IL104260A0 - 2-saccharinylmethyl heterocyclic carboxylates and pharmaceutical compositions containing them - Google Patents

2-saccharinylmethyl heterocyclic carboxylates and pharmaceutical compositions containing them

Info

Publication number
IL104260A0
IL104260A0 IL104260A IL10426092A IL104260A0 IL 104260 A0 IL104260 A0 IL 104260A0 IL 104260 A IL104260 A IL 104260A IL 10426092 A IL10426092 A IL 10426092A IL 104260 A0 IL104260 A0 IL 104260A0
Authority
IL
Israel
Prior art keywords
alkyl
alkylamino
perfluorolower
dilower
piperazinyl
Prior art date
Application number
IL104260A
Other languages
English (en)
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Priority to IL11990592A priority Critical patent/IL119905A/en
Publication of IL104260A0 publication Critical patent/IL104260A0/xx
Priority to IL11990596A priority patent/IL119905A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
IL104260A 1991-12-30 1992-12-29 2-saccharinylmethyl heterocyclic carboxylates and pharmaceutical compositions containing them IL104260A0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL11990592A IL119905A (en) 1991-12-30 1992-12-29 4,5,6,7-Tetrahydro-2- saccharinylmethyl heterocyclic carboxylates and pharmaceutical compositions containing them
IL11990596A IL119905A0 (en) 1991-12-30 1996-12-25 4,5,6,7-tetrahydro-2-saccharinylmethyl heterocyclic carboxylates and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81662191A 1991-12-30 1991-12-30

Publications (1)

Publication Number Publication Date
IL104260A0 true IL104260A0 (en) 1993-05-13

Family

ID=25221159

Family Applications (1)

Application Number Title Priority Date Filing Date
IL104260A IL104260A0 (en) 1991-12-30 1992-12-29 2-saccharinylmethyl heterocyclic carboxylates and pharmaceutical compositions containing them

Country Status (18)

Country Link
US (5) US5376653A (xx)
EP (1) EP0550111B1 (xx)
JP (1) JPH05255287A (xx)
AT (1) ATE178899T1 (xx)
AU (1) AU653279B2 (xx)
CA (1) CA2086346A1 (xx)
CZ (1) CZ386892A3 (xx)
DE (1) DE69228923D1 (xx)
FI (1) FI925947A (xx)
HU (2) HUT65735A (xx)
IL (1) IL104260A0 (xx)
MX (1) MX9207611A (xx)
NO (1) NO301882B1 (xx)
NZ (1) NZ245587A (xx)
RU (1) RU2078081C1 (xx)
SG (1) SG50076A1 (xx)
SK (1) SK16599A3 (xx)
TW (1) TW223633B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380737A (en) * 1989-05-04 1995-01-10 Sterling Winthrop Inc. Saccharin derivative proteolytic enzyme inhibitors
US5306818A (en) * 1990-11-01 1994-04-26 Sterling Winthrop Inc. Tetrahydro 2-saccharinylmerthyl aryl carboxylates
TW226016B (xx) * 1991-12-30 1994-07-01 Sterling Winthrop Inc
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US6673335B1 (en) * 1992-07-08 2004-01-06 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized medicaments
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
GB2355457A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
WO2002069883A2 (en) * 2001-02-06 2002-09-12 Universita Degli Studi Di Padova Cathecin derivatives as leukocyte elastase inhibitors for treating inflammatory disorders
US20030100594A1 (en) * 2001-08-10 2003-05-29 Pharmacia Corporation Carbonic anhydrase inhibitor
EP1507858B1 (en) * 2002-05-29 2008-09-17 DSM IP Assets B.V. Method for the purification of a rhizomucor aspartic protease
BRPI0811651A2 (pt) * 2007-05-18 2014-11-11 Inhibox Ltd Composto, composição farmacêutica, métodos para preparar uma composição farmacêutica, para tratar uma doença, distúrbio ou condição, para inibir a tace em uma célula, in vitro ou in vivo, e de regular (por exemplo, inibir) a liberação da citocina (por exemplo, a liberação da tnf-alfa) em uma célula, in vitro ou in vivo, uso de um composto, e, kit

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002884A (en) * 1959-04-15 1961-10-03 Rohm & Haas Horticultural process with n-halomethyl-1,2-benzisothiazolin - 3 - one-1,1-dioxides for controlling fungus diseases
US3314960A (en) * 1964-08-25 1967-04-18 American Home Prod Benzisothiazol glutarimides
FR1451417A (fr) * 1965-07-15 1966-01-07 Roussel Uclaf Nouveaux esters d'acides cycliques et leur procédé de préparation
JPS4835457A (xx) * 1971-09-02 1973-05-24
US4195023A (en) * 1975-08-20 1980-03-25 Merck & Co., Inc. 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
US4074048A (en) * 1976-05-10 1978-02-14 Warner-Lambert Company Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
US4263393A (en) * 1979-09-06 1981-04-21 Eastman Kodak Company Novel electron donor precursors and photographic element containing them
US4350752A (en) * 1980-12-29 1982-09-21 Eastman Kodak Company Photographic elements and film units containing imidomethyl blocked photographic reagents
US4363865A (en) * 1981-03-04 1982-12-14 Eastman Kodak Company Imido methyl blocked photographic dyes and dye releasing compounds
US4410618A (en) * 1982-06-11 1983-10-18 Eastman Kodak Company Blocked photographic reagents
US4623645A (en) * 1983-04-18 1986-11-18 Merck & Co., Inc. Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4659855A (en) * 1983-05-09 1987-04-21 Georgia Tech Research Corporation Aryl sulfonyl fluoride compounds
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
EP0253029A1 (en) * 1986-07-10 1988-01-20 Keng-Ben Wang A distilled drinking water fountain
US5380737A (en) * 1989-05-04 1995-01-10 Sterling Winthrop Inc. Saccharin derivative proteolytic enzyme inhibitors
WO1990013549A1 (en) * 1989-05-04 1990-11-15 Sterling Winthrop Inc. Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof
US5128339A (en) * 1990-11-01 1992-07-07 Sterling Winthrop Inc. Proteolytic enzyme inhibition method
DE4003541C1 (xx) * 1990-02-06 1991-08-08 Alter S.A., Madrid, Es
FR2659327A1 (fr) * 1990-03-08 1991-09-13 Centre Nat Rech Scient Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases.
AU642537B2 (en) * 1990-11-01 1993-10-21 Sanofi 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5187173A (en) * 1991-12-27 1993-02-16 Sterling Winthrop Inc. 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
JPH07200419A (ja) * 1993-12-28 1995-08-04 Nec Corp バスインタフェース装置
DE4420271B4 (de) * 1994-06-10 2007-09-27 Robert Bosch Gmbh Zündspulensatz für eine Mehrzylinder-Brennkraftmaschine

Also Published As

Publication number Publication date
SG50076A1 (en) 1998-06-15
NO925042L (no) 1993-07-01
FI925947A0 (fi) 1992-12-30
US5376653A (en) 1994-12-27
FI925947A (fi) 1993-07-01
NO925042D0 (no) 1992-12-30
NZ245587A (en) 1994-07-26
AU2966892A (en) 1993-07-01
HUT65735A (en) 1994-07-28
TW223633B (xx) 1994-05-11
EP0550111A1 (en) 1993-07-07
CZ386892A3 (en) 1993-09-15
MX9207611A (es) 1993-06-01
JPH05255287A (ja) 1993-10-05
US5856349A (en) 1999-01-05
US5563163A (en) 1996-10-08
DE69228923D1 (de) 1999-05-20
HU9204167D0 (en) 1993-04-28
US5652254A (en) 1997-07-29
EP0550111B1 (en) 1999-04-14
ATE178899T1 (de) 1999-04-15
NO301882B1 (no) 1997-12-22
AU653279B2 (en) 1994-09-22
RU2078081C1 (ru) 1997-04-27
CA2086346A1 (en) 1993-07-01
US5488062A (en) 1996-01-30
SK16599A3 (en) 1999-07-12
HU211662A9 (en) 1995-12-28

Similar Documents

Publication Publication Date Title
TW223633B (xx)
MY101208A (en) Phenyl-piperazine anti-arrhythmia agents.
NO923197D0 (no) Substituerte heterocykliske forbindelser
FI960155A0 (fi) Terapeuttisia heterosyklisiä yhdisteitä
DK586588A (da) Terapeutiske heterocycliske forbindelser
NO930517L (no) Benzimidazolylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
DK499385D0 (da) Piperazinforbindelser
MX9203262A (es) Agentes quelantes del acido 1,4,7,10-tetraazaciclododecano.
MY108926A (en) Novel 2-saccharinylmelthyl aryl and aryloxy acetates useful aas proteolytic enzyme inhibitors and compositions and method of use thereof
MY116980A (en) Pde iv inhibiting 2-cyanoiminoimidazole derivatives
ATE99936T1 (de) Pyrazin-derivate als arneimittel zur kontrolle und/oder senkung des serum triglyzeridund/oder- cholesterolspiegels in saeugetieren.
NO913331L (no) 4-substituerte dihydropyrido(4,3-d)pyrimidiner for behandling av hudforstyrrelser.
NO165195C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive nye derivater av 4,5-dihydro-oksazolyl-2-((2-pyridyl)-metyl-tio- eller metylsulfinyl)-benz- eller tienoimidazoler.
DE3764667D1 (de) Substituierte carbonsaeureamide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
IL102241A0 (en) Orally active antiviral compounds
IL89257A (en) Antiulcer pyrimidine derivatives, pharmaceutical compositions containing them and intermediates for their preparation
DK0401049T3 (da) Beta-lactam elastase inhibitorer
ATE24512T1 (de) Beta-lactamase hemmendes 6-(alkoxyaminomethyl)penicillans|ure-1,1-dioxid und derivate.
DE3370961D1 (en) Substituted 9h-8-oxo-pyrimido(2,1-f)purine-2,4-diones, process for their production and pharmaceutical compositions containing them
MX9703074A (es) Inhibidores de sintesis de apoliproteina-b.

Legal Events

Date Code Title Description
FF Patent granted
FF Patent granted
RH Patent void