IL162482A - Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron loss - Google Patents
Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron lossInfo
- Publication number
- IL162482A IL162482A IL162482A IL16248204A IL162482A IL 162482 A IL162482 A IL 162482A IL 162482 A IL162482 A IL 162482A IL 16248204 A IL16248204 A IL 16248204A IL 162482 A IL162482 A IL 162482A
- Authority
- IL
- Israel
- Prior art keywords
- chimera
- manufacture
- treatment
- medicament
- neuron loss
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000004770 neurodegeneration Effects 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 abstract 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention provides for the use of IL6R/IL6 chimera for the manufacture of medicaments for the treatment of neurological diseases and disorders.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL162482A IL162482A (en) | 2001-12-31 | 2004-06-13 | Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron loss |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL14741201A IL147412A0 (en) | 2001-12-31 | 2001-12-31 | The use of il6r/il6 chimera in nerve cell regeneration |
PCT/IL2002/001058 WO2003059376A1 (en) | 2001-12-31 | 2002-12-31 | The use of il6r/il6 chimera in nerve cell regeneration |
IL162482A IL162482A (en) | 2001-12-31 | 2004-06-13 | Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron loss |
Publications (1)
Publication Number | Publication Date |
---|---|
IL162482A true IL162482A (en) | 2013-06-27 |
Family
ID=11075915
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14741201A IL147412A0 (en) | 2001-12-31 | 2001-12-31 | The use of il6r/il6 chimera in nerve cell regeneration |
IL162482A IL162482A (en) | 2001-12-31 | 2004-06-13 | Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron loss |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14741201A IL147412A0 (en) | 2001-12-31 | 2001-12-31 | The use of il6r/il6 chimera in nerve cell regeneration |
Country Status (8)
Country | Link |
---|---|
US (1) | US7824670B2 (en) |
EP (1) | EP1461066B1 (en) |
JP (1) | JP4685354B2 (en) |
AU (1) | AU2002361489B2 (en) |
CA (1) | CA2472203C (en) |
ES (1) | ES2535156T3 (en) |
IL (2) | IL147412A0 (en) |
WO (1) | WO2003059376A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2527847C (en) * | 2003-06-12 | 2015-09-29 | Yeda Research & Development Co. Ltd | Enhancement of oligodendrocyte differentiation |
IL157309A0 (en) | 2003-08-07 | 2004-02-19 | Applied Research Systems | Method for the purification of a non-immunoglobulin protein |
EP1784486B1 (en) * | 2004-06-23 | 2011-10-05 | TissueGene, Inc. | Nerve regeneration |
AU2006286149B2 (en) * | 2005-08-29 | 2012-09-13 | Technion Research And Development Foundation Ltd. | Media for culturing stem cells |
GB0815216D0 (en) * | 2008-08-21 | 2008-09-24 | Asterion Ltd | Interleukin |
JP5749659B2 (en) * | 2009-03-12 | 2015-07-15 | ハーゼ インベストメンツ ウーゲー | Bone morphogenetic protein 2 (BMP2) variant with reduced BMP antagonist sensitivity |
US20120219535A1 (en) * | 2009-10-02 | 2012-08-30 | University Of Southern California | Cranial neural crest stem cells and culture condition that supports their growth |
CA2845198A1 (en) * | 2010-08-13 | 2012-02-16 | Georgetown University | Ggf2 and methods of use |
WO2013184938A2 (en) * | 2012-06-08 | 2013-12-12 | Alkermes. Inc. | Fusion polypeptides comprising mucin-domain polypeptide linkers |
WO2020006469A1 (en) * | 2018-06-29 | 2020-01-02 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for treating and reducing traumatic brain injury-associated impairments using sgp130 |
KR20230084470A (en) * | 2020-08-14 | 2023-06-13 | 카이트 파마 인코포레이티드 | Improvement of immune cell function |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0987198A (en) * | 1995-09-19 | 1997-03-31 | Tosoh Corp | Neurocyte extending agent |
IL122818A0 (en) * | 1997-07-10 | 1998-08-16 | Yeda Res & Dev | Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof |
IL130586A0 (en) | 1999-06-21 | 2000-06-01 | Yeda Res & Dev | IL6RIL6 chimera for the treatment of demyelinating diseases |
US6749850B1 (en) * | 1999-08-18 | 2004-06-15 | The General Hospital Corporation | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
WO2001076507A2 (en) * | 2000-04-11 | 2001-10-18 | The University Of Miami | Use of oxygen carriers to improve grafted cell survival in neural transplantation |
ATE324906T1 (en) * | 2000-09-14 | 2006-06-15 | Ares Trading Sa | USE OF CHIMERIC IL6-IL6R IN HUNTINGTON'S DISEASE |
-
2001
- 2001-12-31 IL IL14741201A patent/IL147412A0/en unknown
-
2002
- 2002-12-31 JP JP2003559537A patent/JP4685354B2/en not_active Expired - Fee Related
- 2002-12-31 EP EP02796952.6A patent/EP1461066B1/en not_active Expired - Lifetime
- 2002-12-31 CA CA2472203A patent/CA2472203C/en not_active Expired - Fee Related
- 2002-12-31 AU AU2002361489A patent/AU2002361489B2/en not_active Ceased
- 2002-12-31 ES ES02796952.6T patent/ES2535156T3/en not_active Expired - Lifetime
- 2002-12-31 WO PCT/IL2002/001058 patent/WO2003059376A1/en active Application Filing
- 2002-12-31 US US10/498,899 patent/US7824670B2/en not_active Expired - Fee Related
-
2004
- 2004-06-13 IL IL162482A patent/IL162482A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20050220761A1 (en) | 2005-10-06 |
AU2002361489B2 (en) | 2008-05-08 |
ES2535156T3 (en) | 2015-05-05 |
EP1461066A1 (en) | 2004-09-29 |
US7824670B2 (en) | 2010-11-02 |
JP4685354B2 (en) | 2011-05-18 |
CA2472203A1 (en) | 2003-07-24 |
AU2002361489A1 (en) | 2003-07-30 |
WO2003059376A8 (en) | 2003-10-09 |
JP2005514442A (en) | 2005-05-19 |
WO2003059376A1 (en) | 2003-07-24 |
CA2472203C (en) | 2014-02-18 |
EP1461066B1 (en) | 2015-02-25 |
IL147412A0 (en) | 2002-08-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |