IL159122A0 - Allylmercaptocaptopril compounds and uses thereof - Google Patents
Allylmercaptocaptopril compounds and uses thereofInfo
- Publication number
- IL159122A0 IL159122A0 IL15912202A IL15912202A IL159122A0 IL 159122 A0 IL159122 A0 IL 159122A0 IL 15912202 A IL15912202 A IL 15912202A IL 15912202 A IL15912202 A IL 15912202A IL 159122 A0 IL159122 A0 IL 159122A0
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- allylmercaptocaptopril
- elevated
- allicin
- ace
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 abstract 1
- 206010014486 Elevated triglycerides Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000010081 allicin Nutrition 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29398901P | 2001-05-30 | 2001-05-30 | |
| US30441401P | 2001-07-12 | 2001-07-12 | |
| US31182901P | 2001-08-14 | 2001-08-14 | |
| US33496201P | 2001-12-04 | 2001-12-04 | |
| PCT/US2002/016964 WO2002096871A1 (fr) | 2001-05-30 | 2002-05-30 | Composes d'allylmercapto-captopril et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL159122A0 true IL159122A0 (en) | 2004-05-12 |
Family
ID=31499517
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15912202A IL159122A0 (en) | 2001-05-30 | 2002-05-30 | Allylmercaptocaptopril compounds and uses thereof |
| IL159122A IL159122A (en) | 2001-05-30 | 2003-11-27 | Allylmercaptocaptopril compounds and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL159122A IL159122A (en) | 2001-05-30 | 2003-11-27 | Allylmercaptocaptopril compounds and uses thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7241902B2 (fr) |
| EP (1) | EP1414794B1 (fr) |
| AT (1) | ATE398106T1 (fr) |
| AU (1) | AU2002305744B2 (fr) |
| CA (1) | CA2448896C (fr) |
| DE (1) | DE60227078D1 (fr) |
| IL (2) | IL159122A0 (fr) |
| WO (1) | WO2002096871A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006134591A2 (fr) * | 2005-06-13 | 2006-12-21 | Yeda Research And Development Co. Ltd. | Utilisation d'allylmercaptocaptopril pour traiter ou prevenir l'obesite et des maladies associees a l'obesite |
| EP1984328A2 (fr) * | 2006-01-25 | 2008-10-29 | Yeda Research And Development Co., Ltd. | Procede de preparation d allylmercaptocaptopril (cpssa) et de disulfures asymetriques correspondants |
| US10383839B2 (en) | 2011-06-30 | 2019-08-20 | Johnson & Johnson Vision Care, Inc. | Esters for treatment of ocular inflammatory conditions |
| JP7442777B2 (ja) * | 2019-02-20 | 2024-03-05 | 池田食研株式会社 | 蛋白質加水分解物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4046889A (en) * | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
| US4347371A (en) * | 1978-12-30 | 1982-08-31 | Santen Pharmaceutical Co., Ltd. | Disulfide compounds |
| IL117934A0 (en) * | 1996-04-16 | 1996-08-04 | Yeda Res & Dev | Continuous production of allicin |
-
2002
- 2002-05-30 AU AU2002305744A patent/AU2002305744B2/en not_active Ceased
- 2002-05-30 WO PCT/US2002/016964 patent/WO2002096871A1/fr active Search and Examination
- 2002-05-30 CA CA2448896A patent/CA2448896C/fr not_active Expired - Fee Related
- 2002-05-30 US US10/478,396 patent/US7241902B2/en not_active Expired - Fee Related
- 2002-05-30 AT AT02734587T patent/ATE398106T1/de not_active IP Right Cessation
- 2002-05-30 EP EP02734587A patent/EP1414794B1/fr not_active Expired - Lifetime
- 2002-05-30 DE DE60227078T patent/DE60227078D1/de not_active Expired - Lifetime
- 2002-05-30 IL IL15912202A patent/IL159122A0/xx unknown
-
2003
- 2003-11-27 IL IL159122A patent/IL159122A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002096871A1 (fr) | 2002-12-05 |
| EP1414794A1 (fr) | 2004-05-06 |
| IL159122A (en) | 2010-12-30 |
| US7241902B2 (en) | 2007-07-10 |
| WO2002096871A8 (fr) | 2004-03-25 |
| AU2002305744B2 (en) | 2008-09-11 |
| EP1414794B1 (fr) | 2008-06-11 |
| CA2448896A1 (fr) | 2002-12-05 |
| CA2448896C (fr) | 2010-12-21 |
| US20040210065A1 (en) | 2004-10-21 |
| EP1414794A4 (fr) | 2005-04-06 |
| ATE398106T1 (de) | 2008-07-15 |
| DE60227078D1 (de) | 2008-07-24 |
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