IL129244A - Electrochemical process for the preparation of 4-(desdimethylamino)-tetracyclines - Google Patents
Electrochemical process for the preparation of 4-(desdimethylamino)-tetracyclinesInfo
- Publication number
- IL129244A IL129244A IL12924499A IL12924499A IL129244A IL 129244 A IL129244 A IL 129244A IL 12924499 A IL12924499 A IL 12924499A IL 12924499 A IL12924499 A IL 12924499A IL 129244 A IL129244 A IL 129244A
- Authority
- IL
- Israel
- Prior art keywords
- tetracyclines
- desdimethylamino
- preparation
- electrochemical process
- electrolysis
- Prior art date
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 4
- 229940040944 tetracyclines Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000005868 electrolysis reaction Methods 0.000 abstract 1
- 239000003792 electrolyte Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000012022 methylating agents Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT102160A PT102160B (pt) | 1998-05-26 | 1998-05-26 | Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL129244A0 IL129244A0 (en) | 2000-02-17 |
| IL129244A true IL129244A (en) | 2003-01-12 |
Family
ID=20085765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12924499A IL129244A (en) | 1998-05-26 | 1999-03-30 | Electrochemical process for the preparation of 4-(desdimethylamino)-tetracyclines |
Country Status (17)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101027279B (zh) * | 2004-05-21 | 2013-03-27 | 哈佛大学校长及研究员协会 | 四环素及其类似物的合成 |
| JP5335664B2 (ja) * | 2006-04-07 | 2013-11-06 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | テトラサイクリンおよびその類似体の合成 |
| WO2008127361A2 (en) | 2006-10-11 | 2008-10-23 | President And Fellows Of Harvard College | Synthesis of enone intermediate |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| PT108978B (pt) | 2015-11-24 | 2020-03-09 | Hovione Farm S A | Sais de tetraciclinas |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1349043A (en) * | 1971-04-05 | 1974-03-27 | Pliva Pharm & Chem Works | Process for the preparation of 6-demethyl-6-deoxy-6-methylene tetracyclines |
| JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| US5223248A (en) * | 1991-02-11 | 1993-06-29 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing antiplaque properties |
| CA2094874C (en) * | 1992-04-27 | 2003-02-11 | Thomas F. Mcnamara | Non-antibacterial tetracycline compositons possessing antiplaque properties |
| JPH069523A (ja) * | 1992-06-18 | 1994-01-18 | Kuraray Co Ltd | ４−デジメチルアミノテトラサイクリンの精製法 |
| CA2103189C (en) * | 1992-11-17 | 2005-05-03 | Lorne M. Golub | Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes |
| US5552297A (en) * | 1993-12-21 | 1996-09-03 | Abbott Laboratories | Lead detection method and reggents utilizing aminolevulinic acid dehydratase and tertiary phosphines |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
-
1998
- 1998-05-26 PT PT102160A patent/PT102160B/pt not_active IP Right Cessation
-
1999
- 1999-03-25 HU HU9900761A patent/HUP9900761A3/hu unknown
- 1999-03-26 AU AU22444/99A patent/AU746608B2/en not_active Ceased
- 1999-03-30 IL IL12924499A patent/IL129244A/xx not_active IP Right Cessation
- 1999-03-30 NZ NZ334940A patent/NZ334940A/xx unknown
- 1999-03-31 ZA ZA9902484A patent/ZA992484B/xx unknown
- 1999-04-01 AT AT99302600T patent/ATE213788T1/de active
- 1999-04-01 ES ES99302600T patent/ES2173706T3/es not_active Expired - Lifetime
- 1999-04-01 DE DE69900927T patent/DE69900927T2/de not_active Expired - Lifetime
- 1999-04-01 EP EP99302600A patent/EP0962552B1/en not_active Expired - Lifetime
- 1999-04-09 KR KR1019990012481A patent/KR19990087905A/ko not_active Ceased
- 1999-04-09 IN IN555DE1999 patent/IN192877B/en unknown
- 1999-04-13 JP JP11105105A patent/JP2000034264A/ja active Pending
- 1999-04-21 CN CNB991051548A patent/CN1192016C/zh not_active Expired - Fee Related
- 1999-04-29 NO NO19992072A patent/NO325059B1/no not_active IP Right Cessation
- 1999-05-21 CA CA002272598A patent/CA2272598C/en not_active Expired - Fee Related
- 1999-05-24 US US09/317,396 patent/US6143161A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO992072D0 (no) | 1999-04-29 |
| ATE213788T1 (de) | 2002-03-15 |
| HU9900761D0 (en) | 1999-05-28 |
| CN1236775A (zh) | 1999-12-01 |
| HUP9900761A3 (en) | 2000-06-28 |
| DE69900927D1 (de) | 2002-04-04 |
| EP0962552A1 (en) | 1999-12-08 |
| EP0962552B1 (en) | 2002-02-27 |
| CA2272598C (en) | 2008-01-22 |
| IN192877B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2004-05-29 |
| AU2244499A (en) | 1999-12-02 |
| JP2000034264A (ja) | 2000-02-02 |
| PT102160B (pt) | 2001-04-30 |
| NO992072L (no) | 1999-11-29 |
| ES2173706T3 (es) | 2002-10-16 |
| PT102160A (pt) | 1999-11-30 |
| HUP9900761A2 (hu) | 1999-12-28 |
| NO325059B1 (no) | 2008-01-21 |
| ZA992484B (en) | 1999-10-05 |
| IL129244A0 (en) | 2000-02-17 |
| AU746608B2 (en) | 2002-05-02 |
| DE69900927T2 (de) | 2002-08-29 |
| CA2272598A1 (en) | 1999-11-26 |
| CN1192016C (zh) | 2005-03-09 |
| US6143161A (en) | 2000-11-07 |
| NZ334940A (en) | 2000-05-26 |
| KR19990087905A (ko) | 1999-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |