IE821365L - Androstanes - Google Patents
AndrostanesInfo
- Publication number
- IE821365L IE821365L IE821365A IE136582A IE821365L IE 821365 L IE821365 L IE 821365L IE 821365 A IE821365 A IE 821365A IE 136582 A IE136582 A IE 136582A IE 821365 L IE821365 L IE 821365L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- alkyl
- carbon atoms
- group
- blocking
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This invention relates to novel mono- and bisquaternary ammonium derivatives of 5 alpha -androstanes having the formula: <IMAGE> wherein: R1=H or alkyl (1-4 C); R2 and R3 each are alkyl (1-4 C) or form together with the N-atom a piperidino, pyrrolidino or morpholino group; R4=O or H( beta OR5) and R5=H or acyl derived from an organic carboxylic acid having 1-18, preferably 1-6 carbon atoms; the quaternarizing group being a saturated or unsaturated aliphatic hydrocarbon group having 1-4 carbon atoms the anion being halide; and acid addition salts of the monoquaternary compounds; and to pharmaceutical preparations containing one or more of said androstane compounds as active constituent. The compounds according to the invention are non-depolarizing neuromuscular blocking agents having very quick onset and recovery characteristics, a short duration of action and a favorable dissociation between muscle blocking and vagal blocking effects.
[US4447425A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8118365 | 1981-06-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE821365L true IE821365L (en) | 1982-12-15 |
IE53463B1 IE53463B1 (en) | 1988-11-23 |
Family
ID=10522526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE1365/82A IE53463B1 (en) | 1981-06-15 | 1982-06-08 | Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same |
Country Status (11)
Country | Link |
---|---|
US (1) | US4447425A (en) |
EP (1) | EP0067480B1 (en) |
JP (1) | JPS5813600A (en) |
AU (1) | AU551427B2 (en) |
CA (1) | CA1186681A (en) |
DE (1) | DE3261364D1 (en) |
DK (1) | DK268382A (en) |
ES (1) | ES8308889A1 (en) |
FI (1) | FI72731C (en) |
HU (1) | HU186074B (en) |
IE (1) | IE53463B1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3485647D1 (en) * | 1983-08-02 | 1992-05-21 | Research Corp | STEROIDS AND THERAPEUTIC COMPOSITIONS CONTAINING THEM. |
US5656621A (en) * | 1983-08-02 | 1997-08-12 | Research Corporation Tech., Inc. | Steroids useful as anti-cancer and anti-obesity agents |
US5804576A (en) * | 1983-08-02 | 1998-09-08 | Research Corporation Technologies, Inc. | Derivatives of 5-androsten-17-ones and 5-androstan-17-ones |
US5714481A (en) * | 1983-08-02 | 1998-02-03 | Research Corporation Technologies, Inc. | Derivatives of 5-androsten-17 ones and 5-androstan-17-ones |
GB8708886D0 (en) * | 1987-04-14 | 1987-05-20 | Akzo Nv | 2beta-morpholino-androstane derivatives |
GB8804579D0 (en) * | 1988-02-26 | 1988-03-30 | Akzo Nv | Novel 16-homo-piperidino-androstane derivatives & processes for their preparation |
DE4232656C2 (en) * | 1992-09-29 | 1995-01-12 | Sigma Tau Ind Farmaceuti | Cyclopentane perhydrophenanthrene-17-furyl-3β derivatives, processes for their preparation and pharmaceutical compositions containing them |
CZ300694A3 (en) * | 1993-12-02 | 1996-05-15 | Akzo Nobel Nv | Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof |
IT1277700B1 (en) * | 1995-12-22 | 1997-11-11 | Poli Ind Chimica Spa | PROCESS OF PREPARATION OF 2-BETA, 16-BETA-DIAMINO 3-ALPHA, 17-BETA-DIACYLOSS 5-ALPHAANDROSTANS, STRUCTURED NEUROMUSCULAR BLOCKERS |
JP2008522983A (en) * | 2005-09-13 | 2008-07-03 | シコール インコーポレイティド | Method for synthesizing rocuronium bromide |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1138605A (en) * | 1965-02-19 | 1969-01-01 | Organon Labor Ltd | Improvements in or relating to new 2-ß,16-ß-diamino-androstanes |
GB1454749A (en) * | 1972-11-29 | 1976-11-03 | Akzo Nv | 2beta, 16beta-diamino-androstanes and their preparation |
ATE921T1 (en) * | 1978-09-05 | 1982-05-15 | Akzo N.V. | ACID ADDITIONAL SALTS OF 2-BETA, 16-BETA-BIS-PIPERIDINO-AN DROSTAN-16-BETA-MONOQUATERNARY AMMONIUM DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
IE50675B1 (en) * | 1979-12-12 | 1986-06-11 | Akzo Nv | Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations |
-
1982
- 1982-06-08 IE IE1365/82A patent/IE53463B1/en unknown
- 1982-06-09 US US06/386,756 patent/US4447425A/en not_active Expired - Fee Related
- 1982-06-09 DE DE8282200701T patent/DE3261364D1/en not_active Expired
- 1982-06-09 EP EP82200701A patent/EP0067480B1/en not_active Expired
- 1982-06-11 AU AU84838/82A patent/AU551427B2/en not_active Ceased
- 1982-06-11 CA CA000405039A patent/CA1186681A/en not_active Expired
- 1982-06-14 JP JP57101942A patent/JPS5813600A/en active Granted
- 1982-06-14 ES ES513088A patent/ES8308889A1/en not_active Expired
- 1982-06-14 FI FI822131A patent/FI72731C/en not_active IP Right Cessation
- 1982-06-14 HU HU821917A patent/HU186074B/en not_active IP Right Cessation
- 1982-06-15 DK DK268382A patent/DK268382A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HU186074B (en) | 1985-05-28 |
DE3261364D1 (en) | 1985-01-10 |
AU551427B2 (en) | 1986-05-01 |
FI72731B (en) | 1987-03-31 |
EP0067480B1 (en) | 1984-11-28 |
DK268382A (en) | 1982-12-16 |
FI72731C (en) | 1987-07-10 |
ES513088A0 (en) | 1983-08-16 |
IE53463B1 (en) | 1988-11-23 |
JPH0249320B2 (en) | 1990-10-29 |
FI822131A0 (en) | 1982-06-14 |
AU8483882A (en) | 1982-12-23 |
US4447425A (en) | 1984-05-08 |
CA1186681A (en) | 1985-05-07 |
EP0067480A1 (en) | 1982-12-22 |
ES8308889A1 (en) | 1983-08-16 |
JPS5813600A (en) | 1983-01-26 |
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