IL229235B - נגזרות של h4–כרומן–4–און כמודולטורים של חלבוני קינאז - Google Patents

נגזרות של h4–כרומן–4–און כמודולטורים של חלבוני קינאז

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Publication number
IL229235B
IL229235B IL229235A IL22923513A IL229235B IL 229235 B IL229235 B IL 229235B IL 229235 A IL229235 A IL 229235A IL 22923513 A IL22923513 A IL 22923513A IL 229235 B IL229235 B IL 229235B
Authority
IL
Israel
Prior art keywords
chromen
modulators
derivatives
protein kinases
kinases
Prior art date
Application number
IL229235A
Other languages
English (en)
Other versions
IL229235A0 (he
Inventor
Muthuppalaniappan Meyyappan
Viswanadha Srikant
Babu Govindarajulu
Kumar V S Vakkalanka Swaroop
Kashinath Bhavar Prashnant
Nagarathnam Dhanapalan
Original Assignee
Rhizen Pharmaceuticals S A
Muthuppalaniappan Meyyappan
Viswanadha Srikant
Babu Govindarajulu
Kumar V S Vakkalanka Swaroop
Kashinath Bhavar Prashnant
Nagarathnam Dhanapalan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/036594 external-priority patent/WO2012151525A1/en
Application filed by Rhizen Pharmaceuticals S A, Muthuppalaniappan Meyyappan, Viswanadha Srikant, Babu Govindarajulu, Kumar V S Vakkalanka Swaroop, Kashinath Bhavar Prashnant, Nagarathnam Dhanapalan filed Critical Rhizen Pharmaceuticals S A
Publication of IL229235A0 publication Critical patent/IL229235A0/he
Publication of IL229235B publication Critical patent/IL229235B/he

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    • C07—ORGANIC CHEMISTRY
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
    • C—CHEMISTRY; METALLURGY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
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    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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IL229235A 2011-05-04 2013-11-04 נגזרות של h4–כרומן–4–און כמודולטורים של חלבוני קינאז IL229235B (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1542CH2011 2011-05-04
PCT/US2012/036594 WO2012151525A1 (en) 2011-05-04 2012-05-04 Novel compounds as modulators of protein kinases

Publications (2)

Publication Number Publication Date
IL229235A0 IL229235A0 (he) 2014-01-30
IL229235B true IL229235B (he) 2018-05-31

Family

ID=50023000

Family Applications (3)

Application Number Title Priority Date Filing Date
IL229235A IL229235B (he) 2011-05-04 2013-11-04 נגזרות של h4–כרומן–4–און כמודולטורים של חלבוני קינאז
IL243729A IL243729B (he) 2011-05-04 2016-01-21 תרכובות h4–כרומין–4–און חדשות כמודולאטורים חדשים של חלבוני קינאז
IL259166A IL259166A (he) 2011-05-04 2018-05-06 תרכובות 4h–כרומן–4–און חדשות כמודולטורים של קינאזי חלבון

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IL243729A IL243729B (he) 2011-05-04 2016-01-21 תרכובות h4–כרומין–4–און חדשות כמודולאטורים חדשים של חלבוני קינאז
IL259166A IL259166A (he) 2011-05-04 2018-05-06 תרכובות 4h–כרומן–4–און חדשות כמודולטורים של קינאזי חלבון

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IL243729B (he) 2020-09-30
IL243729A0 (he) 2016-04-21
IL259166A (he) 2018-06-28

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