IL131427A0 - 1-(Isoquinolin-1-yl)-4- (1-phenylmethyl) piperazines dopamine receptor subtype specific ligands - Google Patents

1-(Isoquinolin-1-yl)-4- (1-phenylmethyl) piperazines dopamine receptor subtype specific ligands

Info

Publication number
IL131427A0
IL131427A0 IL13142798A IL13142798A IL131427A0 IL 131427 A0 IL131427 A0 IL 131427A0 IL 13142798 A IL13142798 A IL 13142798A IL 13142798 A IL13142798 A IL 13142798A IL 131427 A0 IL131427 A0 IL 131427A0
Authority
IL
Israel
Prior art keywords
piperazines
isoquinolin
phenylmethyl
dopamine receptor
receptor subtype
Prior art date
Application number
IL13142798A
Other languages
English (en)
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of IL131427A0 publication Critical patent/IL131427A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL13142798A 1997-03-04 1998-03-03 1-(Isoquinolin-1-yl)-4- (1-phenylmethyl) piperazines dopamine receptor subtype specific ligands IL131427A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81072997A 1997-03-04 1997-03-04
PCT/US1998/004051 WO1998039301A1 (en) 1997-03-04 1998-03-03 1-(isoquinolin-1-yl)-4-(1-phenylmethyl)piperazines; dopamine receptor subtype specific ligands

Publications (1)

Publication Number Publication Date
IL131427A0 true IL131427A0 (en) 2001-01-28

Family

ID=25204554

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13142798A IL131427A0 (en) 1997-03-04 1998-03-03 1-(Isoquinolin-1-yl)-4- (1-phenylmethyl) piperazines dopamine receptor subtype specific ligands

Country Status (9)

Country Link
EP (1) EP0970054A1 (ko)
JP (1) JP2001512491A (ko)
KR (1) KR20000075918A (ko)
AU (1) AU6678598A (ko)
CA (1) CA2283256A1 (ko)
HU (1) HUP0001391A3 (ko)
IL (1) IL131427A0 (ko)
NZ (1) NZ337183A (ko)
WO (1) WO1998039301A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008352A (en) * 1997-04-03 1999-12-28 Neurogen Corporation 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands
EP1025097B1 (en) * 1997-10-24 2005-04-27 Neurogen Corporation 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines being dopamine d 4? receptor subtype ligands
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
JP4596792B2 (ja) * 2004-02-24 2010-12-15 あすか製薬株式会社 ５−ｈｔ１ａ作動作用と５−ｈｔ３拮抗作用を併有する薬剤
WO2008115593A1 (en) * 2007-03-21 2008-09-25 The University Of Montana 1-[(2'-substituted)-piperazin-1'-yl]-isoquinolines as norepinephrine transporter inhibitor therapeutics and positron emission tomography imaging agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3423003A1 (de) * 1984-06-22 1986-01-02 Beiersdorf Ag, 2000 Hamburg Benzo(c)(1,8)naphthyridine, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JPS63227570A (ja) * 1987-03-13 1988-09-21 Ss Pharmaceut Co Ltd イソキノリン誘導体
AU645681B2 (en) * 1991-05-02 1994-01-20 John Wyeth & Brother Limited Piperazine derivatives

Also Published As

Publication number Publication date
WO1998039301A1 (en) 1998-09-11
NZ337183A (en) 2001-05-25
EP0970054A1 (en) 2000-01-12
CA2283256A1 (en) 1998-09-11
KR20000075918A (ko) 2000-12-26
HUP0001391A2 (hu) 2000-10-28
JP2001512491A (ja) 2001-08-21
HUP0001391A3 (en) 2001-12-28
AU6678598A (en) 1998-09-22

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