IL128928A0 - Tricyclic inhibitors of farnesyl protein transferase - Google Patents
Tricyclic inhibitors of farnesyl protein transferaseInfo
- Publication number
- IL128928A0 IL128928A0 IL12892897A IL12892897A IL128928A0 IL 128928 A0 IL128928 A0 IL 128928A0 IL 12892897 A IL12892897 A IL 12892897A IL 12892897 A IL12892897 A IL 12892897A IL 128928 A0 IL128928 A0 IL 128928A0
- Authority
- IL
- Israel
- Prior art keywords
- protein transferase
- farnesyl protein
- tricyclic inhibitors
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
- Cereal-Derived Products (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71332396A | 1996-09-13 | 1996-09-13 | |
PCT/US1997/015907 WO1998011093A1 (en) | 1996-09-13 | 1997-09-11 | Tricyclic inhibitors of farnesyl protein transferase |
Publications (1)
Publication Number | Publication Date |
---|---|
IL128928A0 true IL128928A0 (en) | 2000-02-17 |
Family
ID=24865689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12892897A IL128928A0 (en) | 1996-09-13 | 1997-09-11 | Tricyclic inhibitors of farnesyl protein transferase |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0929545B1 (zh) |
JP (1) | JP2001500510A (zh) |
KR (1) | KR20000036120A (zh) |
CN (1) | CN1104427C (zh) |
AT (1) | ATE286046T1 (zh) |
AU (1) | AU4337997A (zh) |
BR (1) | BR9712831A (zh) |
CA (1) | CA2266016C (zh) |
CZ (1) | CZ84399A3 (zh) |
DE (1) | DE69732120T2 (zh) |
ES (1) | ES2235252T3 (zh) |
HU (1) | HUP0000121A2 (zh) |
ID (1) | ID21699A (zh) |
IL (1) | IL128928A0 (zh) |
NO (1) | NO991234L (zh) |
NZ (1) | NZ334453A (zh) |
PL (1) | PL332242A1 (zh) |
SK (1) | SK33899A3 (zh) |
TR (1) | TR199901276T2 (zh) |
WO (1) | WO1998011093A1 (zh) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3962B (en) | 1993-12-21 | 1996-05-27 | Albright & Wilson | Funcional fluids |
US5939416A (en) * | 1997-06-17 | 1999-08-17 | Schering Corporation | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors |
CA2319077A1 (en) | 1998-01-21 | 1999-07-29 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
US6433165B1 (en) | 1998-01-21 | 2002-08-13 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
US8679096B2 (en) | 2007-06-21 | 2014-03-25 | Board Of Regents Of The University Of Nebraska | Multifunctional operational component for robotic devices |
TW200902007A (en) * | 2007-05-25 | 2009-01-16 | Astrazeneca Ab | Spirocyclopropyl piperidine derivatives |
WO2009014917A2 (en) | 2007-07-12 | 2009-01-29 | Board Of Regents Of The University Of Nebraska | Methods and systems of actuation in robotic devices |
EP2178431A4 (en) | 2007-08-15 | 2017-01-18 | Board of Regents of the University of Nebraska | Medical inflation, attachment, and delivery devices and related methods |
JP6174017B2 (ja) | 2011-06-10 | 2017-08-02 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | 生体内血管シールエンドエフェクタおよび生体内ロボット装置 |
CA3082073C (en) | 2011-07-11 | 2023-07-25 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
CA2860754C (en) | 2012-01-10 | 2020-12-29 | Shane Farritor | Methods, systems, and devices for surgical access and insertion |
JP2015531608A (ja) | 2012-05-01 | 2015-11-05 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | 単孔式ロボット機器および関連システムと方法 |
US9010214B2 (en) | 2012-06-22 | 2015-04-21 | Board Of Regents Of The University Of Nebraska | Local control robotic surgical devices and related methods |
US9770305B2 (en) | 2012-08-08 | 2017-09-26 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
JP2015526171A (ja) | 2012-08-08 | 2015-09-10 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | ロボット手術用デバイス、システム及び関連の方法 |
CA2906672C (en) | 2013-03-14 | 2022-03-15 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to force control surgical systems |
CA2905948C (en) | 2013-03-14 | 2022-01-11 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers |
US10667883B2 (en) | 2013-03-15 | 2020-06-02 | Virtual Incision Corporation | Robotic surgical devices, systems, and related methods |
EP3021779A4 (en) | 2013-07-17 | 2017-08-23 | Board of Regents of the University of Nebraska | Robotic surgical devices, systems and related methods |
EP3191009B1 (en) | 2014-09-12 | 2021-03-31 | Board of Regents of the University of Nebraska | Quick-release end effectors and related systems |
US10376322B2 (en) | 2014-11-11 | 2019-08-13 | Board Of Regents Of The University Of Nebraska | Robotic device with compact joint design and related systems and methods |
WO2017024081A1 (en) | 2015-08-03 | 2017-02-09 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices systems and related methods |
US10751136B2 (en) | 2016-05-18 | 2020-08-25 | Virtual Incision Corporation | Robotic surgical devices, systems and related methods |
CN110248614B (zh) | 2016-08-25 | 2023-04-18 | 内布拉斯加大学董事会 | 快速释放工具耦接器以及相关系统和方法 |
JP7090615B2 (ja) | 2016-08-30 | 2022-06-24 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | ロボットデバイス |
JP2020500674A (ja) | 2016-11-22 | 2020-01-16 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | 改良された全体的位置決めデバイスならびに関連するシステムおよび方法 |
JP7099728B2 (ja) | 2016-11-29 | 2022-07-12 | バーチャル インシジョン コーポレイション | ユーザの存在検出機能を備えたユーザコントローラ、関連システムおよび方法 |
WO2018112199A1 (en) | 2016-12-14 | 2018-06-21 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
EP3687370A4 (en) | 2017-09-27 | 2021-06-30 | Virtual Incision Corporation | ROBOTIC SURGICAL DEVICES WITH TRACK CAMERA TECHNOLOGY AND RELATED SYSTEMS AND PROCEDURES |
CN117140580A (zh) | 2018-01-05 | 2023-12-01 | 内布拉斯加大学董事会 | 具有紧凑型关节设计的单臂机器人装置及相关系统和方法 |
CA3125742A1 (en) | 2019-01-07 | 2020-07-16 | Virtual Incision Corporation | Robotically assisted surgical system and related devices and methods |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
JPH0676403B2 (ja) * | 1991-01-18 | 1994-09-28 | エスエス製薬株式会社 | 新規なベンゾ[5,6 シクロヘプタ[1,2−b ピリジン誘導体及びこれを含有する抗アレルギー剤 |
US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
JP2875393B2 (ja) * | 1993-10-15 | 1999-03-31 | シェーリング コーポレイション | G−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物 |
IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
HUT76057A (en) * | 1993-10-15 | 1997-06-30 | Schering Corp | Tricyclic sulfonamide compounds, pharmaceutical compositions containing them, which are useful for inhibition of g-protein function and for treatment of proliferative diseases and process for producing them |
US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
SK86198A3 (en) * | 1995-12-22 | 1999-02-11 | Schering Corp | Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases |
-
1997
- 1997-09-11 ES ES97941480T patent/ES2235252T3/es not_active Expired - Lifetime
- 1997-09-11 AU AU43379/97A patent/AU4337997A/en not_active Abandoned
- 1997-09-11 WO PCT/US1997/015907 patent/WO1998011093A1/en active IP Right Grant
- 1997-09-11 CZ CZ99843A patent/CZ84399A3/cs unknown
- 1997-09-11 CA CA002266016A patent/CA2266016C/en not_active Expired - Fee Related
- 1997-09-11 CN CN97199598A patent/CN1104427C/zh not_active Expired - Fee Related
- 1997-09-11 NZ NZ334453A patent/NZ334453A/xx unknown
- 1997-09-11 DE DE69732120T patent/DE69732120T2/de not_active Expired - Fee Related
- 1997-09-11 EP EP97941480A patent/EP0929545B1/en not_active Expired - Lifetime
- 1997-09-11 BR BR9712831-7A patent/BR9712831A/pt unknown
- 1997-09-11 IL IL12892897A patent/IL128928A0/xx unknown
- 1997-09-11 PL PL97332242A patent/PL332242A1/xx unknown
- 1997-09-11 HU HU0000121A patent/HUP0000121A2/hu unknown
- 1997-09-11 SK SK338-99A patent/SK33899A3/sk unknown
- 1997-09-11 JP JP10513765A patent/JP2001500510A/ja not_active Ceased
- 1997-09-11 TR TR1999/01276T patent/TR199901276T2/xx unknown
- 1997-09-11 KR KR1019997002149A patent/KR20000036120A/ko not_active Application Discontinuation
- 1997-09-11 AT AT97941480T patent/ATE286046T1/de not_active IP Right Cessation
- 1997-11-09 ID IDW990086A patent/ID21699A/id unknown
-
1999
- 1999-03-12 NO NO991234A patent/NO991234L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1998011093A1 (en) | 1998-03-19 |
DE69732120D1 (de) | 2005-02-03 |
NO991234L (no) | 1999-05-12 |
ES2235252T3 (es) | 2005-07-01 |
AU4337997A (en) | 1998-04-02 |
CN1104427C (zh) | 2003-04-02 |
DE69732120T2 (de) | 2005-12-08 |
ATE286046T1 (de) | 2005-01-15 |
CZ84399A3 (cs) | 1999-11-17 |
HUP0000121A2 (hu) | 2001-04-28 |
EP0929545B1 (en) | 2004-12-29 |
ID21699A (id) | 1999-07-15 |
SK33899A3 (en) | 2000-02-14 |
EP0929545A1 (en) | 1999-07-21 |
CA2266016A1 (en) | 1998-03-19 |
JP2001500510A (ja) | 2001-01-16 |
KR20000036120A (ko) | 2000-06-26 |
NZ334453A (en) | 2000-08-25 |
NO991234D0 (no) | 1999-03-12 |
BR9712831A (pt) | 1999-11-16 |
TR199901276T2 (xx) | 1999-09-21 |
CN1237165A (zh) | 1999-12-01 |
CA2266016C (en) | 2004-06-01 |
PL332242A1 (en) | 1999-08-30 |
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