IL215584A - Use of 5- (fluoromethyl) piperidine-3,4-diol, 5- (chloromethyl) piperidine-3,4-diol for the preparation of a drug for the prevention and / or treatment of degenerative diseases of the central nervous system - Google Patents
Use of 5- (fluoromethyl) piperidine-3,4-diol, 5- (chloromethyl) piperidine-3,4-diol for the preparation of a drug for the prevention and / or treatment of degenerative diseases of the central nervous systemInfo
- Publication number
- IL215584A IL215584A IL215584A IL21558411A IL215584A IL 215584 A IL215584 A IL 215584A IL 215584 A IL215584 A IL 215584A IL 21558411 A IL21558411 A IL 21558411A IL 215584 A IL215584 A IL 215584A
- Authority
- IL
- Israel
- Prior art keywords
- piperidine
- diol
- fluoromethyl
- chloromethyl
- medicament
- Prior art date
Links
- KTXBXDGOZMHNIC-UHFFFAOYSA-N 5-(chloromethyl)piperidine-3,4-diol Chemical compound OC1CNCC(CCl)C1O KTXBXDGOZMHNIC-UHFFFAOYSA-N 0.000 title 1
- BEQPGACEJJJLEA-UHFFFAOYSA-N 5-(fluoromethyl)piperidine-3,4-diol Chemical compound OC1CNCC(CF)C1O BEQPGACEJJJLEA-UHFFFAOYSA-N 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 title 1
- 230000003412 degenerative effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16810109P | 2009-04-09 | 2009-04-09 | |
| PCT/US2010/030470 WO2010118282A1 (en) | 2009-04-09 | 2010-04-09 | Methods for preventing and/or treating degenerative disorders of the central nervous system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL215584A0 IL215584A0 (en) | 2011-12-29 |
| IL215584A true IL215584A (en) | 2016-11-30 |
Family
ID=42934882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL215584A IL215584A (en) | 2009-04-09 | 2011-10-06 | Use of 5- (fluoromethyl) piperidine-3,4-diol, 5- (chloromethyl) piperidine-3,4-diol for the preparation of a drug for the prevention and / or treatment of degenerative diseases of the central nervous system |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8304429B2 (enExample) |
| EP (1) | EP2416655B1 (enExample) |
| JP (1) | JP5634498B2 (enExample) |
| CN (1) | CN102448306B (enExample) |
| AU (1) | AU2010233187B2 (enExample) |
| BR (1) | BRPI1015472A2 (enExample) |
| CA (1) | CA2758187C (enExample) |
| ES (1) | ES2505243T3 (enExample) |
| IL (1) | IL215584A (enExample) |
| NZ (1) | NZ595630A (enExample) |
| WO (1) | WO2010118282A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5645918B2 (ja) * | 2009-04-09 | 2014-12-24 | アミカス セラピューティックス インコーポレイテッド | リソソーム蓄積障害の予防および／または治療方法 |
| RU2015147509A (ru) * | 2009-10-19 | 2019-01-14 | Амикус Терапьютикс, Инк. | Новые композиции для предупреждения и/или лечения дегенеративных расстройств центральной нервной системы |
| WO2011049737A1 (en) | 2009-10-19 | 2011-04-28 | Amicus Therapeutics, Inc. | Novel compositions for preventing and/or treating lysosomal storage disorders |
| EP3521451A1 (en) | 2010-11-17 | 2019-08-07 | Ionis Pharmaceuticals, Inc. | Modulation of alpha synuclein expression |
| WO2013070981A2 (en) * | 2011-11-08 | 2013-05-16 | University Of Central Florida Research Foundation, Inc. | Treating er stress related disorders by stabilizing intracellular calcium homeostasis |
| US9155695B2 (en) | 2013-03-14 | 2015-10-13 | Medtronic, Inc. | Injectable ropinirole compositions and methods for making and using same |
| JP2017502961A (ja) | 2013-12-23 | 2017-01-26 | アレクトス セラピューティックス インコーポレイテッド | グルコセレブロシダーゼモジュレーターおよびその使用 |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| US10300155B2 (en) | 2015-12-31 | 2019-05-28 | Washington University | Alpha-synuclein ligands |
