IE820197L - Carbapenem compounds - Google Patents
Carbapenem compoundsInfo
- Publication number
- IE820197L IE820197L IE820197A IE19782A IE820197L IE 820197 L IE820197 L IE 820197L IE 820197 A IE820197 A IE 820197A IE 19782 A IE19782 A IE 19782A IE 820197 L IE820197 L IE 820197L
- Authority
- IE
- Ireland
- Prior art keywords
- substituted
- unsubstituted
- group
- well
- compounds
- Prior art date
Links
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004468 heterocyclylthio group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
There are described bicyclic compounds of the general formula <IMAGE> wherein one of the symbols R<1> and R<2> represents hydrogen and the other represents hydrogen or a substituted or unsubstituted C1-4-alkylgroup and X represents a substituted or unsubstituted C1-3-alkanoyloxy group, an unsubstituted or substituted C3-7- cycloalkylthio, C2-6-alkenylthio or heterocyclylthio group or a substituted C1-4-alkylthio or phenylthio group, their readily hydrolyzable esters, pharmaceutically compatible salts as well as hydrates of these compounds. There are also described the manufacture of these substances and their use in the treatment or prophylaxis of infectious diseases as well as intermediates useful in the manufacturing process.
[GB2092147A]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH62081A CH646171A5 (en) | 1981-01-30 | 1981-01-30 | Bicyclic compounds |
CH7802/81A CH651564A5 (en) | 1981-12-07 | 1981-12-07 | 7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
IE820197L true IE820197L (en) | 1982-07-30 |
IE52421B1 IE52421B1 (en) | 1987-10-28 |
Family
ID=25685143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE197/82A IE52421B1 (en) | 1981-01-30 | 1982-01-29 | Carbapenen compounds |
Country Status (15)
Country | Link |
---|---|
AT (1) | AT377762B (en) |
AU (1) | AU7979882A (en) |
CA (1) | CA1179675A (en) |
DE (1) | DE3201957A1 (en) |
DK (1) | DK32082A (en) |
FR (1) | FR2499081B1 (en) |
GB (1) | GB2092147B (en) |
IE (1) | IE52421B1 (en) |
IL (1) | IL64859A (en) |
IT (1) | IT1153416B (en) |
LU (1) | LU83906A1 (en) |
NL (1) | NL8200217A (en) |
NZ (1) | NZ199487A (en) |
PH (1) | PH19227A (en) |
SE (1) | SE8200515L (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4680292A (en) * | 1984-12-13 | 1987-07-14 | Merck & Co., Inc. | Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent |
US4729993A (en) * | 1984-12-13 | 1988-03-08 | Merck & Co., Inc. | Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent |
US4725594A (en) * | 1984-12-13 | 1988-02-16 | Merck & Co., Inc. | Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent |
GB8607921D0 (en) * | 1986-04-01 | 1986-05-08 | Fujisawa Pharmaceutical Co | 3,4-disubstituted-2-azetidinone derivatives |
ZA912279B (en) * | 1990-04-09 | 1992-02-26 | Hoffmann La Roche | Carbapenem compounds |
US5068232A (en) * | 1990-04-10 | 1991-11-26 | American Cyanamid Company | Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them |
US5607928A (en) * | 1994-08-05 | 1997-03-04 | Zeneca Limited | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives |
US7632828B2 (en) * | 2004-06-10 | 2009-12-15 | Fob Synthesis, Inc. | Gram-positive carbapenem antibacterials and processes for their preparation |
US20110118462A1 (en) * | 2009-11-18 | 2011-05-19 | Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical Factory | N-heterocyclic substituent-containing antibiotic, preparation and use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1593524A (en) * | 1976-11-19 | 1981-07-15 | Merck & Co Inc | 1-carba-2-penem-3-carboxylic acids |
DE2811514A1 (en) * | 1977-03-19 | 1978-09-21 | Beecham Group Ltd | ESTER OF 7-OXO-1-AZABICYCLO SQUARE CLAMP ON 3.2.0 SQUARE CLAMP FOR HEPT-2-EN-2-CARBONIC ACID AND ITS DERIVATIVES, METHOD FOR PRODUCING THESE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS |
GB2021656B (en) * | 1978-05-11 | 1982-08-25 | Ladd Harley G F | Pleat forming means and method |
US4260627A (en) * | 1978-10-24 | 1981-04-07 | Merck & Co., Inc. | 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids |
JPS56122379A (en) * | 1980-03-03 | 1981-09-25 | Sankyo Co Ltd | 1-carba-2-penem-3-carboxylic acid derivative |
-
1982
- 1982-01-08 CA CA000393840A patent/CA1179675A/en not_active Expired
- 1982-01-14 NZ NZ199487A patent/NZ199487A/en unknown
- 1982-01-19 IT IT19187/82A patent/IT1153416B/en active
- 1982-01-21 NL NL8200217A patent/NL8200217A/en not_active Application Discontinuation
- 1982-01-22 DE DE19823201957 patent/DE3201957A1/en not_active Withdrawn
- 1982-01-22 PH PH26771A patent/PH19227A/en unknown
- 1982-01-25 AU AU79798/82A patent/AU7979882A/en not_active Abandoned
- 1982-01-25 IL IL64859A patent/IL64859A/en unknown
- 1982-01-25 DK DK32082A patent/DK32082A/en not_active Application Discontinuation
- 1982-01-28 FR FR828201345A patent/FR2499081B1/en not_active Expired
- 1982-01-28 LU LU83906A patent/LU83906A1/en unknown
- 1982-01-29 SE SE8200515A patent/SE8200515L/en not_active Application Discontinuation
- 1982-01-29 IE IE197/82A patent/IE52421B1/en unknown
- 1982-01-29 AT AT0034082A patent/AT377762B/en not_active IP Right Cessation
- 1982-01-29 GB GB8202523A patent/GB2092147B/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
SE8200515L (en) | 1982-07-31 |
GB2092147A (en) | 1982-08-11 |
IT1153416B (en) | 1987-01-14 |
DE3201957A1 (en) | 1982-09-09 |
AU7979882A (en) | 1982-09-23 |
FR2499081A1 (en) | 1982-08-06 |
NZ199487A (en) | 1986-02-21 |
IT8219187A0 (en) | 1982-01-19 |
ATA34082A (en) | 1984-09-15 |
IL64859A (en) | 1985-06-30 |
CA1179675A (en) | 1984-12-18 |
GB2092147B (en) | 1984-12-05 |
FR2499081B1 (en) | 1985-07-26 |
PH19227A (en) | 1986-02-12 |
NL8200217A (en) | 1982-08-16 |
DK32082A (en) | 1982-07-31 |
AT377762B (en) | 1985-04-25 |
IE52421B1 (en) | 1987-10-28 |
LU83906A1 (en) | 1983-09-02 |
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