IL229187A - Radioactively labeled glutaminyl inhibitors - Google Patents
Radioactively labeled glutaminyl inhibitorsInfo
- Publication number
- IL229187A IL229187A IL229187A IL22918713A IL229187A IL 229187 A IL229187 A IL 229187A IL 229187 A IL229187 A IL 229187A IL 22918713 A IL22918713 A IL 22918713A IL 229187 A IL229187 A IL 229187A
- Authority
- IL
- Israel
- Prior art keywords
- substituted
- phenyl
- alkyl
- optionally
- compound
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims description 48
- 108010081484 glutaminyl-peptide cyclotransferase Proteins 0.000 title claims description 17
- 102000003642 glutaminyl-peptide cyclotransferase Human genes 0.000 title claims description 17
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- 150000002367 halogens Chemical class 0.000 claims description 44
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 37
- -1 cyano, hydroxyl Chemical group 0.000 claims description 36
- 125000001072 heteroaryl group Chemical group 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 35
- 238000001514 detection method Methods 0.000 claims description 34
- 125000003118 aryl group Chemical group 0.000 claims description 24
- 125000000623 heterocyclic group Chemical group 0.000 claims description 21
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- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 5
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| US5304367A (en) * | 1990-11-16 | 1994-04-19 | New York University | In vivo brain imaging agent and method for diagnosis of psychiatric disorders |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| KR101099206B1 (ko) * | 2004-02-05 | 2011-12-27 | 프로비오드룩 아게 | 신규한 글루타미닐 시클라제 저해제 |
| US8703096B2 (en) | 2006-04-21 | 2014-04-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Beta-amyloid PET imaging agents |
| WO2008055945A1 (en) * | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| NZ590658A (en) * | 2008-07-31 | 2012-07-27 | Probiodrug Ag | Glutaminyl cyclase as a diagnostic / prognostic indicator for neurodegenerative diseases |
| EP2344157B1 (en) | 2008-09-04 | 2016-05-25 | Probiodrug AG | Novel inhibitors |
| EP2411057B1 (en) | 2009-03-23 | 2020-05-06 | Eli Lilly and Company | Imaging agents for detecting neurological disorders |
| ES2548913T3 (es) * | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| CA2789440C (en) | 2010-03-10 | 2020-03-24 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
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2012
- 2012-05-24 SG SG2013081567A patent/SG194770A1/en unknown
- 2012-05-24 AU AU2012264951A patent/AU2012264951A1/en not_active Abandoned
- 2012-05-24 SG SG10201604304RA patent/SG10201604304RA/en unknown
- 2012-05-24 CN CN201280025603.6A patent/CN103561776B/zh not_active Expired - Fee Related
- 2012-05-24 MX MX2013013946A patent/MX2013013946A/es unknown
- 2012-05-24 US US13/479,826 patent/US8945510B2/en not_active Expired - Fee Related
- 2012-05-24 BR BR112013030341A patent/BR112013030341A2/pt not_active IP Right Cessation
- 2012-05-24 EA EA201301334A patent/EA028533B1/ru not_active IP Right Cessation
- 2012-05-24 EP EP12723476.3A patent/EP2714098A1/en not_active Withdrawn
- 2012-05-24 WO PCT/EP2012/059649 patent/WO2012163773A1/en not_active Ceased
- 2012-05-24 KR KR20137033449A patent/KR20140028076A/ko not_active Withdrawn
- 2012-05-24 JP JP2014511862A patent/JP2014515364A/ja active Pending
- 2012-05-24 CA CA 2835014 patent/CA2835014A1/en not_active Abandoned
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- 2013-10-31 IL IL229187A patent/IL229187A/en not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2014515364A (ja) | 2014-06-30 |
| BR112013030341A2 (pt) | 2016-11-29 |
| CN103561776A (zh) | 2014-02-05 |
| US9610368B2 (en) | 2017-04-04 |
| CA2835014A1 (en) | 2012-12-06 |
| US8945510B2 (en) | 2015-02-03 |
| EA201301334A1 (ru) | 2014-05-30 |
| SG10201604304RA (en) | 2016-07-28 |
| MX2013013946A (es) | 2014-01-31 |
| IL229187A0 (en) | 2013-12-31 |
| ZA201308329B (en) | 2015-02-25 |
| SG194770A1 (en) | 2013-12-30 |
| KR20140028076A (ko) | 2014-03-07 |
| US20120301398A1 (en) | 2012-11-29 |
| WO2012163773A1 (en) | 2012-12-06 |
| EA028533B1 (ru) | 2017-11-30 |
| CN103561776B (zh) | 2016-08-31 |
| NZ617581A (en) | 2016-03-31 |
| US20150104389A1 (en) | 2015-04-16 |
| EP2714098A1 (en) | 2014-04-09 |
| AU2012264951A1 (en) | 2013-12-12 |
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