IL135938A - Process for preparing a racemic mixture of n-acetonylbenzamides or nicotinamides - Google Patents
Process for preparing a racemic mixture of n-acetonylbenzamides or nicotinamidesInfo
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- IL135938A IL135938A IL13593897A IL13593897A IL135938A IL 135938 A IL135938 A IL 135938A IL 13593897 A IL13593897 A IL 13593897A IL 13593897 A IL13593897 A IL 13593897A IL 135938 A IL135938 A IL 135938A
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- alkenyl
- alkynyl
- halo
- independently selected
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Abstract
A process for preparing a racemic mixture of the (R) and (S) enantiomers of the compound of the formula wherein: (1) A is selected from N and C-R5; (2) R1 is independently selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, and halo (C1-C6) alkyl; and R2 is selected from (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl and halo (C1-C6) alkyl; and 1443 כ" ג בסיון התשס" א - June 14, 2001 R2 is stereochemically larger than R1; (3) R3, R4, and R5 are independently selected from H, halo, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, halo (C1-C6) alkoxy, cyano, nitro, -CR6=NOR7,- NR8R9, -CONR10R11, and -NH-CO-OR12 wherein R6 is selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, and (C2-C6) alkynyl, R7 is selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, and (C1-C6) alkylcarbonyl, R8 and R9 are independently selected from H, (C1-C6) alkyl, and (C1-C6) alkylcarbonyl, R10 and R11 are independently selected from H and (C1-C6) alkyl; and R12 is selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, and (C2-C6) alkynyl; and (4) X, Y, and Z are independently selected from H, halo, cyano, thiocyano, isothiocyano, and (C1-C4) alkylsulfonyloxy; provided that X, Y, and Z are not all H; comprising the steps of: (a) reacting a protonated amino acid ester of the formula: R1 is indpendently selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, and halo (C1-C6) alkyl; and R2 is selected from (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl and halo (C1-C6) alkyl; and R2 is stereochemically larger than R1; with an acyl chloride of the formula: wherein A is selected from N and C-R5 and R3, R4, and R5 are independently selected from H, halo, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, halo (C1-C6) alkoxy, cyano, nitro, -CR=NOR7, -NR8R9, -CONR10R11, and -NH-CO-OR12 wherein R6 is selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, and (C2-C6) alkynyl, R7 is selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, and (C1-C6) alkylcarbonyl, R8 and R9 are independently selected from H, (C1-C6) alkyl, and (C1-C6) alkylcarbonyl, R10 and R11 are independently selected from H and (C1-C6) alkyl; anr R12 is selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, and (C2-C6) alkynyl; to produce a benzamide or nicotinamide-ester of the formula 1444 כ" ג בסיון התשס" א - June 14, 2001 (b) hydrolyzing the ester moiety of the benzamide or nicotinamide-ester to produce a benzamide-acid of the formula: (c) cyclizing the benzamide or nicotinamide-acid to produce an oxazolinone of the formula: and (d) forming the racemic mxiture of the (R) and (S) enantiomers of the compound of formula I by ring opening the oxazolinone. 1445 כ" ג בסיון התשס" א - June 14, 2001
Description
135938/2
G»T»ttWi»5)p»3 W 0>Tttmja»3WSN -N ¾> t)>M J-M*)J>n JU-»fli> 1>^1Λ
A process for preparing a racemic mixture of N-acetonylbenzamides or nicotinamides
Rohm And Haas Company
C.124061
The present invention relates to a process for preparing a racemic mixture of two N-acetonylbenzamide or nicotinamide enantiomers. Such N-acetonylbenzamides, or nicotinamide which contain an asymetric carbon atom, are used as fungicides. However, the fungicidal activity arises from only one of the enantiomers. A fungicidal composition containing predominantly one of the enantiomers and a process for its production are described and claimed in Israel Patent Application No. 120970 from which the present application was divided,
N-acetonylbenzamide fungicides are known, see, e. g., U. S. Patent Nos. 5,254,584 and 5,304,572. One advantage of these known fungicides is that they have high fungicidal activity. Such compounds are particularly advantageous because their high activity allows them to be used at low application rates. However, there is always a need for fungicidal compounds of even higher activity. This results in lower use rates and, therefore, less environmental contamination.
In the parent application it is described that with certain N-acetonylbenzamide or nicotinamide fungicides
which contain an assymetric carbon atom, the fungicidal activity results primarily from one enantiomer. Thus,.fungicidal compositions containing only the active enantiomer provide higher fungicidal activity than compositions containing both enantiomers, when used at the same use rate.
This invention provides a process for preparing a racemic mixture of the (R) and (S) enantiomers of the compound of formula I,
wherein: j
1. A is selected from N and C-R^;
2. R1 is independently selected from H,
(Cl-C6)alkyL (C2-C6)alkenyl, (C2-C6)alkynyl, and halo(Ci- C6)alkyi ,·;
R2 is selected from (CrC6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl and
halo(C!-C6)alkyl; and
R is stereochemicaliy larger than R ;
. , , , a o, i- C6)alkyl, (C2-C6)alkenyL (C2-C6)alkynyl, halo(Ci-C6)a!kyl,
(Ci-C6)alkoxy, halo(Ci-C6)alkosy, cyano, nitro, -CR6=NOR7, - N 8 9 -CON IORH. and -NH-CO-OR12 wherein R6 is
selected from H, (Ci-C6)alkyl, (C2-C6)alkenyi, and (C2- C6)alkynyl, R7 is selected from H, (Ci-C6)alkyl, (C2- C6)alkenyL (C2-C6)aII∑ynyl, and (Ci-C6)alkylcarbonyl, R8 and
R9 are independently selected from H, (Ci-C6)aLkyl, and (Ci- C6)aIkylcarbonyL RlOand EH are independently selected from
H and (Cl-C6)aE∑yl; and R*2 is selected from H, (Ci-C6)alkyl,
(C2-C6)alkimyL and (C2^6 aU∑ynyl; and
4. X, Y, and Z are independently selected from H, halo, cyano,
thiocyano, isothiocyano, and (Ci J4)alkylsnlfonyloxy; provided
that X, Y, and Z are not all H;
comprising the steps of :
a. reacting a protonated amino acid ester of the formula:
1 is independen ly selected from H ,
(Cl-C6)aB∑yL (C2-C6)al]senyl, (C2-C6)al3∑ynyL and halo(Ci- C6)all--yi ;. and
R2 is selected from '(C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl and halo(C1-C6)alkyl; and
2
R is stereochemically larger than R t ;
with an acyl chloride of the formula:
wherein A is selected from N and C-R^ and R^, R*, and R^ are >
independently selected from H, halo, (Ci-C6)alkyL (C2-C6)alkeiiyl>
(C2-C6)alkynyL halo(Ci-C6)alkyl, (Ci-C^alkoxy, halo(Ci-C6)a!ko∑y, cyano, nitro, -CR6=NOR7, -NR8R9, -CONRIOR11. and -NH-CO-OR1-2 wherein R6 is selected from H, (Ci-C6)alkyl, (C2-C6)alkenyl, and (C2- C6)a¾ynyl, R7 is selected from H, (Ci-C6)alkyl, (C2-C6)alkenyl, (C2- C6)alkynyl, and (Ci-C6)a3_kylcarbonyl, R8 and R^ are independently selected from H, (Ci-C6)alkyl, and (Ci-C6)al3sylcarbonyl, R10and R11 are independently selected from H and (Cl-C6)alkyl; and R*2 is
- - -
to produce a benzamide or nicotinamide-ester of the formula
hydrolyzing the ester moiety of the benzamide or nicotinamide-ester to prod benzamide-acid of the formula:
c. cyclizing the benzamide-acid to produce an oxazolinone of the formula:
d. forming the racemic mixture of the (R) and (S) enantiomers of the compound of- formula I by ring opening the oxazolinone ,
The term "halo" means chloro, fluoro, bromo, or iodo. The terms "alky!" and "alkenyl" include straight-chain, branched-chain, and cycloalkyl and alkenyl groups. The term "alkynyl" includes straight-chain and branched-chain alkynyl groups. The term "alkos " includes as the alkyl portion straight-chain,
branched-chain, and cyclic alkyl and alkenyl groups. The term "halo" preceeding any one of alkyl, alkenyl, alkynyl, or alkoxy means that one or more of the hydrogens of the group is substituted with a halogen.
The term "stereochemically larger" means the group in question is more space-filling than the group to which it is being compared. When the R* and R2 groups in formula I contain only carbon and hydrogen atoms, since R2 is the stereochemically larger group, the stereochemistry about the atom to which the R1 and R2 groups are attached will take on an "S" configuration. Throughout th application, the term "S enantiomer" means that the four groups on the carbon to which R1 and R2 are attached, when ranked according to the set of sequence rules of the Cahn-Ingold-Prelog system (Angew. Chem. Int. Ed. Engl. 5, 385-415(1966)), de ine the carbon as having an S configuration.
Because of. their high fungicidal activity preferred compounds are those of formula I wherein: ^ is selected from halo, cyano, nitro, and -CH=NOCH3; ^ is selected from H, halo, cyano, (Ci-C6)alkyl, -NH-CO-OR12,and -NE^R11; 5 is selected from halo, cyano, and (Ci-C6)alkyl; R* and R2 are independently selected from (Ci-C6)alkyl; X and Y are H; and Z is chloro.
Because of their outstanding fungicidal activity and selectivity the most preferred compounds of formula I are those wherein: Bp is selected from chloro, bromo, CN, and -CH=NOCH3; R4 is selected from H, -N¾, CN, and -CH3; R5 is selected from chloro, bromo, CN, and -CH3; R* is methyl; R2 is ethyl; X and T are H; and Z is chloro.
The protonated amino acid ester may be prepared using standard esterification procedures such as treatment of the corresponding amino acid with an alcohol under acidic conditions. We have found that methanol is the preferred alcohol because of the ease of removal of a methyl group during the hydrolyzing step.
In a similar manner, the hydrolyzing step is conducted using standard conditions. Base catalyzed hydrolysis using sodium hydroxide as the base is preferred. The only limitations to the reaction conditions used in the
hydrolyzing step are that the conditions must be sufficiently selective so that the ester bond is hydrolyzed but the amide bond is not. Strong base catalysts must be avoided when R1 or R2 is hydrogen to eliminate side reactions resulting from abstraction of the hydrogens.
The osazolinone is produced in the cyclization step by dehydration of the benzamide-acid. Such dehydrations may be conducted using a variety of dehydrating agents such as acetic anhydride at elevated temperatures (90°-10G° C), phosphorous oxychloride, phosphorous pentachloride, and ethyl
cHoroformate triethylamine. Mild dehydrating agents such as acetic anhydride are preferred because they are easily removed and side reactions are avoided.
Ring opening of the osazolinone to form the compound of formula I may be conducted in a single or in multiple steps. An example of a single step ring opening is treating the oxazolinone with chloromethyllithium which produces the compound of formula I wherein X and Y are H and Z is CI. An example of a multiple step ring opening is treating the oxazolinone first with methylHthium to form the compound of formula I wherein X, Y, and Z are all H, cHorinating the ketone to produce a mixture of compounds of formula I wherein one or two of X, Y, and Z are CI and the remaining are H, followed by selective removal of one chlorine atom from any compound in which two of X, Y, and Z are CI to give a compound of formula I wherein two of Y, and Z are H and the remaining is CI. The removal of one chlorine atom may be accomphshed by hydrogenation of the dichloro compound in the presence of a catalyst such as palladium.
Compositions containing compounds of formula I and an agronomically acceptable carrier as described in the parent application are useful in controlling a broad spectrum of phytopathogenic fungi such as those of the classes Oomycetes, Deuteromycetes, and Ascomycetes.
The compositions and compounds of the parent invention (compounds of formula I) are useful for the control of phytopathogenic fungi on crops and may be used as seed protectants, soil fungicides and/or foliar fungicides. As a seed' protectant, a compound of the present invention is coated on seed at a dosage rate of about 5 grams (g) compound per 50 kilograms (kg) seed to about 250 g compound per 50 kg seed. As a soil fungicide, a compound of the present invention can be incorporated in the soil or applied to the surface of the soil at a dosage rate of about 0.25 kg compound per hectare to about 10 kg compound per hectare and preferably at a rate of about 0.5 kg compound per hectare to about 2.5 kg compound per hectare.
The compositions and compounds of the parent . invention can be applied to plant foliage as fungicidal sprays by methods commonly employed, such as conventional high-gallonage hydraulic sprays, low-gallonage sprays, air-blast, aerial sprays and dusts. While the dilution and rate of application will depend upon the type of equipment employed, the method and frequency of application
desired and diseases to be controlled, the effective amount is typically from about 0.005 kg compound per hectare to about 1.0 kg compound per hectare, preferably from about 0.05 kg compound per hectare to about 0.5 kg compound per hectare and mora preferably from about 0.0625 kg compound per hectare to about 0.25 kg compound per hectare.
For the above disclosed purposes these compounds can be used in the pure form, also known as technical in the art, as prepared, or as solutions or as formulations. The compounds are usually provided with a carrier or are formulated so as to render them suitable for subsequent use as fungicides. For example, the compounds can be formulated as wettable powders, dry powders, emulsifiable concentrates, dusts, granular formulations, aerosols, or flowable emulsion concentrates. In such formulations, the compounds are extended with a liquid or solid carrier and, when dried, suitable surfactants are incorporated. : It is usually desirable, particularly in the case of foliar spray
foniiiulations, to include adjuvants; such as wetting agents, spreading agents, dispersing agents, stickers, adhesives and the like in accordance with
agricultural practices. Such adjuvants commonly used in the art can be found in McCutcheon's Emulsifiers and Detergents, McCutcheon's EmulsifLers and
Detergents Functional Materials and McCutcheon's Functional Materials all published annually by McCutcheon Division of MC Publishing Company (New Jersey).
In general, the compounds utilized in this invention can be dissolved in appropriate solvents such as acetone, methanol, ethanol, dimethylformamide or dimethyl sulfoxide and such solutions extended with water. The concentrations of the solution can vary from 1% to 90% with a preferred range being 5% to 50%-.
For the preparation of emulsifiable concentrates of the parent invention the compounds used in
the invention can be dissolved in suitable organic solvents or a mixture of solvents, together with an emulsifying agent which permits dispersion of the fungicide in water. The concentration of the active ingredient in emulsifiable concentrates is usually 10% to 90% and in flowable emulsion concentrates, this can be as high as 75%. Wettable powders suitable for spraying, can be prepared by admixing the compound with a finely divided solid or mixture of solids, such as clays, inorganic silicates, inorganic carbonates, and silicas and incorporating wetting agents, sticking agents, and/or dispersing agents in such mixtures. The concentration of active ingredients in such formulations is usually in the range of 20% to 98%, preferably 40% to 75%.
Dusts are prepared by mixing the compounds of the present invention salts and complexes thereof with finely divided inert solids which can be organic
or inorgariic in nature. Inert materials useful for this purpose include botanical flours, silicas, silicates, carbonates and clays. One convenient method of
preparing a dust is to dilute a wettable powder with a finely divided carrier.
Dust concentrations containing 20% to 80% of the active ingredient are
commonly made and are subsequently diluted to 1% to 10% use concentration.
The compounds of the parent invention can also be utilized in
combination with other fungicides such as, for example, those disclosed in U. S.
Patent No. 5,304,572 (column 3, line 30 to column 4, line 52) as well as
acylalanines such as , furalaxyl, <7profuram, ofurace, benalaxyl, and oxadixyl; , fluazinam, flumetover, phenylbenzamide derivatives such as those disclosed in EP 578586 Al, amino acid derivatives such -as valine derivatives disclosed in EP 550788 Al, methoxyacrylates such as methyl (E)-2-(2-(6-(2-cyanopheno-^)pyrimidin-4-ylo∑y)phenyl)^-metho∑yacrylate;
benzo(l,2,3)tMadiazole-7-<^bothioic acid S-methyl ester: propamocarb; imazalil; carbendazim; myelobutanil; fenbuconazolej tridemorph; pyrazophos,- fenarimol;
fenpiclonil; pyrimethanil; and tin fungicides. Those skilled in the art will
recognize that mixtures of the respective compositions and compounds of the present invention with other fungicidally active compounds may provide
advantages such as a broader spectrum of antifungal activity than the respective compositions and compounds of the present invention alone.
In a similar manner, the compositions and compounds ofthe parent invention may be applied in combination with one or more insecticides such as those
disclosed in U. S. Patent No. 5,075,471 (columns 14 and 15). Again, those
skilled in the art will recognize that mixtures of the respective compositions and compounds of the present invention with insectiddally active compounds may provide advantages such as fewer total applications than if the fu girides and insectiddes are applied separately.
The following examples describe in detail some of the embodiments of this invention.
Methods of Preparation
Preparation of racemic isovaline KR.S 2-aT nn-¾-methylbutanmn arid].
The preparation of this compound was carried out by a modified procedure from
Chirality (1992) 302-7.
A 2-liter stainless steel autodave containing 5-ethyl-5-methyIhydantoin (Frinton Labs) (100.0 g, 0.70 mole), barium hydroxide octahydrate (440 g, 1.395 mole) and deionized water (1.25 L) was sealed and heated to 175 °C for 15 hours.
The cooled reaction mixture was filtered through diatomaceous earth (Celite)..
The resulting white cake was washed thoroughly with deionized water. The:
combined aqueous filtrate and water washings were treated with carbon dioxide gas (from 120 g of dry ice). The solid formed was separated by filtration and the clear aqueous solution was concentrated in the rotary evaporator until the wet solids coated the sides of the flask. The resulting suspension was triturated with a misture of 1:1 acetone:ethanol (300 ml) to afford a white solid that after drying yielded 71.5 g (87.3%) of the expected racemic isovaline.
Preparation of N-chloroacetyl ianvfllrne.
Procedure adapted from J. Amer. Chem. Soc. 4701 (1952).
To a well-stirred misture chilled to 0 eC to 5 °C (ice bath) of racemic isovaline ((B,S) 2-amino-2-methylbutanoic acid) (350 g, 2.99 mole) and 2N aqueous sodium hydroside (1.5 L) were added simultaneously chloroacetyl chloride (373 g, 3.31 mole) and 2N aqueous sodium hydroside (1,718 ml, 3.44 mole) over 1.5 hours . The base was added at such a rate as to keep the reaction misture basic at all times. The reaction misture was wanned up to room temperature, treated with concentrated aqueous hydrochloric acid until acidic to litmus paper. A white solid formed which was separated by filtration and dried to yield 454 g (78.5%) of the espected racemic N-cMoroacetylisovaline ((R,S) 2-chloroacetamido-2-methylbutanoic acid).
Enz matic resolution nf r ran^n N-rTilnroacetylisnvaliTifi ffF^ff) 9-chloroac fe¾Tnif¾n.¾-methylbTi aTimff arid]
Adapted from J. Amer. Chem. Soc. 4701 (1952) and Chemistry of Amino Acids Volume 3 page 2575. John Wiley and Sons Edited by J.P.Greensteins and M. Winitz.
Racemic N-cMoroaceiyHsovaline ((R,S) 2-chloroacetam do-2-methylbutanoic acid) (120 g, 0.62 mole) was suspended in purified deionized water (1 L) and brought into solution by the addition of 2N aqueous sodium hydroside to a pH of 7.5. Acylase I powder 75% (Sigma Chemicals Catalog Number A-3010) (1 g) was added and the pH was adjusted to 7.5. The resulting misture was digested at 38 °C for 72 to 96 hours. The pH of the reaction misture was adjusted to 5, and the resulting mixture stirred at 95 °C for approximately 2 hours. The aqueous misture was filtered yielding a clear, slightly yellow solution. A total of 5 batches were run under the same conditions. All the batches were combined and divided in three. Each of these three batches was poured into a Dowes 50 (H+) column (1.75 L of wet resin) and washed with water until the pH of the eluate was greater than 5. The eluate was
concentrated yielding ( )-N-cUoroacetylisovaline. The (S)-isovaline on the Dowes 50 resin column was eluted with 2.5N aqueous hydrochloric acid
(approximately 4 L). The combined acidic eluate was concentrated in vacuo The
resulting white solid was vacuum dried yielding a total of 355 g of a mixture of (SHsovaline hydrochloride and sodium chloride used as such in the nest step. Preparation of (SVisnvflliTifi methyl ester hydrochloride [Methyl (S)-2-aTmnn-¾-methylbutanoatel
To a well-stirred suspension of the previous mixture of (SHsovaline hydrochloride and sodium chloride in methanol (3 L) was slowly added thionyl chloride (373 g, 3.13 mole). After the addition was complete the reaction mixture was refluxed for 3 hours. The resulting mixture was cooled to room temperature and filtered. The resulting white filter cake was washed several times with methanol. The combined methanol filtrate and washings were concentrated using a rotary evaporator. Toluene was added to the resulting crude residue and then removed using the rotary evaporator yielding 187 g of the expected (S -isovalme methyl ester hydrochloride.
Preparation of (S)-N-(3.5-dichloro-4-methylbenzoate) isn alTne methyl ester
In a 5-liter round-bottomed flask were placed the previously prepared (S)-isovaline methyl ester hydrochloride (280 g, 1.67 mole), 3,5-dichloro-4-methylbenzoyl chloride (381 g, 1.705 mole) and methylene chloride (2.2 L). The mixture was cooled to 0 °C. To the resulting cooled (0 °C) mixture was added slowly triethylamine (540 ml) keeping the reaction mixture at 0 °C. When the addition was complete the reaction mixture was stirred at 0 °C for 30 minutes and then allowed to warm up to room temperature. The reaction mixture was washed sequentially with water, 2% aqueous hydrochloric acid, water, saturated aqueous sodium bicarbonate and finally brine. The organic layer was dried over anhydrous magnesium sulfate and solvent eliminated using a rotary evaporator yielding 505.9 g of the expected (S) N-(3,5-dichloro-4-methylbenzoate) isovaline methyl ester which was used as such in the next step.
Preparation of (S -N-(3.5-dichloro-4-methylbenzoate) isovaline .
To a mixture of the previously prepared (S N-(3,5-dichloro-4-methylbenzoate) isovaline methyl ester (315 g) and methanol (3 L) at 55 °C was added slowly aqueous sodium hydroxide (10% solution, 869 g, 2.17 mole). When the addition was complete the reaction mixture was refluxed for 1 hour. The reaction mixture was cooled to room temperature and the solvent eliminated using a rotary evaporator. The crude reaction product was taken up in water, the resulting aqueous solution was washed 3 times with ethyl acetate, and made acidic with concentrated aqueous hydrochloric acid. The product settled first as an oil which quickly solidified. The solids were separated by filtration, washed several times with water and dried in a vacuum oven yielding 279 g of the
expected (S) N-(3,5-dicMoro-4-met-hylbeiizoate) isovaline which was used as such in the nest step.
Preparation of (S)~2-(3.5^cMorc^methylbenzoyl)^^thyl-4-methyl-1.3-o∑azol-5-one.
A mixture of the previously prepared (S)-N-(3,5-dichloro-4-methylbenzoate) isovaline (279 g, 0.917 mole) and acetic anhydride (1.25 L) was refluxed for 1 hour. The reaction mixture was cooled to room temperature and the solvent was eliminated in the rotary evaporator yielding a thick oily residue. This residue was treated with xylene and the solvent was eliminated using a rotary evaporator. The resulting crude product was dried in a vacuum oven yielding 275.5 g of the expected (S)-2 3,5^<Moro^metiyll)en2oyl)- -ethyl-4-methyl- 1 , 3-oxazol-5-one as an oil that quickly solidified. The compound was used as such in the next step.
Preparation of (S)-N-(l^thyl-l-methyl-2^xopropy1V3T5-diR ilnrn- -methvlbe^ ?a -mi p.
In a 3-liter four-necked round-bottomed flask equipped with mechanical stirrer, condenser with nitrogen inlet on top, thermometer, and addition funnel were placed the previously prepared 2-(3,5-dichloro-4-methylbenzoyl)-4-ethyl-4-methyl-l,3-oxazol-5-one (107 g, 0.374 mole) and dry tetrahydrofuran (1.4 L). To the resulting mixture cooled down to -70 °C was added slowly dropwise methylMtbium (1.4 M solution, 280 ml, 0.392 mole) over 20 minutes period. After the addition was complete the reaction mixture was warmed up to room
temperature and poured into a saturated aqueous solution of ammonium chloride. The organic phase was separated and the aqueous layer was extracted three times with ethyl acetate. The combined organic layers were dried over anhydrous magnesium sulfate and the solvent eliminated in the rotary
evaporator yielding 117.3 g of the expected (S)-N-(l-ethyl-l-metiiyl-2-oxopropyl)-3,5-dic oiO-4-methylbenzamide as a thick oil.
Preparation of (S N-(3- b1nm-^ ^thyl-l-methyl-2-oxoDropyl')-3.5-dichloro-4-methylbepttflTnrndft and (SVN-(3.3-dicMoro-l-ethyl-l-methyl-2-oxopropyl)-3.5-dichloro-4-methylbftn sa-miri
In a 2-liter four-necked round-bottomed flask equipped with mechanical stirrer, condenser with inlet on top connected to an acid scrubber, thermometer, and gas inlet tube were placed the previously prepared (S)-N-(l-ethyl-l-methyl-2-oxopi pyl)-3,5-di<Woro-4^methylbenzamide (115 g, 0.38 mole) and glacial acetic acid (1 L). The resulting mixture was warmed up to 60 °C and chlorine gas was admitted into the well-stirred reaction mixture. Chlorine was bubbled in until thin layer chromatography showed no more starting material. The reaction
mixture was cooled down to room temperature and the solvent eliminated in the rotary evaporator yielding the crude product. This residue was triturated with hexane and filtered yielding 121.2 g of a mixture of (S)-N-(3-chloro-l-ethyl-l-methyl-2 >2opropyl)-3,5^cMoro-4-methylbenzamide and (S)-N-(3,3-dichloro-l-ethyl- l-methyl-2^sopropyl)-3,5-dicMoro^methylbenzamide which* was used as such in the nest step.
Preparation of (S)-N-(3^MoiO-l^tfayl-l-me1hyl-2^∑opropyI)^.5-dichloro-4-methylben EflTnid
The mixture (87 g) prepared in the previous step, 1.35 L of ethanol and 800 mg of 5% palladium over charcoal were placed in a hydrogenation bottle and hydrogenated in a Parr apparatus (50 psi, room temperature) for 3 hours. The reaction mixture was filtered through Celite and the solvent eliminated under reduced pressure, to yield a crude product. The crude product was triturated with hexane and filtered yielding after drying 56.6 g of the expected (S>N-(3-cHoro-l-ethyl-l-methyl-2-oxopi pyl}-3,5
methylbenzamide (mp. 154-155° C, [a]D = -4.1 in ethanol).
Preparation of (R an aline methyl ester
In a 2-liter round-bottomed flask equipped with a condenser and a magnetic stirrer were placed 70 g of the (R)-N-chloro acetylisovaliae obtained from the enzymatic resolution of racemic N-<^oroacety]isova]ine, 696 ml of water, and 696 ml of concentrated hydrochloric acid. The resulting -mixture was heated at reflux for 2.25 hours. The mixture was then cooled to room
temperature and the solvent was removed using rotary evaporation yielding a solid residue, the residue was washed with dry acetone and then dried in a vacuum oven at 40° C yielding a crude product. The crude product was esterified with methanol using the above-described procedure for preparation of (SHsc aline methyl ester hydrochloride to give 47.52 g of the corresponding (R)-isovaline methyl ester hydrochloride.
The (R)-isovaline methyl ester hydrochloride may be converted to (R)-N-(3-cWoro-l-e1ihyl-l-methyl-2-oxopropyl)-3,5-dicn^ (mp. 155.5-156° C, [<x]D = +4.14 in ethanol) using the above-described sequence for preparation of the (S)-enantiomer.
All passages of the description, which are not within the scope of the claims, do not form part of the invention
Claims (1)
- CLAIMS A process for preparing a racemic mixture of the and enantiomners of the compound of formula I A is selected N and is independently selected from n and and R2 is selected from and and 2 is stereochemically larger than R and are independently selected from and wherein is selected from and R7 is selected from R8 and are independently selected from and are independently selected from H and and is selected from and and and Z are independently selected from and provided that and Z are not all comprising the steps 13 reacting a protonated amino acid ester of the Rl is independently selected from and R2 is selected from and and is stereochemically larger R with an acyl chloride of the wherein A is selected from N and and and Bp are independently selected from and wherein R6 is selected from and is selected from and and are independently selected from and selected from H and selected from and to produce a benzamide or of the formula 14 the ester moiety of the benzamide or to produce a acid of the cyclizi Lg the benzamide or to produce an oxazolinone of the forming the racemic mixture of the and enantiomers of the compound formula I by ring opening the The process of 1 wherein the forming step treating the oxazolinone with an organometallic halogenating the resulting and hydrogenating of the The process of Claim 2 wherein the organometallic agent is For the Applicants REINHOLD COHN AND PARTNERS insufficientOCRQuality
Applications Claiming Priority (2)
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US2051696P | 1996-06-28 | 1996-06-28 | |
IL12097097A IL120970A (en) | 1996-06-28 | 1997-06-02 | N-acetonylbenzamides or nicotinamides, their preparation and fungicidal compositions comprising them |
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IL135938A0 IL135938A0 (en) | 2001-05-20 |
IL135938A true IL135938A (en) | 2001-06-14 |
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IL13593897A IL135938A (en) | 1996-06-28 | 1997-06-02 | Process for preparing a racemic mixture of n-acetonylbenzamides or nicotinamides |
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IL (1) | IL135938A (en) |
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