IL229702A - Methods and Methods for Active Cellular Immunotherapy of Cancer Using High-Hydrostatic Pressure and Dendritic Tumors - Google Patents

Methods and Methods for Active Cellular Immunotherapy of Cancer Using High-Hydrostatic Pressure and Dendritic Tumors

Info

Publication number
IL229702A
IL229702A IL229702A IL22970213A IL229702A IL 229702 A IL229702 A IL 229702A IL 229702 A IL229702 A IL 229702A IL 22970213 A IL22970213 A IL 22970213A IL 229702 A IL229702 A IL 229702A
Authority
IL
Israel
Prior art keywords
tumor
cells
tumor cells
ceils
hydrostatic pressure
Prior art date
Application number
IL229702A
Other languages
English (en)
Hebrew (he)
Other versions
IL229702A0 (en
Inventor
Bartunkova Jirina
Spisek Radek
Original Assignee
Sotio As
Bartunkova Jirina
Spisek Radek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11172622A external-priority patent/EP2543386A1/en
Application filed by Sotio As, Bartunkova Jirina, Spisek Radek filed Critical Sotio As
Publication of IL229702A0 publication Critical patent/IL229702A0/en
Publication of IL229702A publication Critical patent/IL229702A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0639Dendritic cells, e.g. Langherhans cells in the epidermis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5152Tumor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells or macrophages

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL229702A 2011-07-05 2013-11-28 Methods and Methods for Active Cellular Immunotherapy of Cancer Using High-Hydrostatic Pressure and Dendritic Tumors IL229702A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161504387P 2011-07-05 2011-07-05
EP11172622A EP2543386A1 (en) 2011-07-05 2011-07-05 Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure
PCT/EP2012/062950 WO2013004708A1 (en) 2011-07-05 2012-07-04 Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure and dendritic cells

Publications (2)

Publication Number Publication Date
IL229702A0 IL229702A0 (en) 2014-01-30
IL229702A true IL229702A (en) 2016-09-29

Family

ID=50023029

Family Applications (2)

Application Number Title Priority Date Filing Date
IL229702A IL229702A (en) 2011-07-05 2013-11-28 Methods and Methods for Active Cellular Immunotherapy of Cancer Using High-Hydrostatic Pressure and Dendritic Tumors
IL24778116A IL247781B (en) 2011-07-05 2016-09-12 Means and methods for active cellular immunotherapy of cancer using tumor cells killed by high hydrostatic pressure and dendritic cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL24778116A IL247781B (en) 2011-07-05 2016-09-12 Means and methods for active cellular immunotherapy of cancer using tumor cells killed by high hydrostatic pressure and dendritic cells

Country Status (7)

Country Link
JP (1) JP6235085B2 (hr)
CL (1) CL2013003282A1 (hr)
CY (1) CY1115803T1 (hr)
HR (1) HRP20141230T1 (hr)
IL (2) IL229702A (hr)
MX (1) MX2013013243A (hr)
ZA (1) ZA201307886B (hr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2852672C (en) 2011-10-17 2021-07-20 Massachusetts Institute Of Technology A microfluidic system and method for delivering a payload into a cell by causing perturbations in a cell membrane of the cell
JP6502940B2 (ja) 2013-08-16 2019-04-17 マサチューセッツ インスティテュート オブ テクノロジー 細胞への物質の選択的送達
KR20170074235A (ko) 2014-10-31 2017-06-29 메사추세츠 인스티튜트 오브 테크놀로지 면역 세포로의 생체분자의 전달
CN113897285A (zh) 2014-11-14 2022-01-07 麻省理工学院 化合物和组合物向细胞中的破坏和场实现的递送
CN107250373A (zh) 2015-01-12 2017-10-13 麻省理工学院 通过微流体递送实现的基因编辑
EP4257675A3 (en) 2015-07-09 2024-01-03 Massachusetts Institute of Technology Delivery of materials to anucleate cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2872199A (en) * 1998-02-20 1999-09-06 Rockefeller University, The Apoptotic cell-mediated antigen presentation to dendritic cells
WO2006095330A2 (en) * 2005-03-10 2006-09-14 Yeda Research And Development Co. Ltd. Methods and immunogenic cell preparations for treating antigen-associated diseases

Also Published As

Publication number Publication date
IL229702A0 (en) 2014-01-30
JP2017025066A (ja) 2017-02-02
IL247781A0 (en) 2016-11-30
CY1115803T1 (el) 2017-01-25
CL2013003282A1 (es) 2014-10-10
JP6235085B2 (ja) 2017-11-22
ZA201307886B (en) 2015-03-25
IL247781B (en) 2019-11-28
HRP20141230T1 (hr) 2015-02-13
MX2013013243A (es) 2014-05-30

Similar Documents

Publication Publication Date Title
AU2016234915B2 (en) Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure and dendritic cells
AU2012280322A1 (en) Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure and dendritic cells
US10918704B2 (en) Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure and dendritic cells
JP6235085B2 (ja) 高静水圧によって死滅させた腫瘍細胞および樹状細胞を用いた活性細胞癌免疫療法のための手段および方法
JP6134763B2 (ja) GM−CSF及びインターフェロンαを用いて生成され、且つ熱処理され死滅したがん細胞を取り込んだ樹状細胞
Van Driessche et al. Clinical-grade manufacturing of autologous mature mRNA-electroporated dendritic cells and safety testing in acute myeloid leukemia patients in a phase I dose-escalation clinical trial
US20130129713A1 (en) Method of antigen loading for immunotherapy
Su et al. Anti-tumor efficacy of a hepatocellular carcinoma vaccine based on dendritic cells combined with tumor-derived autophagosomes in murine models
Lemoine et al. Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer
WO2016081554A1 (en) Immunogenic compositions prepared from tumor cells derived from peripheral blood and originating from a solid tumor and their use
Shan et al. Cytokine-induced killer cells co-cultured with dendritic cells loaded with the protein lysate produced by radiofrequency ablation induce a specific antitumor response
JP2006518219A (ja) 電気穿孔法による細胞への抗原の負荷方法
Baek et al. Dendritic cell (DC) vaccine in mouse lung cancer minimal residual model; comparison of monocyte-derived DC vs. hematopoietic stem cell derived-DC
KR20150082836A (ko) 겔솔린을 유효성분으로 포함하는 수지상세포 분화 유도용 조성물 및 이의 분화 유도방법
Radej et al. Immunomodelling characteristics of mature dendritic cells stimulated by colon cancer cells lysates
NZ618000B2 (en) Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure and dendritic cells
US10030227B2 (en) Canine autologous immunotherapy using dendritic cell induced cancer killing immunocytes
Akiyama et al. Retrospective analysis of the clinical efficacy of a dendritic cell-based cancer vaccine in patients with advanced or recurrent breast cancer

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed