but from at least two parts/layers (e.g., such as the
above-described upper and bottom assemblies), since such designs inevitably require
drainage of uncured materials and drilling of holes and/or support structures.
After assembling the wafer 39 of fluid flow structures 10 of MEMSs/devices 30 a
sealing sheet 36 is sealably attached over the upper side of the wafer 39. The sealing
sheet 36 comprises a respective array of sensor units/circuitries 36i aligned so as to
place each sensor unit/circuitry 36i of the sealing sheet 36 precisely over a respective
top opening 31p of one of the fluid flow structures 10 of MEMSs/devices 30. The
sealing sheet 36 can be attached to the upper face of the wafer 39 by gluing, laser
welding, lamination, ultrasonic welding or hot welding. Alternatively, the array of
sensor units/circuitries 36i can be patterned (or mounted) on the sealing sheet/foil 36
after it is attached to layered structure. Thereafter, the MEMSs/devices 30 can be
diced/cut out from the wafer 39 using any suitable dicing technique known in the art.
In the different wafer embodiments disclosed herein, the sensor units/circuitries 36i
can be calibrated before the dicing, or after the dicing. In some embodiments all of the
sensor units/circuitries 36i placed on the wafer are calibrated in a single calibration step
by applying to the finalized wafer of MEMSs/devices the same calibration conditions at
the same time, using any of the wafer calibration techniques described in US
Provisional Patent application No. 62,470/407, of the same applicant hereof, the
disclosure of which is incorporated herein by reference.- 24 -
Figs. 4A and 4B schematically illustrate fluidic MEMS/device 40 of some
possible embodiments configured for temperature measurements. In this specific and
non-limiting example the fluid flow structure 10 is of substantially the same fluid flow
structure described hereinabove with reference to Figs. 3A to 3F. The top opening 31p
of the fluid flow structure 10 is sealed by a sensor sheet 41 having at least one
temperature sensor 41e patterned or mounted thereon such that it is precisely placed
over the top opening 31p of the fluid flow structure 10. The sensor sheet 41 further
comprises at least two contact pads 41p, electrically coupled to the temperature sensor
41e by conducing lines 41n patterned thereon. In this specific and non-limiting example
the sensor sheet 41 comprises four contact pads 41p, where one pair of contact pads 41p
is electrically coupled to one side of the temperature sensor 41e by conducting lines
41n, and another pair of the contact pads 41p is electrically coupled by conducting lines
41n to the other side of the temperature sensor 41e, which can be used to minimize of
electrical resistance differences by conducting the measurements via the pairs of contact
pads 41p provided at the extremities of the temperature sensor 41e.
Optionally, and in some embodiments preferably, the temperature sensor 41e is
a type of resistive temperature detector (RTD) made of an electrically conductive
material (e.g. NiCr, Platinum, copper, gold, etc.) having a periodic zigzagged structure,
or rectangular-wave structure, or any other wavy structure. The temperature sensor 41e
can be patterned using metal deposition techniques (evaporation, sputtering,
electroplating, electroless plating) or lamination processes combined with lithography
processes, and the contact pads 41p and the conducting lines 41n can be patterned using
NiCr, Platinum, copper, gold, etc. The sensor sheet 41 can be made from a thin film or
foil made of polymeric material (e.g., polyimide, polycarbonate, peek, ultem,
polyurethane, etc.) having good thermal coupling properties (i.e., high thermal
conductivity), and it may be either rigid or flexible/elastic, per implementation
requirements.
After attaching the sensor sheet 41 to the upper surface of the fluid flow
structure 10, a rigid shielding element 42 is attached thereon to substantially immobilize
and prevent deformations of the sensor sheet 41 portion located over the top opening
31p when pressure forces are applied thereon when fluids are introduced into the cavity
of the fluid flow structure 10, and to provide thermal insulation from the external
environment. The shielding element 42 is configured to substantially prevent- 25 -
measurements errors that can be induced due to deformations of the temperature sensor
41e patterned on the sensor sheet 41, and due to temperature differences between the
fluid substance introduced into the cavity 31c and the external environment.
The shielding element 42 can have any shape suitable to substantially cover the
top opening 31p and prevent deformations of the sensor sheet 41, and it can be
fabricated from any suitable material having poor/low thermal conductivity properties.
Optionally, and in some embodiments preferably, the shielding element 42 has a type of
celtic-cross shape having an elongated arm 42a extending substantially along the length
of the fluid flow structure 10, two short transversal arms 42b extending in sideway
directions from the center of, and substantially perpendicular to, the elongated arm 42a,
and a central disk-shaped portion 42c merging into the arms 42a and 42b at their
connection area and substantially covering the top opening 31p of the fluid flow
structure 10. This configured is particularly advantageous to construct a plurality of
fluidic MEMSs/devices 40 in a multilayered wafer form, as shown in Fig. 4B.
The wafer 39 of fluid flow structures 10 in Fig. 4B is substantially of the same
multilayered structure shown in Figs. 3E and 3F. In some embodiments a protective
layer 39p is applied over the top surface of the wafer 39, which can be implemented by
a thin film or foil made of polymeric sheet/foil/film (e.g., polyimide, peek, ultem,
polycarbonate, polyurethane) attached to the wafer 39 by laser welding, gluing,
ultrasonic welding. An array of sensor sheets A41 is attached to the wafer 39 by laser
welding, gluing, ultrasonic welding such that a respective sensor sheet 41 is placed over
each one of the fluid flow structures 10 and a respective temperature sensor 41e is
precisely placed over each top opening 31p of each fluid flow structures 10 of the wafer
39. After attaching the array of sensor sheets A41 to the wafer 39, an array of shielding
elements A42 is attached to the wafer on top of the array of sensor sheets A41 such that
a respective shielding element 42 is precisely placed over each temperature sensor 41e
of the array of sensor sheets A41, while substantially covering the respective top
openings 31p. The finalized wafer, with or without the optional protective layer 39p,
and with the arrays of sensor sheets A41 and shielding elements A42, can be then diced
using any suitable dicing technique, to cut out the temperature measurement
MEMSs/devices 40.
It is noted that the opening 31p used with the temperature sensor 41e can assume
one of various different shapes, such as, but not limited to, rectangular, circular, oval,- 26 -
etc. For example, an elongated long and narrow rectangular-shaped opening 31p will
guarantee that less deformations of the sealing element 41 attached over the opening
31p occur, than in circular configurations thereof.
Figs. 5A to 5H schematically illustrate structure and construction of fluidic
MEMS 55 of some possible embodiments comprising a male connector 31b-32b and
female connector 51a-52a. Optionally, and in some embodiments preferably, the male
connector 31b-32b and the female connector 51a-52a are configured as Luer lock
connectors, or any other type of quick connector structure e.g., barbed fittings, screw
threading, or suchlike. The fluidic MEMS/device 55 comprises a multilayered fluid
flow structure 50 assembled from top and bottom casing elements, 53 and 54
respectively, configured to be attached one to the other and form an enclosure for
packaging top and bottom fluid channel portions, 51 and 52, respectively. The top and
bottom casing elements 53 and 54 are generally "U"-shaped elements, each having two
substantially parallel arms perpendicularly extending from a base section optionally
having a threading portion extending substantially perpendicular to the plane of the
parallel arms.
More particularly, the casing element 53 comprises the two parallel arms 53r
perpendicularly extending from the base section 53b having the threading portion 33b
extending substantially perpendicular to the plane of the parallel arms 53r, and the
casing element 54 comprises the two parallel arms 54r perpendicularly extending from
the base section 54b having the threading portion 34b extending substantially
perpendicular to the plane of the parallel arms 53r. The casing elements 53 and 54 also
comprise support extensions extending longitudinally from each one of the arms and
configured to provide support for the multilayered fluid flow structure 50 and facilitate
attachment of a sealing element 36' having one or more sensor elements/circuitries
patterned/mounted thereon.
Particularly, the top casing element 53 comprises two elongated support
extensions 53d extending longitudinally from its parallel arms 53r and configured to
provide support for attachment of the sealing element 36' thereover, and the bottom
casing element 54 comprises two elongated support extensions 54d extending
longitudinally from its parallel arms 54r and configured to provide support to the
multilayered fluid flow structure 50. The elongated support extensions 53d and 54d are
also useful for the construction of an array of the fluid flow structure 50, as shown in- 27 -
Figs. 5E to 5G, where they are also used for connecting between adjacently located
casing elements. Optionally, and in some embodiments preferably, after assembling the
fluid flow structure 50 and attaching the sealing element 36 thereover, the support
extensions 53d and 54d are removed from the MEMS/device 55 using any suitable
partial depth (not through) dicing technique (e.g., laser cutting, mechanical sawing, hot
wire cutting, etc.), to obtain the final MEMS/device configuration readily operable for
use shown in Figs. 5C and 5D.
When the casing elements 53 and 54 are attached one to the other the threading
portions 53b and 54b form a circular passage comprising a complete threading structure
on inner surface thereof, and configured to enclose a male connector 31b-32b
assembled by the fluid channel portions, 51 and 52. In the assembled state the parallel
arms 53r of casing element 53 and the parallel arms 54r of casing element 54 are
aligned in two parallel plains, and thus define respective top and bottom socket, 53s and
54s respectively, and two lateral sockets 50s.
As seen, except for the threading portions 34a-34b the top and bottom casing
elements 33 and 34 can be substantially symmetric about the plane of their connection
i.e., a plane substantially centered between the planes of the parallel arms 53r and 54r.
The top fluid channel portion 51 comprises a female connector portion 51a and a
male connector portion 31b, extending from its extremities towards its center. Each of
the connectors portions 51a and 31b comprises a central open channel extending along
its length from the extremities towards the center of the top fluid channel portion 51,
wherein a partition portion 51n is formed to partition between the two open channels.
The fluid port portions 51a and 31b are connected to a central hub element 51t
configured to snugly fit into the top socket 53s in abutment to the base section 53b of
the top casing element 53. The central hub element 51t comprises a cavity 51c located
above and in fluid communication with the open channels of the fluid port portions 31a
and 31b through respective vertical lumens 51i and 51j partitioned by the partition
portion 51n passing therebetween, a top opening 31p that opens into the cavity 51c, and
two lateral shoulders 32s.
The bottom fluid channel portion 52 comprises corresponding female connector
portion 52a and male connector portion 32b extending from its extremities towards its
center. Each of the connector portions 52a and 32b comprises a central open channel
extending along its length from the extremities towards the center of the bottom fluid- 28 -
channel portion 52, wherein a partition portion 52n is formed to partition between the
two open channels. The connector portions 52a and 32b are connected to a central hub
element 52t configured to snugly fit into the bottom socket 52s of the bottom casing
element 34 in abutment to the base section 54b of the bottom casing element 54. The
central hub element 52t comprises two lateral shoulders 32s.
The male connector portions 31b and 32b can be configured as a frusta-conical
elements halved along their lengths, bored along their central axis to form the open
channel passing along the central axis, and that gradually taper from the center of their
fluid channel portions towards the extremity of the male connector portion. The male
connector portions 31b and 32b are thus substantially symmetric about the plane of
their connection, where lateral edges of their open channels reside. The female
connector portion 51b of the fluid channel portion 51 and the female connector portion
32b of the fluid channel portion 52 have a generally halved-cylinder shape that are
substantially symmetric about the plane of their connection, where lateral edges of their
open channels reside.
When the casing elements, 53 and 54, with their respective fluid channel
portions 51 and 52, are attached one to the other, the lateral shoulders 31s and 32s of the
fluid channel portions 51 and 52 are joined to form two lateral fastening steps 31s-32s
snugly received in the lateral sockets 50s. In this way, in the assembled state the fluid
channel portions 51 and 52 are joined to form an assembly comprising the male
connector 31b-32b enclosing fluid lumen b sealed along its length, and the female
connector 51a-52a leading to fluid lumen a sealed along its length, and the assembly is
held immobilized by the central hub elements and lateral fastening steps of the fluid
channel portions 51 and 52, that snugly fit into their respective sockets. The male
connector 31b-32b has a frusta-conical shape tapering towards the extremity of the fluid
flow structure 50, and the female connector 51a-52b has a generally cylindrical shape.
As seen in Fig. 5D, in the assembled state, the partition portions 51n and 52n of
the fluid channel portions 51 and 52 are attached one to the other to form a continuous
partition 51n-52n sealably partitioning between the fluid lumens a and b. In this way a
continuous fluid passage 57 is formed along the device (55) extending along the sealed
lumen b formed by the fluid port portions 31b and 32b, passing upwardly through the
lumen 51i into the cavity 31c and therefrom downwardly through the lumen 51j that are
formed in the central hub 51t, and therefrom extending along the sealed lumen a. As- 29 -
shown in Fig. 5D, after assembling the fluid flow structure 50 a sealing element 36' is
sealably attached over the top surface of the top casing element 53, to sealably close the
top opening 31p of the central hub element 31t and place thereover sensor and/or
circuitry elements 36i formed/mounted thereon.
As seen in Figs. 5C and 5D, when all parts of the fluid flow structure 50 are
assembled, the threading portions 33b and 34b are joined to form connector threading
that can be used to secure a fluid connector to the formed male connector 31b-32b. The
device 55 can be connected to a fluid source either by the male connector 31b-32b
formed at one side thereof, or by the female connector 51a-52a formed at the other side,
for flowing a fluid through the fluid passage 57, thereby filling the cavity 51c with the
streamed fluid and causing it to interact with the sealing element 36' sealing its top
opening 31p. The sensor elements/circuitries 36i patterned/mounted on the sealing
element 36' can be used to measure properties of the liquid substance introduced into
the cavity 31c.
In some embodiments the sealing element comprises sensors elements
configured to contact the fluid introduced into the cavity 31c and measure properties
thereof (e.g., using electrodes), such as, but not limited to pH level, electrical
conductivity, and suchlike. Additionally, or alternatively, the sealing element 36' can
comprise contactless sensor elements (not shown) configured to measure properties of
the liquid in the cavity 31c, such as, but not limited to, temperature of the liquid (e.g.,
using piezoelectric sensing elements). Optionally, and in some embodiments preferably,
the sealing element 36' is elastically (or flexible) deformable element (thin foil/film)
comprising one or more piezoelectric elements configured to measure forces applied
over the sealing element 36' as it is deformed in response to the fluid streamed through
the device 55, that can be used to determine fluid pressure and/or flow rate. In some
embodiments the sealing elements comprises two or more different sensors configured
to measure two or more different properties of the liquid.
As seen and described above, the device 55 is assembled from four parts (also
referred to herein as body elements) and a sealing elements attached over the top
opening 31p, and each one of the different parts, 51, 52, 53 and 54, can be easily
fabricated by any conventional 3D object production technique without presenting
undercuts and/or need to form partially or fully closed cavities.- 30 -
Optionally, and in some embodiments preferably, each of the different parts of the
device 55 is fabricated as an integral part of an array of such parts configured to be
attached to arrays of parts to be attached thereto, such that four different arrays of parts
are formed for attachment one to other in to from a layered structure. With reference to
Fig. 5E, in this embodiment each top fluid channel portion 51 is fabricated as an
integral part of an array of top fluid channel portion parts A51, each bottom fluid
channel portion 52 is fabricated as an integral part of an array of bottom fluid channel
portion parts A52, each top casing element 53 is fabricated as an integral part of an
array of top shell elements A53, and each bottom casing element 54 is fabricated as an
integral part of an array of such bottom casing elements A54.
As seen in Fig. 5F, a plurality of fluid flow structures 50 of MEMSs/devices 55 are
assembled by attaching the array of top casing elements A53 to the array of top fluid
channel portion parts A51 to form a top assembly, attaching the array of bottom casing
elements A54 to the array of bottom fluid channel portion parts A52 to from a bottom
assembly, and attaching the top assembly to the bottom assembly. In some
embodiments the array of top casing elements A53 is arranged in an upper support
frame 33f and the array of bottom shell elements A34 is arranged in a bottom support
frame 34f. The array of top and bottom casing elements are attached one to the other to
encase the different layers of the fluid flow structures attached one to other and form a
wafer 39 comprising an array of the fluid flow structures 50 of the MEMSs/devices 55.
In this specific and non-limiting example an array of 4x9 MEMSs/devices 55 is
constructed in the wafer 59, and the fluid flow structure is arranged such that at each
side of the array the first two rows of 9 MEMSs/devices 55 are connected one to the
other by their female connectors, and the two central rows of 9 MEMSs/devices 55 are
connected one to the other by their male connectors. It is however noted that in possible
embodiments the wafer may be configured to construct an array consisted of a single
row, or of a single column, of the MEMSs/devices 55
It is noted that the arrays of the parts A53, A51, A52 and A54, can be attached one
to other in any suitable order, and not limited to the above-provided example. The
arrays of parts A53, A51, A52 and A54, can be attached one to the other as shown in
Figs. 5E and 5F using any suitable technique, such as, but not limited to, gluing, laser
welding, ultrasonic welding, hot welding, and suchlike. as in the previous embodiments,
in case the wafer 59 is fabricated by injection molding, the wafer 59 cannot be built- 31 -
from one or two parts because undercuts are inevitably present in such designs, and in
case the wafer 59 is fabricated by 3D printing (SLA, DLP, SLS, etc..), while undercuts
can be printed, there is an inevitable need to clean uncured material, as it is impossible
to otherwise print closed empty volumes in such techniques. It is also noted that this
specific and non-limiting example the wafer 59 of fluid flow structures 50 of
MEMSs/devices 55 cannot be built as one integral (monolithic) part, but from at least
two parts/layers (e.g., such as the above-described upper and bottom assemblies), since
such designs inevitably require drainage of uncured materials and drilling of holes.
After assembling the wafer 59 of fluid flow structures 50 of MEMSs/devices 55 a
sealing sheet 36 (e.g., thin foil/film) is sealably attached over the upper side of the wafer
59. The sealing sheet 36 comprises a respective array of sensor units/circuitries 36i
aligned so as to place each sensor unit/circuitry 36i of the sealing sheet 36 precisely
over a respective top opening 31p of one of the fluid flow structures 50 of
MEMSs/devices 55.
As seen, the sealing sheet 36 covers the elongated openings 59w formed in the
wafer 59 over the female connectors between the elongated support extensions 53d of
the top casing element 53. In some embodiments the sealing sheet is attached to the
wafer 59 before deposition of the conductive/sensing elements 36i, and in this case the
sensors/circuitries 36i can be applied on a flat wafer covered by the sealing sheet 36,
which thus allows use of standard lithography and/or metal deposition techniques.
The sealing sheet 36 can be attached to the upper face of the wafer 59 by gluing,
laser welding, ultrasonic welding or lamination. Thereafter, the MEMSs/devices 55 can
be diced/cut out from the wafer 59 in a two steps dicing process using any suitable
dicing technique known in the art, as illustrated in Figs. 5F and 5G.
Particularly, the dicing process comprises in some embodiments a preliminary
dicing step illustrated by dashed lines D1 in Fig. 5F, in which partial cuts D1 are
transversally applied along the top side and the bottom side (not shown) of the wafer 59
in a relatively short depth sufficient to only cut off the support top and bottom
extensions 53d and 54d and remove portions of the sealing sheet located over the
elongated openings 59w. Accordingly, the partial cuts D1 don’t pass all the way through
the wafer 59, and in some embodiments their depths is in the range of 0.01% to 25% of
the wafer thickness. In further dicing steps pass through cuts are then applied, as
illustrated by the dashed-dotted lines D2 and D3 shown in Fig. 5G, to remove the- 32 -
MEMSs/devices 55 from the wafer 59. In these dicing steps one or more traversal pass
through cuts D2 are applied to separate the the rows of the MEMSs/devices 55 one from
the other, and one or more longitudinal pass through cuts D3 are applied to separate the
columns of the MEMSs/devices 55 one from the other.
Fig. 5H shows a possible embodiment wherein a wafer 59' comprising the array of
MEMSs/devices 55 is assembled using an array A53' of top casing elements 53'
fabricated without the elongated support extensions. In this embodiment a plurality of
sealing sheets 36'' are used to seal the top openings 31p i.e., the sealing sheets 36''
transversally cover a portion of a row, or portions of two rows, of the MEMSs/devices
55 of the wafer, comprising the base sections 53b, top parallel arms 53r and central
hubs 31t, without covering the elongated openings 59w. As seen, in this specific and
non-limiting example the MEMS devices 55 do not have the elongated support
extensions parallel arms 53d and 54d, and thus the three separated sealing sheets 36''
are used, wherein each of the two sealing sheets 36'' applied over the first and last rows
of MEMSs/devices 55 comprises a single row of sensor and/or circuitry elements 36i,
and the sealing sheet 36'' applied over the second and third rows of MEMSs/devices 55
comprises corresponding two rows of sensor and/or circuitry elements 36i.
Figs. 6A to 6C schematically illustrate structure and construction of a fluidic
MEMS/device 60 of some possible embodiments comprising two female connectors
51a-52a and 51b-52b. The MEMS/device 60 comprises a top and bottom elongated
elements 61 and 62 configured to be attached one to the other and form the two female
connectors 51a-52a and 51b-52b and a fluid passage along the length of the
MEMS/device 60. Optionally, and in some embodiments preferably, the female
connectors 51a-52a and 51b-52b are Luer lock connectors or any other type of quick
connector structure (e.g., barbed fittings, screw threading, or suchlike).
The top elongated element 61 comprises first and second female connector
portions, 51a and 51b respectively, at its extremities and having threading portions
formed thereon, and a base portion 61s from which the first and second female
connector portions 51a and 51b longitudinally extend. A first open channel 61a is
formed along a bottom portion of the top element 61 longitudinally extending from the
first female connector portion 51a and communicating with a first cavity 63a formed in
the base portion 61s and having a first opening 65a at the upper side of the base portion
61s. A second open channel 61b is formed along a bottom portion of the top element 61- 33 -
longitudinally extending from the second female connector portion 51b and
communicating with a second cavity 63b formed the in base portion 61s and having a
second opening 65b at the upper side of the base portion 61s.
The base portion 61s of the top element 61 can further comprise two support
arms 61d extending longitudinally therefrom at the sides and in parallel to one of the
female connector portions, and configured to provide support for extension arms 66d of
a sealing element 66' configured to attach to the upper side of the top element 61. In this
example the support arms 61d extend along sides of female connector portion 51b, and
the extremities of the support arms 61d are substantially aligned with the extremity of
the female connector portion 51b. The sealing element 66' is configured to seal the
openings 65a and 65b formed in the base portion 61s, and comprises sensor and/or
circuitry elements 66a configured to be precisely placed over the opening 65a, and
sensor and/or circuitry elements 66b configured to be precisely placed over the opening
65b.
The bottom elongated element 62 comprises first and second female connector
portions, 52a and 52b respectively, at its extremities and having threading portions
formed thereon, and a base portion 62s from which the first and second female
connector portions 52a and 52b longitudinally extend. A first open channel 62a is
formed along an upper portion of the bottom element 62 longitudinally extending from
the first female connector portion 52a and communicating with a first end of a slender
fluid channel 62c transversally zigzagged (e.g., having a rectangular wave pattern)
along a surface of the upper side of the bottom element 62. A second open channel 62b
is formed along an upper portion of the bottom element 62 longitudinally extending
from the second female connector portion 52b and communicating with a second end of
the slender fluid channel 62c.
The base portion 62s of the bottom elongated element 62 can comprise one or
more fastening pins 62i configured to be snugly received in corresponding one or more
fastening sockets 61i formed in the base portion 61s of the top elongated element 61
when the top and bottom elements are attached one to the other. In possible
embodiments the fastening pins can be in the top element and the fastening sockets in
the bottom element.
When the elongated top and bottom portions are attached one to the other the
female connector portions 51a and 52a at one side of the elongated elements are joint to- 34 -
form the female connector 51a-52a, and their threading portions are also joined to form
a complete threading structure cable of securing a corresponding male connector to the
female connector 51a-52a. Likewise, the female connector portions 51b and 52b at the
other side of the elongated elements are joint to form the female connector 51b-52b,
and their threading portions are also joined to form a complete threading structure cable
of securing a corresponding male connector to the female connector 51b-52b. In the
assembled state the open channels 61a and 62a respectively extending from the female
connector portions 51a and 52a are joined to form a fluid lumen La sealed along its
length, a portion of the base portion 61s of the top element 61 sealably cover the slender
fluid channel 62c, and the open channels 61b and 62b respectively extending from the
female connector portions 51b and 52b are joined to form a fluid lumen Lb sealed
along its length.
The sealing element 66' is then attached over the top elongated element 61 such
that its arm extensions 66d are placed over the two support arms 61d of the base
portion, and such that the first sensor and/or circuitry elements 66a are precisely
positioned over the first opening 65a and the sensor and/or circuitry elements 66b are
precisely positioned over the second opening 65b.
The cross sectional area of the slender channel 62c is substantially smaller then
and cross sectional areas of the lumens La and Lb, which have approximately the same
cross area. In some embodiments the cross sectional area of the slender channel 62c is
about 1000 to 1.5 times smaller than the cross sectional area of the lumen La and/or Lb,
and its length can be set according to cross-sectional area of the slender channel 62c
itself and the fluid flow rate which need to be measured. Thus, when a fluid is streamed
through the MEMS/device 60, a pressure difference evolves between the first and
second cavities 63a and 63b, that can be measured by the respective first and second
sensor circuitry elements 66a and 66b. This configuration of the MEMS/device 60 can
be used to implement a fluid flow rate sensor, but it can be used as well to measure fluid
pressure and/or flow rates.
A fluid source can be attached either to the female connector 51a-52a or 51b-
52b for streaming a fluid substance through the MEMS/device 60 and measuring
properties of the fluid flowing through the device by the sensor/circuitry elements 66a
and/or 66b. For example, and without being limiting, a fluid source (not shown) can be
connected to the female connector 51a-52a for introducing a fluid stream into the lumen- 35 -
La, filing the first cavity 63a with the fluid, streaming the fluid through the slender
channel 62c into the lumen Lb and filling the second cavity 63b, which in effect
introduce a pressure difference between the first and second cavities. The slender
channel 62c acts as a flow restrictor, such that as fluid is streamed into the device 60
through the female connector 51a-52a the fluid pressure acting on the portion of the
sealing element 66' located over the opening 65a of the first cavity 63a is greater than
the fluid pressure acting on the portion of the sealing element 66' located over the
opening 65b of the second cavity 63b.
The first and second sensor/circuitry elements 66a and 66b are configured to
measure the fluid pressures P1 and P2 in the first and second cavities 63a and 63b,
respectively, responsive to deformations of the respective regions of the sealing element
66' covering the first and second opening, 65a and 65b, respectively. Optionally, and in
some embodiments preferably, at least one of the first and second sensor/circuitry
elements 66a and/or 66b is also configured to determine the pressure difference
between the first and second cavities 63a and 63b, and/or the fluid flow rate through the
MEMS/device 60, based on the fluid pressures measured in the first and second cavities
63a and 63b.
As will be understood from the following description, the support arms 61d of
the MEMS/device 60 are provided to facilitate the production of an array of the
MEMS/device 60 in a wafer, and the arm extensions 66d of the sealing element 66' are
configured to facilitate attachment of a corresponding array of sealing elements
comprising respective array of first and second sensor and/or circuitry elements 66a and
66b, as illustrated in Fig. 6D.
This is needed in this specific embodiment because thickness T of the main
body of the MEMS/device 60 is smaller than the outer diameter D of the female
connectors 51a-52a and 51b-52b. In this case, the main body of the MEMS/device 60 is
thinner than the connectors 51a-52a and 51b-52b, which is convenient for depositing
(e.g., metal deposition techniques as, but limited to, evaporation, sputtering,
electroplating, electroless plating, or lamination processes combined with lithography
processes) the sensor/circuitry elements 66a and 66b on the sealing sheet 66 (e.g., thin
foil/film) before the sealing sheet 66 is attached to the assembled arrays A61 and A62.
It is noted that in case the thickness of the main bodies of the MEMSs/devices 60 is
greater than the outer diameter of the female connectors any suitable fabrication- 36 -
technique can be used i.e., the sensor/circuitry elements 66a and 66b can be deposited
before or after attaching the sealing element 66'.
Fig. 6C shows a variant of the fluidic MEMS comprising an upper slender
channel 61c configured to fluidly communicate between the first and second openings
65a and 65b. The upper slender channel 61c is sealably closed by the sealing element
66', and it may be provided instead of the bottom slender channel 62c, or in addition to
the bottom slender channel 62c.
In Fig. 6D an array of the MEMSs/devices 60 is assembled from an array A61 of the
top elongated elements 61 that is attached to a corresponding array A62 of the bottom
elongated elements 62, and a corresponding array of sealing elements 66' arranged in a
sealing sheet 66. The sealing sheet 66 is configured to sealably cover the first and
second openings 65a and 65b, and place respective arrays of first and second
sensor/circuitry elements 66a and 66b over them. In this embodiment the sealing sheet
66 is pre-cut to form elongated windows 66w therein at the regions wherein the female
connectors 51a-52a and 51b-52b are located.
Fig. 6E illustrates a dicing process for cutting the MEMSs/devices 60 out of the
wafer 69. The dicing process comprises in some embodiments a preliminary dicing step
illustrated by dashed lines D1, in which partial cuts D1 are transversally applied along
the top side of the wafer 69 in a relatively short depth sufficient to only cut off the
support arms 61d and the arm extensions 66d of the sealing element attached over them.
Accordingly, the partial cuts D1 don’t pass all the way through the wafer 69, and in
some embodiments their depths is in the range of few micrometers to few millimeters.
In further dicing steps pass-through cuts are applied, as illustrated by the dashed-dotted
lines D2 and D3, to separate the MEMSs/devices 60 from the wafer 69. In these dicing
steps one or more traversal pass through cuts D2 are applied to separate the rows of the
MEMSs/devices 60 one from the other, and one or more longitudinal pass through cuts
D3 are applied to separate the columns of the MEMSs/devices 60 one from the other.
Fig. 6F illustrates a possible embodiment wherein a wafer 69' of the
MEMSs/devices 60 is constructed without the support arms 61d. Accordingly, an array
A61' of top elongated elements 61', in which there are no support arms 61d, is attached
to the array A62 of bottom elongated elements, and separate sealing sheets 66x, each
comprising an array of the first and second sensor/circuitry elements 66a and 66b, are
then attached over the rows of main bodies of the MEMSs/devices 60 in the array.- 37 -
As seen and described above, the MEMS/device 60 is assembled from two parts
(also referred to herein as body elements) and a sealing element attached over the top
openings 63a and 63b, and each one of the different parts 61 and 62 can be easily
fabricated by any conventional 3D object production technique without presenting
undercuts and/or need to form partially or fully closed cavities.
Figs. 7A to 7E schematically illustrate structure and construction of a fluidic
MEMS/device 70 of some possible embodiments comprising a differential flow sensing
element. The structure of the main body of MEMS/device 70 is similar in some aspects
to that of MEMS/device 60 of Figs. 6A to 6F, comprising the elongated bottom element
62 having the same/similar elements, and an elongated top element 61' that is mainly
different from elongated top element 61 Figs. 6A to 6F in having only the first cavity
65b at one side of the slender channel 62c and in having an open fluid passage 73a at
the other side of the slender channel 62c. Accordingly, the sealing element 76' attached
over the upper surface of the elongated top element 61' has only one sensor and/or
circuitry elements 73i patterned/mounted on a surface area thereof located above the
opening 63b of the cavity 65b. The sealing element 76' further comprises a pass
through bore 76e configured to provide fluid passage through the fluid passage 73a to
the upper side of the sealing element 76'.
The fluidic MEMS/device 70 further comprises a pressure differentiator
element 75 (also referred to herein flow transmission body element) configured to form
an upper cavity 75c (also referred to herein as fluid transmission passage) over a top
region of the sealing element 76' for affecting a fluid pressure thereover from above.
The shape of the pressure differentiator 75 substantially complies with the shape of the
sealing element 76', and mainly differs in having two lateral indentations 75n
configured to provide access to the contact pads (not shown) patterned on the sealing
element 76' and in electrical contact with the sensor and/or circuitry elements 73i
patterned/mounted over the opening 63b. The pressure differentiator 75 is sealably
attached over the sealing element 76' and configured to thereby form an elongated
cavity 75c by an open channel formed along a bottom side thereof.
The elongated cavity 75c is configured to receive fluids flowing at one side of
the slender channel 62c and affect fluid pressure over the upper side of the portion
sealing element 76' covering the opening 63b located at the other side of the slender
channel 62c. Due to flow changes affected by the slender channel 62c, two different- 38 -
pressure levels acts over the portion sealing element 76' covering the opening 63b,
namely, the fluid pressure P1 in the cavity 65b and the fluid pressure P2 in the
elongated cavity 75c. This way, the sensor/circuitry elements 73i placed over the
portion of the sealing element covering the opening 63b measures the pressure
difference |P1-P2| responsive to deformations thereof.
In some embodiments the elongated cavity progressively transversally tappers
towards the opening 63b to reduce the internal volume. Optionally, and in some
embodiments preferably, an air ejector hole 75a is formed in the upper side of the
pressure differentiator 75 configured for ejecting air/gases trapped inside the elongated
cavity 75c. The ejector hole 75a is sealed in some embodiments by a gas permeable
membrane 75q. If the MEMS/device 70 is used to measure fluid flow rate, a priming
step can be carried out in which the opening of the female connector 51b-52b is
temporarily sealably closed and fluid is streamed into the device 70 via the female
connector 51a-52a in order to fill the elongated channel 75c and eject air/gases
therefrom through the permeable membrane 75q. Alternatively, the ejector hole 75a is
sealed in some embodiments after the priming step by sealably attaching thereover a
desiccant cap element (not shown), or by a combination of both the permeable
membrane 75q and the desiccant cap element attached thereover. In some embodiment
the MEMS/device 70 can be used for bidirectional flow rate measurements (i.e., the
fluid flow can be introduced either via the connector 51a-52a or the connector 51b-
52b), and in this case the desiccant cap element can be used prevent suction of air via
the gas permeable membrane 75q.
As shown in Fig. 7D, in this specific and non-limiting example the sealing
element 76' can be comprised of at least three different layers, L1, L2 and L3, wherein
the topmost layer L1 is a protective/biocompatible layer (film/foil), the intermediate
layer L2 comprises the sensor/circuitries 73i, and the bottommost layer L3 is a
protective/biocompatible layer (foil/film). With this configuration the electrical
components of the sensor/circuitries 73i in the intermediate layer L2, that are usually
not biocompatible, are sealably isolated by the protective/biocompatible layers L1 and
L3 sandwiching it, and thereby enable use of MEMS/device 70 with medicinal and/or
body fluids (e.g., blood, medicaments, etc.).
Fig. 7E schematically illustrates construction of an array of the fluidic
MEMSs/devices 70 in a form of a wafer 79. This is achieved by fabricating an array- 39 -
A62 of the elongated bottom elements 62, an array A61' of the elongated top elements
61׳, an array A75 of the pressure differentiator elements 75, and a sealing sheet 76
comprising a respective array of the sealing elements 76׳. The wafer 79 is constructed
by attaching the array A62 to the array A61׳ to form the lumens a and b and the
connectors 51a-52a and 51b-52b, attaching the sealing sheet 76 over the upper surface
of the array A61׳ to seal the openings 63b and place the sensor and/or circuitry elements
73i thereover while placing the pass-through bores 76e over the openings of the open
fluid passages 73a, and attaching the array A75 over the sealing sheet 76 such that the
open channels at the bottom side thereof form the elongated cavities 75c for passing
fluids from the fluid passages 73a to the upper side of the sealing elements 76'.
The dicing of the wafer 79 can comprise several dicing steps, including a
preliminary dicing step illustrated by dashed lines D1, in which partial cuts D1 are
transversally applied along the top side and the bottom side (not shown) of the wafer 79
in a relatively short depth sufficient to only cut off the support arms 61d and portions
66d of the sealing sheet attached thereover, and corresponding arms 75d of the pressure
differentiator element 75. Accordingly, the partial cuts D1 don’t pass all the way
through the wafer 79, and in some embodiments their depths is in the range of 0.1% to
% of the wafer thickness. In further dicing steps pass through cuts are then applied, as
illustrated by the dashed-dotted lines D2 and D3, to separate the MEMSs/devices 70
from the wafer 79. In these dicing steps one or more traversal pass through cuts D2 are
applied to separate the rows of the MEMSs/devices 70 one from the other, and one or
more longitudinal pass through cuts D3 are applied to separate the columns of the
MEMSs/devices 70 one from the other.
The MEMSs/devices 70 in the wafer 79 can be calibrated using the wafer
calibration techniques described hereinabove. In some embodiments the wafer
calibration comprises a pressure calibration step performed without the pressure
differentiator element 75 by temporarily sealing the pass-through bore 76e and the open
fluid passage 73a therebeneath e.g., by adhesive patch (not shown). The calibration can
comprise a flow calibration step performed after removing the temporary seal from the
pass-through bore 76e and sealably attaching the pressure differentiator element 75 on
top of the sealing element 76'.
The MEMS/device 70 is assembled from three body parts/elements and the
sealing element 76׳. Each one of the different parts 75, 61' and 62, can be easily- 40 -
fabricated by any conventional 3D object production technique without presenting
undercuts and/or need to form partially or fully closed cavities.
Figs. 8A to 8D schematically illustrate structure and construction of a fluidic
MEMS/device 80 comprising a conductivity sensor unit 88 patterned or mounted on its
sealing element 66". The elongated top and bottom elements 61" and 62" of the
MEMS/device 80 have shape and structure similar to those of the elongated top and
bottom elements 61 and 62 of Figs. 6A and 6B, and its shielding element 75" have
shape and structure similar to those of the pressure differentiator element 75 of Figs. 7A
to 7C. The main differences are that the base section 62s" of the elongated bottom
element 62" comprises a partition 62p between its first and second open channels, 62a
and 62b (i.e., without the slender wavy channel 62c), the elongated top element 61"
comprises an open upper channel 73e communicating with the first open channel 61a
via passage 73a and with the second open channel 61b at its other side via the passage
73b, and that the shielding element 75" is a full and solid element (i.e., not including
fluid channels or opening).
