IL111185A0 - Quinolizinone type compounds - Google Patents
Quinolizinone type compoundsInfo
- Publication number
- IL111185A0 IL111185A0 IL11118594A IL11118594A IL111185A0 IL 111185 A0 IL111185 A0 IL 111185A0 IL 11118594 A IL11118594 A IL 11118594A IL 11118594 A IL11118594 A IL 11118594A IL 111185 A0 IL111185 A0 IL 111185A0
- Authority
- IL
- Israel
- Prior art keywords
- loweralkyl
- amino
- cycloalkyl
- aryl
- nitrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Abstract
Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R<1> is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R<2>is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R<3> is halogen; R<4> is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R<5> is hydrogen, loweralkyl, halo(loweralkyl), or -NR<13>R<14>; and R<6> is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13723693A | 1993-10-14 | 1993-10-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL111185A0 true IL111185A0 (en) | 1994-12-29 |
Family
ID=22476419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11118594A IL111185A0 (en) | 1993-10-14 | 1994-10-06 | Quinolizinone type compounds |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0723545B1 (en) |
JP (1) | JPH09503783A (en) |
KR (1) | KR960704887A (en) |
CN (1) | CN1053188C (en) |
AT (1) | ATE217309T1 (en) |
AU (1) | AU689809B2 (en) |
BR (1) | BR9407806A (en) |
CA (1) | CA2173459A1 (en) |
DE (1) | DE69430581D1 (en) |
IL (1) | IL111185A0 (en) |
WO (1) | WO1995010519A1 (en) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5599816A (en) * | 1990-05-02 | 1997-02-04 | Abbott Laboratories | Quinolizinone type compounds |
DE69428206T2 (en) * | 1993-10-28 | 2002-06-13 | Kaken Pharma Co Ltd | CHINOLINE CARBONIC ACID DERIVATIVES AND THEIR SALTS |
CZ12097A3 (en) * | 1994-07-18 | 1997-09-17 | Ube Industries | Trifluoromethylquinolinecarboxylic acid derivatives and pharmaceutical composition containing thereof |
AU6181296A (en) * | 1995-04-27 | 1996-11-18 | Kaken Pharmaceutical Co., Ltd. | Optically active quinolinecarboxylic acid derivatives and sa lts thereof |
US5618813A (en) * | 1995-05-26 | 1997-04-08 | Abbott Laboratories | Benzo[5.6]pyrano[2.3.4-ij]quinolizine and benzo[5.6]thiopyrano[2.3.4-ij]quinolizine derivatives as antibacterial and antineoplastic agents |
IL122296A0 (en) * | 1995-06-06 | 1998-04-05 | Abbott Lab | Quinolizinone type compounds |
US5789591A (en) * | 1996-10-23 | 1998-08-04 | Abbott Laboratories | Process for preparing 1-substituted 8-chloro-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester compounds |
US5703244A (en) * | 1996-11-21 | 1997-12-30 | Abbott Laboratories | Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds |
US5693813A (en) * | 1997-02-26 | 1997-12-02 | Abbott Laboratories | Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid |
ID24434A (en) * | 1997-05-21 | 2000-07-20 | Daiichi Seiyaku Co | CIS-SUBSTITUTED CIS-SUBSTITUTED AMINOSICLOALCYLPIROLIDIN DERIVATES |
KR100241673B1 (en) * | 1997-08-09 | 2000-03-02 | 김충섭 | Quinolizine Carboxylic acid Derivatives |
PL339408A1 (en) | 1997-09-15 | 2000-12-18 | Procter & Gamble | Antimicrobial quinolones, agents containing them and their applications |
US6630488B1 (en) | 1998-09-21 | 2003-10-07 | Biochem Pharma, Inc. | Quinolizinones as integrin inhibitors |
US6197974B1 (en) | 1998-10-26 | 2001-03-06 | Abbott Laboratories | Enantioselective synthesis of 3-aminopyrrolidines |
WO2001029035A1 (en) * | 1999-10-19 | 2001-04-26 | Sato Pharmaceutical Co., Ltd. | 4-oxoquinolizine antimicrobials having 2-pyridone skeletons as the partial structure |
NZ525570A (en) | 2000-12-14 | 2005-04-29 | Procter & Gamble | Antimicrobial 2-pyridones, their compositions and uses |
AU3089102A (en) | 2000-12-14 | 2002-06-24 | Procter & Gamble | Antimicrobial quinolones |
DE60208541D1 (en) | 2001-05-30 | 2006-03-30 | Warner Lambert Co | ANTIBACTERIAL AGENTS |
DOP2002000386A (en) * | 2001-05-30 | 2002-12-15 | Warner Lambert Co | ANTIBACTERIAL AGENTS |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
HUP0400183A2 (en) | 2001-06-11 | 2004-07-28 | Xenoport Inc. | Orally administered dosage forms of gaba analog prodrugs having reduced toxicity |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
JP4101754B2 (en) * | 2001-09-28 | 2008-06-18 | 佐藤製薬株式会社 | 4-oxoquinolidine antibacterial agent having 2-pyridone skeleton as a partial structure |
US6900224B2 (en) * | 2002-07-31 | 2005-05-31 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
EP1599468B1 (en) * | 2003-01-14 | 2007-10-03 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
DE602004019555D1 (en) * | 2003-09-22 | 2009-04-02 | Janssen Pharmaceutica Nv | HETEROCYCLIC 7-AMINOALKYLIDENYLCHINOLONE AND -NAPHTHYRIDONE |
US7977346B2 (en) | 2006-01-17 | 2011-07-12 | Guoqing Paul Chen | Spiro compounds and methods of use |
MX2008012328A (en) | 2006-03-28 | 2008-10-09 | Procter & Gamble | Malate salts, and polymorphs of (3s,5s)-7-[3-amino-5-methyl-piper idinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecar boxylic acid. |
JP2009531418A (en) | 2006-03-28 | 2009-09-03 | ザ プロクター アンド ギャンブル カンパニー | Coupling method for the preparation of quinolone intermediates |
US8278313B2 (en) | 2008-03-11 | 2012-10-02 | Abbott Laboratories | Macrocyclic spiro pyrimidine derivatives |
US8436005B2 (en) | 2008-04-03 | 2013-05-07 | Abbott Laboratories | Macrocyclic pyrimidine derivatives |
CL2009001152A1 (en) | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compounds derived from n- (4- (nitrogen cycloalkyl-1-yl) -1h-pyrrolo [2,3-b] pyridin-3-yl) amide, kinase inhibitors; Preparation process; pharmaceutical composition; and its use for the treatment of a proliferative disease. |
WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
WO2011149995A1 (en) | 2010-05-25 | 2011-12-01 | Abbott Laboratories | Novel substituted octahydrocyclopenta [c]pyrrol-4-amines as calcium channel blockers |
WO2011149993A2 (en) * | 2010-05-25 | 2011-12-01 | Abbott Laboratories | SUBSTITUTED OCTAHYDROCYCLOPENTA[c]PYRROLES AS CALCIUM CHANNEL MODULATORS |
US8962842B2 (en) | 2010-09-27 | 2015-02-24 | Evolva Sa | 2-pyridone antimicrobial compositions |
WO2012104305A1 (en) * | 2011-02-01 | 2012-08-09 | Evolva Sa | Antimicrobial 4-oxoquinolizines |
CN105001216B (en) * | 2015-07-08 | 2017-03-01 | 中国科学院兰州化学物理研究所 | A kind of preparation method of quinolizine ketone |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3508816A1 (en) * | 1985-01-10 | 1986-07-10 | Bayer Ag, 5090 Leverkusen | 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTYRIDINE-3-CARBONIC ACIDS |
US4921857A (en) * | 1987-09-18 | 1990-05-01 | Merck & Co., Inc. | 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof |
ATE195122T1 (en) * | 1990-05-02 | 2000-08-15 | Abbott Lab | QUINOLIZINONE TYPE COMPOUNDS |
-
1994
- 1994-09-30 CN CN94194479A patent/CN1053188C/en not_active Expired - Fee Related
- 1994-09-30 KR KR1019960701906A patent/KR960704887A/en not_active Application Discontinuation
- 1994-09-30 DE DE69430581T patent/DE69430581D1/en not_active Expired - Lifetime
- 1994-09-30 AT AT94929998T patent/ATE217309T1/en not_active IP Right Cessation
- 1994-09-30 BR BR9407806A patent/BR9407806A/en not_active Application Discontinuation
- 1994-09-30 JP JP7511876A patent/JPH09503783A/en active Pending
- 1994-09-30 EP EP94929998A patent/EP0723545B1/en not_active Expired - Lifetime
- 1994-09-30 CA CA002173459A patent/CA2173459A1/en not_active Abandoned
- 1994-09-30 WO PCT/US1994/011166 patent/WO1995010519A1/en active IP Right Grant
- 1994-09-30 AU AU79258/94A patent/AU689809B2/en not_active Ceased
- 1994-10-06 IL IL11118594A patent/IL111185A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1137273A (en) | 1996-12-04 |
DE69430581D1 (en) | 2002-06-13 |
BR9407806A (en) | 1997-08-19 |
AU7925894A (en) | 1995-05-04 |
ATE217309T1 (en) | 2002-05-15 |
WO1995010519A1 (en) | 1995-04-20 |
CN1053188C (en) | 2000-06-07 |
CA2173459A1 (en) | 1995-04-20 |
KR960704887A (en) | 1996-10-09 |
EP0723545B1 (en) | 2002-05-08 |
AU689809B2 (en) | 1998-04-09 |
EP0723545A1 (en) | 1996-07-31 |
JPH09503783A (en) | 1997-04-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL111185A0 (en) | Quinolizinone type compounds | |
MX9709416A (en) | Quinolizinone type compounds. | |
IL96550A0 (en) | Amino acid derivatives,their manufacture and pharmaceutical compositions containing them | |
TW221053B (en) | ||
HU9302329D0 (en) | 7-(substituted)-9-|(substituted glycyl)-amino¨-6-desmethyl-6-desoxy-tetracyclines, pharmaceutical preparatives containing them and methods for producing them | |
HU9302330D0 (en) | 7-(substituted)-9-|(substituted glycyl)-amino¨-6-desmethyl-6-desoxy-tetracyclines, pharmaceutical preparatives containing them and methods for producing them | |
IL110151A0 (en) | Amide and urea derivatives and pharmaceutical compositions containing the same | |
GR3004482T3 (en) | ||
IL97535A0 (en) | Squalene synthetase inhibitor dioxabicyclo(1,2,3)octanes,their production and pharmaceutical compositions containing them | |
IL105020A0 (en) | Carbapenem derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
AU561132B2 (en) | Biologically active heptapeptides | |
ZA941196B (en) | Angiopeptin cyclopeptide compounds process for the preparation thereof and pharmaceutical compositions containing them | |
IL98394A0 (en) | Ws7622a mono or di-sulfate,salts thereof,processes for the preparation thereof and pharmaceutical compositions containing the same | |
HUT42492A (en) | Process for producing cepheme-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents | |
AP2001002154A0 (en) | Hygromycin a derivatives (changed by the ISA to read hygromycin a derivatives as antibacterial agents. | |
AU4706489A (en) | Oxadiazol-azabicycl compounds and their pharmaceutical use | |
IL109227A0 (en) | Leustroducsin h, pharmaceutical composition containing the same, and processes for the preparation thereof | |
HUT45036A (en) | Process for producing new crystalline semi-hydrate of 3-methoxy-4-(4'-amino-benzenesulfonamido)-1,2,5-thiadiazole | |
HUT53654A (en) | Process for producing cefemcarboxylic acid compounds and pharmaceutical compositions comprising such compounds | |
MY111630A (en) | Amino acid derivatives. |