IL117224A - 1,2,5-thiadiazole derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines and antimigraine pharmaceutical compositions comprising them - Google Patents
1,2,5-thiadiazole derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines and antimigraine pharmaceutical compositions comprising themInfo
- Publication number
- IL117224A IL117224A IL11722496A IL11722496A IL117224A IL 117224 A IL117224 A IL 117224A IL 11722496 A IL11722496 A IL 11722496A IL 11722496 A IL11722496 A IL 11722496A IL 117224 A IL117224 A IL 117224A
- Authority
- IL
- Israel
- Prior art keywords
- pyrimidinylpiperazines
- indolylalkyl
- antimigraine
- pyridinyl
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/396,825 US5618816A (en) | 1995-03-02 | 1995-03-02 | Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL117224A0 IL117224A0 (en) | 1996-06-18 |
| IL117224A true IL117224A (en) | 2000-06-29 |
Family
ID=23568771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11722496A IL117224A (en) | 1995-03-02 | 1996-02-22 | 1,2,5-thiadiazole derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines and antimigraine pharmaceutical compositions comprising them |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5618816A (no) |
| EP (1) | EP0729958A2 (no) |
| JP (1) | JPH08253479A (no) |
| KR (1) | KR960034200A (no) |
| CN (1) | CN1063177C (no) |
| AR (1) | AR002281A1 (no) |
| AU (1) | AU707770B2 (no) |
| CA (1) | CA2169804A1 (no) |
| CZ (1) | CZ46896A3 (no) |
| HU (1) | HUP9600498A3 (no) |
| IL (1) | IL117224A (no) |
| NO (1) | NO305248B1 (no) |
| NZ (1) | NZ286090A (no) |
| PL (1) | PL313022A1 (no) |
| RU (1) | RU2165420C2 (no) |
| TW (1) | TW331558B (no) |
| ZA (1) | ZA961392B (no) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU694226B2 (en) * | 1994-05-19 | 1998-07-16 | Merck Sharp & Dohme Limited | Piperazine, piperidine and tetrahydropyridine derivatives ofindol-3-ylalkyl as 5-HT1D-alpha agonists |
| GB9415575D0 (en) * | 1994-08-02 | 1994-09-21 | Merck Sharp & Dohme | Therapeutic agents |
| GB9501865D0 (en) * | 1995-01-31 | 1995-03-22 | Merck Sharp & Dohme | Therapeutic agents |
| US5872145A (en) * | 1996-08-16 | 1999-02-16 | Pozen, Inc. | Formulation of 5-HT agonist and NSAID for treatment of migraine |
| US8022095B2 (en) | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| US6586458B1 (en) | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| US7332183B2 (en) * | 2002-12-26 | 2008-02-19 | Pozen Inc. | Multilayer dosage forms containing NSAIDs and triptans |
| JP2006527195A (ja) * | 2003-06-06 | 2006-11-30 | グラクソ グループ リミテッド | トリプタンおよびｎｓａｉｄを含む組成物 |
| CN104337812B (zh) | 2013-07-29 | 2018-09-14 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其使用方法和用途 |
| WO2016192657A1 (en) | 2015-06-03 | 2016-12-08 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3468882A (en) * | 1966-10-07 | 1969-09-23 | Sterling Drug Inc | Phenylhydrazone derivatives as intermediates for preparing indoles |
| NL189197C (nl) * | 1979-09-04 | 1993-02-01 | Bristol Myers Squibb Co | 3,4-digesubstitueerde-1,2,5-thiadiazool-1-oxiden en 1,1-dioxiden, bereiding daarvan alsmede farmaceutische preparaten. |
| US4600779A (en) * | 1982-03-29 | 1986-07-15 | Bristol-Myers Company | Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity |
| IT1170387B (it) * | 1982-06-07 | 1987-06-03 | Glaxo Group Ltd | Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono |
| US4440933A (en) * | 1983-03-16 | 1984-04-03 | Bristol-Myers Company | Process for preparing 1,2,5-thiadiazoles |
| GB2162522B (en) * | 1984-08-01 | 1988-02-24 | Glaxo Group Ltd | An indole derivative |
| US4954502A (en) * | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
| FR2635104B1 (fr) * | 1988-08-03 | 1992-04-30 | Synthelabo | Derives d'indolone, leur preparation et leur application en therapeutique |
| FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
| US5077293A (en) * | 1990-06-29 | 1991-12-31 | Bristol-Myers Squibb Co. | 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines |
| CA2043709C (en) * | 1990-06-29 | 2002-01-22 | David W. Smith | Antimigraine alkoxypyrimidine derivatives |
| DE4101686A1 (de) * | 1991-01-22 | 1992-07-23 | Merck Patent Gmbh | Indolderivate |
| CA2084531A1 (en) * | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
| CA2130078A1 (en) * | 1993-09-16 | 1995-03-17 | Jonas A. Gylys | Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines |
| GB9410031D0 (en) * | 1994-05-19 | 1994-07-06 | Merck Sharp & Dohme | Therapeutic agents |
| AU694226B2 (en) * | 1994-05-19 | 1998-07-16 | Merck Sharp & Dohme Limited | Piperazine, piperidine and tetrahydropyridine derivatives ofindol-3-ylalkyl as 5-HT1D-alpha agonists |
| GB9415575D0 (en) * | 1994-08-02 | 1994-09-21 | Merck Sharp & Dohme | Therapeutic agents |
-
1995
- 1995-03-02 US US08/396,825 patent/US5618816A/en not_active Expired - Lifetime
-
1996
- 1996-02-03 TW TW085101358A patent/TW331558B/zh active
- 1996-02-16 CZ CZ96468A patent/CZ46896A3/cs unknown
- 1996-02-19 CA CA002169804A patent/CA2169804A1/en not_active Abandoned
- 1996-02-21 ZA ZA9601392A patent/ZA961392B/xx unknown
- 1996-02-22 NO NO960699A patent/NO305248B1/no not_active IP Right Cessation
- 1996-02-22 IL IL11722496A patent/IL117224A/xx not_active IP Right Cessation
- 1996-02-28 NZ NZ286090A patent/NZ286090A/en unknown
- 1996-02-29 KR KR1019960005354A patent/KR960034200A/ko not_active Application Discontinuation
- 1996-02-29 HU HU9600498A patent/HUP9600498A3/hu unknown
- 1996-03-01 JP JP8044338A patent/JPH08253479A/ja active Pending
- 1996-03-01 EP EP96103214A patent/EP0729958A2/en not_active Ceased
- 1996-03-01 PL PL96313022A patent/PL313022A1/xx unknown
- 1996-03-01 AU AU45819/96A patent/AU707770B2/en not_active Ceased
- 1996-03-01 AR ARP960101598A patent/AR002281A1/es unknown
- 1996-03-01 CN CN96105542A patent/CN1063177C/zh not_active Expired - Fee Related
- 1996-03-01 RU RU96103685/04A patent/RU2165420C2/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ46896A3 (en) | 1996-09-11 |
| HUP9600498A2 (en) | 1997-10-28 |
| AR002281A1 (es) | 1998-03-11 |
| JPH08253479A (ja) | 1996-10-01 |
| HU9600498D0 (en) | 1996-04-29 |
| AU707770B2 (en) | 1999-07-22 |
| EP0729958A2 (en) | 1996-09-04 |
| PL313022A1 (en) | 1996-09-16 |
| NZ286090A (en) | 1997-12-19 |
| NO305248B1 (no) | 1999-04-26 |
| KR960034200A (ko) | 1996-10-22 |
| NO960699L (no) | 1996-09-03 |
| CN1063177C (zh) | 2001-03-14 |
| RU2165420C2 (ru) | 2001-04-20 |
| EP0729958A3 (no) | 1996-10-02 |
| IL117224A0 (en) | 1996-06-18 |
| AU4581996A (en) | 1996-09-12 |
| CN1138042A (zh) | 1996-12-18 |
| CA2169804A1 (en) | 1996-09-03 |
| TW331558B (en) | 1998-05-11 |
| HUP9600498A3 (en) | 1998-10-28 |
| ZA961392B (en) | 1997-08-21 |
| NO960699D0 (no) | 1996-02-22 |
| US5618816A (en) | 1997-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |