IL136343A0 - Combined chemo-immunotherapy with liposomal drugs and cytokines - Google Patents

Combined chemo-immunotherapy with liposomal drugs and cytokines

Info

Publication number
IL136343A0
IL136343A0 IL13634398A IL13634398A IL136343A0 IL 136343 A0 IL136343 A0 IL 136343A0 IL 13634398 A IL13634398 A IL 13634398A IL 13634398 A IL13634398 A IL 13634398A IL 136343 A0 IL136343 A0 IL 136343A0
Authority
IL
Israel
Prior art keywords
encapsulated
immunotherapy
cytokines
liposomes
administration
Prior art date
Application number
IL13634398A
Original Assignee
Yissum Res Dev Co
Hadasit Med Res Service
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co, Hadasit Med Res Service filed Critical Yissum Res Dev Co
Publication of IL136343A0 publication Critical patent/IL136343A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method of antitumor therapy is described in which administration of a chemotherapeutic drug, encapsulated in liposomes, is supplemented by administration of an immunostimulating cytokine. The cytokine is preferably also encapsulated in liposomes. In tumor models for lung and colon carcinomas, this method produced a significantly greater therapeutic effect, as evidenced by survival rate and tumor size, than a combination of the effects produced by the free or liposome-encapsulated components administered individually.
IL13634398A 1997-12-04 1998-12-01 Combined chemo-immunotherapy with liposomal drugs and cytokines IL136343A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6769797P 1997-12-04 1997-12-04
PCT/IL1998/000586 WO1999027908A1 (en) 1997-12-04 1998-12-01 Combined chemo-immunotherapy with liposomal drugs and cytokines

Publications (1)

Publication Number Publication Date
IL136343A0 true IL136343A0 (en) 2001-05-20

Family

ID=22077764

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13634398A IL136343A0 (en) 1997-12-04 1998-12-01 Combined chemo-immunotherapy with liposomal drugs and cytokines

Country Status (8)

Country Link
EP (1) EP1033971B1 (en)
JP (1) JP2001524512A (en)
AT (1) ATE442128T1 (en)
AU (1) AU756109B2 (en)
CA (1) CA2312778A1 (en)
DE (1) DE69841142D1 (en)
IL (1) IL136343A0 (en)
WO (1) WO1999027908A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002078672A2 (en) * 2001-03-30 2002-10-10 Alza Corporation Liposomal tumor necrosis factor compositions and methods
US8034791B2 (en) 2001-04-06 2011-10-11 The University Of Chicago Activation of Egr-1 promoter by DNA damaging chemotherapeutics
DE10157994A1 (en) * 2001-05-25 2003-01-02 G O T Therapeutics Gmbh Liposomally encapsulated hydrophobic active ingredients with a high active ingredient content> 50% and methods for producing pharmaceutical preparations which comprise liposomally encapsulated hydrophobic active ingredients
JP4555569B2 (en) * 2001-11-13 2010-10-06 セレーター ファーマシューティカルズ， インコーポレイテッド Lipid carrier composition having enhanced blood stability
AU2002360762A1 (en) * 2001-12-19 2003-07-09 Alza Corporation Liposomal tumor necrosis factor compositions
KR20060015534A (en) 2003-04-25 2006-02-17 더 펜 스테이트 리서치 파운데이션 Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
WO2017153993A1 (en) * 2016-03-09 2017-09-14 Technion Research And Development Foundation Ltd. Liposomal formulations and methods of using same in agriculture

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000968A1 (en) * 1983-09-06 1985-03-14 Health Research, Inc. Liposome delivery method for decreasing the toxicity of an antitumor drug
JPS6348225A (en) * 1986-08-19 1988-02-29 Green Cross Corp:The Carcinostatic agent
EP0429585A4 (en) * 1989-04-28 1992-03-25 Syracuse University Cytochalasin compositions and therapeutic methods
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
IT1238231B (en) * 1989-12-18 1993-07-12 Consiglio Nazionale Ricerche USE OF IMMUNOMODULANTS AS SYNERGIC AGENTS OF CHEMOTHERAPY IN CANCER THERAPY
EP0546951A1 (en) * 1991-12-13 1993-06-16 The Liposome Company, Inc. Combination of liposome encapsulated antineoplastic agents, such as doxorubicin with colony stimulating factors
DE4447770C2 (en) * 1994-08-20 2002-12-19 Max Delbrueck Centrum Process for the production of liposomally encapsulated taxol

Also Published As

Publication number Publication date
EP1033971A1 (en) 2000-09-13
DE69841142D1 (en) 2009-10-22
AU1445199A (en) 1999-06-16
ATE442128T1 (en) 2009-09-15
CA2312778A1 (en) 1999-06-10
EP1033971B1 (en) 2009-09-09
WO1999027908A1 (en) 1999-06-10
JP2001524512A (en) 2001-12-04
AU756109B2 (en) 2003-01-02

Similar Documents

Publication Publication Date Title
AU4801497A (en) Dosage form and method for administering drug
GR1000074B (en) Lipoid vesicula for endoperitoneal supplying of therapeutical elements
HK1031197A1 (en) Osmotic dosage form comprising first and second coats
AU2941489A (en) Reduction of side effects of cancer therapy
EP1669067A3 (en) Flavonoids for cystic fibrosis therapy
CA2301057A1 (en) A method of administering liposomal encapsulated taxane
HRP960300B1 (en) Inhaler for administration of blister-packed medicaments
HK1028943A1 (en) Methods of preparing gas-filled liposomes
PL340994A1 (en) Method of administering therapeutic substances by inhalation and inhaler therefor
NO942116L (en)
HUP0102892A2 (en) Drug delivery system comprising a tightly compacted solid medicament stock, process for its preparation and for its use
IL136343A0 (en) Combined chemo-immunotherapy with liposomal drugs and cytokines
NZ335938A (en) Prodrug forms and new analogues of camptothecin, their use as medicaments
AU9190401A (en) Liposomes encapsulating anticancer drugs and the use thereof in the treatment ofmalignant tumors
AU2162202A (en) Antitumor therapy comprising distamycin derivatives
CA2081043A1 (en) Antitumor vaccines comprising il-6 transfected cells
AU2001259596A1 (en) Method and apparatus for the administration of continuous positive airway pressure therapy
AU2003296385A1 (en) Therapeutic single dose gas administration system
AU1926988A (en) Opioid analgesic liposomal delivery-release system
GR3025713T3 (en) Granulocyte colony-stimulating factor solution delivery method.
UA42534A (en) Method for treating pneumocystosis in patients with chronic non-specific diseases of lungs
WO1993013779A3 (en) Use of udpg as cancer therapy rescue agent
MD1780F1 (en) Method of treatment of patients with hepatic cirrhosis
UA49523A (en) Method for chemotherapy of cervical cancer
UA32029A (en) Medicinal film for therapy of diseases of pariodontium and oral mucosa

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed