CA2758187C - Methods for preventing and/or treating degenerative disorders of the central nervous system - Google Patents
Methods for preventing and/or treating degenerative disorders of the central nervous system Download PDFInfo
- Publication number
- CA2758187C CA2758187C CA2758187A CA2758187A CA2758187C CA 2758187 C CA2758187 C CA 2758187C CA 2758187 A CA2758187 A CA 2758187A CA 2758187 A CA2758187 A CA 2758187A CA 2758187 C CA2758187 C CA 2758187C
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- Prior art keywords
- compound
- diol
- therapeutic agent
- piperdine
- degenerative disorder
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US16810109P | 2009-04-09 | 2009-04-09 | |
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| PCT/US2010/030470 WO2010118282A1 (en) | 2009-04-09 | 2010-04-09 | Methods for preventing and/or treating degenerative disorders of the central nervous system |
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| CA2758187A1 CA2758187A1 (en) | 2010-10-14 |
| CA2758187C true CA2758187C (en) | 2017-03-07 |
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| NZ (1) | NZ595630A (enExample) |
| WO (1) | WO2010118282A1 (enExample) |
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| ES2564093T3 (es) * | 2009-04-09 | 2016-03-17 | Amicus Therapeutics, Inc. | Métodos para prevenir y/o tratar trastornos del almacenamiento lisosomal |
| EP3143875B1 (en) | 2009-10-19 | 2020-05-27 | Amicus Therapeutics, Inc. | Novel compositions for preventing and/or treating degenerative disorders of the central nervous system |
| PT2995306T (pt) | 2009-10-19 | 2019-03-29 | Amicus Therapeutics Inc | Novas composições para prevenção e/ou tratamento de disfunções de armazenamento lisossomal |
| WO2012068405A2 (en) | 2010-11-17 | 2012-05-24 | Isis Pharmaceuticals, Inc. | Modulation of alpha synuclein expression |
| WO2013070981A2 (en) * | 2011-11-08 | 2013-05-16 | University Of Central Florida Research Foundation, Inc. | Treating er stress related disorders by stabilizing intracellular calcium homeostasis |
| US9155695B2 (en) | 2013-03-14 | 2015-10-13 | Medtronic, Inc. | Injectable ropinirole compositions and methods for making and using same |
| US9796680B2 (en) | 2013-12-23 | 2017-10-24 | Alectos Therapeutics Inc. | Glucocerebrosidase modulators and uses thereof |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| US10300155B2 (en) | 2015-12-31 | 2019-05-28 | Washington University | Alpha-synuclein ligands |
| US10300077B2 (en) * | 2016-09-12 | 2019-05-28 | Steven Hoffman | Compositions and methods for treating dementia |
| MA46836A (fr) | 2016-11-15 | 2019-09-25 | H Lundbeck As | Agents, utilisations et procédés pour le traitement d'une synucléinopathie |
| US11447775B2 (en) | 2018-01-12 | 2022-09-20 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| CN111819283A (zh) | 2018-01-12 | 2020-10-23 | 百时美施贵宝公司 | 靶向α-突触核蛋白的反义寡核苷酸及其用途 |
| CN119606967B (zh) * | 2024-12-13 | 2025-09-05 | 合肥工业大学 | 氯雷他定在制备用于预防和治疗血管钙化药物中的应用 |
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| ATE243196T1 (de) * | 1994-03-09 | 2003-07-15 | Novo Nordisk As | Piperidine und pyrrolidine |
| AU2002306848A1 (en) * | 2001-03-23 | 2002-10-08 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
| US6770625B2 (en) * | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
| US6670625B1 (en) * | 2002-06-18 | 2003-12-30 | Ge Medical Systems Global Technology Company, Llc | Method and apparatus for correcting multipole aberrations of an electron beam in an EBT scanner |
| JP2006507359A (ja) * | 2002-10-28 | 2006-03-02 | ノボ・ノルデイスク・エー／エス | 心循環器疾患の治療のためのグリコーゲンホスホリラーゼ阻害剤の使用 |
| MX2007015602A (es) | 2005-06-08 | 2008-02-21 | Amicus Therapeutics Inc | Tratamiento de trastornos del sistema nervioso central asociados con mutaciones en genes que codifican las enzimas lisosomicas. |
| AU2007260812B2 (en) | 2006-06-23 | 2012-08-16 | Amicus Therapeutics, Inc. | Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase |
| US20080009156A1 (en) | 2006-07-10 | 2008-01-10 | Malin Glen K | System and method for bonding coaxial cable |
| ES2564093T3 (es) * | 2009-04-09 | 2016-03-17 | Amicus Therapeutics, Inc. | Métodos para prevenir y/o tratar trastornos del almacenamiento lisosomal |
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| AU2010233187B2 (en) | 2015-10-08 |
| ES2505243T3 (es) | 2014-10-09 |
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| NZ595630A (en) | 2013-04-26 |
| US8304429B2 (en) | 2012-11-06 |
| JP2012523430A (ja) | 2012-10-04 |
| CN102448306A (zh) | 2012-05-09 |
| EP2416655A1 (en) | 2012-02-15 |
| BRPI1015472A2 (pt) | 2015-11-24 |
| AU2010233187A1 (en) | 2011-11-03 |
| US20100261753A1 (en) | 2010-10-14 |
| CN102448306B (zh) | 2014-07-02 |
| EP2416655A4 (en) | 2012-09-05 |
| CA2758187A1 (en) | 2010-10-14 |
| EP2416655B1 (en) | 2014-06-25 |
| IL215584A (en) | 2016-11-30 |
| IL215584A0 (en) | 2011-12-29 |
| WO2010118282A1 (en) | 2010-10-14 |
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