IL222466A - An algorithm that identifies paths while integrating data into genomic models - Google Patents

An algorithm that identifies paths while integrating data into genomic models

Info

Publication number
IL222466A
IL222466A IL222466A IL22246612A IL222466A IL 222466 A IL222466 A IL 222466A IL 222466 A IL222466 A IL 222466A IL 22246612 A IL22246612 A IL 22246612A IL 222466 A IL222466 A IL 222466A
Authority
IL
Israel
Prior art keywords
paradigm
recognition algorithm
data integration
pathway recognition
genomic models
Prior art date
Application number
IL222466A
Other languages
English (en)
Hebrew (he)
Other versions
IL222466A0 (en
Inventor
J Vaske Charles
C Benz Stephen
M Stuart Joshua
Haussler David
Original Assignee
Univ California
J Vaske Charles
C Benz Stephen
M Stuart Joshua
Haussler David
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, J Vaske Charles, C Benz Stephen, M Stuart Joshua, Haussler David filed Critical Univ California
Publication of IL222466A0 publication Critical patent/IL222466A0/en
Publication of IL222466A publication Critical patent/IL222466A/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/30—Dynamic-time models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20—Probabilistic models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Evolutionary Biology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Genetics & Genomics (AREA)
  • Physiology (AREA)
  • Bioethics (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Software Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Public Health (AREA)
  • Artificial Intelligence (AREA)
  • Probability & Statistics with Applications (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL222466A 2010-04-29 2012-10-15 An algorithm that identifies paths while integrating data into genomic models IL222466A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34357510P 2010-04-29 2010-04-29
PCT/US2011/000752 WO2011139345A2 (en) 2010-04-29 2011-04-29 Pathway recognition algorithm using data integration on genomic models (paradigm)

Publications (2)

Publication Number Publication Date
IL222466A0 IL222466A0 (en) 2012-12-31
IL222466A true IL222466A (en) 2016-11-30

Family

ID=44904280

Family Applications (4)

Application Number Title Priority Date Filing Date
IL222466A IL222466A (en) 2010-04-29 2012-10-15 An algorithm that identifies paths while integrating data into genomic models
IL248378A IL248378B (en) 2010-04-29 2016-10-18 An algorithm that identifies pathways while integrating data into genomic models
IL26290918A IL262909B (en) 2010-04-29 2018-11-11 An algorithm that identifies pathways while integrating data into genomic models
IL269416A IL269416B (en) 2010-04-29 2019-09-18 An algorithm that identifies pathways while integrating data into genomic models

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL248378A IL248378B (en) 2010-04-29 2016-10-18 An algorithm that identifies pathways while integrating data into genomic models
IL26290918A IL262909B (en) 2010-04-29 2018-11-11 An algorithm that identifies pathways while integrating data into genomic models
IL269416A IL269416B (en) 2010-04-29 2019-09-18 An algorithm that identifies pathways while integrating data into genomic models

Country Status (10)

Country Link
US (5) US10770169B2 (zh)
EP (2) EP3699915A1 (zh)
JP (3) JP6073217B2 (zh)
KR (3) KR101903547B1 (zh)
CN (2) CN102985927B (zh)
AU (2) AU2011249015B2 (zh)
CA (4) CA3052912A1 (zh)
DK (1) DK2564340T3 (zh)
IL (4) IL222466A (zh)
WO (1) WO2011139345A2 (zh)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011139345A2 (en) 2010-04-29 2011-11-10 The Regents Of The University Of California Pathway recognition algorithm using data integration on genomic models (paradigm)
US10192641B2 (en) 2010-04-29 2019-01-29 The Regents Of The University Of California Method of generating a dynamic pathway map
CN103384887B (zh) 2010-05-25 2017-01-18 加利福尼亚大学董事会 Bambam：高通量测序数据的平行比较分析
US9646134B2 (en) 2010-05-25 2017-05-09 The Regents Of The University Of California Bambam: parallel comparative analysis of high-throughput sequencing data
US20120095735A1 (en) * 2010-10-13 2012-04-19 Ayyadurai V A Shiva Method of Integration of Molecular Pathway Models
WO2013150420A2 (en) * 2012-04-02 2013-10-10 Koninklijke Philips N.V. Pathway visualization for clinical decision support
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP2870581B1 (en) * 2012-07-06 2023-11-29 Nant Holdings IP, LLC Healthcare analysis stream management
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
EP3536807B1 (en) 2012-09-20 2023-11-29 The Chinese University of Hong Kong Non-invasive determination of methylome of tumor from plasma
CN104822844B (zh) * 2012-10-01 2019-05-07 米伦纽姆医药公司 预测对抑制剂的反应的生物标记物和方法以及其用途
WO2014059036A1 (en) * 2012-10-09 2014-04-17 Five3 Genomics, Llc Systems and methods for learning and identification of regulatory interactions in biological pathways
US9489627B2 (en) * 2012-11-19 2016-11-08 Bottomline Technologies (De), Inc. Hybrid clustering for data analytics
US10395756B2 (en) * 2012-12-11 2019-08-27 Wayne State University Genetic, metabolic and biochemical pathway analysis system and methods
CN111961726A (zh) * 2012-12-26 2020-11-20 皇家飞利浦有限公司 使用靶基因表达的线性组合评价细胞信号传导途径活性
US10323281B2 (en) 2013-03-20 2019-06-18 Padma Arunachalam Kits and methods for evaluating, selecting and characterizing tissue culture models using micro-RNA profiles
JP6216044B2 (ja) * 2013-05-28 2017-10-18 ファイヴ３ ゲノミクス，エルエルシー Ｐａｒａｄｉｇｍ薬剤反応ネットワーク
US11011273B2 (en) * 2013-06-28 2021-05-18 Nantomics, Llc Pathway analysis for identification of diagnostic tests
US10114925B2 (en) 2013-07-26 2018-10-30 Nant Holdings Ip, Llc Discovery routing systems and engines
WO2015048546A1 (en) 2013-09-26 2015-04-02 Five3 Genomics, Llc Systems, methods, and compositions for viral-associated tumors
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2016004340A (es) 2013-10-04 2016-08-08 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
PT3119397T (pt) 2014-03-19 2022-04-11 Infinity Pharmaceuticals Inc Compostos heterocíclicos para utilização no tratamento de distúrbios mediados por pi3k-gama
KR101890792B1 (ko) 2014-03-25 2018-08-22 파이브3 제노믹스, 엘엘씨 암 돌연변이의 기능적 검증을 위한 rna 분석 시스템 및 방법
KR102014054B1 (ko) * 2014-05-30 2019-08-23 난토믹스, 엘엘씨 다중 종양 및 생식세포 유전자 엑솜에 걸친 분자 프로파일의 종합 분석을 위한 시스템 및 방법
TW202409295A (zh) 2014-07-18 2024-03-01 香港中文大學 Dna混合物中之組織甲基化模式分析
EP3201810A4 (en) * 2014-09-30 2018-06-20 Brown University Heat diffusion based genetic network analysis
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
WO2016114567A1 (ko) * 2015-01-13 2016-07-21 이화여자대학교 산학협력단 신규 항체 라이브러리 제조방법 및 이로부터 제조된 라이브러리
WO2016118513A1 (en) * 2015-01-20 2016-07-28 The Broad Institute, Inc. Method and system for analyzing biological networks
US11101038B2 (en) 2015-01-20 2021-08-24 Nantomics, Llc Systems and methods for response prediction to chemotherapy in high grade bladder cancer
US10546019B2 (en) 2015-03-23 2020-01-28 International Business Machines Corporation Simplified visualization and relevancy assessment of biological pathways
US11762989B2 (en) 2015-06-05 2023-09-19 Bottomline Technologies Inc. Securing electronic data by automatically destroying misdirected transmissions
US10160761B2 (en) 2015-09-14 2018-12-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
KR20240010089A (ko) 2015-10-12 2024-01-23 난토믹스, 엘엘씨 네오에피토프의 반복적 발견 및 이에 대한 적응성 면역치료 및 방법
US20170147743A1 (en) * 2015-11-23 2017-05-25 University Of Miami Rapid identification of pharmacological targets and anti-targets for drug discovery and repurposing
US20170163664A1 (en) 2015-12-04 2017-06-08 Bottomline Technologies (De) Inc. Method to secure protected content on a mobile device
AU2017219901B2 (en) 2016-02-19 2022-07-14 Nant Holdings Ip, Llc Methods of immunogenic modulation
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
KR20180117227A (ko) 2016-03-24 2018-10-26 난트셀, 인크. 네오에피토프 제시를 위한 시퀀스들 및 시퀀스 배열들
US20190147976A1 (en) * 2016-05-05 2019-05-16 Nantomics, Llc Checkpoint failure and methods therefor
US9710544B1 (en) * 2016-05-19 2017-07-18 Quid, Inc. Pivoting from a graph of semantic similarity of documents to a derivative graph of relationships between entities mentioned in the documents
US11163955B2 (en) 2016-06-03 2021-11-02 Bottomline Technologies, Inc. Identifying non-exactly matching text
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2018015796A (es) 2016-06-30 2019-05-16 Nant Holdings Ip Llc Vacuna contra el cáncer nant.
SG11201811286SA (en) 2016-06-30 2019-01-30 Nantomics Llc Synthetic wgs bioinformatics validation
US11875877B2 (en) 2016-08-25 2024-01-16 Nantomics, Llc Immunotherapy markers and uses therefor
US20190371427A1 (en) 2016-11-17 2019-12-05 Nantbio, Inc. Validation of inferred anticancer pathways
CA3044424C (en) 2016-11-21 2023-05-23 Nant Holdings Ip, Llc Fractal combination therapy
KR20230062684A (ko) 2016-11-30 2023-05-09 더 차이니즈 유니버시티 오브 홍콩 소변 및 기타 샘플에서의 무세포 dna의 분석
AU2018219862B2 (en) 2017-02-07 2020-09-17 Nant Holding IP, LLC Maximizing T-cell memory and compositions and methods therefor
US20180251849A1 (en) * 2017-03-03 2018-09-06 General Electric Company Method for identifying expression distinguishers in biological samples
IL314202A (en) 2017-04-24 2024-09-01 Nantcell Inc Vectors of putative neoepitopes, and methods therefor
EP3635137A4 (en) * 2017-06-08 2021-03-03 Nantomics, LLC INTEGRATIVE PANOMIC APPROACH FOR PHARMACOGENOMIC SCREENING
US11636917B2 (en) * 2017-06-28 2023-04-25 The Regents Of The University Of California Simulating the metabolic pathway dynamics of an organism
US10636512B2 (en) 2017-07-14 2020-04-28 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
US20210063379A1 (en) * 2017-09-07 2021-03-04 Samsung Life Public Welfare Foundation Customized Growth Factor Screening System for Cell Culture
EP3622520A1 (en) * 2017-10-16 2020-03-18 Illumina, Inc. Deep learning-based techniques for training deep convolutional neural networks
US11861491B2 (en) 2017-10-16 2024-01-02 Illumina, Inc. Deep learning-based pathogenicity classifier for promoter single nucleotide variants (pSNVs)
US11773187B2 (en) 2018-01-17 2023-10-03 Nantbio, Inc. Enhanced immunogenicity for GPI-anchored antigens
US10692254B2 (en) * 2018-03-02 2020-06-23 International Business Machines Corporation Systems and methods for constructing clinical pathways within a GUI
AU2019234843A1 (en) 2018-03-13 2020-09-24 Grail, Llc Anomalous fragment detection and classification
EP3765634A4 (en) 2018-03-16 2021-12-01 Scipher Medicine Corporation METHODS AND SYSTEMS FOR PREDICTING THE RESPONSE TO ANTI-TNF THERAPIES
US11823773B2 (en) 2018-04-13 2023-11-21 Nant Holdings Ip, Llc Nant cancer vaccine strategies
TW202345890A (zh) 2018-04-23 2023-12-01 美商南特細胞公司 新抗原表位疫苗及免疫刺激組合物及方法
US11564980B2 (en) 2018-04-23 2023-01-31 Nantcell, Inc. Tumor treatment method with an individualized peptide vaccine
US11003999B1 (en) 2018-11-09 2021-05-11 Bottomline Technologies, Inc. Customized automated account opening decisioning using machine learning
EP4369356A3 (en) * 2018-11-30 2024-07-24 Caris MPI, Inc. Next-generation molecular profiling
JP7526188B2 (ja) * 2019-01-08 2024-07-31 カリス エムピーアイ インコーポレイテッド ゲノムプロファイリングの類似性
US11409990B1 (en) 2019-03-01 2022-08-09 Bottomline Technologies (De) Inc. Machine learning archive mechanism using immutable storage
US11416713B1 (en) 2019-03-18 2022-08-16 Bottomline Technologies, Inc. Distributed predictive analytics data set
US11687807B1 (en) 2019-06-26 2023-06-27 Bottomline Technologies, Inc. Outcome creation based upon synthesis of history
MX2022000128A (es) 2019-06-27 2022-04-27 Scipher Medicine Corp Desarrollo de clasificadores para estratificar pacientes.
US11042555B1 (en) 2019-06-28 2021-06-22 Bottomline Technologies, Inc. Two step algorithm for non-exact matching of large datasets
WO2021022185A1 (en) * 2019-08-01 2021-02-04 Massachusetts Institute Of Technology Poly(beta-thioester) polymers and polymeric nanoparticles
WO2021070039A2 (en) * 2019-10-09 2021-04-15 Immunitybio, Inc. Detecting homologous recombination deficiencies (hrd) in clinical samples
JP2022551921A (ja) * 2019-10-09 2022-12-14 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 癌表現型を決定する為のｄｎａコピー数異常（ｃｎａ）
US11269841B1 (en) 2019-10-17 2022-03-08 Bottomline Technologies, Inc. Method and apparatus for non-exact matching of addresses
US11526859B1 (en) 2019-11-12 2022-12-13 Bottomline Technologies, Sarl Cash flow forecasting using a bottoms-up machine learning approach
US11532040B2 (en) 2019-11-12 2022-12-20 Bottomline Technologies Sarl International cash management software using machine learning
JP2023504270A (ja) 2019-12-02 2023-02-02 カリス エムピーアイ インコーポレイテッド 汎がんのプラチナ反応予測子
US20210225460A1 (en) * 2020-01-21 2021-07-22 Genialis Inc. Evaluating the robustness and transferability of predictive signatures across molecular biomarker datasets
US11704671B2 (en) 2020-04-02 2023-07-18 Bottomline Technologies Limited Financial messaging transformation-as-a-service
WO2021237117A1 (en) * 2020-05-22 2021-11-25 Insitro, Inc. Predicting disease outcomes using machine learned models
US11102304B1 (en) 2020-05-22 2021-08-24 Vignet Incorporated Delivering information and value to participants in digital clinical trials
US11449870B2 (en) 2020-08-05 2022-09-20 Bottomline Technologies Ltd. Fraud detection rule optimization
US20220208305A1 (en) * 2020-12-24 2022-06-30 Tempus Labs, Inc. Artificial intelligence driven therapy curation and prioritization
US11367521B1 (en) * 2020-12-29 2022-06-21 Kpn Innovations, Llc. System and method for generating a mesodermal outline nourishment program
EP4039825A1 (en) * 2021-02-09 2022-08-10 Koninklijke Philips N.V. Comparison and standardization of cell and tissue culture
US11694276B1 (en) 2021-08-27 2023-07-04 Bottomline Technologies, Inc. Process for automatically matching datasets
US11544798B1 (en) 2021-08-27 2023-01-03 Bottomline Technologies, Inc. Interactive animated user interface of a step-wise visual path of circles across a line for invoice management
US11705230B1 (en) 2021-11-30 2023-07-18 Vignet Incorporated Assessing health risks using genetic, epigenetic, and phenotypic data sources
US11901083B1 (en) 2021-11-30 2024-02-13 Vignet Incorporated Using genetic and phenotypic data sets for drug discovery clinical trials
CN115273975A (zh) * 2022-08-05 2022-11-01 中国医科大学附属第一医院 一种预测tp53突变分型的方法及其应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4736866A (en) 1984-06-22 1988-04-12 President And Fellows Of Harvard College Transgenic non-human mammals
US5175383A (en) 1989-02-17 1992-12-29 President And Fellows Of Harvard College Animal model for benign prostatic disease
US5834248A (en) 1995-02-10 1998-11-10 Millennium Pharmaceuticals Inc. Compositions and methods using rchd534, a gene uregulated by shear stress
US5767337A (en) 1995-07-31 1998-06-16 Duke University Creation of human apolipoprotein E isoform specific transgenic mice in apolipoprotein deficient "knockout" mice
US7709454B2 (en) 1997-06-20 2010-05-04 New York University Methods and compositions for inhibiting tumorigenesis
US6980958B1 (en) 2000-01-11 2005-12-27 Zycare, Inc. Apparatus and methods for monitoring and modifying anticoagulation therapy of remotely located patients
US7356416B2 (en) * 2000-01-25 2008-04-08 Cellomics, Inc. Method and system for automated inference creation of physico-chemical interaction knowledge from databases of co-occurrence data
EP1419472A2 (en) * 2001-08-16 2004-05-19 Biotech Research Ventures Pte Ltd Method for modelling biochemical pathways
US20040167763A1 (en) * 2002-05-31 2004-08-26 Liebman Michael N Information processing method for evaluating biochemical pathway models using clinical data
US8005620B2 (en) 2003-08-01 2011-08-23 Dna Twopointo Inc. Systems and methods for biopolymer engineering
US20070038386A1 (en) 2003-08-05 2007-02-15 Schadt Eric E Computer systems and methods for inferring casuality from cellular constituent abundance data
EP1739584A4 (en) 2004-03-30 2008-07-23 Shigeo Ihara DOCUMENT INFORMATIONSVERARBEITUNGSSSYSTEM
KR20060045950A (ko) * 2004-05-06 2006-05-17 베리덱스, 엘엘씨 혈액학적 악성종양에 대한 예후
JP4599989B2 (ja) * 2004-10-28 2010-12-15 日立造船株式会社 アンモニアの製造方法および脱硝方法
JP2006185412A (ja) 2004-12-03 2006-07-13 Kazusa Dna Kenkyusho 情報処理装置、情報処理方法及びそのプログラム
US7848890B2 (en) * 2004-12-08 2010-12-07 Electronics And Telecommunications Research Institute Method and system for predicting gene pathway using gene expression pattern data and protein interaction data
US20060293859A1 (en) 2005-04-13 2006-12-28 Venture Gain L.L.C. Analysis of transcriptomic data using similarity based modeling
US20090186024A1 (en) 2005-05-13 2009-07-23 Nevins Joseph R Gene Expression Signatures for Oncogenic Pathway Deregulation
CN101268373A (zh) 2005-05-17 2008-09-17 塞尔艾克特制药有限公司 作为检测早期免疫激活的标记物的tirc7
WO2006135904A2 (en) * 2005-06-13 2006-12-21 Kohne David E Method for producing improved results for applications which directly or indirectly utilize gene expression assay results
JP2007011996A (ja) * 2005-07-04 2007-01-18 Fujitsu Ltd 発現情報の解析方法及びそのシステム
JP2007052766A (ja) 2005-07-22 2007-03-01 Mathematical Systems Inc パスウェイ表示方法、情報処理装置及びパスウェイ表示プログラム
JP2007119966A (ja) 2005-10-31 2007-05-17 Toppan Printing Co Ltd 非接触ｉｃ内蔵用紙およびその製造方法
WO2008115497A2 (en) 2007-03-16 2008-09-25 Gene Security Network System and method for cleaning noisy genetic data and determining chromsome copy number
WO2010059742A1 (en) 2008-11-18 2010-05-27 Collabrx, Inc. Individualized cancer treatment
JP5429567B2 (ja) 2009-06-29 2014-02-26 株式会社ジェイテクト アンギュラ玉軸受用樹脂保持器
GB2474694B (en) 2009-10-23 2011-11-02 Innovia Films Ltd Biodegradable composites
WO2011055820A1 (ja) 2009-11-09 2011-05-12 大日本住友製薬株式会社 支援装置、支援方法、及びコンピュータプログラム
US10192641B2 (en) 2010-04-29 2019-01-29 The Regents Of The University Of California Method of generating a dynamic pathway map
WO2011139345A2 (en) 2010-04-29 2011-11-10 The Regents Of The University Of California Pathway recognition algorithm using data integration on genomic models (paradigm)

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