IE832926L - Process for the preparation of 2-substituted-5-nitroso-¹4,6-diaminopyrimidines - Google Patents

Process for the preparation of 2-substituted-5-nitroso-¹4,6-diaminopyrimidines

Info

Publication number
IE832926L
IE832926L IE292683A IE292683A IE832926L IE 832926 L IE832926 L IE 832926L IE 292683 A IE292683 A IE 292683A IE 292683 A IE292683 A IE 292683A IE 832926 L IE832926 L IE 832926L
Authority
IE
Ireland
Prior art keywords
substituted
nitroso
salt
general formula
amino
Prior art date
Application number
IE292683A
Other versions
IE56419B1 (en
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of IE832926L publication Critical patent/IE832926L/en
Publication of IE56419B1 publication Critical patent/IE56419B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)

Abstract

1. A process for producing 2-substituted 5-nitroso-4,6-diamino pyrimidine of the general formula : see diagramm : EP0115325,P5,F1 wherein R is aryl, alkyl, alkylthio, amino, amino substituted by one or two C1 to C4 alkyl groups, or arylalkyl, which comprises the steps of reacting malonic dinitrile with an amidine or guanidine of the general formula : see diagramm : EP0115325,P5,F2 wherein A is Cl, 1/2 SO4 , HSO4 , NO3 , acetate, or 1/3 PO4 , and R has the meaning stated above, in water or alcohol in an acid milieu and in the presence of a nitrite salt to form the respective amidino or guanidino salt of isonitroso-malonitrile, and converting the salt thus obtained in a manner known per se by thermal treatment in dimethyl formamide or a pyridine base in a basic milieu to produce the respective 2-substituted 5-nitroso-4,6-diamino pyrmidine. [EP0115325A2]
IE292683A 1983-01-28 1983-12-12 Process for the preparation of 2-substituted 5-nitroso-4,6-diaminopyrimidines IE56419B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH48283A CH660589A5 (en) 1983-01-28 1983-01-28 METHOD FOR PRODUCING 2-SUBSTITUTED 5-NITROSO-4,6-DIAMINO-PYRIMIDINES.

Publications (2)

Publication Number Publication Date
IE832926L true IE832926L (en) 1984-07-28
IE56419B1 IE56419B1 (en) 1991-07-31

Family

ID=4188010

Family Applications (1)

Application Number Title Priority Date Filing Date
IE292683A IE56419B1 (en) 1983-01-28 1983-12-12 Process for the preparation of 2-substituted 5-nitroso-4,6-diaminopyrimidines

Country Status (7)

Country Link
EP (1) EP0115325B1 (en)
JP (1) JPS59141566A (en)
CA (1) CA1241958A (en)
CH (1) CH660589A5 (en)
DE (1) DE3465083D1 (en)
DK (1) DK159681C (en)
IE (1) IE56419B1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH667089A5 (en) * 1985-12-06 1988-09-15 Lonza Ag METHOD FOR PRODUCING 2-SUBSTITUTED 5-NITROSO-4,6-DIAMINO-PYRIMIDINES.
US4959475A (en) * 1989-01-04 1990-09-25 Lonza Ltd. Process for the production of 2,4-diamino-6-piperidinyl-pyrimidine-3-N-oxide
AU780907B2 (en) * 1999-04-15 2005-04-21 Basf Aktiengesellschaft Process for the preparation of substituted pyrimidines
US6281358B1 (en) 1999-04-15 2001-08-28 American Cyanamid Company Process for the preparation of substituted pyrimidines
DE10024886A1 (en) * 2000-05-19 2001-11-22 Henkel Kgaa Colorant for keratin fibers, especially human hair, contains optionally substituted nitrosopyridine and -pyrimidine compound(s) as coloring component

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1364734A (en) * 1963-05-15 1964-06-26 Lumiere Lab Process for the preparation of acyclic and cyclic derivatives of guanidine
DE2651794C2 (en) * 1976-11-12 1982-09-23 Henkel KGaA, 4000 Düsseldorf Process for the preparation of 5-nitroso-2,4,6-triaminopyrimidine
JPS5818367A (en) * 1981-07-27 1983-02-02 Kohjin Co Ltd Preparation of nitrosopyrimidine derivative

Also Published As

Publication number Publication date
EP0115325B1 (en) 1987-07-29
CH660589A5 (en) 1987-05-15
JPH0549666B2 (en) 1993-07-26
JPS59141566A (en) 1984-08-14
IE56419B1 (en) 1991-07-31
DK159681B (en) 1990-11-19
DK19784D0 (en) 1984-01-17
CA1241958A (en) 1988-09-13
DE3465083D1 (en) 1987-09-03
EP0115325A2 (en) 1984-08-08
EP0115325A3 (en) 1984-09-12
DK159681C (en) 1991-04-29
DK19784A (en) 1984-07-29

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Legal Events

Date Code Title Description
MM4A Patent lapsed