IE872567L - Treatment of infertility - Google Patents

Treatment of infertility

Info

Publication number
IE872567L
IE872567L IE872567A IE256787A IE872567L IE 872567 L IE872567 L IE 872567L IE 872567 A IE872567 A IE 872567A IE 256787 A IE256787 A IE 256787A IE 872567 L IE872567 L IE 872567L
Authority
IE
Ireland
Prior art keywords
spermatozoa
treatment
vitro
application
penetration
Prior art date
Application number
IE872567A
Original Assignee
James Anthony Haughton
Paul Theodore Tomkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James Anthony Haughton, Paul Theodore Tomkins filed Critical James Anthony Haughton
Priority to IE872567A priority Critical patent/IE872567L/en
Priority to PCT/GB1988/000788 priority patent/WO1989002743A1/en
Priority to AU24891/88A priority patent/AU2489188A/en
Priority to EP88908291A priority patent/EP0380536A1/en
Priority to JP63507878A priority patent/JPH03501203A/en
Publication of IE872567L publication Critical patent/IE872567L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/52—Sperm; Prostate; Seminal fluid; Leydig cells of testes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Reproductive Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Medical Informatics (AREA)
  • Transplantation (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A method of inducing the acrosome reaction in spermatozoa comprises subjecting spermatozoa in vitro to electropermeabilisation involving application of an electric field sufficient to raise the spermatozoal plasma membrane potential from about -70 mV to +1 V to allow an influx of Ca<++> ions. Using this method one is able to achieve up to 75 % penetration in the so-called sperm penetration assay (SPA) with oligospermic samples. The method has application in the assessment of spermatozoa, in preparing spermatozoa for in vitro fertilisation and in the treatment of male infertility. [WO8902743A1]
IE872567A 1987-09-23 1988-09-22 Treatment of infertility IE872567L (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IE872567A IE872567L (en) 1988-09-22 1988-09-22 Treatment of infertility
PCT/GB1988/000788 WO1989002743A1 (en) 1987-09-23 1988-09-23 In vitro method for the induction of the spermatozoal acrosome reaction and application of said method to the assessment of spermatozoa and the treatment of male-related infertility
AU24891/88A AU2489188A (en) 1987-09-23 1988-09-23 In vitro method for the induction of the spermatozoal acrosome reaction and application of said method to the assessment of spermatozoa and the treatment of male-related infertility
EP88908291A EP0380536A1 (en) 1987-09-23 1988-09-23 In vitro method for the induction of the spermatozoal acrosome reaction and application of said method to the assessment of spermatozoa and the treatment of male-related infertility
JP63507878A JPH03501203A (en) 1987-09-23 1988-09-23 Method for in vitro induction of acrosome reaction in sperm, use of this method in sperm testing and treatment of male-related infertility

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IE872567A IE872567L (en) 1988-09-22 1988-09-22 Treatment of infertility

Publications (1)

Publication Number Publication Date
IE872567L true IE872567L (en) 1989-03-23

Family

ID=11035474

Family Applications (1)

Application Number Title Priority Date Filing Date
IE872567A IE872567L (en) 1987-09-23 1988-09-22 Treatment of infertility

Country Status (5)

Country Link
EP (1) EP0380536A1 (en)
JP (1) JPH03501203A (en)
AU (1) AU2489188A (en)
IE (1) IE872567L (en)
WO (1) WO1989002743A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0517802A4 (en) * 1990-03-02 1993-10-20 Brigham & Women's Hospital Complement components and binding ligands in fertility
US5250417A (en) * 1991-04-23 1993-10-05 Rhomed Incorporated Method for acrosome reaction assay
JPH06197665A (en) * 1993-01-07 1994-07-19 Norin Suisansyo Chikusan Shikenjo Medium for ectosomatic fertilization and ectosomatic fertilization method

Also Published As

Publication number Publication date
EP0380536A1 (en) 1990-08-08
AU2489188A (en) 1989-04-18
WO1989002743A1 (en) 1989-04-06
JPH03501203A (en) 1991-03-22

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