IL151235A0 - Novel crystal forms of 9-substituted hypoxanthine derivatives - Google Patents
Novel crystal forms of 9-substituted hypoxanthine derivativesInfo
- Publication number
- IL151235A0 IL151235A0 IL15123501A IL15123501A IL151235A0 IL 151235 A0 IL151235 A0 IL 151235A0 IL 15123501 A IL15123501 A IL 15123501A IL 15123501 A IL15123501 A IL 15123501A IL 151235 A0 IL151235 A0 IL 151235A0
- Authority
- IL
- Israel
- Prior art keywords
- crystal forms
- novel crystal
- substituted hypoxanthine
- hypoxanthine derivatives
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2001/005462 WO2003011863A1 (fr) | 2001-02-21 | 2001-02-21 | Formes cristallines de derives d'hypoxanthine substitues en 9 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL151235A0 true IL151235A0 (en) | 2003-06-24 |
Family
ID=21742354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15123501A IL151235A0 (en) | 2001-02-21 | 2001-02-16 | Novel crystal forms of 9-substituted hypoxanthine derivatives |
Country Status (8)
Country | Link |
---|---|
US (1) | US6407237B1 (fr) |
EP (1) | EP1368350A1 (fr) |
JP (1) | JP2004521956A (fr) |
CN (1) | CN1232521C (fr) |
CA (1) | CA2417337A1 (fr) |
IL (1) | IL151235A0 (fr) |
MX (1) | MXPA02007997A (fr) |
WO (1) | WO2003011863A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8637449B2 (en) * | 2009-08-27 | 2014-01-28 | Merck Sharp & Dohme Corp. | Processes for preparing protease inhibitors of hepatitis C virus |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3300380A (en) | 1963-12-26 | 1967-01-24 | Upjohn Co | Diminishing toxicity of antiviral nu6-(hydroxyalkyl) adenines with 4-hydroxypyrazolo(3, 4-d) pyrimidine |
US3321369A (en) | 1965-05-26 | 1967-05-23 | Abbott Lab | Method of enhancing learning rate and retention level in warm blooded animals |
US3438968A (en) | 1966-06-23 | 1969-04-15 | Int Chem & Nuclear Corp | Substituted ammonium basic addition salts of ribonucleic acid |
BE759011A (fr) | 1969-11-17 | 1971-05-17 | Wellcome Found | Aminopurines |
DE2554453A1 (de) | 1974-12-18 | 1976-06-24 | Experimentales Et Cliniques De | Medikament zur glykaemieregulierung |
GB1530912A (en) | 1975-02-13 | 1978-11-01 | Wellcome Found | Compositions containing 9-(2-hydroxy-3-alkyl)-adenines |
US4138562A (en) | 1977-02-09 | 1979-02-06 | The Regents Of The University Of Minnesota | Adenosine deaminase resistant antiviral purine nucleosides and method of preparation |
US4221910A (en) | 1978-09-15 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | 9-(Hydroxy alkyl)purines |
US4221909A (en) | 1978-09-15 | 1980-09-09 | Sloan-Kettering Institute For Cancer Research | P-Acetamidobenzoic acid salts of 9-(hydroxyalkyl) purines |
US4221794A (en) | 1979-06-21 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | Method of imparting immunomodulating and antiviral activity |
US4340726A (en) | 1980-03-14 | 1982-07-20 | Newport Pharmaceuticals International, Inc. | Esters |
US4347360A (en) | 1980-09-16 | 1982-08-31 | Ens Bio Logicals Inc. | Ring open nucleoside analogues |
US4451478A (en) | 1982-03-12 | 1984-05-29 | Newport Pharmaceuticals International, Inc. | Imidazole compounds |
US4643992A (en) | 1982-11-09 | 1987-02-17 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
