IL156272A - Method of determining the level of ercc1 gene expression and use of chemotherapeutic regimen selected by a method in the preparation of a medicament - Google Patents
Method of determining the level of ercc1 gene expression and use of chemotherapeutic regimen selected by a method in the preparation of a medicamentInfo
- Publication number
- IL156272A IL156272A IL156272A IL15627203A IL156272A IL 156272 A IL156272 A IL 156272A IL 156272 A IL156272 A IL 156272A IL 15627203 A IL15627203 A IL 15627203A IL 156272 A IL156272 A IL 156272A
- Authority
- IL
- Israel
- Prior art keywords
- ercc1
- medicament
- level
- preparation
- determining
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and determine a platinum-based chemotherapy by examination of the amount of ERCC1 mRNA in a patient's tumor cells and comparing it to a predetermined threshold expression level. More specifically, the invention provides to oligonucleotide primer pair ERCC1 and methods comprising their use for detecting levels of ERCC1 mRNA.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25012100P | 2000-12-01 | 2000-12-01 | |
US25047000P | 2000-12-04 | 2000-12-04 | |
US09/796,491 US6518416B1 (en) | 2000-12-01 | 2001-03-02 | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
US09/877,095 US6573052B2 (en) | 2000-12-01 | 2001-06-11 | Method of determining a chemotherapeutic regimen based on ERCCI expression |
US09/988,784 US6602670B2 (en) | 2000-12-01 | 2001-11-20 | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
PCT/US2001/044519 WO2002061128A2 (en) | 2000-12-01 | 2001-11-29 | Method of determining a chemotherapeutic regimen based on ercc1 expression |
Publications (1)
Publication Number | Publication Date |
---|---|
IL156272A true IL156272A (en) | 2013-12-31 |
Family
ID=45773848
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL156272A IL156272A (en) | 2000-12-01 | 2003-06-02 | Method of determining the level of ercc1 gene expression and use of chemotherapeutic regimen selected by a method in the preparation of a medicament |
IL215130A IL215130A0 (en) | 2000-12-01 | 2011-09-13 | Method of determining a chemotherapeutic regimen based on ercci expression |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL215130A IL215130A0 (en) | 2000-12-01 | 2011-09-13 | Method of determining a chemotherapeutic regimen based on ercci expression |
Country Status (14)
Country | Link |
---|---|
US (2) | US6602670B2 (en) |
EP (1) | EP1364054B1 (en) |
JP (1) | JP4503922B2 (en) |
KR (1) | KR100966271B1 (en) |
CN (1) | CN1636069B (en) |
AR (1) | AR031455A1 (en) |
AU (1) | AU2002249768B2 (en) |
CA (1) | CA2437044C (en) |
ES (1) | ES2439873T3 (en) |
HK (1) | HK1078328A1 (en) |
IL (2) | IL156272A (en) |
MX (1) | MXPA03004930A (en) |
NZ (1) | NZ526710A (en) |
WO (1) | WO2002061128A2 (en) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003534292A (en) * | 2000-05-19 | 2003-11-18 | ジェネンテック・インコーポレーテッド | ERBB antagonist gene detection assays to increase the likelihood of effective response to cancer treatment |
US6602670B2 (en) * | 2000-12-01 | 2003-08-05 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
US7049059B2 (en) * | 2000-12-01 | 2006-05-23 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression |
WO2003078662A1 (en) * | 2002-03-13 | 2003-09-25 | Genomic Health | Gene expression profiling in biopsied tumor tissues |
WO2004011625A2 (en) * | 2002-07-31 | 2004-02-05 | University Of Southern California | Polymorphisms for predicting disease and treatment outcome |
EP1572105B1 (en) | 2002-11-14 | 2011-08-31 | John Wayne Cancer Institute | Detection of micro metastasis of melanoma and breast cancer in paraffin-embedded tumor draining lymph nodes by multimaker quantitative rt-pcr |
US8039218B2 (en) * | 2002-11-14 | 2011-10-18 | John Wayne Cancer Institute | Detection of cancer cells in body fluids |
AU2003295598B2 (en) * | 2002-11-15 | 2009-12-24 | Genomic Health, Inc. | Gene expression profiling of EGFR positive cancer |
US8580498B2 (en) * | 2002-11-15 | 2013-11-12 | University Of South Florida | Predictive value of nuclear excision repair genes for cancer survival |
US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
WO2004071572A2 (en) * | 2003-02-06 | 2004-08-26 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
ATE412779T1 (en) * | 2003-02-20 | 2008-11-15 | Genomic Health Inc | USE OF INTRONIC RNA SEQUENCES TO QUANTIFY GENE EXPRESSION |
CA2527285A1 (en) * | 2003-05-28 | 2004-12-23 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
JP2007506442A (en) * | 2003-05-30 | 2007-03-22 | ゲノミック ヘルス, インコーポレイテッド | Gene expression markers for response to EGFR inhibitors |
ES2787475T3 (en) | 2003-06-24 | 2020-10-16 | Genomic Health Inc | Prediction of probability of cancer recurrence |
ES2905579T3 (en) * | 2003-07-10 | 2022-04-11 | Genomic Health Inc | Expression profiling algorithm and test for prognosis of breast cancer relapse |
US20050196782A1 (en) * | 2003-12-23 | 2005-09-08 | Kiefer Michael C. | Universal amplification of fragmented RNA |
EP2947160B1 (en) | 2004-04-09 | 2017-07-12 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
US20060115827A1 (en) * | 2004-07-01 | 2006-06-01 | University Of Southern California | Genetic markers for predicting disease and treatment outcome |
ATE550440T1 (en) | 2004-11-05 | 2012-04-15 | Genomic Health Inc | MOLECULAR INDICATORS FOR BREAST CANCER PROGNOSIS AND PREDICTION OF TREATMENT RESPONSE |
AU2005304824B2 (en) * | 2004-11-05 | 2011-12-22 | Genomic Health, Inc. | Predicting response to chemotherapy using gene expression markers |
KR20130089280A (en) | 2005-01-21 | 2013-08-09 | 제넨테크, 인크. | Fixed dosing of her antibodies |
CA2595395A1 (en) * | 2005-02-09 | 2006-08-17 | Genentech, Inc. | Inhibiting her2 shedding with matrix metalloprotease antagonists |
MY152164A (en) | 2005-02-23 | 2014-08-15 | Genentech Inc | Extending time to disease progression or survival in cancer patients |
WO2006096861A2 (en) * | 2005-03-08 | 2006-09-14 | Genentech, Inc. | METHODS FOR IDENTIFYING TUMORS RESPONSIVE TO TREATMENT WITH HER DIMERIZATION INHIBITORS (HDIs) |
CN101218353A (en) * | 2005-05-04 | 2008-07-09 | 南佛罗里达大学 | Predicting treatment response in cancer subjects |
JP2006316040A (en) | 2005-05-13 | 2006-11-24 | Genentech Inc | Herceptin(r) adjuvant treatment |
EP1835285A1 (en) | 2006-03-14 | 2007-09-19 | Institut Gustave Roussy | ERCC1 expression in predicting response for cancer chemotherapy |
US9702875B2 (en) | 2006-03-14 | 2017-07-11 | Institute Gustave-Roussy | Expression of isoform 202 of ERCC1 for predicting response to cancer chemotherapy |
BRPI0808418A2 (en) | 2007-03-02 | 2014-07-22 | Genentech Inc | PREDICTION OF RESPONSE TO A HER INHIBITOR |
DK2171090T3 (en) * | 2007-06-08 | 2013-06-10 | Genentech Inc | Gene expression markers for tumor resistance to HER2 inhibitor therapy |
US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
KR20100044780A (en) * | 2007-06-15 | 2010-04-30 | 유니버시티 오브 사우스 플로리다 | Methods of diagnosing and treating cancer |
US20100273711A1 (en) * | 2007-09-28 | 2010-10-28 | Anil Potti | Individualized cancer treatments |
CN101140241B (en) * | 2007-09-30 | 2010-11-03 | 浙江省肿瘤医院 | Platinum kind anti-cancer drugs susceptibility related gene inspect reagent kit and applications thereof |
BRPI0812682A2 (en) | 2008-06-16 | 2010-06-22 | Genentech Inc | metastatic breast cancer treatment |
US8632984B2 (en) * | 2009-02-16 | 2014-01-21 | Atlas Antibodies Ab | RBM3 as a marker for malignant melanoma prognosis |
CN102356092B (en) | 2009-03-20 | 2014-11-05 | 霍夫曼-拉罗奇有限公司 | Bispecific anti-HER antibodies |
EP2435071A1 (en) | 2009-05-29 | 2012-04-04 | F. Hoffmann-La Roche AG | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
RU2587619C2 (en) | 2010-02-18 | 2016-06-20 | Дженентек, Инк. | Neuregulin antagonists and use thereof in treating malignant growth |
WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
JP5769952B2 (en) * | 2010-11-12 | 2015-08-26 | 株式会社Lsiメディエンス | Highly sensitive detection method for EML4-ALK fusion gene |
WO2012069466A1 (en) | 2010-11-24 | 2012-05-31 | Novartis Ag | Multispecific molecules |
WO2012076582A1 (en) * | 2010-12-09 | 2012-06-14 | F. Hoffmann-La Roche Ag | Agtr1 as a marker for bevacizumab combination therapies |
SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
US9626650B2 (en) | 2011-04-14 | 2017-04-18 | Elwha Llc | Cost-effective resource apportionment technologies suitable for facilitating therapies |
US10445846B2 (en) | 2011-04-14 | 2019-10-15 | Elwha Llc | Cost-effective resource apportionment technologies suitable for facilitating therapies |
US8514067B2 (en) | 2011-08-16 | 2013-08-20 | Elwha Llc | Systematic distillation of status data relating to regimen compliance |
EP2744824A1 (en) | 2011-08-17 | 2014-06-25 | F.Hoffmann-La Roche Ag | Neuregulin antibodies and uses thereof |
WO2013063229A1 (en) | 2011-10-25 | 2013-05-02 | The Regents Of The University Of Michigan | Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells |
SG11201402510TA (en) | 2011-11-30 | 2014-06-27 | Genentech Inc | Erbb3 mutations in cancer |
US9376715B2 (en) | 2011-12-09 | 2016-06-28 | Roche Molecular Systems, Inc | Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene |
US10528913B2 (en) | 2011-12-30 | 2020-01-07 | Elwha Llc | Evidence-based healthcare information management protocols |
US10475142B2 (en) | 2011-12-30 | 2019-11-12 | Elwha Llc | Evidence-based healthcare information management protocols |
US10340034B2 (en) | 2011-12-30 | 2019-07-02 | Elwha Llc | Evidence-based healthcare information management protocols |
US10552581B2 (en) | 2011-12-30 | 2020-02-04 | Elwha Llc | Evidence-based healthcare information management protocols |
US10559380B2 (en) | 2011-12-30 | 2020-02-11 | Elwha Llc | Evidence-based healthcare information management protocols |
US20130173294A1 (en) | 2011-12-30 | 2013-07-04 | Elwha LLC, a limited liability company of the State of Delaware | Evidence-based healthcare information management protocols |
US10679309B2 (en) | 2011-12-30 | 2020-06-09 | Elwha Llc | Evidence-based healthcare information management protocols |
EP2831115A1 (en) | 2012-03-27 | 2015-02-04 | F. Hoffmann-La Roche AG | Diagnosis and treatments relating to her3 inhibitors |
CN102676661B (en) * | 2012-04-27 | 2014-12-31 | 中国人民解放军第四军医大学 | Fluorescent polarization based homogeneous phase detection method of single nucleotide polymorphism of codon118 of ERCC1 (excision repair cross-complementing 1) gene |
CA2874035C (en) * | 2012-05-22 | 2021-11-09 | The Johns Hopkins University | A quantitative multiplex methylation specific pcr method- cmethdna, reagents, and its use |
JP6998646B2 (en) | 2012-11-30 | 2022-02-04 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Identification of patients in need of PD-L1 inhibitor combination therapy |
EP3014505A4 (en) * | 2013-06-28 | 2017-03-08 | Nantomics, LLC | Pathway analysis for identification of diagnostic tests |
GB201316024D0 (en) * | 2013-09-09 | 2013-10-23 | Almac Diagnostics Ltd | Molecular diagnostic test for lung cancer |
CN103451303B (en) * | 2013-09-12 | 2015-02-11 | 江苏康克生物技术有限公司 | Kit for detecting expression level of human ERCC1 (excision repair cross complementation 1) through PCR (polymerase chain reaction) method |
CN105219881B (en) * | 2015-11-17 | 2018-11-20 | 东南大学 | The kit of quantitative detection ERCC1-202 a kind of and application |
WO2017194554A1 (en) | 2016-05-10 | 2017-11-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Combinations therapies for the treatment of cancer |
US20190338363A1 (en) * | 2016-12-18 | 2019-11-07 | Selonterra, Inc. | Use of apoe4 motif-mediated genes for diagnosis and treatment of alzheimer's disease |
AU2018289369A1 (en) * | 2017-06-20 | 2020-01-16 | Nantomics, Llc | Use of cell-free circulating rna (cfRNA) expression of PD-L1 and ERCC1 in plasma to monitor response to therapy in NSCLC |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4830969A (en) | 1981-08-31 | 1989-05-16 | The Research Foundation Of State University Of New York | Process for the rapid and simple isolation of nucleic acids |
US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
US5128247A (en) | 1989-08-14 | 1992-07-07 | Board Of Regents, The University Of Texas System | Methods for isolation of nucleic acids from eukaryotic and prokaryotic sources |
US5284940A (en) | 1990-11-14 | 1994-02-08 | Hri Research, Inc. | Preparation for nucleic acid samples |
US5654179A (en) | 1990-11-14 | 1997-08-05 | Hri Research, Inc. | Nucleic acid preparation methods |
US5620852A (en) | 1990-11-14 | 1997-04-15 | Hri Research, Inc. | Nucleic acid preparation methods |
JP3171863B2 (en) * | 1991-01-16 | 2001-06-04 | 伊藤製油株式会社 | Amphoteric surfactant composition |
US5346994A (en) | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
US5502166A (en) | 1992-02-26 | 1996-03-26 | Mitsubishi Chemical Corporation | NMDH receptor proteins and genes encoding the same |
JP3615545B2 (en) | 1993-02-01 | 2005-02-02 | キアゲン・エヌ・ブイ | Quaternary ammonium salt surfactant and its RNA isolator |
US5637687A (en) | 1993-08-31 | 1997-06-10 | Wiggins; James C. | Methods and compositions for isolating nucleic acids |
WO1995028489A1 (en) | 1994-04-13 | 1995-10-26 | The Uab Research Foundation | Dihydropyrimidine dehydrogenase compositions and methods of use |
US5643767A (en) | 1994-05-02 | 1997-07-01 | The Rockefeller University | Process for isolating cellular components |
JP3125633B2 (en) * | 1994-07-06 | 2001-01-22 | 和光純薬工業株式会社 | Method and kit for processing paraffin-embedded tissue specimen as sample for gene analysis |
CA2153215A1 (en) | 1994-07-06 | 1996-01-07 | Lu Wang | Treatment of paraffin embedded tissue for gene analysis |
US5707802A (en) | 1995-01-13 | 1998-01-13 | Ciba Corning Diagnostics Corp. | Nucleic acid probes for the detection and identification of fungi |
US5777099A (en) | 1995-02-24 | 1998-07-07 | Biotecx Laboratories, Inc. | RNA separation |
US5705336A (en) * | 1995-03-07 | 1998-01-06 | The United States Of America As Represented By The Department Of Health And Human Services | Assay for sensitivity of tumors to DNA-platinating chemotherapy |
US5945515A (en) | 1995-07-31 | 1999-08-31 | Chomczynski; Piotr | Product and process for isolating DNA, RNA and proteins |
DE29601618U1 (en) | 1996-01-31 | 1996-07-04 | InViTek GmbH, 13125 Berlin | Multiple simultaneous isolation device |