Accordingly, when the elongated top and bottom elements 61" and 62"
respectively are attached one to the other they form the female connectors 51a-52a and
51b-52b, and the respective lumens a and b communicating between the connectors
51a-52a and 51b-52b and the open upper channel 73e of the top elongated element 61".
The open upper channel 73e is sealed by the sealing element 66", which thereby forms
a continuous fluid passage 80c along the length of the MEMS/device 80, starting from
connector 51a-52a through lumen a and fluid passage 73a into the upper channel 73e,
and therefrom through the fluid passage 73b and the lumen b to the connector 51b-52b
(or the other way around). The sealing element 66" is similar in shape to the sealing
element 66' of Fig. 6A, and therefore will not be described in details. The shielding
element 75'' is then attached over the sealing element 66'' to substantially immobilize
and prevent deformations of the portion of the sealing element 66'' located over the
open upper channel 73e of the top elongated element 61'' when pressure forces are
applied thereon by fluids flowing through the channel 73e, and to provide thermal
insulation from the external environment.
With reference to Fig. 8C, the conductivity sensor unit 88 comprises electrically
conducting patterns formed on the upper and bottom sides of the sealing element 66''.
The upper side of the sealing element 66'' comprises four contact pads, 81p and 84p- 41 -
located at one lateral side of the sealing element 66", and 82p and 83p located at the
other lateral side of the sealing element 66". Four electrodes 81, 82, 83 and 84, are
patterned or mounted on the bottom side of the sealing element 66", each electrically
coupled with a respective one of the contact pads via a respective via and conducting
lines 88n. More particularly, the bottom side electrode 81 is electrically connected to
the upper side contact pad 81p through the via 81v, the bottom side electrode 82 is
electrically connected to the upper side contact pad 82p through the via 82v, the bottom
side electrode 83 is electrically connected to the upper side contact pad 83p through the
via 83v, the bottom side electrode 84 is electrically connected to the upper side contact
pad 84p through the via 84v.
In this specific and non-limiting example the electrodes 81, 82, 83 and 84, are
aligned in a row on the bottom side of the sealing element 66", such they become
aligned along the upper channel 73e after the sealing elements 66" is attached to the
elongated top element 61". This configuration thus provides a four point measurement
setup when a fluid substance is streamed through the channel 80c and the electrode 81,
82, 83 and 84, are in contact with the streamed fluid.
The contact pads 81p, 82p, 83p and 84p, electrodes 81, 82, 83 and 84, and the
electrically conducting lines 88n, can be made from gold, platinum, titanium patterned
on the sealing element 66", which can be alternatively made of by any nonconductive
polymer (e.g., polycarbonate, peek, polyimide, etc.). The same materials and processes
can be used in fabrication of the electrical/sensor elements in the various different
sealing and/or deformable elements of the other embodiments disclosed herein. After
assembling together the various elements of the MEMS/device 80 its contact pads 81p,
82p, 83p and 84p, can be accessed and electrically contacted via the lateral indentations
75n formed in the lateral sides of the shielding element 75".
Fig. 8D and 8E schematically illustrates construction of an array of
MEMSs/devices 80 in a layered fashion to form a multilayered wafer 89 of the
MEMSs/devices 80. The wafer 89 is constructed from an array A62" of a plurality of
elongated bottom elements 62" aligned in rows and columns attached to a respective
array A61" of a plurality of elongated top element 61". A respective array of sealing
elements 66" is attached in a form of a sealing sheet A66" similar in shape to the
sealing sheet 66 of Figs. 6D and 6E i.e., comprising the support arms 61d and the
elongated windows 66w, but further comprising a respective array of the conductivity- 42 -
sensor unit 88 patterned or mounted on its bottom and upper sides, as described
hereinabove and shown in Fig. 8C, for sealing the open upper channels 73e of the
elongated top elements 61" and placing the electrodes 81, 82, 83 and 84, of each sensor
unit 88 aligned therealong. A respective array A75" of the shielding elements 75" is
attached over the sealing sheet A66" to immobilize and thermally isolate the portions of
the sealing sheet A66" covering the open upper channels 73e and carrying the
electrodes 81, 82, 83 and 84.
Figs. 9A to 9D schematically illustrate structures and constructions of fluidic
MEMSs/devices 90, 90' and 90", of some possible embodiments, comprising several
different sensing elements. The MEMS/device 90 in Figs. 9A and 9B generally
comprises elongated top and bottom elements, 91 and 92 respectively, configured to
attached one to the other and form a fluid passage 98 of the MEMS/device 90, a sealing
element 96 configured to sealably attach to the upper surface of elongated top element
91 over openings/channels thereof and place electrical/sensing elements thereover, and
a shielding element 97 configured to attach over the sealing element 96, immobilize
and/or thermally isolate the portions of the sealing elements placed over the
openings/channels and carrying the electrical/sensing elements of the MEMS/device 90.
The bottom elongated element 92 comprises at its extremities female connector
portions 52a and 52b, and a first open channel 62a extending from the connector
portion 52a, and a second open channel 62b extending from the connector portion 52b,
as described and shown in Figs. 6A-B, 7A-B and 8A-B. The bottom elongated element
92 also comprises an intermediate open channel 62k passing along a length about the
center of the base portion 92s of the bottom elongated element 92. A first partition
portion 62g formed in the base portion 92s of the bottom elongated element 92
partitions between the first open channel 62a and the intermediate open channel 62k,
and a second partition member 62f formed in the base portion 92s partitions between
the second open channel 62b and the intermediate open channel 62k.
The elongated top element 91 comprises at its extremities female connector
portions 51a and 51b, and a first open channel 61a extending from the connector
portion 51a, and a second open channel 61b extending from the connector portion 51b,
as described and shown in Figs. 6A-B, 7A-B and 8A-B. The top elongated element 91
also comprises an upper open channel 91c extending from one end along a length of the
base portion 91s thereof and overlapping an end portion of the second open channel- 43 -
61b, a bottom intermediate channel 61k extending along a length of base portion 91s
and overlapping with an end portion of the upper open channel 91c, and an upper open
cavity 91d near another end of the base portion 91s overlapping with an end portion of
the bottom intermediate channel 61k at one side thereof and overlapping with an end
portion of the first open channel 61a at another side thereof.
The base portion 91s of the elongated top element 91 comprises a first partition
portion 61g partitioning between the first open channel 61a and the bottom intermediate
channel 61k, an intermediate partition portion 91k partitioning between the upper open
channel 91c and the upper open cavity 91d, and a second partition portion 61f
partitioning between the second open channel 61b and the bottom intermediate channel
61k. A fluid passage 61w formed in the base portion 91s communicates between the
first open channel 61a and the upper open cavity 91d, a fluid passage 61z
communicates between the upper open cavity 91d and the bottom intermediate channel
61k, a fluid passage 61y communicates between bottom intermediate channel 61k and
the upper open channel 91c, and a fluid passage 61x communicates between upper open
channel 91c and the second open channel 61b.
When the elongated bottom element 92 is attached to the elongated top element
91 the connector portions 51a and 52a are joint to form a connector 51a-52a and their
threading portions are joined to form a complete threading structure, and the connector
portions 51b and 52b are joint to form a connector 51b-52b and their threading portions
are joined to form a complete threading structure. In this assembled state the first open
channels 61a and 62a are joint to form the first lumen a, the second open channels 61b
and 62b are joint to form the second lumen b, and the intermediate channels 61k and
62k are joined to form the intermediate lumen k. Also, the first partition portions 61g
and 62g are joined to form a partition 61g-62g between the first lumen a and the
intermediate lumen k, and the second partition portions 61f and 62f are joined to form a
partition 61f-62f between the second lumen b and the intermediate lumen k.
The sealing element 96 is attached over the an upper surface of the base portion
91s of the top elongated element 91 to seal the upper open cavity 91d and place
thereover a first sensing unit 96d, and to seal the upper open channel 91c and place
thereover a second sensing unit 96c. This way a fluid channel 98 is formed along the
MEMS/device 90, passing from the connector 51a-52a to the first lumen a, from the
first lumen a through the fluid passage 61w into the upper open cavity 91d and- 44 -
therefrom through the fluid passage 61z into the intermediate lumen k, from the
intermediate lumen k through the fluid passage 61y into the upper open channel 91c and
therefrom through the fluid passage 61x into the second lumen b and to the connector
51b-52b.
The shielding element 97 is attached over the sealing element 96 to immobilize
and thermally isolate the portion of the sealing element covering the upper open channel
91c and carrying the second sensing unit 96c. The shielding element 97 comprises a
bottom open cavity 97d configured to form a closed cavity 91d-97d when attached over
the sealing element 96 for allowing deformations of the portion of the sealing element
96 enclosed therewithin and thermally and physically isolating it from the external
environment. The shielding element 97 is generally a "H"-shaped element having two
lateral support elements 97a and 97b and an intermediate section 97c extending
between them, thereby forming two lateral indentations 97n that provide access to
contact pads (not shown) of the first and second sensor units 96d and 96c
formed/mounted on lateral portions of the sealing element 96. The intermediate section
97c can comprise a disk shaped portion 97u configured to accommodate the bottom
open cavity 97d.
The first sensor unit 96d can thus be a type of tension sensor configured to
measure pressure and/or flow rate of fluid passing through the upper open cavity 91d
and causing deformations of the portion of the sealing element 96 located thereon in (or
out) of the bottom open cavity 97d of the shielding element 97. In this embodiment the
portion of the sealing element 96 covering the upper open cavity 91d is sealed from the
external environment. In some embodiments the sealing created by the bottom open
cavity 97d is configured to maintain a specific predefined pressure level inside the
cavity 97d and thereby implement by the first sensor unit 96d an absolute pressure
sensor. The second sensor unit 96c can comprise a temperature sensor, such as, but not
limited to, the temperature sensor 41e of Fig. 4A, and/or a type of sensor configured to
contact the fluid in the upper open channel 91c, such as, but not limited to, the
conductivity sensor 88 of Fig. 8c.
Figs. 9C and 9D schematically illustrate variants 90' and 90'' respectively, of
the MEMS/device 90 wherein the portion of the sealing element 96 covering the upper
open cavity 91d is exposed to environmental pressure. In Fig. 9C the disk shaped
portion 97u of the shielding element 97 comprises two or more lateral openings 97g- 45 -
configured to allow air flow from the external environment into the cavity 97d. In Fig.
9D the disk shaped portion 97u of the shielding element 97 is a thin disk element
forming two lateral air passages 97g' such that no cavity 97d is formed, and air can
freely flow from the external environment therethrough. In some embodiments the first
sensor unit 96d of MEMSs/devices 90' and 90" is configured to implement a gauge
pressure sensor.
It is noted that though the air passages 97g' in this specific embodiment are
formed on the sides of the disk shaped portion 97u, they can be also implemented on the
top surface are of the disk shaped portion 97u. Accordingly, in this embodiment there is
no cavity that can maintain a specific pressure over the sealing element portion covering
the upper open cavity 91d, such that the upper side of the sealing element covering the
upper open cavity 91d is subject to the atmospheric pressure at all times i.e., it cannot
implement an absolute pressure sensor.
The configurations illustrated in Figs. 9B and 9C advantageously: (i) protect the
first sensing unit 96d, which can a be a delicate and sensitive elements, from the
external contact (e.g., of the user hands/fingers when handling the sensor); add
mechanical force at the sides of the sealing element and thereby prevent detachment
thereof; and/or (iii) in the configuration shown in Fig. 9B, implement an absolute
pressure sensor.
The larger air passages 97g' provided in Fig. 9D are configured to reside
relatively distant from the edges of the sealing element. In this configuration the
assembly process of the MEMS/device 90' is simplified since it does not require
accurate alignment of the shielding element 97 with the elongated top element 91
located therebeneath. There is no need to precisely align the shielding element 97 with
the edges of the portion of the sealing element covering the upper open cavity 91d,
since at worse case misalignment of the shielding element 97 can affect the performance
of the sensor and the repeatability among different sensors.
Fig. 9E is a sectional view schematically illustrating attachment of the shielding
element 97 to the bottom elongated element 92 by attachment pins or plugs 97i. In the
configuration of Fig. 9E the first sensing unit 96d provided on the sealing element 96 is
enclosed by the open cavity 97d in the shielding element 97, thereby allowing free
movement/deformations of the portion of sealing element placed over the upper open
cavity 91d, and can press the membrane edges to avoid detachment thereof. The- 46 -
attachment pins 97i can have sharp ends configured to penetrate into the body of the
bottom elongated element 92 to obtain firm attachment thereto, or alternatively, they
can be configured to be received in respective fitting sockets 97k. The attachment pins
or plugs 97i of the shielding element 97 can be bonded, glued, and/or snapped inside, or
around lateral edges of, the base elements. This configuration improves the mechanical
robustness and helps to prevent detachment of the sealing element 96 on which the
shielding element 97 is attached about the lateral edges. In some embodiments the
shielding element 97 is prepared without the open cavity 97d e.g., when the first sensing
unit 96d does not require deformations of the sealing element 96 for the measurements.
Optionally, the shielding element 97 comprises one or more pass-through holes
configured to allow flow of air to the surface area of the sealing sheet 96 comprising the
electrical/sensing elements, to form an open (unsealed) chamber thereabout.
The MEMS/device 90, 90' and 90", are assembled from three body
parts/elements and a sealing element 96, and each one of the different body elements
97/97797", 91 and 92 can be easily fabricated by any conventional 3D object
production technique without presenting undercuts and/or need to form partially or fully
closed cavities.
It is noted that the shielding elements used in MEMS embodiments disclosed
herein advantageously also prevent detachment of the sealing element on which it is
attached at the edges. In some embodiments the shielding element can be of smaller
dimensions than the sealing element, and it can be implemented mutatis mutandis in all
of the embodiments disclosed herein.
Figs. 10A to 10C schematically illustrate arrangements configured for holding
an array of fluidic MEMSs, for attachment of sealing elements thereon and/or for
conducting wafer level calibration. Fig. 10A shows a perspective view of an
arrangement 100 for holding a wafer including a single row 103 of MEMSs/devices
103t. The arrangement 100 comprises a holder structure 101 comprising an array of
sockets 101t, each configured to snugly receive, hold and immobilize a respective
MEMS/device 103t of the array 103. In this specific and non-limiting example the
holder structure 101 is configured to hold a single row of MEMSs/devices 103t. The
array 103 can be in a pre-diced wafer form wherein the MEMSs/devices 103t are
integrally connected one to the other as a multilayered structure.- 47 -
Alternatively, the array 103 can be an array of discrete mechanically separate
MEMSs/devices 103t, each of which is separately located in a respective socket 101t of
the holder structure 101 i.e., the MEMSs/devices 103t are manufactured as separated
units and then placed in holder 101. The sockets 101t of the holder 101 are located one
adjacent the other such that the MEMSs/devices 103t placed in them form a wafer/array
103.
After placing each MEMS/device 103t in a respective socket 101t a sealing
sheet 104 comprising a respective array of electric/sensor elements 104t can be placed
over the array 103 such that each of electric/sensor elements 104t thereof is precisely
placed over an opening 103p in the respective MEMS/device 103t. In some
embodiments a holding frame 102 is placed on the holder structure 101 over the array
103 to further stabilize and immobilize the MEMSs/devices 103t. The holding frame
102 comprises a respective array of sockets 102t, each configured to snugly fit over a
respective MEMS/device 103t of the array 103, and an elongated window 102w
configured to provide access to the upper surfaces if the base bodies of the
MEMSs/devices 103t of the array 103 for facilitating accurate placement of the sealing
sheet 104 thereon.
Optionally, after placing each MEMS/device 103t in a respective socket 101t a
sealing element comprising an electric/sensor elements 104t is discretely attached
separately to each MEMS/device 103t.
The holder arrangement 100 can be advantageously used to conduct wafer level
calibration for simultaneously calibrating all of the MEMSs/devices 103t of the array
103 under the same calibration conditions and measuring the same by their
electric/sensor elements 104t.
Figs. 10B shows a holder arrangement 100' comprising a holder structure 105
comprising an array of sockets 105t, each configured to snugly receive, hold and
immobilize a respective discrete separately fabricated MEMS/device 103t. The sockets
105t are arranged such that after placing the MEMSs/devices 103t in them a wafer of
the MEMSs/devices 103t is practically obtained. A support frame 106 comprising a
respective array of sockets 106t, each configured to snugly fit over a respective one of
the MEMSs/devices 103t, hold and immobilize it in place, can be used to further
stabilize the array structure. The support frame 106 can be further configured to
sealably communicate between the fluid channels of the MEMSs/devices 103t in each- 48 -
row R and thereby obtain fluidic continuity between the MEMSs/devices 103t in each
row R, to thereby facilitate wafer level calibration of at least one row the
MEMSs/devices 103t per calibration step.
After placing the MEMSs/devices 103t in respective sockets of the holder 105
and placing the support frame 106 thereover, sealing sheets 104 can be accurately
attached thereon via the elongated windows 106w of the support frame 106. Optionally,
and in some embodiment preferably the holder structure 105 comprises an array of
protuberance (not shown) provide a flat surface between the top surfaces of each pair of
locally adjacent MEMSs/devices 103t, to thereby facilitate the attachment of the
sealing sheets 104 thereover, as a continuous flat surface is thereby obtained.
Fig. 10C shows a holder arrangement 100" comprising a holder structure 107
comprising an array of sockets, each configured to snugly receive, hold and immobilize
a respective discrete separately fabricated MEMS/device 103t. A support frame 108
comprising a respective array of sockets, each configured to snugly fit over a respective
one of the MEMSs/devices 103t, hold and immobilize it in place, is also provided. The
support frame 108 is further configured to sealably communicate between the fluid
channels of the MEMSs/devices 103t in each row and thereby obtain fluidic continuity
between the MEMSs/devices 103t in each row, to thereby facilitate wafer level
calibration of at least one row the MEMSs/devices 103t per calibration step.
The holder structure 107 comprising front and back panels 107a and 107b, each
comprising a set of connectors 107c, each being in fluid communication with one of the
rows of the MEMSs/devices 103t. The arrangement 100" is adapted to facilitate wafer
level pressure calibration by connecting a fluid source 109 to the plurality of rows of
MEMSs/devices 103t via a manifold of fluid connectors 109m, thereby allowing to
concurrently apply the same conditions to all of the MEMSs/devices 103t in each row.
This way wafer lever pressure calibration can be conducted without directly connecting
a fluid source to the to the connector of the MEMSs/devices 103t. It is noted that for
flow rate calibration the manifold 109m is not necessary since there is no reliable way
to determine the exact flow rate through each of MEMSs/devices 103t in each row R.
Figs. 11A to 11C schematically illustrate fluidic MEMS/device 110 of some
possible embodiments implemented without fluidic channel(s). Figs. 11A shows an
application of the fluidic MEMS/device for a sealing object 111 (e.g., container/bottle
cup). The MEMS/device 110 comprises a pass through bore 110b and a sealing element- 49 -
110s sealably attached over the bore 110b, and comprising one or more electrical/sensor
elements patterned/mounted thereon (not shown). The sealing object 111 comprises a
pass through bore 111p for communicating with the interior of a container (not shown)
of the sealing object 111, and a socket 111s formed about the pass through bore 111p
for sealably attaching the MEMS/device 110 thereover for measuring pressure condition
in the container of the sealing object 111.
Fig.11B shows fabrication of an array 119 of the fluidic MEMSs 110. The array
119 comprises a plurality of rows and columns of the fluidic MEMSs 110 forming a
wafer having a substantially flat upper surface on which a sealing sheet 112 comprising
a respective array of electrical/sensor elements (not shown) is attached for precisely
placing them over respecting pass through bores of the MEMSs 110.
Fig. 11C demonstrates applications of the fluidic MEMS 110 in a syringe hub
115 and/or in a syringe barrel 117.
The thickness of the sealing sheet/element in some embodiments is in the range
of 0.1 to 2000 micrometer, optionally between 10 to 200 micrometer. In possible
embodiments at least some of the electrical contacts/patterns, and/or the additional
circuitries, and/or the electrical conducting lines, and/or the sensing elements, and/or
actuating means, are mounted/deposited on the sealing sheet/element before it is
attached to the wafer.
Terms such as top, bottom, front, back, right, and left and similar adjectives in
relation to orientation of the MEMSs/device and their components refer to the manner
in which the illustrations are positioned on the paper, not as any limitation to the
orientations in which the apparatus can be used in actual applications. It should also be
understood that throughout this disclosure, where a process or method is shown or
described, the steps of the method may be performed in any order or simultaneously,
unless it is clear from the context that one step depends on another being performed
first.
As described hereinabove and shown in the associated figures, the present
disclosure provides structures and construction techniques of fluidic MEMSs/device
configured to measure properties and/or conditions of a fluidic substance. While
particular embodiments of the invention have been described, it will be understood,
however, that the invention is not limited thereto, since modifications may be made by
those skilled in the art, particularly in light of the foregoing teachings. As will be- 50 -
appreciated by the skilled person, the invention can be carried out in a great variety of
ways, employing more than one technique from those described above, all without
exceeding the scope of the claims.
1/19
165
161c 161
166
162f
160
162p
162p
162t
162t
162
161'
165
162'
162
167
170a
2/19
165
170
174a
172b
170b
174b
170a
174b
165
174a
172a
174b
170
170b
161'
165
162
170a
170
170b
3/19
33b
33r
33p
33
31b
31t
33a
31p
32b
31s
31
31a
32
33
31p 32s
33p 32a
34b
32t
34r
34r
33b
31b
31c
31s
31a
34p
31n
34a
32s
34
32n
32a
32b
32t
31t
36'
33p
31p
33
36i
34
34p
33a
31a
31s
32a
32s
30t
34
34a
31p
4/19
31t
33
31c
31a
31b
32n
37 31
b
32b
a
32a 31n
32
33p
34
36
36i
33
A33
33f
A31
33i
31
A32
32
34s
33
A34
36i
34f
33p
36
31p
39
42a
/19
42b
40
42
41
42c
42b
41p
41p
41n
41e
31p
33
31
32
34
42
A42
41
31p
A41
39p
33f
10
34f
39
41e
53s
53r
6/19
53
53d
53b
31p
31t
31s
33b
31b
51a
31s
51
32s
52 50
32b
52a
32s
34b
54b
31p
51t
53s
52t
54
53b
54r
53r
53d
53
54s
54d
51a
51
54
52
52a
50
31p
51c
51t
50s
53s
53r
54b
51i
33b
53
51j
52s
54r
54d
31b
57
51
51n
51a
b
a
32b 52a
51t
51a
52 36i
36'
52n
54
50
34b
31p
52t
31b
50
33b
53
51
55
32b
52
54
52a
34b
50s
7/19
36
36i
A53
53
A51
51
33f
52
A52
54
34f
54
53r
A54
53d
50
59w
55
33f
36
36i
31p
33f D1
59
34f
53r D3
53r
55
36 36i
31p
D2
8/19
36''
36i
36i
36i
53'
31p
55
A53'
33f
59'
34f
66d
51b
61d
66'
65b
61
60 65a
66b
61s
63a
51a
66a 63b
62b
61i
62a
52b
62
62c
62i
62s
52a
9/19
61a 51b
66a
51a 61
61b
65b 66b
66'
65a
63a
63b
61s
D
La Lb
T
62s
60
P1 P2
62c
62b
62
52a
62a
52b
52b
66'
61c
65b
65a
61'
62
60
66
66d
A66
66'
66w
69
66a
66b
A61
A62
61d
61
51b-52b
65a
51a-52a
62
65b
/19
D1
D3
61d
69
66
60
D2
66a
66x
61'
69'
66b
A61'
66x
66a
66b
A62
11/19
75d
75
75n
75t
75a
75s
76'
76e
70
65b
51a
73i
75n
51b
66d
61'
73a
62i
61s
61d
52b
62
62b
62c
62a
52a
62s
75
75a
51a
75d
75s
61a
73a
70
75c
73i
76'
76e
66d
51b
63b 61s
65b
62c
62s
52a
61'
61d
62a
62
62b
61b
52b
12/19
75
75s
P2
75q 76'
73i
73a
61'
63b
75a
c
70
51b-52b a 51a-52a
b
65b
62c
P1
75c
62
76'
L1
L2 (73i)
Protective/biocompatible foil
L3
Conductive/sensing elements foil
Protective/biocompatible foil
D3
70
D1
76'
D2
75d
D1
75d
79
A75
76
A61'
66d
75
61'
A62
62
13/19
75d
75n
75''
75n
80
51a
75s
75t
66d
84p
83
84
84v
81p
66''
88
83p
81
73e
61''
82
51b
61s''
82p
61d
62s''
52a
62a
62b
62''
52b
75''
61''
61b
83
66''
81
84
82
73e
61a
80c
73b
73a
61s''
b
51b-52b
a
51a-52a
62s''
80
62a
62b
62''
62p
14/19
88
66''
82p
83v
81p
82v
81v 84p
88n
83p
81
84
82
83
84v
66d
75''
A75''
66w
80
89
A66''
A61''
66''
61'' 88
62''
A62''
/19
89 A75''
A61''
A66''
A62''
97a
97c
97u
97n
97
97b
96d
51a
96
91d
96c
92c
90
91
52a
91s
51b
62a
92s
62k
62b
52b
92
16/19
97a
98
97c
61g
91c
97u
91
97b
97
97d
96
91k 51a
61f 91d
90
a
k
91s
51b
52a
92s
b
52b
61z
61y 61w 61a
61x 61k
61b 62a
62k
62f
62g
62b
92
97u
97'
97g
90'
51b
97d
96
91
52b
51a
92
52a
97g'
97u
96
97g'
97''
51a
90''
91
51b
52a
92
52b
17/19
96d
97d
96
97
97i
91
97k
97k
91d
F
92
104
104t
102w
102
102t
103
103t
103p
101
11
100
101t
18/19
104
106w
106
104
106w
104
103t
106t
106w
100'
R
105
105t
104
104
106w
108
106w
104
106w
107a
107c
100''
107c
109m
109
103t
107b
107
19/19
110b
110
110s
111p
111
111s
112
110b
110
119
117
110
110
115
264544/2
Claims (18)
1. A fluidic sensor device comprising: a base body structure comprising a fluid channel or cavity passing therealong and at least one opening in an external face of said base body structure and being in fluid communication with said fluid channel or cavity; and a sealing element comprising a deformable portion and one or more sensing elements a priori patterned thereon, wherein said sealing element is sealably attached over said external face of said base body structure comprising said at least one opening such that the one or more sensing elements a priori patterned thereon become located over said at least one opening, said one or more sensing elements are configured to measure at least one property or condition of a fluid substance responsive to deformations of said deformable portion when said fluid substance is introduced into said fluid channel or cavity and interact with said sealing element located over said at least one opening, and at least said deformable portion of said sealing element is a multilayered structure having an inner layer comprising the one or more sensing elements a priori patterned thereon, and at least two protective layers, and said inner layer with its one or more sensing elements is sealably sandwiched between said two protective layers.
2. A wafer comprising an array of fluidic sensor devices according to claim 1 integrally assembled therein by attaching two or more layers one to the other, said wafer comprising a sealing sheet comprising a respective array of the sealing elements and sealably attached to a respective array of base body structures for covering their openings and placing the a priori patterned or mounted sensing elements thereover.
3. The device of claim 1 wherein the base body structure comprises at least one of the following: (i) at least one open cavity in fluid communication with the fluid channel; (ii) at least one fluid port adapted to couple to a fluid source, or to a fluid passage or reservoir, said at least one fluid port being in fluid communication with the fluid channel or cavity; and (iii) at least one fluid restrictor formed inside the fluid channel.
4. The device of claim 1 wherein the base body structure comprises first and second cavities with respective first and second openings formed in a wall thereof, each opening opens into its respective cavity and sealably covered by a portion of the sealing element comprising a respective sensing element, and a slender channel having first and second ends configured to 51264544/2 respectively fluidly communicate with said first and second cavities, said slender channel is sealably closed by the sealing element.
5. The device of claim 1 wherein the base body structure is assembled from two or more separate body elements configured to attach one to the other and thereby form the fluid channel or cavity of said base body structure, at least one of said two or more separate body structures comprises at least one opening configured to form the at least one opening in the external face of said base body structure being in fluid communication with said fluid channel or cavity when said two or more separate body elements are attached one to the other to assemble said base body structure.
6. The device of claim 5 wherein the at least two body elements comprise at least one of the following: (i) two channel forming body elements, each of said two channel forming body elements comprises a base portion and at least one open channel extending along a length of said base portion, said at least one open channel of said channel forming body elements configured to form at least a portion of the fluid channel being in fluid communication with the at least one opening when attached one to the other; and (ii) the base portion of one of the two channel forming body elements comprises first and second cavities with respective first and second openings formed in a wall thereof, each opening opens into a respective cavity and sealably covered by a portion of the sealing element comprising a respective sensing element, and wherein at least one of the two channel forming body elements comprises a channel having first and second ends configured to respectively fluidly communicate with said first and second cavities when said body elements are attached one to the other.
7. The device of claim 6 wherein the sealing element comprises a pass through bore configured to be located over the first opening and fluidly communicate therewith to thereby form a fluid transmission passage and the second opening being sealably covered by a portion of the sealing element comprising the at least one sensing element, and wherein the at least two body elements comprises a flow transmission body element comprising an elongated open channel, said flow transmission body element configured to sealably attach over a portion of the sealing element and fluidly communicate between said fluid transmission passage and the portion of the sealing element sealably covering said second opening.
8. The device of claim 7 wherein the flow transmission body element comprises an opening formed in a wall thereof covered by a gas discharge component, said gas discharge 52264544/2 component configured to eject gasses trapped inside the elongated channel of the flow reversing body element.
9. A fluidic sensor device comprising: a base body structure comprising a fluid channel or cavity passing therealong and at least one opening in an external face of said base body structure and being in fluid communication with said fluid channel or cavity; and a sealing element comprising one or more sensing elements a priori patterned or mounted thereon, said sealing element sealably attached over said external face of said base body structure comprising said at least one opening such that its one or more sensing elements become located over said at least one opening, said one or more sensing elements configured to measure at least one property or condition of a fluid substance when said fluid substance is introduced into said fluid channel or cavity and interact with a portion of said sealing element located over said at least one opening; wherein the one or more sensing elements comprises at least one electrode positioned on an underside of the sealing element and configured to become in physical contact with the fluid substance when introduced into the fluid channel or cavity.
10. The device of claim 9 wherein the sealing element comprises at least one via for electrically coupling to the at least one electrode by means of contacts pads on the upper side of the sealing element.
11. A fluidic sensor device comprising: a base body structure comprising a fluid channel or cavity passing therealong and at least one opening in an external face of said base body structure and being in fluid communication with said fluid channel or cavity; a sealing element comprising one or more sensing elements a priori patterned or mounted thereon, said sealing element sealably attached over said external face of said base body structure comprising said at least one opening such that its one or more sensing elements become located over said at least one opening, said one or more sensing elements configured to measure at least one property or condition of a fluid substance when said fluid substance is introduced into said fluid channel or cavity and interact with a portion of said sealing element located over said at least one opening; and a shielding element attached to the base body structure and a portion of the sealing element comprising the at least one sensing element and configured to prevent deformations of said portion of the sealing element. 53264544/2
12. A fluidic sensor device comprising: a base body structure comprising a fluid channel or cavity passing therealong and at least one opening in an external face of said base body structure and being in fluid communication with said fluid channel or cavity; a sealing element comprising one or more sensing elements a priori patterned or mounted thereon, said sealing element sealably attached over said external face of said base body structure comprising said at least one opening such that its one or more sensing elements become located over said at least one opening, said one or more sensing elements configured to measure at least one property or condition of a fluid substance when said fluid substance is introduced into said fluid channel or cavity and interact with a portion of said sealing element located over said at least one opening; and a shielding element attached to the base body structure and a portion of the sealing element comprising the at least one sensing element, the shielding element comprises an open cavity configured to be placed over a portion of the sealing element covering one of the at least one opening and thereby enable deformation of said portion of the sealing element while thermally and/or physically isolating it from the external environment.
13. The device of claim 12 wherein the open cavity comprises one or more openings configured to allow entry of air from the external environment into the cavity.
14. The device of claim 12 wherein the open cavity is configured to maintain a predetermined pressure level over a portion of the sealing elements covering one of the at least one opening.
15. A method of constructing fluidic sensor device, the method comprising: forming a base body structure comprising a fluid channel or cavity passing therealong and being in fluid communication with at least one opening in an external face of said base body structure; constructing a sealing element having a deformable portion by sandwiching an inner layer comprising one or more a priori patterned sensing elements between at least two protective layers; and attaching said sealing element over said external face of said base body structure comprising said at least one opening such that its one or more sensing elements become located over said at least one opening, said one or more sensing elements configured to measure at least one property or condition of a fluid substance responsive to deformations of said deformable portion, when said fluid substance is introduced into said fluid channel or cavity 54264544/2 and interact with said deformable portion of said sealing element located over said at least one opening.
16. The method of claim 15 comprising assembling the base body structure by attaching two or more separate body elements to thereby form at least one of: (i) the fluid channel or cavity in fluid communication with the at least one opening; (ii) at least one fluid port in fluid communication with the fluid channel or cavity; and (iii) at least one fluid restrictor in the fluid channel.
17. A method of constructing a wafer integrally comprising an array of the fluidic sensor devices of claim 15, the method comprising preparing an array of body base structures, patterning or mounting on a sealing sheet an array of one or more sensing elements, and attaching the sealing sheet over said array of the base body structures so as to seal the respective at least one opening of the base body structures and place respective one or more sensing elements thereover.
18. A fluidic sensor device comprising: a base body structure comprising a fluid channel passing therealong and at least one opening in an external face of said base body structure and being in fluid communication with said fluid channel; at least one fluid restrictor formed inside the fluid channel; and a sealing element comprising one or more sensing elements a priori patterned or mounted thereon, said sealing element sealably attached over said external face of said base body structure comprising said at least one opening such that its one or more sensing elements become located over said at least one opening, wherein said one or more sensing elements are configured to measure at least one property or condition of a fluid substance responsive to deformations of said deformable portion when said fluid substance is introduced into said fluid channel and interact with said sealing element located over said at least one opening. 55
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/227,278 US10350593B2 (en) | 2014-02-01 | 2016-08-03 | Chip device for monitoring and regulating fluid flow, and methods of manufacture thereof |
PCT/IL2017/050851 WO2018025264A1 (en) | 2016-08-03 | 2017-08-01 | Fluidic microelectromechanical sensors/devices and fabrication methods thereof |
Publications (2)
Publication Number | Publication Date |
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IL264544A true IL264544A (en) | 2019-02-28 |
IL264544B IL264544B (en) | 2022-04-01 |
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IL264544A IL264544B (en) | 2016-08-03 | 2019-01-30 | Fluidic microelectromechanical sensors/devices and fabrication methods thereof |
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EP (1) | EP3485249A4 (en) |
IL (1) | IL264544B (en) |
WO (1) | WO2018025264A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2020012263A1 (en) * | 2018-07-09 | 2020-01-16 | Presens Precision Sensing Gmbh | System for analysis of a fluid sample |
US12000741B2 (en) | 2018-11-03 | 2024-06-04 | Ezmems Ltd. | Pluggable sensor device for measuring properties of fluid substance |
US11692965B2 (en) * | 2019-01-31 | 2023-07-04 | Femtodx, Inc. | Nanowire-based sensors with integrated fluid conductance measurement and related methods |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4398542A (en) * | 1980-12-15 | 1983-08-16 | Ivac Corporation | Pressure diaphragm |
US5848971A (en) * | 1993-06-30 | 1998-12-15 | Medex, Inc. | Modular medical pressure transducer |
US20060144151A1 (en) * | 2002-07-16 | 2006-07-06 | Peter Krause | Pressure transmitter having a pressure sensor of micromechanical design |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6247369B1 (en) * | 1995-04-04 | 2001-06-19 | The United States Of America As Represented By The Administrator Of The National Aeronautics Of Space Administration | Multi-channel electronically scanned cryogenic pressure sensor and method for making same |
AU2001279289A1 (en) | 2000-07-06 | 2002-01-21 | California Institute Of Technology | Surface-micromachined pressure sensor and high pressure application |
US7021148B2 (en) * | 2002-04-30 | 2006-04-04 | Baxter International Inc. | Apparatus and method for sealing pressure sensor membranes |
US7842234B2 (en) * | 2002-12-02 | 2010-11-30 | Epocal Inc. | Diagnostic devices incorporating fluidics and methods of manufacture |
US20070028683A1 (en) | 2005-06-07 | 2007-02-08 | The Regents Of The University Of California | Apparatus and method for sensing pressure utilizing a deformable cavity |
US7261003B2 (en) * | 2006-01-03 | 2007-08-28 | Freescale Semiconductor, Inc. | Flowmeter and method for the making thereof |
US8297125B2 (en) * | 2008-05-23 | 2012-10-30 | Honeywell International Inc. | Media isolated differential pressure sensor with cap |
US20130127879A1 (en) * | 2011-11-18 | 2013-05-23 | Qualcomm Mems Technologies, Inc. | Glass-encapsulated pressure sensor |
-
2017
- 2017-08-01 EP EP17836522.7A patent/EP3485249A4/en active Pending
- 2017-08-01 WO PCT/IL2017/050851 patent/WO2018025264A1/en unknown
-
2019
- 2019-01-30 IL IL264544A patent/IL264544B/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4398542A (en) * | 1980-12-15 | 1983-08-16 | Ivac Corporation | Pressure diaphragm |
US5848971A (en) * | 1993-06-30 | 1998-12-15 | Medex, Inc. | Modular medical pressure transducer |
US20060144151A1 (en) * | 2002-07-16 | 2006-07-06 | Peter Krause | Pressure transmitter having a pressure sensor of micromechanical design |
Also Published As
Publication number | Publication date |
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EP3485249A4 (en) | 2020-01-22 |
EP3485249A1 (en) | 2019-05-22 |
WO2018025264A1 (en) | 2018-02-08 |
IL264544B (en) | 2022-04-01 |
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