IE912997A1

IE912997A1 - Substituted valinamide derivatives

Info

Publication number: IE912997A1
Application number: IE299791A
Authority: IE
Inventors: Thomas Seitz; Detlef Wollweber; Wilhelm Brandes; Heinz-Wilhelm Dehne
Original assignee: Bayer Ag
Priority date: 1990-08-25
Filing date: 1991-08-23
Publication date: 1992-02-26
Also published as: HU912775D0; IE66012B1; DE59104468D1; ZA916691B; KR920004338A; EP0550788A1; PL291508A1; PL165204B1; PL294789A1; PT98696B; GR3015191T3; HU209456B; JPH04230652A; PL167500B1; BR9103637A; KR100190298B1; JPH0768200B2; HUT59082A; EP0472996B1; MX9100720A

Abstract

There are described novel valinamide derivatives of the formula (I) in which R<1> represents i-propyl or s-butyl and R<2> represents chlorine, methyl, ethyl or methoxy, their preparation, and their use as pesticides.

Description

The invention relates to new valinamide derivatives, to a process for their preparation, and to their use as pesticides, in particular as fungicides.

The substances according to the invention have an 5 outstanding action in the control of pests. In particular, they can be used as fungicides, mainly in plant protection.

Certain amino acid amides have already been disclosed (cf., for example, EP-A 236,874). However, the use of these compounds in pesticides has not been described.

New valinamide derivatives of the general formula (I) in which (I) R1 represents i-propyl or s-butyl and R2 represents chlorine, methyl, ethyl or methoxy, have now been found.

The compounds of the formula (I) contain two centres of Le A 27 895 - 1ftIE 912997 chirality and can therefore exist in various mixtures of enantiomers and diastereomers, which, if appropriate, can be resolved in the customary fashion. The invention claims the pure enantiomers and diastereomers as well as the mixtures.

For simplicity's sake, the following text will always mention compounds of the formula (I), even though this is understood as meaning the pure compounds as well as the mixtures having various proportions of isomeric, enantiomeric and diastereomeric compounds.

The valinamide derivatives of the general formula (I) in which R1 R2 H3Cv xCH3 CH R1-O-CO-NH-CH-CO-NH-C represents represents (I) » I ch3 i-propyl or s-butyl and chlorine, methyl, ethyl or methoxy are obtained when a substituted amino acid of the formula (II) H3C^ /CH3 CH . ι rI-O-CO-NH-CH-COOH * Le A 27 895 in which R1 represents i-propyl or s-butyl, or their carboxyl-activated derivatives, is reacted with an amine of the formula (III) ch3 in which R2 represents chlorine, methyl, ethyl or methoxy, if appropriate in the presence of a catalyst, if appropriate in the presence of an acid-binding agent and if appropriate in the presence of a diluent.

If, for example, i-propyloxycarbonyl-L-valine and 4-chlorophenethylamine are used as starting materials, the course of the process according to the invention can be illustrated by the following equation: Le A 27 895 (CH3)2ch-o-co-nh-ch-co- ch3 Preferred compounds of the formula (I) are those in which the basic amino acid of the formula (II) is i-propyloxycarbonyl-L-valine or s-butoxycarbonyl-L-valine and the phenethylamine of the formula (III) employed, in which R2 represents chlorine, methyl, ethyl or methoxy, is either racemic or has the R(+) configuration or the S(-) configuration on the asymmetric centre.

Particularly preferred compounds of the formula (I) are those in which Le A 27 895 the basic amino acid is i-propyloxy-carbonyl-L-valine or s-butoxycarbonyl-L-valine and the phenethylamine employed, in which R2 represents chlorine, methyl, ethyl or methoxy, is either racemic or has the R( + ) configuration on the asymmetric centre.

Formula (II) provides a general definition of the amino acid derivatives to be used as starting substances for carrying out the process according to the invention. In this formula, R1 and R2 preferably have the meanings which have already been mentioned in connection with the description of the substances of the formula (I) according to the invention as being preferred for these substituents.

The amino acid derivatives of the formula (II) are generally known (cf., for example, Houben-Weyl, Methoden der organischen Chemie [Methods in Organic Chemistry], Volume XV, parts 1 and 2, pages 46 et seq. and 112 et seq., Georg Thieme Verlag, Stuttgart 1974; D. Keller et. al., Org. Synth. 60., 2145 (1981); or R.C. Sheppard, A Specialist Periodical Report, Amino-acids, Peptids and Proteins, The Royal Society of Chemistry, Burlington House, London 1978, or I.P. Greenstein and M. Winitz, Chemistry of Amino Acids, I. Wiley Sons Inc., New York, London 1961; or E. Schrdder and K. Liibke, The Peptides Le A 27 895 Vol. I, Academic Press, New York, London 1965) or they can be obtained by the processes described in these publications.

The carboxyl-activated derivatives of the amino acid of 5 the formula (II) which are furthermore to be used as starting substances for carrying out the process according to the invention are generally known.

Suitable carboxyl-activated derivatives of the amino acids of the formula (II) are all carboxyl-activated derivatives, such as acid halides such as, for example, acid chlorides, acid azides, furthermore symmetric and mixed anhydrides such as, for example, the mixed 0alkylcarbonic anhydrides, furthermore activated esters such as, for example, p-nitrophenyl esters or N-hydroxy15 succinimide esters, or activated forms of the amino acids which have been prepared in situ using condensing agents such as, for example, dicyclohexylcarbodiimide or carbonyldiimidazol.

It is preferred to employ the acid chlorides and mixed anhydrides which correspond to the amino acids of the formula (II). They can be prepared by reacting the amino acids of the formula (II) or their salts with a halogenating agent or with one of the generally known agents for the preparation of mixed anhydrides, such as, for example, phosphorus pentachloride, thionyl chloride, oxalyl chloride or isobutyl chloroformate, in a generally known fashion. The use of isobutyl chloroformate is Le A 27 895 preferred.

The reaction can be carried out in the presence of inert diluents such as, for example, aromatic, non-aromatic or halogenated hydrocarbons such as: ketones such as, for example, acetone; esters such as, for example, ethyl acetate; amides such as, for example, dimethylformamide, nitriles such as, for example, acetonitrile, chlorohydrocarbons such as, for example, methylene chloride, hydrocarbons such as, for example, toluene; or ethers such as, for example, tetrahydrofuran, or their mixtures, and/or in the presence of an acid-binding agent such as, preferably, a tertiary amine such as, for example, triethylamine, pyridine or N-methylpiperidine, at temperatures from -78’C to 100eC, preferably from -60°C to 25eC.

Formula (III) provides a general definition of the amines furthermore to be used as starting substances for carrying out the process according to the invention. In these formulae, R2 has the abovementioned meanings.

The amines of the formula (III) are generally known compounds of organic chemistry.

Diluents which are suitable for the process according to the invention are inert, organic solvents such as: ketones such as acetone or ethyl methyl ketone; esters such as ethyl acetate or methyl acetate; amides such as dimethylformamide; nitriles such as acetonitrile; chlorohydrocarbons such as methylene chloride or carbon Le A 27 895 tetrachloride; hydrocarbons such as toluene, or ethers such as tetrahydrofuran, and, if appropriate, water, and mixtures of the above.

Acid-binding agents which are suitable for the process 5 according to·the invention are customary inorganic and organic acid binders. These preferably include tertiary amines such as triethylamine, pyridine or N-methylpiper idine, and also inorganic bases, such as metal hydroxides such as sodium hydroxide and potassium hydroxide, or metal carbonates such as sodium carbonate or calcium carbonate.

If appropriate, the process according to the invention is carried out in the presence of a catalyst. The following may be mentioned by way of example: 4-dime thyl amino15 pyridine, l-hydroxy-benzotriazole or dimethylformamide.

When carrying out the process, the temperatures can be varied within a substantial range. In general, the process is carried out between -78 to +120°C, preferably at -60 to +40°C.

It is preferred to carry out the process according to the invention in equimolar amounts.

In this context, the amino acid derivatives of the formula (II) are employed as pure optical isomers (D or L form) or as racemates.

Le A 27 895 The invention embraces the pure isomers as well as the mixtures. These mixtures can be resolved into the components by customary methods, for example selective crystallisation from suitable solvents or chromatography on silica gel or on aluminium oxide. Racemates can be resolved to give the individual enantiomers using customary methods, for example by salt formation with optically active acids such as camphorsulphonic acid or dibenzoyltartaric acid and selective crystallisation, or by the formation of the derivatives with suitable, optically active reagents, separation of the diastereomeric derivatives and cleavage or separation on optically active column material.

The active compounds of the formula (I) according to the invention have a powerful action against pests and can be employed in practice for combating undesired harmful organisms. The active compounds are suitable for use as plant protection agents, in particular as fungicides.

Fungicides in plant protection are employed for combating Plasmodiophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes.

Some causative organisms of fungal diseases which come under the generic names listed above may be mentioned as examples, but not by way of limitation: Pythium species, such as, for example, Pythium ultimum; Phytophthora species, such as, for example, Phytophthora Le A 27 895 infestans; Pseudoperonospora species, such as, for example, Pseudoperonospora humuli or Pseudoperonospora cubensis; Plasmopara species, such as, for example, Plasmopara viticola; Peronospora species, such as, for example, Peronospora pisi or P. brassicae; Erysiphe species, such as, for example, Erysiphe graminis; Sphaerotheca species, such as, for example, Sphaerotheca fuliginea; Podosphaera species, such as, for example, Podosphaera leucotricha; Venturia species, such as, for example, Venturia 15 inaequalis; Pyrenophora species, such as, for example, Pyrenophora teres or P. graminea (conidia form: Drechslera, syn: Helminthosporium); Cochliobolus species, such as, for example, Cochliobolus sativus (conidia form: Drechslera, syn: Helminthosporium); Uromyces species, such as, for example, Uromyces appendiculatus; Puccinia species, such as, for example, Puccinia recon25 dita; Tilletia species, such as, for example, Tilletia caries; Ustilago species, such as, for example, Ustilago nuda or Ustilago avenae; Pellicularia species, such as, for example, Pellicularia 30 sasakii; Le A 27 895 Pyricularia species, such as, for example, Pyricularia oryzae; Fusarium species, such as, for example, Fusarium culmorum; Botrytis species, such as, for example, Botrytis cinerea; Septoria species, such as, for example, Septoria nodorum; Leptosphaeria species, such as, for example, Leptosphaeria nodorum; Cercospora species, such as, for example, Cercospora canescens; Altemaria species, such as, for example, Alternaria brassicae and Pseudocercosporella species, such as, for example, Pseudocercosporella herpotrichoides.

The good toleration, by plants, of the active compounds, in the concentrations required for combating plant diseases, permits treatment of above-ground parts of plants, of vegetative propagation stock and seeds, and of the soil.

The active compounds according to the invention are particularly suitable for protectively combating Phytophthora species on tomatoes or Plasmopara species on vines.

Moreover, the active compounds also show a leaf-acting 25 insecticidal action.

Depending on their particular physical and/or chemical Le A 27 895 properties, the active compounds can be converted into customary formulations, such as solutions, emulsions, suspensions, powders, foams, pastes, granules, aerosols, very fine capsules in polymeric substances and in coating compositions for seed, as well as ULV cold mist and warm mist formulations.

These formulations are produced in a known manner, for example by mixing the active compounds with extenders, that is, liquid solvents, liquefied gases under pressure and/or solid carriers, optionally with the use of surface-active agents, that is, emulsifying agents and/or dispersing agents and/or foam-forming agents. In the case of the use of water as an extender, organic solvents can, for example, also be used as auxiliary solvents. As liquid solvents, there are suitable in the main: aromatics, such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics or chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons, such as cyclohexane or paraffins, for example mineral oil fractions, alcohols, such as butanol or glycol as well as their ethers and esters, ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents, such as dimethylformamide and dimethyl sulphoxide, as well as water; by liquefied gaseous extenders or carriers are meant liquids which are gaseous at ambient temperature and under atmospheric pressure, for example aerosol propellants, such as halogenated hydrocarbons as well as butane, propane, Le A 27 895 nitrogen and carbon dioxide; as solid carriers there are suitable: for example ground natural minerals, such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as highly-disperse silica, alumina and silicates; as solid carriers for granules there are suitable: for example crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, as well as synthetic granules of inorganic and organic meals, and granules of organic material such as sawdust, coconut shells, maize cobs and tobacco stalks; as emulsifying and/or foam-forming agents there are suitable: for example non-ionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxy15 ethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulphonates, alkyl sulphates, arylsulphonates as well as albumen hydrolysis products; as dispersing agents there are suitable: for example lignin sulphite waste liquors and methylcellulose.

Adhesives such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or latexes, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, as well as natural phospholipids, such as cephalins and lecithins, and synthetic phospholipids, can be used in the formulations. Other additives can be mineral and vegetable oils.

It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Le A 27 895 Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestuffs and metal phthalocyanine dyestuffs, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

The formulations in general contain between 0.1 and 95 per cent by weight of active compound, preferably between 0.5 and 90%.

The active compounds according to the invention can be present in the formulations as a mixture with other known active compounds, such as fungicides, insecticides, acaricides and herbicides, and in mixtures with fertilisers and growth regulators.

The active compounds can be used as such, in the form of their formulations or of the use forms prepared there15 from, such as ready-for-use solutions, suspensions, wettable powders, pastes, soluble powders, dusts and granules. They are applied in the customary manner, for example by pouring, spraying, atomising, scattering, dusting, foaming, brushing on and the like. It is furthermore possible to apply the active compounds by the ultra-low volume method or to inject the preparation of active compound, or the active compound itself, into the soil. The seed of plants can also be treated.

In the treatment of parts of plants, the active compound concentrations in the use forms can be varied within a substantial range. They are generally between 1 and Le A 27 895 0.0001% by weight, preferably between 0.5 and 0.001%.

In the treatment of seed, amounts of active compound of 0.001 to 50 g, preferably 0.01 to 10 g, are generally required per kilogram of seed.

In the treatment of the soil, active compound concentrations of 0.00001 to 0.1% by weight, preferably 0.0001 to 0.02%, are required at the site of action.

In the treatment of animal pests, the active compound concentrations are generally between 0.0000001 up to 95% of active compound, preferably between 0.0001 to 1%.

Preparation Examples Example 1 H3C\ x^H3 2.3 g (0.023 mol) of N-methylpiperidine were added at -20 °C to 4.67 g of i-propoxycarbonyl-L-valine (0.023 mol), dissolved in 50 ml of CH2C12. 3.2 g (0.023 mol) of isobutyl chloroformate are then rapidly added dropwise at -2O’C, stirring is continued at the same temperature for 10 minutes, and the mixture is then cooled to -60eC, and 3.5 g (0.023 mol) of 4-methoxy-l-phenylethyl amine are run in, during which process the temperature is kept below Le A 27 895 -15°C. After 2 hours at -15°C, stirring is continued for 15 hours at room temperature, solids are filtered off and rinsed with CH2C12, the filtrate is concentrated, the residue is introduced into water, the mixture is extracted twice using ethyl acetate, and the combined ethyl acetate phases are washed with NaHCO3 solution and water, dried and concentrated. 4.64 g (60% of theory) of N- (i-propyl-oxycarbonyl) -L-valine-4-methoxyphenylethylamide of melting point 167C are obtained.

The following compounds of the formula (I) are obtained analogously to Example 1 h3c^ ζη3 CH . 1 R1-O-CO-NH-CH-CO-NH-C « I (I) CHLe A 27 895 Example Rl R2 Physical Amino acid No. constant used Φ U Φ C ι β Φ -Η •Η ♦Η R —4 <—4 rH Η β «0 (0 Η ► > ► Φ 1 ί ί > ►3 ι 1 1 1 ►4 «Η γΗ «-4 1 >1 >. >1 •Μ C C C >1 Μ 2 Κ4 Μ C Ο Xi «α (β Φ Μ Ρ 0 ρ β >1 X >1 X 5? Φ υ >. 0 0 0 Ό X η < ι 1 0 >, >4 >4 Ε 1—( Ci CU 04 3 >1 0 ο Ο t +J U Μ Μ 9 Λ α, (λ + Λ 1 ι I Κ 1 —4 •Η •Η (0 U U Ο U • • • • U3 ο ο to Γ Γ to •Η »-< rttββ α (Χ IX Ci • • • • Ε R κ Ε ΓΜ (Μ ΓΜ «flh. χ·\ rt. η η Γ» χ X X U U U «»* X S X U υ υ I I I xz υ ιΛ X υ k3. Α-27.,895 143*C ε-butyl-Jxycarbonyl-L-valine tO ω χ X Ν Ο Ο \χζ U ΓΜ tn to fl) 1 c 0) G G •H G •H •H Ή ι—I rH fl >-4 fl fl > fl > > 1 > 1 pi 1 u I ►q 1 » £ 1 r-1 «Η >1 «Η Si >1 G >1 G G O G 0 0 Λ Q ' Λ b Δ 0 o fl fl a U fl CJ υ >r υ t> >. >» Φ X •H X X Ό 0 X U o 0 •H rM 0 <0 rH r—i g ►K >1 >1 3 Λ >« o *) 4-> I O 4J c Ό 3 3 M □ •H fl) Λ Λ CU Λ s (0 1 1 « 1 1 a ω (Q •H m U U B • · CN U a •H i-l • « t I •H +j ra <—1 fl g in ra υ fl l-l iH «Ή **4 •H +) « to . • • . c CU Λ CM Ol x: o 4 « • P< CJ e e B B Ol d Table 1; - Continuation ω rl Ol B <0 X ω ΙΓ5 X n nj χ U ΙΛ X CJ \X/ (J ι n x CJ O X CJ X u » in X r> .*> X CJ CJ \X/ O ι CO <Λ Le A 27 895 - 18 IE 912997 Ό •P υ o c •P Ό 0) to I I c -P » α 13 •P 1 c r-l P < 1 •P a r-l 0 r-l > <0 > «3 t > 1 ► 1 u 1 I >3 t J r-l 1 r-t 1 >. r-l >1 -1 c >1 C o C O c Λ O 2 0 P J3 ρ 2 <0 P β P υ (0 υ nJ >1 O ΪΡ o X Qi >t Qi X 0) ►. <1> o Ό X Ό 0 Ό X •o r-1 >P 0 M-( r-1 ♦rl 0 •H >t 6 rH E >1 ε β CU (D ►. 3 Pt 3 >1 3 0 « P 1 0 1 P 1 P . 3 P 3 a + Λ + cu + Λ + 1 1 (X 1 cc 1 z w *—*· VO *»· I c •P r-l « > I (8 U Ή (0 >1 X CU p c <0 P ω c o o o CJ o o u> CJ tn +· r-t r-( i 1 -+ o m + CJ u • « cn r-1 r* r- e-M r-t I I Ch Γ-* to *n: Continuation CX Q> r-l J3 Φ r-l O' fO X o w z ►3 1 r-l >, c o fi <0 & X Q) 0 Ό r-l •H ΪΡ CU o § 1 P r**« a + 1 sx -P CJ • m co r4 » CO CO • « * « λ cu o< a. ή. * * ♦ · ε s ggg cj CO X u X o I LO X cj O \X/ CJ co X u CJ co X ϋ > ι .-3 I υ ip X r-| rP U Λ I to CJ © ¢0 r-l I CO Γ-ω Ό *P n X CJ CO X u CJ co X o X U I to X co X X/ CJ CJ X CJ rj co X u •wr X CJ I IO x co CJ X5Z CJ X CJ CO in to Π G «3 Ο R •H •a φ W 1 it $ » rH Λ Λ « nH Π53 X X'.J X X >*2 c c Er c c e c £ 0 0 < 0 o c O < J2 Λ j a JO JO Λ J L L. r-. L L . L L λ IS ft·* a m a Λ» υ u K u υ υ υ QC X * X X X X ~ □ % χ 1 0 c X φ 0 R χ Φ 0 c X Q) o r. * I 0 c *4 τ-ί -< -H —1 -rl —1 r-« —J -, -H ί>> »“* X —t X Ή X I—I X iM X —. 2. rt η rt c. r. CL π CL rt Q. c 0 > . o > o > 0 > 0 > o > L | u I L 1 L ι L I u 1 £b M cl a 2. J CL J CL J CL L5 1 1 «. t * 1 ·. 1 «. 1 . -- O - C Q ·- Q ·-, Q — C3 Γ-Ι +1 o U rt R Φ O υ rt C\i & ·—1 +> <0 to to r-n h fi jd 0 Ch u U u CJ u o o % o O o X XT i'> w V r-« r-< r* CO 'a: cn tn x u im tn Table 1: - Continuation φ I—t Cu ·<* N Λ5 N M N X“* X*. — *—· n re Ο cn cn CJ X 3; X X X X o a o u o o s-x M_x X t· •f· 25 X X X fj a υ u u υ 1 1 1 » 1 1 is co Use Examples Example A Phytophthora Test (tomato)/protective Solvent: 4.7 parts by weight of acetone 5 Emulsifier: 0.3 parts by weight of alkylaryl polyglycol ether To prepare a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

To test for protective activity, young plants are sprayed with the preparation of active compound until dripping wet. When the spray coating has dried on, the plants are inoculated with an aqueous spore suspension of Phytophthora infestans.

The plants are placed in an incubation cabin at 100% relative atmospheric humidity and approx. 20°C.

The test is evaluated 3 days after the inoculation.

In this test, an excellent fungicidal activity is shown, for example, by the compounds of Preparation Examples (1), (2), (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14), (15) and (16).

Le A 27 895 Example Bi Plasmopara Test (vines)/protective Solvent: 4.7 parts by weight of acetone Emulsifier: 0.3 parts by weight of alkylaryl polyglycol 5 ether To prepare a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

To test for protective activity, young plants are sprayed with the preparation of active compound until dripping wet. When the spray coating has dried on, the plants are inoculated with an aqueous spore suspension of Plasmopara viticola and then remain for 1 day in a humid chamber at 20 to 22 °C and 100% relative atmospheric humidity. The plants are subsequently placed in a greenhouse at 22*C and approx. 80% atmospheric humidity for 5 days. Then, the plants are moistened and placed in a humid chamber for 1 day.

The test is evaluated 7 days after the inoculation.

In this test, an excellent fungicidal activity is shown, for example, by the compounds of Preparation Examples (1), (2), (3), (4), (5), (6), (7), (8), (9.), (10), (11), Le A 27 895 (12), (13), (14), (15) and (16) Le A 27 895

Claims

1. Patent Claims Valinamide derivatives of the formula (I) h 3 c^ xCh 3 CH H^ 1 2.

2. 3.

3. in which R 1 represents i-propyl or s-butyl and R 2 represents chlorine, methyl, ethyl or methoxy. Valinamide derivatives according to Claim 1, in which the basic amino acid is i-propyloxycarbonylL-valine or s-butoxycarbonyl-L-valine and the phenethylamine employed, in which R 2 represents chlorine, methyl, ethyl or methoxy, is either racemic or has the R(+) configuration or the S(-) configuration on the asymmetric centre. Valinamide derivatives according to Claim 1, in which Le A 27 895 the basic amino acid is i-propyloxycarbonyl-L-valine or s-butoxycarbonyl-L-valine and the phenethylamine employed, in which 5 R z represents chlorine, methyl, ethyl or methoxy, is either racemic or has the R( + ) configuration on the asymmetric centre.

4. Process for the preparation of valinamide derivatives of the general formula h 3 Cx, >:h 3 ch 10 1 1 * 2 ( 1 ) R 1 -O-CO-NH-CH-CO-NH-CH—/~ R ch 3 in which R 1 represents i-propyl or s-butyl and R z represents chlorine, methyl, ethyl or methoxy, characterised in that 15 a substituted amino acid of the formula (II) Le A 27 895 h 3 c^ sCH 3 CH (II) R 1 -0-CO-NH-CH-COOH * in which R 1 represents i-propyl or s-butyl, or their carboxyl-activated derivatives, is reacted with an amine of the formula (III) h 2 n-ch (Hi) chin which R 2 represents chlorine, methyl, ethyl or methoxy, if appropriate in the presence of a catalyst, if 10 appropriate in the presence of an acid-binding agent and if appropriate in the presence of a diluent.

5. Pesticides, characterised in that they contain at least one valinamide derivative of the formula (I) according to Claims 1 to 4.

6. Use of valinamide derivatives of the formula (I) according to Claims 1 to 4, for combating pests.

7. Method of combating pests, characterised in that Le A 27 895

8. 8.

9. 9.

10. 10. 12. 12. 13. 13. 14. 14. valinamide derivatives of the formula (I) according to Claims 1 to 4 are allowed to act on pests and/or their environment. Process for the preparation of pesticides, characterised in that valinamide derivatives of the formula (I) according to Claims 1 to 4 are mixed with extenders and/or surface-active agents. A valinamide derivative of the formula (I) given and defined in Claim 1, substantially as hereinbefore described and exemplified. A process for the preparation of a valinamide derivative of the formula (I) given and defined in Claim 1, substantially as hereinbefore described and exemplified. A valinamide derivative of the formula (I) given and defined in Claim 1, whenever prepared by a process claimed in Claim 4 or 10. A pesticide according to Claim 5, substantially as hereinbefore described and exemplified. Use according to Claim 6, substantially as hereinbefore described. A method according to Claim 7 of combating pests, substantially as hereinbefore described.