EP0791654A1 (en) | 1996-02-21 | 1997-08-27 | Jürgen A. Dr. Richt | Polypeptides corresponding to the amino acid sequences of proteins p57 or p9.5 of Borna disease virus, nucleic acid fragments coding therefore and their use for diagnostic and immunization purposes |
CA2249364C (en) | 1996-03-20 | 2009-07-07 | Frank J. Gonzalez | Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations |
EP0912726A4 (en) | 1996-05-10 | 2001-07-18 | Phylomed Corp | Methods for oxidizing disulfide bonds using ozone |
AU6764398A (en) | 1997-03-20 | 1998-10-12 | Variagenics, Inc. | Target genes for allele-specific drugs |
US5994076A (en) | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
ES2313752T3 (en) | 1997-08-20 | 2009-03-01 | The University Of Miami | A METHOD OF FIXATION-DEHYDRATION-ELIMINATION OF FAT-IMPREGNATION OF CONTINUOUS PRODUCTION FABRICS, OF HIGH QUALITY. |
US5952202A (en) | 1998-03-26 | 1999-09-14 | The Perkin Elmer Corporation | Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification |
US6204375B1 (en) | 1998-07-31 | 2001-03-20 | Ambion, Inc. | Methods and reagents for preserving RNA in cell and tissue samples |
US6248535B1 (en) | 1999-12-20 | 2001-06-19 | University Of Southern California | Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens |
US6602670B2 (en) * | 2000-12-01 | 2003-08-05 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
US7049059B2 (en) * | 2000-12-01 | 2006-05-23 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression |
-
2001
- 2001-11-20 US US09/988,784 patent/US6602670B2/en not_active Expired - Fee Related
- 2001-11-29 CA CA2437044A patent/CA2437044C/en not_active Expired - Fee Related
- 2001-11-29 JP JP2002561063A patent/JP4503922B2/en not_active Expired - Fee Related
- 2001-11-29 WO PCT/US2001/044519 patent/WO2002061128A2/en active IP Right Grant
- 2001-11-29 NZ NZ526710A patent/NZ526710A/en not_active IP Right Cessation
- 2001-11-29 MX MXPA03004930A patent/MXPA03004930A/en active IP Right Grant
- 2001-11-29 EP EP01998006.9A patent/EP1364054B1/en not_active Expired - Lifetime
- 2001-11-29 KR KR1020037007375A patent/KR100966271B1/en not_active IP Right Cessation
- 2001-11-29 AU AU2002249768A patent/AU2002249768B2/en not_active Ceased
- 2001-11-29 ES ES01998006.9T patent/ES2439873T3/en not_active Expired - Lifetime
- 2001-11-29 CN CN018224423A patent/CN1636069B/en not_active Expired - Fee Related
- 2001-12-03 AR ARP010105610A patent/AR031455A1/en not_active Application Discontinuation
-
2003
- 2003-06-02 IL IL156272A patent/IL156272A/en not_active IP Right Cessation
- 2003-06-04 US US10/453,784 patent/US7132238B2/en not_active Expired - Lifetime
-
2005
- 2005-11-14 HK HK05110187.7A patent/HK1078328A1/en not_active IP Right Cessation
-
2011
- 2011-09-13 IL IL215130A patent/IL215130A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2002061128A2 (en) | 2002-08-08 |
ES2439873T3 (en) | 2014-01-27 |
WO2002061128A3 (en) | 2003-09-25 |
EP1364054B1 (en) | 2013-09-25 |
HK1078328A1 (en) | 2006-03-10 |
EP1364054A2 (en) | 2003-11-26 |
US20040005621A1 (en) | 2004-01-08 |
US7132238B2 (en) | 2006-11-07 |
IL215130A0 (en) | 2011-10-31 |
JP2004518429A (en) | 2004-06-24 |
AR031455A1 (en) | 2003-09-24 |
CN1636069B (en) | 2012-03-07 |
JP4503922B2 (en) | 2010-07-14 |
AU2002249768B2 (en) | 2007-01-04 |
KR20030074639A (en) | 2003-09-19 |
US6602670B2 (en) | 2003-08-05 |
CA2437044A1 (en) | 2002-08-08 |
KR100966271B1 (en) | 2010-06-28 |
CN1636069A (en) | 2005-07-06 |
CA2437044C (en) | 2013-03-12 |
US20020086315A1 (en) | 2002-07-04 |
NZ526710A (en) | 2005-09-30 |
MXPA03004930A (en) | 2005-06-06 |
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