IE881338L - A process for the preparation of foreign proteins in¹streptomycetes - Google Patents

A process for the preparation of foreign proteins in¹streptomycetes

Info

Publication number
IE881338L
IE881338L IE881338A IE133888A IE881338L IE 881338 L IE881338 L IE 881338L IE 881338 A IE881338 A IE 881338A IE 133888 A IE133888 A IE 133888A IE 881338 L IE881338 L IE 881338L
Authority
IE
Ireland
Prior art keywords
preparation
foreign proteins
tendamistat
gene
excreted
Prior art date
Application number
IE881338A
Other versions
IE62522B1 (en
Inventor
Klauspeter Koller
Guenther Johannes Riess
Original Assignee
Timothy Gerard Vaughan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Timothy Gerard Vaughan filed Critical Timothy Gerard Vaughan
Publication of IE881338L publication Critical patent/IE881338L/en
Publication of IE62522B1 publication Critical patent/IE62522B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Abstract

The tendamistat gene can be used for the construction of gene fusions with which fusion proteins can be expressed and excreted in Streptomycetes host cells. The tendamistat portion can be modified, in particular truncated at the C-terminal end. <IMAGE> [EP0289936A2]
IE133888A 1987-05-05 1988-05-04 A process for the preparation of foreign proteins in streptomycetes IE62522B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873714866 DE3714866A1 (en) 1987-05-05 1987-05-05 METHOD FOR THE PRODUCTION OF FOREIGN PROTEINS IN STREPTOMYCETES

Publications (2)

Publication Number Publication Date
IE881338L true IE881338L (en) 1988-11-05
IE62522B1 IE62522B1 (en) 1995-02-08

Family

ID=6326841

Family Applications (1)

Application Number Title Priority Date Filing Date
IE133888A IE62522B1 (en) 1987-05-05 1988-05-04 A process for the preparation of foreign proteins in streptomycetes

Country Status (19)

Country Link
EP (1) EP0289936B1 (en)
JP (1) JP2671260B2 (en)
KR (1) KR970001235B1 (en)
CN (1) CN1029989C (en)
AR (1) AR241658A1 (en)
AT (1) ATE94905T1 (en)
AU (1) AU612144B2 (en)
CA (1) CA1338338C (en)
DE (2) DE3714866A1 (en)
DK (1) DK175525B1 (en)
ES (1) ES2045004T3 (en)
FI (1) FI97549C (en)
HU (1) HU204094B (en)
IE (1) IE62522B1 (en)
IL (1) IL86277A0 (en)
NO (1) NO178036C (en)
NZ (1) NZ224464A (en)
PT (1) PT87400B (en)
ZA (1) ZA883168B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5426036A (en) * 1987-05-05 1995-06-20 Hoechst Aktiengesellschaft Processes for the preparation of foreign proteins in streptomycetes
DE4012818A1 (en) 1990-04-21 1991-10-24 Hoechst Ag METHOD FOR THE PRODUCTION OF FOREIGN PROTEINS IN STREPTOMYCETES
ATE132531T1 (en) * 1988-11-03 1996-01-15 Hoechst Ag METHOD FOR PRODUCING AN INSULIN PREPRODUCT IN STREPTOMYCETES
DE3844211A1 (en) * 1988-12-29 1990-07-05 Hoechst Ag NEW INSULINE DERIVATIVES, THE PROCESS FOR THEIR PRODUCTION, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM
DE3936876A1 (en) * 1989-11-06 1991-05-23 Hoechst Ag NEW INSULINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THE SAME

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3331860A1 (en) * 1983-09-03 1985-03-21 Hoechst Ag, 6230 Frankfurt Process for the preparation of tendamistat
DE3418274A1 (en) * 1984-05-17 1985-11-21 Hoechst Ag, 6230 Frankfurt SIGNAL PEPTIDE FOR THE EXCRETION OF PEPTIDES IN STREPTOMYCETS
ATE63757T1 (en) * 1985-03-28 1991-06-15 Chiron Corp EXPRESSION THROUGH USE OF FUSION GENES FOR PROTEIN PRODUCTION.
DE3707150A1 (en) * 1987-03-06 1988-09-15 Hoechst Ag TENDAMISTAT DERIVATIVES
ATE132531T1 (en) * 1988-11-03 1996-01-15 Hoechst Ag METHOD FOR PRODUCING AN INSULIN PREPRODUCT IN STREPTOMYCETES

Also Published As

Publication number Publication date
AU1555988A (en) 1988-11-10
CA1338338C (en) 1996-05-21
EP0289936A3 (en) 1989-11-23
KR970001235B1 (en) 1997-02-04
DK241688A (en) 1988-11-06
FI882059A (en) 1988-11-06
DK241688D0 (en) 1988-05-04
JPS63301793A (en) 1988-12-08
CN1029989C (en) 1995-10-11
DE3884261D1 (en) 1993-10-28
FI882059A0 (en) 1988-05-03
AR241658A1 (en) 1992-10-30
ZA883168B (en) 1989-11-29
IE62522B1 (en) 1995-02-08
CN88102568A (en) 1988-11-23
IL86277A0 (en) 1988-11-15
NO881942L (en) 1988-11-07
EP0289936A2 (en) 1988-11-09
ES2045004T3 (en) 1994-01-16
HU204094B (en) 1991-11-28
FI97549C (en) 1997-01-10
PT87400B (en) 1992-09-30
NZ224464A (en) 1990-02-26
PT87400A (en) 1989-05-31
NO178036B (en) 1995-10-02
AU612144B2 (en) 1991-07-04
ATE94905T1 (en) 1993-10-15
EP0289936B1 (en) 1993-09-22
DK175525B1 (en) 2004-11-22
DE3714866A1 (en) 1988-11-24
HUT46941A (en) 1988-12-28
JP2671260B2 (en) 1997-10-29
KR880014102A (en) 1988-12-22
NO881942D0 (en) 1988-05-04
FI97549B (en) 1996-09-30
NO178036C (en) 1996-01-10

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