IL147887A0 - Use of chemical chelators as reversal agents for drug-induced neuromuscular block - Google Patents

Use of chemical chelators as reversal agents for drug-induced neuromuscular block

Info

Publication number
IL147887A0
IL147887A0 IL14788700A IL14788700A IL147887A0 IL 147887 A0 IL147887 A0 IL 147887A0 IL 14788700 A IL14788700 A IL 14788700A IL 14788700 A IL14788700 A IL 14788700A IL 147887 A0 IL147887 A0 IL 147887A0
Authority
IL
Israel
Prior art keywords
drug
reversal agents
neuromuscular block
induced neuromuscular
chemical chelators
Prior art date
Application number
IL14788700A
Other languages
English (en)
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of IL147887A0 publication Critical patent/IL147887A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL14788700A 1999-08-13 2000-08-07 Use of chemical chelators as reversal agents for drug-induced neuromuscular block IL147887A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99306411 1999-08-13
PCT/EP2000/007694 WO2001012202A2 (en) 1999-08-13 2000-08-07 Use of chemical chelators as reversal agents for drug-induced neuromuscular block

Publications (1)

Publication Number Publication Date
IL147887A0 true IL147887A0 (en) 2002-08-14

Family

ID=8241574

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14788700A IL147887A0 (en) 1999-08-13 2000-08-07 Use of chemical chelators as reversal agents for drug-induced neuromuscular block

Country Status (11)

Country Link
US (3) US7265099B1 (es)
EP (1) EP1210090B1 (es)
JP (1) JP4782334B2 (es)
CN (1) CN1241576C (es)
AR (1) AR025103A1 (es)
AU (1) AU780416B2 (es)
BR (1) BR0013126A (es)
CA (1) CA2380920C (es)
IL (1) IL147887A0 (es)
MX (1) MXPA02001545A (es)
WO (1) WO2001012202A2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
AU2002238939A1 (en) * 2002-03-18 2003-09-29 Nihon University Cyclic etheramine derivatives as medicaments for malignant tumors
US8461338B2 (en) * 2007-03-08 2013-06-11 Chemagis Ltd. (1R, 1′R)-atracurium salts separation process
AU2008231470A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
WO2009007946A1 (en) * 2007-07-09 2009-01-15 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
CA2685491A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
US8357807B2 (en) * 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
US8357805B2 (en) * 2007-06-18 2013-01-22 Chemagis Ltd. (1R,1′R)-atracurium salts separation process
WO2009057086A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
US20110185796A1 (en) * 2008-05-01 2011-08-04 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8466278B2 (en) 2008-09-22 2013-06-18 Arcarios B.V. Carboxyethylated cyclodextrin polysulfates useful as medicaments
US11013750B2 (en) 2017-01-20 2021-05-25 Aurin Biotech Inc. Methods for treating and preventing nociceptive pain
WO2020028448A1 (en) 2018-08-02 2020-02-06 Pliva Hrvatska D.O.O. Solid state forms of sugammadex sodium
US11324692B2 (en) 2019-07-03 2022-05-10 Galenicum Health S.L.U. Method to prepare pharmaceutical compositions of suggamadex
US11097023B1 (en) 2020-07-02 2021-08-24 Par Pharmaceutical, Inc. Pre-filled syringe containing sugammadex
EP3932391A1 (en) 2020-07-03 2022-01-05 Galenicum Health S.L.U. Method to prepare pharmaceutical compositions
CN113387798B (zh) * 2021-05-08 2022-10-11 上海大学 用作逆转神经肌肉阻滞剂的水溶性柱[n]芳烃及其应用
CN113509486B (zh) * 2021-06-16 2022-07-19 南开沧州渤海新区绿色化工研究有限公司 Cca-cd共组装体在制备大分子毒素解毒药物中的应用
CN115057797B (zh) * 2022-02-24 2023-06-23 上海大学 一种水溶性联苯芳烃的合成及生物毒素解毒的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929813A (en) 1973-12-26 1975-12-30 Interx Research Corp Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and process for preparing same
EP0447171B1 (en) 1990-03-15 1994-11-02 Tanabe Seiyaku Co., Ltd. Polysulfate of cyclodextrin derivative and process for preparing the same
US5180716A (en) 1990-08-01 1993-01-19 The Regents Of The University Of California Cyclodextrin complexes for neuraxial administration of drugs
US5840881A (en) 1992-11-27 1998-11-24 Takeda Chemical Industries, Ltd. Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility
US5767112A (en) 1994-10-21 1998-06-16 Poli Industria Chimica, S.P.A. Muscle relaxant pharmaceutical compositions
AU708107B2 (en) * 1994-11-04 1999-07-29 Commonwealth Scientific And Industrial Research Organisation Method for treating animals
US5834446A (en) 1996-06-21 1998-11-10 Queen's University At Kingston Nerve process growth modulators
JP4249282B2 (ja) 1998-02-27 2009-04-02 日本食品化工株式会社 新規シクロデキストリン誘導体及びその製造方法

Also Published As

Publication number Publication date
MXPA02001545A (es) 2002-08-30
CN1241576C (zh) 2006-02-15
EP1210090A2 (en) 2002-06-05
JP2003507335A (ja) 2003-02-25
CA2380920A1 (en) 2001-02-22
AU780416B2 (en) 2005-03-17
WO2001012202A2 (en) 2001-02-22
US20070299035A1 (en) 2007-12-27
AR025103A1 (es) 2002-11-06
WO2001012202A3 (en) 2001-11-15
JP4782334B2 (ja) 2011-09-28
AU7508900A (en) 2001-03-13
EP1210090B1 (en) 2014-06-18
BR0013126A (pt) 2002-04-23
CN1370073A (zh) 2002-09-18
US20100075938A1 (en) 2010-03-25
CA2380920C (en) 2011-07-19
US7265099B1 (en) 2007-09-04

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