US5093318A (en) | 1983-11-01 | 1992-03-03 | Scripps Clinic And Research Foundation | Immunostimulating guanosine derivatives and their pharmaceutical compositions |
US4952693A (en) | 1984-10-12 | 1990-08-28 | Warner-Lambert Company | Oxazolo-pyrimidine derivatives |
US5495010A (en) | 1987-04-17 | 1996-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | Acid stable purine dideoxynucleosides |
EP0691348A1 (fr) | 1988-04-19 | 1996-01-10 | Institut Pasteur | Composition immunogéniques préparés à partir de l'adénylate-cyclose de B.parapertussis |
IT1227389B (it) | 1988-07-07 | 1991-04-08 | Mini Ricerca Scient Tecnolog | Dispersioni acquose di polimeri uretano-acrilici e loro impiego come vernici. |
US5256677A (en) | 1989-05-23 | 1993-10-26 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5187162A (en) | 1989-09-15 | 1993-02-16 | Gensia Pharmaceuticals | Methods of treating neurodegenerative conditions |
US5026687A (en) | 1990-01-03 | 1991-06-25 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds |
US5091432A (en) | 1990-03-28 | 1992-02-25 | Glasky Alvin J | 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use |
US5237051A (en) | 1990-12-06 | 1993-08-17 | Vanderbilt University | Purified enterotoxin receptor protein |
US5801184A (en) | 1994-07-25 | 1998-09-01 | Glasky; Alvin J. | Carbon monoxide dependent guanylyl cyclase modifiers and methods of use |
US5447939A (en) | 1994-07-25 | 1995-09-05 | Glasky; Alvin J. | Carbon monoxide dependent guanylyl cyclase modifiers and methods of use |
US5795756A (en) | 1995-12-11 | 1998-08-18 | Johnson; Roger A. | Method and compounds for the inhibition of adenylyl cyclase |
US5948771A (en) | 1996-01-31 | 1999-09-07 | The Trustees Of Columbia University In The City Of New York | Method for treating heart failure using tetrapyrroles and metallotetrapyrroles |
US5801159A (en) | 1996-02-23 | 1998-09-01 | Galileo Laboratories, Inc. | Method and composition for inhibiting cellular irreversible changes due to stress |
AU3879899A (en) | 1998-05-04 | 1999-11-23 | Neotherapeutics, Inc. | Novel dopamine-like 9-substituted hypoxanthine and methods of use |
AU3785799A (en) | 1998-05-04 | 1999-11-23 | Neotherapeutics, Inc. | Method for treating migraine in mammals |
US6303617B1 (en) | 1998-05-04 | 2001-10-16 | Neotherapeutics, Inc. | Serotonin-like 9-substituted hypoxanthine and methods of use |
-
2000
- 2000-02-16 US US09/505,984 patent/US6407237B1/en not_active Expired - Fee Related
-
2001
- 2001-02-16 IL IL15123501A patent/IL151235A0/xx unknown
- 2001-02-21 MX MXPA02007997A patent/MXPA02007997A/es active IP Right Grant
- 2001-02-21 JP JP2003517055A patent/JP2004521956A/ja not_active Withdrawn
- 2001-02-21 CA CA002417337A patent/CA2417337A1/fr not_active Abandoned
- 2001-02-21 WO PCT/US2001/005462 patent/WO2003011863A1/fr not_active Application Discontinuation
- 2001-02-21 CN CNB01808138XA patent/CN1232521C/zh not_active Expired - Fee Related
- 2001-02-21 EP EP01911020A patent/EP1368350A1/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN1232521C (zh) | 2005-12-21 |
WO2003011863A1 (fr) | 2003-02-13 |
EP1368350A1 (fr) | 2003-12-10 |
JP2004521956A (ja) | 2004-07-22 |
MXPA02007997A (es) | 2005-07-01 |
CA2417337A1 (fr) | 2003-02-13 |
CN1427841A (zh) | 2003-07-02 |
US6407237B1 (en) | 2002-06-18 |
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