IL106065A - Synthetic peptides for the treatment of myasthenia gravis and preparations containing them - Google Patents
Synthetic peptides for the treatment of myasthenia gravis and preparations containing themInfo
- Publication number
- IL106065A IL106065A IL10606593A IL10606593A IL106065A IL 106065 A IL106065 A IL 106065A IL 10606593 A IL10606593 A IL 10606593A IL 10606593 A IL10606593 A IL 10606593A IL 106065 A IL106065 A IL 106065A
- Authority
- IL
- Israel
- Prior art keywords
- peptide
- response
- amino acid
- inhibiting
- accordance
- Prior art date
Links
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- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 108010092114 histidylphenylalanine Proteins 0.000 description 1
- QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000005462 in vivo assay Methods 0.000 description 1
- 238000012750 in vivo screening Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
- 229940011051 isopropyl acetate Drugs 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 235000018977 lysine Nutrition 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 108091005601 modified peptides Proteins 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 230000036473 myasthenia Effects 0.000 description 1
- QCOXCILKVHKOGO-UHFFFAOYSA-N n-(2-nitramidoethyl)nitramide Chemical compound [O-][N+](=O)NCCN[N+]([O-])=O QCOXCILKVHKOGO-UHFFFAOYSA-N 0.000 description 1
- 229960002362 neostigmine Drugs 0.000 description 1
- LULNWZDBKTWDGK-UHFFFAOYSA-M neostigmine bromide Chemical compound [Br-].CN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 LULNWZDBKTWDGK-UHFFFAOYSA-M 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 210000000715 neuromuscular junction Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 108010054442 polyalanine Proteins 0.000 description 1
- 239000012985 polymerization agent Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000001242 postsynaptic effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 108010079317 prolyl-tyrosine Proteins 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 229910001426 radium ion Inorganic materials 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12244593A IL122445A (en) | 1992-06-18 | 1993-06-18 | Peptide polymers and pharmaceutical compositions comprising them for treatment of myasthenia gravis |
| IL12244597A IL122445A0 (en) | 1992-06-18 | 1993-06-18 | Peptide polymers and pharmaceutical compositions comprising them for treatment of myasthenia gravis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90039392A | 1992-06-18 | 1992-06-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL106065A0 IL106065A0 (en) | 1993-10-20 |
| IL106065A true IL106065A (en) | 1999-10-28 |
Family
ID=25412446
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10606593A IL106065A (en) | 1992-06-18 | 1993-06-18 | Synthetic peptides for the treatment of myasthenia gravis and preparations containing them |
| IL12244593A IL122445A (en) | 1992-06-18 | 1993-06-18 | Peptide polymers and pharmaceutical compositions comprising them for treatment of myasthenia gravis |
| IL12244597A IL122445A0 (en) | 1992-06-18 | 1993-06-18 | Peptide polymers and pharmaceutical compositions comprising them for treatment of myasthenia gravis |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12244593A IL122445A (en) | 1992-06-18 | 1993-06-18 | Peptide polymers and pharmaceutical compositions comprising them for treatment of myasthenia gravis |
| IL12244597A IL122445A0 (en) | 1992-06-18 | 1993-06-18 | Peptide polymers and pharmaceutical compositions comprising them for treatment of myasthenia gravis |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0646016B1 (de) |
| JP (1) | JP3996635B2 (de) |
| AT (1) | ATE183652T1 (de) |
| AU (1) | AU678372B2 (de) |
| CA (1) | CA2138258C (de) |
| DE (1) | DE69326145T2 (de) |
| DK (1) | DK0646016T3 (de) |
| ES (1) | ES2139667T3 (de) |
| GR (1) | GR3031371T3 (de) |
| IL (3) | IL106065A (de) |
| WO (1) | WO1994000148A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6066621A (en) * | 1989-12-10 | 2000-05-23 | Yeda Research And Development Co. Ltd. | Synthetic peptides for the treatment of myasthenia gravis |
| US5843462A (en) * | 1995-11-30 | 1998-12-01 | Regents Of The University Of Minnesota | Diphtheria toxin epitopes |
| CA2315537A1 (en) | 1997-12-16 | 1999-06-24 | Regents Of The University Of Minnesota | Methods to treat undesirable immune responses |
| JP2003521448A (ja) | 1998-07-23 | 2003-07-15 | ザ・プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | 合成ペプチドおよび自己免疫疾患治療のための使用方法 |
| WO2022260579A2 (en) | 2021-06-07 | 2022-12-15 | Toleranzia Ab | Fusion protein in myasthenia gravis |
| CN121175067A (zh) * | 2023-03-24 | 2025-12-19 | 库尔制药开发公司 | 用于重症肌无力治疗的耐受性免疫修饰纳米颗粒 |
-
1993
- 1993-06-18 AU AU46429/93A patent/AU678372B2/en not_active Ceased
- 1993-06-18 CA CA002138258A patent/CA2138258C/en not_active Expired - Fee Related
- 1993-06-18 IL IL10606593A patent/IL106065A/en not_active IP Right Cessation
- 1993-06-18 ES ES93916644T patent/ES2139667T3/es not_active Expired - Lifetime
- 1993-06-18 AT AT93916644T patent/ATE183652T1/de not_active IP Right Cessation
- 1993-06-18 JP JP50250294A patent/JP3996635B2/ja not_active Expired - Fee Related
- 1993-06-18 IL IL12244593A patent/IL122445A/xx not_active IP Right Cessation
- 1993-06-18 WO PCT/US1993/005906 patent/WO1994000148A1/en not_active Ceased
- 1993-06-18 IL IL12244597A patent/IL122445A0/xx unknown
- 1993-06-18 EP EP93916644A patent/EP0646016B1/de not_active Expired - Lifetime
- 1993-06-18 DK DK93916644T patent/DK0646016T3/da active
- 1993-06-18 DE DE69326145T patent/DE69326145T2/de not_active Expired - Fee Related
-
1999
- 1999-09-29 GR GR990402465T patent/GR3031371T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0646016B1 (de) | 1999-08-25 |
| JP3996635B2 (ja) | 2007-10-24 |
| DE69326145T2 (de) | 2000-04-27 |
| ES2139667T3 (es) | 2000-02-16 |
| AU678372B2 (en) | 1997-05-29 |
| EP0646016A4 (de) | 1995-07-12 |
| IL106065A0 (en) | 1993-10-20 |
| WO1994000148A1 (en) | 1994-01-06 |
| CA2138258C (en) | 2003-08-19 |
| IL122445A (en) | 2000-08-31 |
| IL122445A0 (en) | 1998-06-15 |
| ATE183652T1 (de) | 1999-09-15 |
| GR3031371T3 (en) | 2000-01-31 |
| AU4642993A (en) | 1994-01-24 |
| DK0646016T3 (da) | 2000-03-20 |
| DE69326145D1 (de) | 1999-09-30 |
| EP0646016A1 (de) | 1995-04-05 |
| JPH07508521A (ja) | 1995-09-21 |
| CA2138258A1 (en) | 1994-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| RH | Patent void | ||
| NE | Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967) | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |