IL229187A - Radioactively labeled glutaminyl inhibitors - Google Patents
Radioactively labeled glutaminyl inhibitorsInfo
- Publication number
- IL229187A IL229187A IL229187A IL22918713A IL229187A IL 229187 A IL229187 A IL 229187A IL 229187 A IL229187 A IL 229187A IL 22918713 A IL22918713 A IL 22918713A IL 229187 A IL229187 A IL 229187A
- Authority
- IL
- Israel
- Prior art keywords
- substituted
- phenyl
- alkyl
- optionally
- compound
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims description 48
- 108010081484 glutaminyl-peptide cyclotransferase Proteins 0.000 title claims description 17
- 102000003642 glutaminyl-peptide cyclotransferase Human genes 0.000 title claims description 17
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- 150000002367 halogens Chemical class 0.000 claims description 44
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 37
- -1 cyano, hydroxyl Chemical group 0.000 claims description 36
- 125000001072 heteroaryl group Chemical group 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 35
- 238000001514 detection method Methods 0.000 claims description 34
- 125000003118 aryl group Chemical group 0.000 claims description 24
- 125000000623 heterocyclic group Chemical group 0.000 claims description 21
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- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 5
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- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
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| US5304367A (en) * | 1990-11-16 | 1994-04-19 | New York University | In vivo brain imaging agent and method for diagnosis of psychiatric disorders |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| WO2005075436A2 (en) * | 2004-02-05 | 2005-08-18 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| WO2007124345A2 (en) | 2006-04-21 | 2007-11-01 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services | Beta-amyloid pet imaging agents |
| US8278345B2 (en) * | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EA025107B1 (ru) * | 2008-07-31 | 2016-11-30 | Пробиодруг Аг | Способ диагностирования болезни альцгеймера, нейродегенерации при синдроме дауна или легкого когнитивного нарушения у субъекта (варианты) и набор для осуществления способа |
| MX2011002106A (es) * | 2008-09-04 | 2011-04-07 | Probiodrug Ag | Inhibidores novedosos. |
| CN102438660A (zh) | 2009-03-23 | 2012-05-02 | 美国西门子医疗解决公司 | 用于检测神经障碍的显像剂 |
| PL2475428T3 (pl) * | 2009-09-11 | 2015-12-31 | Probiodrug Ag | Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej |
| MX2012010470A (es) | 2010-03-10 | 2012-10-09 | Probiodrug Ag | Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5). |
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2012
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- 2012-05-24 CN CN201280025603.6A patent/CN103561776B/zh not_active Expired - Fee Related
- 2012-05-24 AU AU2012264951A patent/AU2012264951A1/en not_active Abandoned
- 2012-05-24 US US13/479,826 patent/US8945510B2/en not_active Expired - Fee Related
- 2012-05-24 EA EA201301334A patent/EA028533B1/ru not_active IP Right Cessation
- 2012-05-24 SG SG10201604304RA patent/SG10201604304RA/en unknown
- 2012-05-24 EP EP12723476.3A patent/EP2714098A1/en not_active Withdrawn
- 2012-05-24 MX MX2013013946A patent/MX2013013946A/es unknown
- 2012-05-24 WO PCT/EP2012/059649 patent/WO2012163773A1/en not_active Ceased
- 2012-05-24 KR KR20137033449A patent/KR20140028076A/ko not_active Withdrawn
- 2012-05-24 BR BR112013030341A patent/BR112013030341A2/pt not_active IP Right Cessation
- 2012-05-24 JP JP2014511862A patent/JP2014515364A/ja active Pending
- 2012-05-24 CA CA 2835014 patent/CA2835014A1/en not_active Abandoned
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|---|---|
| SG10201604304RA (en) | 2016-07-28 |
| US9610368B2 (en) | 2017-04-04 |
| US8945510B2 (en) | 2015-02-03 |
| US20120301398A1 (en) | 2012-11-29 |
| MX2013013946A (es) | 2014-01-31 |
| JP2014515364A (ja) | 2014-06-30 |
| WO2012163773A1 (en) | 2012-12-06 |
| EA201301334A1 (ru) | 2014-05-30 |
| AU2012264951A1 (en) | 2013-12-12 |
| KR20140028076A (ko) | 2014-03-07 |
| ZA201308329B (en) | 2015-02-25 |
| CA2835014A1 (en) | 2012-12-06 |
| BR112013030341A2 (pt) | 2016-11-29 |
| SG194770A1 (en) | 2013-12-30 |
| CN103561776B (zh) | 2016-08-31 |
| IL229187A0 (en) | 2013-12-31 |
| EP2714098A1 (en) | 2014-04-09 |
| NZ617581A (en) | 2016-03-31 |
| CN103561776A (zh) | 2014-02-05 |
| EA028533B1 (ru) | 2017-11-30 |
| US20150104389A1 (en) | 2015-04-16 |
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