| EP3509639A1 (en) * | 2016-09-12 | 2019-07-17 | Steven Hoffman | Compositions for treating dementia |
| RU2019114679A (ru) | 2016-11-15 | 2020-12-17 | Х. Лундбекк А/С | Средства, пути применения и способы лечения синуклеопатии |
| MY203356A (en) | 2018-01-12 | 2024-06-25 | Bristol Myers Squibb Co | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| WO2019140236A1 (en) | 2018-01-12 | 2019-07-18 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| CN119606967B (zh) * | 2024-12-13 | 2025-09-05 | 合肥工业大学 | 氯雷他定在制备用于预防和治疗血管钙化药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1890295A (en) * | 1994-03-09 | 1995-09-25 | Novo Nordisk A/S | Piperidines and pyrrolidines |
| WO2002076440A2 (en) * | 2001-03-23 | 2002-10-03 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
| US6770625B2 (en) * | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
| US6670625B1 (en) * | 2002-06-18 | 2003-12-30 | Ge Medical Systems Global Technology Company, Llc | Method and apparatus for correcting multipole aberrations of an electron beam in an EBT scanner |
| JP2006507359A (ja) * | 2002-10-28 | 2006-03-02 | ノボ・ノルデイスク・エー／エス | 心循環器疾患の治療のためのグリコーゲンホスホリラーゼ阻害剤の使用 |
| ES2485369T3 (es) * | 2005-06-08 | 2014-08-13 | Amicus Therapeutics, Inc. | Tratamiento de trastornos del SNC asociados con mutaciones en genes que codifican enzimas lisosómicas |
| DK2040548T3 (da) * | 2006-06-23 | 2012-08-13 | Amicus Therapeutics Inc | Fremgangsmåde til behandling af neurologiske forstyrrelser ved forøgelse af aktiviteten af beta-glucocerebrosidase |
| US20080009156A1 (en) | 2006-07-10 | 2008-01-10 | Malin Glen K | System and method for bonding coaxial cable |
| JP5645918B2 (ja) * | 2009-04-09 | 2014-12-24 | アミカス セラピューティックス インコーポレイテッド | リソソーム蓄積障害の予防および／または治療方法 |
-
2010
- 2010-04-09 CA CA2758187A patent/CA2758187C/en not_active Expired - Fee Related
- 2010-04-09 BR BRPI1015472A patent/BRPI1015472A2/pt not_active Application Discontinuation
- 2010-04-09 EP EP10762468.6A patent/EP2416655B1/en active Active
- 2010-04-09 AU AU2010233187A patent/AU2010233187B2/en not_active Ceased
- 2010-04-09 NZ NZ595630A patent/NZ595630A/xx not_active IP Right Cessation
- 2010-04-09 CN CN201080024142.1A patent/CN102448306B/zh not_active Expired - Fee Related
- 2010-04-09 US US12/757,144 patent/US8304429B2/en not_active Expired - Fee Related
- 2010-04-09 WO PCT/US2010/030470 patent/WO2010118282A1/en not_active Ceased
- 2010-04-09 JP JP2012504880A patent/JP5634498B2/ja active Active
- 2010-04-09 ES ES10762468.6T patent/ES2505243T3/es active Active
-
2011
- 2011-10-06 IL IL215584A patent/IL215584A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ595630A (en) | 2013-04-26 |
| US8304429B2 (en) | 2012-11-06 |
| BRPI1015472A2 (pt) | 2015-11-24 |
| US20100261753A1 (en) | 2010-10-14 |
| HK1168005A1 (zh) | 2012-12-21 |
| CA2758187A1 (en) | 2010-10-14 |
| JP2012523430A (ja) | 2012-10-04 |
| AU2010233187A1 (en) | 2011-11-03 |
| JP5634498B2 (ja) | 2014-12-03 |
| WO2010118282A1 (en) | 2010-10-14 |
| CA2758187C (en) | 2017-03-07 |
| IL215584A0 (en) | 2011-12-29 |
| EP2416655B1 (en) | 2014-06-25 |
| ES2505243T3 (es) | 2014-10-09 |
| EP2416655A4 (en) | 2012-09-05 |
| CN102448306A (zh) | 2012-05-09 |
| AU2010233187B2 (en) | 2015-10-08 |
| EP2416655A1 (en) | 2012-02-15 |
| CN102448306B (zh) | 2014-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |