IL197722A0 - Mglur5 modulators - Google Patents

Mglur5 modulators

Info

Publication number
IL197722A0
IL197722A0 IL197722A IL19772209A IL197722A0 IL 197722 A0 IL197722 A0 IL 197722A0 IL 197722 A IL197722 A IL 197722A IL 19772209 A IL19772209 A IL 19772209A IL 197722 A0 IL197722 A0 IL 197722A0
Authority
IL
Israel
Prior art keywords
mglur5 modulators
mglur5
modulators
Prior art date
Application number
IL197722A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Slassi Abdelmalik
Isaac Methvin
Xin Tao
Stefanac Tomislav
Dove Peter
Edwards Louise
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39032082&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL197722(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Slassi Abdelmalik, Isaac Methvin, Xin Tao, Stefanac Tomislav, Dove Peter, Edwards Louise filed Critical Astrazeneca Ab
Publication of IL197722A0 publication Critical patent/IL197722A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
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    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
IL197722A 2006-10-05 2009-03-19 Mglur5 modulators IL197722A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82832506P 2006-10-05 2006-10-05
PCT/IB2007/002784 WO2008041075A1 (en) 2006-10-05 2007-09-25 Mglur5 modulators

Publications (1)

Publication Number Publication Date
IL197722A0 true IL197722A0 (en) 2009-12-24

Family

ID=39032082

Family Applications (1)

Application Number Title Priority Date Filing Date
IL197722A IL197722A0 (en) 2006-10-05 2009-03-19 Mglur5 modulators

Country Status (21)

Country Link
US (1) US7772235B2 (cg-RX-API-DMAC7.html)
EP (1) EP2079730A1 (cg-RX-API-DMAC7.html)
JP (1) JP2010505809A (cg-RX-API-DMAC7.html)
KR (1) KR20090060328A (cg-RX-API-DMAC7.html)
CN (1) CN101547916A (cg-RX-API-DMAC7.html)
AR (1) AR062965A1 (cg-RX-API-DMAC7.html)
AU (1) AU2007303889B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0719155A2 (cg-RX-API-DMAC7.html)
CA (1) CA2665083A1 (cg-RX-API-DMAC7.html)
CL (1) CL2007002757A1 (cg-RX-API-DMAC7.html)
CO (1) CO6220935A2 (cg-RX-API-DMAC7.html)
IL (1) IL197722A0 (cg-RX-API-DMAC7.html)
MX (1) MX2009003227A (cg-RX-API-DMAC7.html)
NO (1) NO20091626L (cg-RX-API-DMAC7.html)
NZ (1) NZ575657A (cg-RX-API-DMAC7.html)
PE (1) PE20081378A1 (cg-RX-API-DMAC7.html)
RU (1) RU2439068C2 (cg-RX-API-DMAC7.html)
SA (1) SA07280518B1 (cg-RX-API-DMAC7.html)
TW (1) TW200821305A (cg-RX-API-DMAC7.html)
UY (1) UY30610A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008041075A1 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009054793A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Thiophene 1,2,4-triazole derivatives as modulators of mglur5
WO2009054785A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole ether derivatives as modulators of mglur5
WO2009054786A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole aryl n-oxides derivatives as modulators of mglur5
CN101918399A (zh) * 2007-10-26 2010-12-15 阿斯利康(瑞典)有限公司 作为mglur5调节剂的氨基1,2,4-三唑衍生物
WO2009054790A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Amide linked heteroaromatic derivatives as modulators of mglur5
WO2009054787A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole carboxylic acid derivatives as modulators of mglur5
US20110224261A1 (en) * 2008-08-12 2011-09-15 Astrazeneca Ab Crystalline form of 4-(5--4-methyl-4h-1,2,4-triazol-3-yl)pyridine
US20100041706A1 (en) * 2008-08-12 2010-02-18 Astrazeneca Ab Compounds 501
SG171755A1 (en) * 2008-12-18 2011-07-28 Astrazeneca Ab New process for the preparation of 1- [5- (3-chloro-phenyl) - isooxazol-3-yl] -ethanone and (r) -1- [5- (3-chloro-phenyl) - isooxazol-3-yl] -ethanol
US20100273805A1 (en) * 2009-04-23 2010-10-28 Astrazeneca Ab Sulphide bridged derivatives as modulators of mglur5 733
AU2010295288A1 (en) * 2009-09-21 2012-05-03 Johnson & Johnson O-benzyl nicotinamide analogs as mGluR5 positive allosteric modulators
US20130203735A1 (en) * 2010-10-28 2013-08-08 John T. Sisko Caprolactam mglur5 receptor modulators
EP2648723A4 (en) 2010-12-08 2014-04-02 Univ Vanderbilt Bicyclic pyrazole compounds as allergic Mglur5 receptor modulators
AU2011343477A1 (en) * 2010-12-17 2013-07-04 Vanderbilt University Bicyclic triazole and pyrazole lactams as allosteric modulators of mGluR5 receptors
US8471027B2 (en) 2011-04-06 2013-06-25 Hoffmann-La Roche Inc. Adamantyl compounds
EP2857387A1 (en) 2013-10-07 2015-04-08 Boehringer Ingelheim International Gmbh Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid
EP3486235A4 (en) 2016-07-15 2020-02-12 Oriental (Luzhou) Agrochemicals. Co., Ltd. SYNTHETIC PROCESS FOR THE COMPOUND 1,2,4-TRIAZOLE-3-THIONE AND ITS INTERMEDIATE
AU2018334290A1 (en) 2017-09-18 2020-04-02 Goldfinch Bio, Inc. Pyridazinones and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050033070A (ko) * 2002-08-09 2005-04-08 아스트라제네카 에이비이 메타보트로픽 글루타메이트 수용체-5의 조절제로서[1,2,4]옥사디아졸
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
GB0514296D0 (en) 2005-07-12 2005-08-17 Novartis Ag Organic compounds
UY29796A1 (es) * 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor
TW200808800A (en) 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V
TW200811157A (en) * 2006-05-05 2008-03-01 Astrazeneca Ab mGluR5 modulators I

Also Published As

Publication number Publication date
WO2008041075A1 (en) 2008-04-10
NZ575657A (en) 2011-03-31
RU2009111113A (ru) 2010-11-10
MX2009003227A (es) 2009-04-06
EP2079730A1 (en) 2009-07-22
NO20091626L (no) 2009-05-04
CL2007002757A1 (es) 2008-06-20
RU2439068C2 (ru) 2012-01-10
PE20081378A1 (es) 2008-11-12
KR20090060328A (ko) 2009-06-11
BRPI0719155A2 (pt) 2014-02-04
AR062965A1 (es) 2008-12-17
US20080125436A1 (en) 2008-05-29
CO6220935A2 (es) 2010-11-19
UY30610A1 (es) 2008-05-02
AU2007303889B2 (en) 2011-02-24
AU2007303889A2 (en) 2010-07-15
CN101547916A (zh) 2009-09-30
AU2007303889A1 (en) 2008-04-10
JP2010505809A (ja) 2010-02-25
TW200821305A (en) 2008-05-16
US7772235B2 (en) 2010-08-10
SA07280518B1 (ar) 2011-01-15
CA2665083A1 (en) 2008-04-10

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GB0612303D0 (en) Corcost1406
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GB0615316D0 (en) Corcost1406
GB0613259D0 (en) Shred-safe
GB0615324D0 (en) Corcost706
GB0615329D0 (en) Corcost806