MX9709416A - Quinolizinone type compounds. - Google Patents

Quinolizinone type compounds.

Info

Publication number
MX9709416A
MX9709416A MX9709416A MX9709416A MX9709416A MX 9709416 A MX9709416 A MX 9709416A MX 9709416 A MX9709416 A MX 9709416A MX 9709416 A MX9709416 A MX 9709416A MX 9709416 A MX9709416 A MX 9709416A
Authority
MX
Mexico
Prior art keywords
loweralkyl
compounds
loweralkoxy
halo
halogen
Prior art date
Application number
MX9709416A
Other languages
Spanish (es)
Inventor
Daniel T Chu
Qun Li
Curt S Cooper
Anthony K Fung
Cheuk M Lee
Jacob J Plattner
Zhenkun Ma
Wei-Bo Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX9709416A publication Critical patent/MX9709416A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Antibacterial compounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds wherein A is =CR6-; R1 is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R2 is selected from the group consisting of (a), (b), (c) and (d); R3 is halogen; R4 is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R5 is hydrogen, loweralkyl, halo(loweralkyl), or -NR13R14; and R6 is halogen, loeralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy, or amino(loweralkyl), as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.
MX9709416A 1995-06-06 1997-12-02 Quinolizinone type compounds. MX9709416A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46915995A 1995-06-06 1995-06-06
US63811296A 1996-05-29 1996-05-29

Publications (1)

Publication Number Publication Date
MX9709416A true MX9709416A (en) 1998-07-31

Family

ID=27042662

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9709416A MX9709416A (en) 1995-06-06 1997-12-02 Quinolizinone type compounds.

Country Status (8)

Country Link
EP (1) EP0871628A1 (en)
JP (1) JPH11510478A (en)
KR (1) KR19990022524A (en)
AU (1) AU6153096A (en)
CA (1) CA2222322A1 (en)
IL (1) IL122296A0 (en)
MX (1) MX9709416A (en)
WO (1) WO1996039407A1 (en)

Families Citing this family (43)

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EP0920306A2 (en) 1996-07-12 1999-06-09 Leukosite, Inc. Chemokine receptor antagonists and methods of use therefor
US5693813A (en) * 1997-02-26 1997-12-02 Abbott Laboratories Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid
KR100241673B1 (en) * 1997-08-09 2000-03-02 김충섭 Quinolizine Carboxylic acid Derivatives
EP1015445B1 (en) 1997-09-15 2009-02-25 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
US6630488B1 (en) 1998-09-21 2003-10-07 Biochem Pharma, Inc. Quinolizinones as integrin inhibitors
ES2244248T3 (en) * 1998-11-24 2005-12-01 Daiichi Pharmaceutical Co., Ltd. AMINOMETILPIRROLIDINE DERIVATIVES REPLACED BY CYCLALQUILOS.
KR100768034B1 (en) 1999-03-17 2007-10-17 다이이찌 세이야꾸 가부시기가이샤 Pharmaceutical composition
JP2003516988A (en) * 1999-12-14 2003-05-20 ニューロサーチ、アクティーゼルスカブ New heteroaryl-diazabicycloalkanes
DE19962470A1 (en) * 1999-12-22 2001-07-12 Schulz Hans Herrmann Use of chemotherapy drugs
SE0100326D0 (en) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
ATE404558T1 (en) * 2001-09-28 2008-08-15 Sato Pharma ANTIMICROBIAL 4-OXOCINOLICINE COMPOUNDS THAT HAVE A 2-PYRIDONE SKELETON AS A PARTIAL STRUCTURE
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
JP2007522093A (en) * 2003-09-22 2007-08-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 7-aminoalkylidenyl-heterocyclic quinolones and naphthyridones
EP1693364B1 (en) 2003-12-12 2015-05-20 Daiichi Sankyo Company, Limited Intermediates for the production of optically active cyclopropylamine derivatives and process for the production of the intermediates
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
SMP200800058B (en) 2006-03-28 2009-09-07 Procter & Gamble Diseased salts and polymorphs of an acid (3s, 5s) -7- [3-amino-5-methylpiperidinyl] -1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolincarboxylic
US7456279B2 (en) 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
CN101622240B (en) * 2007-01-05 2014-07-23 第一三共株式会社 Fused substituted aminopyrrolidine derivative
NZ577214A (en) 2007-01-05 2011-11-25 Daiichi Sankyo Co Ltd Fused substituted aminopyrrolidine derivatives useful as antibacterial reagents
EP2236494B1 (en) 2007-12-26 2016-08-31 Msd K.K. Sulfonyl substituted 6-membered ring derivative
JP5433992B2 (en) * 2008-06-26 2014-03-05 Ｄｉｃ株式会社 Method for producing fluorochromanol derivative
JP5433996B2 (en) * 2008-07-10 2014-03-05 Ｄｉｃ株式会社 Method for producing fluorophenol derivative
EP2423211B1 (en) * 2009-04-20 2014-04-16 Kaneka Corporation Processes for producing (1s,6s)- or (1r,6r)-cis-2,8-diazabicyclo[4.3.0]nonane and intermediate thereof
US8796297B2 (en) 2009-06-30 2014-08-05 Abbvie Inc. 4-substituted-2-amino-pyrimidine derivatives
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
JP5487425B2 (en) * 2009-09-11 2014-05-07 毅 野田 Optically active 2-substituted-3-aminopiperidine derivatives and production method
EP2491038B1 (en) 2009-10-23 2016-04-06 Janssen Pharmaceutica N.V. Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators
WO2013119916A2 (en) 2012-02-10 2013-08-15 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
WO2016196386A1 (en) 2015-05-30 2016-12-08 Ptc Therapeutics, Inc. Methods for modulating rna splicing
CN113717154A (en) 2015-12-10 2021-11-30 Ptc医疗公司 Methods for treating huntington's disease
MY197558A (en) 2016-03-10 2023-06-23 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
CN106543170B (en) * 2016-10-27 2018-02-23 丹诺医药(苏州）有限公司 The carboxylate of 8 chlorine, 1 cyclopropyl, 7 fluorine, 9 methyl, 4 oxygen, 4 hydrogen quinolizine 3 and its synthetic method
US11702646B2 (en) 2016-11-28 2023-07-18 Ptc Therapeutics, Inc. Methods for modulating RNA splicing
WO2018226622A1 (en) 2017-06-05 2018-12-13 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
CN111372611A (en) 2017-06-14 2020-07-03 Ptc医疗公司 Methods of modifying RNA splicing
BR112019027717A2 (en) 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. methods to treat huntington's disease
EP3645121A4 (en) 2017-06-28 2021-03-17 PTC Therapeutics, Inc. Methods for treating huntington's disease
KR20210005559A (en) 2018-03-27 2021-01-14 피티씨 테라퓨틱스, 인크. Huntington's Disease Treatment Compound
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
CA3103976A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating huntington's disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE911472A1 (en) * 1990-05-02 1991-11-06 Abbott Lab Quinolizinone type compounds
ATE217309T1 (en) * 1993-10-14 2002-05-15 Abbott Lab QUINOLIZINONE TYPE COMPOUNDS

Also Published As

Publication number Publication date
WO1996039407A1 (en) 1996-12-12
KR19990022524A (en) 1999-03-25
AU6153096A (en) 1996-12-24
JPH11510478A (en) 1999-09-14
EP0871628A1 (en) 1998-10-21
IL122296A0 (en) 1998-04-05
CA2222322A1 (en) 1996-12-12

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