IL107554A - Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them - Google Patents
Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing themInfo
- Publication number
- IL107554A IL107554A IL10755493A IL10755493A IL107554A IL 107554 A IL107554 A IL 107554A IL 10755493 A IL10755493 A IL 10755493A IL 10755493 A IL10755493 A IL 10755493A IL 107554 A IL107554 A IL 107554A
- Authority
- IL
- Israel
- Prior art keywords
- taxanes
- chain
- pharmaceutical compositions
- compositions containing
- substituted side
- Prior art date
Links
- 125000004369 butenyl group Chemical group C(=CCC)* 0.000 title abstract 2
- 229940123237 Taxane Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/975,705 US5284864A (en) | 1991-09-23 | 1992-11-13 | Butenyl substituted taxanes and pharmaceutical compositions containing them |
| US08/005,229 US5338872A (en) | 1993-01-15 | 1993-01-15 | Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof |
| US08/010,798 US5399726A (en) | 1993-01-29 | 1993-01-29 | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
| US08/026,978 US5990325A (en) | 1993-03-05 | 1993-03-05 | Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof |
| US08/034,247 US5430160A (en) | 1991-09-23 | 1993-03-22 | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US9471993A | 1993-07-20 | 1993-07-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL107554A0 IL107554A0 (en) | 1994-02-27 |
| IL107554A true IL107554A (en) | 2005-03-20 |
Family
ID=27555508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10755493A IL107554A (en) | 1992-11-13 | 1993-11-10 | Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0668762B1 (xx) |
| JP (2) | JPH08503218A (xx) |
| CN (2) | CN1065240C (xx) |
| AT (1) | ATE249826T1 (xx) |
| CA (1) | CA2147984C (xx) |
| DE (1) | DE69333208T2 (xx) |
| DK (1) | DK0668762T3 (xx) |
| ES (1) | ES2206465T3 (xx) |
| IL (1) | IL107554A (xx) |
| PT (1) | PT668762E (xx) |
| WO (1) | WO1994010996A1 (xx) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5710287A (en) | 1991-09-23 | 1998-01-20 | Florida State University | Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them |
| US5405972A (en) * | 1993-07-20 | 1995-04-11 | Florida State University | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes |
| FR2712289B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| GB9405400D0 (en) * | 1994-03-18 | 1994-05-04 | Erba Carlo Spa | Taxane derivatives |
| US6500858B2 (en) | 1994-10-28 | 2002-12-31 | The Research Foundation Of The State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| AU4133096A (en) * | 1994-10-28 | 1996-05-23 | Research Foundation Of The State University Of New York, The | Taxoid derivatives, their preparation and their use as antitumor agents |
| US6458976B1 (en) | 1994-10-28 | 2002-10-01 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods |
| EP1391459A1 (en) * | 1999-08-11 | 2004-02-25 | Bristol-Myers Squibb Company | Process for the preparation of a paclitaxel C-4 methyl carbonate analog and intermediates |
| PL1664033T3 (pl) | 2003-09-25 | 2008-04-30 | Tapestry Pharmaceuticals Inc | Analogi 9,10-alfa, alfa-OH-taksanu i sposoby ich wytwarzania |
| EP1810968A3 (en) * | 2003-09-25 | 2007-08-08 | Tapestry Pharmaceuticals, Inc. | 9, 10-a, a-OH-taxane analogs and methods for production thereof |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
-
1993
- 1993-11-01 AT AT94902223T patent/ATE249826T1/de not_active IP Right Cessation
- 1993-11-01 JP JP6512298A patent/JPH08503218A/ja active Pending
- 1993-11-01 CA CA002147984A patent/CA2147984C/en not_active Expired - Fee Related
- 1993-11-01 DK DK94902223T patent/DK0668762T3/da active
- 1993-11-01 ES ES94902223T patent/ES2206465T3/es not_active Expired - Lifetime
- 1993-11-01 DE DE69333208T patent/DE69333208T2/de not_active Expired - Fee Related
- 1993-11-01 WO PCT/US1993/010813 patent/WO1994010996A1/en active IP Right Grant
- 1993-11-01 EP EP94902223A patent/EP0668762B1/en not_active Expired - Lifetime
- 1993-11-01 PT PT94902223T patent/PT668762E/pt unknown
- 1993-11-10 IL IL10755493A patent/IL107554A/xx not_active IP Right Cessation
- 1993-11-13 CN CN93112764A patent/CN1065240C/zh not_active Expired - Fee Related
-
1999
- 1999-08-18 CN CNB991180607A patent/CN1205184C/zh not_active Expired - Fee Related
-
2006
- 2006-07-06 JP JP2006186450A patent/JP2006257108A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08503218A (ja) | 1996-04-09 |
| CN1270958A (zh) | 2000-10-25 |
| CN1205184C (zh) | 2005-06-08 |
| CN1092416A (zh) | 1994-09-21 |
| CN1065240C (zh) | 2001-05-02 |
| WO1994010996A1 (en) | 1994-05-26 |
| CA2147984A1 (en) | 1994-05-26 |
| EP0668762A1 (en) | 1995-08-30 |
| DE69333208T2 (de) | 2004-04-08 |
| DE69333208D1 (de) | 2003-10-23 |
| AU677267B2 (en) | 1997-04-17 |
| ES2206465T3 (es) | 2004-05-16 |
| AU2621097A (en) | 1997-09-18 |
| IL107554A0 (en) | 1994-02-27 |
| CA2147984C (en) | 2006-03-14 |
| AU5667094A (en) | 1994-06-08 |
| DK0668762T3 (da) | 2004-01-05 |
| EP0668762A4 (en) | 1995-12-20 |
| ATE249826T1 (de) | 2003-10-15 |
| AU706985B2 (en) | 1999-07-01 |
| PT668762E (pt) | 2004-02-27 |
| JP2006257108A (ja) | 2006-09-28 |
| EP0668762B1 (en) | 2003-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |