IE831080L - Process for the preparation of amitriptylin oxide from the¹amine using h2o2. - Google Patents

Process for the preparation of amitriptylin oxide from the¹amine using h2o2.

Info

Publication number
IE831080L
IE831080L IE831080A IE108083A IE831080L IE 831080 L IE831080 L IE 831080L IE 831080 A IE831080 A IE 831080A IE 108083 A IE108083 A IE 108083A IE 831080 L IE831080 L IE 831080L
Authority
IE
Ireland
Prior art keywords
oxide
preparation
the1amine
amitriptylin
cyclohepten
Prior art date
Application number
IE831080A
Other versions
IE55158B1 (en
Original Assignee
Nattermann A & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nattermann A & Cie filed Critical Nattermann A & Cie
Publication of IE831080L publication Critical patent/IE831080L/en
Publication of IE55158B1 publication Critical patent/IE55158B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

1. Process for the preparation of 3-(10,11-dihydro-5H-dibenzo [a,d]-cyclohepten-5-ylidene)- N,N-dimethyl-1-propanamine-N-oxide dihydrate and its acid addition salts which comprises reacting 3-(10,11-dihydro-5H-dibenzo [a,d]- cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine with 25 - 85% hydrogen peroxide solution at 30 - 95 degrees C for a period of 20 minutes to 4 hours, isolating the resulting N-oxide from the reaction mixture as such or as acid addition salt in known manner.
IE1080/83A 1982-05-13 1983-05-10 Process for the preparation of 3-(10,11-dihydro-5h-dibenzo(a,d)-cyclohepten-5-ylidene)-n,n-dimethyl-1-propanamine-n-oxide dihydrate IE55158B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3218026A DE3218026C2 (en) 1982-05-13 1982-05-13 Process for the preparation of 3- (10,11-dihydro-5H-dibenzo [a, d] -cyclohepten-5-ylidene) -N, N-dimethyl-1-propanamine-N-oxide dihydrate

Publications (2)

Publication Number Publication Date
IE831080L true IE831080L (en) 1983-11-13
IE55158B1 IE55158B1 (en) 1990-06-20

Family

ID=6163494

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1080/83A IE55158B1 (en) 1982-05-13 1983-05-10 Process for the preparation of 3-(10,11-dihydro-5h-dibenzo(a,d)-cyclohepten-5-ylidene)-n,n-dimethyl-1-propanamine-n-oxide dihydrate

Country Status (6)

Country Link
EP (1) EP0094560B1 (en)
AT (1) ATE22437T1 (en)
DE (2) DE3218026C2 (en)
DK (1) DK211983A (en)
ES (1) ES522311A0 (en)
IE (1) IE55158B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693861A (en) * 1991-08-05 1997-12-02 Albemarle Corporation Process for preparing solid amine oxides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3215741A (en) * 1963-01-08 1965-11-02 Du Pont Process for preparing maine oxides
GB991651A (en) * 1963-02-20 1965-05-12 Dumex Ltd As Dibenzocycloheptadiene derivatives
BR6572744D0 (en) * 1964-09-14 1973-08-07 Merck & Co Inc PROCESS FOR THE PREPARATION OF NEW DIBENZOCYCLEHEPTENIC DERIVATIVES
DE1518104B1 (en) * 1965-05-21 1970-05-14 Pennsalt Chemicals Corp Process for the preparation of tertiary amine oxides
US3432555A (en) * 1967-04-05 1969-03-11 Millmaster Onyx Corp Process for producing amine oxides
GB1538199A (en) * 1974-12-19 1979-01-10 Albright & Wilson Preparation of amine oxides

Also Published As

Publication number Publication date
DK211983D0 (en) 1983-05-11
ATE22437T1 (en) 1986-10-15
EP0094560A1 (en) 1983-11-23
DK211983A (en) 1983-11-14
DE3218026A1 (en) 1983-12-15
DE3366400D1 (en) 1986-10-30
ES8403106A1 (en) 1984-03-01
DE3218026C2 (en) 1984-03-29
ES522311A0 (en) 1984-03-01
IE55158B1 (en) 1990-06-20
EP0094560B1 (en) 1986-09-24

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Legal Events

Date Code Title Description
MM4A Patent lapsed