IE811069L - Esters of substituted benzoic acid - Google Patents
Esters of substituted benzoic acidInfo
- Publication number
- IE811069L IE811069L IE811069A IE106981A IE811069L IE 811069 L IE811069 L IE 811069L IE 811069 A IE811069 A IE 811069A IE 106981 A IE106981 A IE 106981A IE 811069 L IE811069 L IE 811069L
- Authority
- IE
- Ireland
- Prior art keywords
- esters
- benzoic acid
- substituted benzoic
- formula
- image
- Prior art date
Links
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title 1
- 239000005711 Benzoic acid Substances 0.000 title 1
- 235000010233 benzoic acid Nutrition 0.000 title 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- LODHFNUFVRVKTH-ZHACJKMWSA-N 2-hydroxy-n'-[(e)-3-phenylprop-2-enoyl]benzohydrazide Chemical compound OC1=CC=CC=C1C(=O)NNC(=O)\C=C\C1=CC=CC=C1 LODHFNUFVRVKTH-ZHACJKMWSA-N 0.000 abstract 1
- 150000005166 2-hydroxybenzoic acids Chemical class 0.000 abstract 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Natural products OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000001156 gastric mucosa Anatomy 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/89—Benzo [c] furans; Hydrogenated benzo [c] furans with two oxygen atoms directly attached in positions 1 and 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Abstract
Derivatives of 2-hydroxybenzoic acid have the formula (I> <IMAGE> wherein R1 represents a hydroxy or C2-5 acyloxy group; R2 represents a radical of the formula (II> <IMAGE> in which R4 and R5 each represent a hydrogen atom or together form an aromatic ring fused to the heterocyclic ring and R3 represents a hydrogen or halogen atom, the compounds have a greater analgesic and anti-inflammatory activity than 2-hydroxybenzoic acid without the irritation of the gastric mucosa which has been given by the other derivatives previously known in the art.
[GB2086881A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE2/58723A BE884978A (en) | 1980-08-29 | 1980-08-29 | NEW ESTERS OF SUBSTITUTED BENZOIC ACID |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE811069L true IE811069L (en) | 1982-02-28 |
| IE51324B1 IE51324B1 (en) | 1986-12-10 |
Family
ID=3865514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1069/81A IE51324B1 (en) | 1980-08-29 | 1981-05-03 | Esters of substituted benzoic acid |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS5742680A (en) |
| DE (1) | DE3105908A1 (en) |
| FR (1) | FR2489328B1 (en) |
| GB (1) | GB2086881B (en) |
| IE (1) | IE51324B1 (en) |
| IT (1) | IT1167704B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3042890B2 (en) * | 1994-11-21 | 2000-05-22 | ファイザー製薬株式会社 | Phthalide compound and method for producing the same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2877236A (en) * | 1956-08-03 | 1959-03-10 | Dow Chemical Co | Phthalidyl esters of aromatic acids |
| US3981857A (en) * | 1973-03-19 | 1976-09-21 | Konishiroku Photo Industry Co., Ltd. | Gelatin hardening process |
| NL7510622A (en) * | 1974-09-17 | 1976-03-19 | Rhone Poulenc Ind | PROCESS FOR THE PREPARATION OF MEDICINAL PRODUCTS HAVING INCLUDED AN ANTI-INFLAMMATORY, ANALGETIC AND ANTI-PYROLYTIC ACTION, THE PREPARED MEDICINAL PRODUCTS AND A PROCESS FOR THE PREPARATION OF THE FINDED ACYLOGEN TREASURIES. |
| FR2300571A1 (en) * | 1975-02-12 | 1976-09-10 | Union Pharma Scient Appl | Stable, water soluble acetylsalicyclic acid addition salts - with 2-amino 2-methyl propanol or corresp. 1,3-propanediol |
| US4029810A (en) * | 1976-01-02 | 1977-06-14 | American Home Products Corporation | Lactone esters of phenoxyisobutyric acids |
| US4046887A (en) * | 1976-10-28 | 1977-09-06 | Abbott Laboratories | Glycerides with anti-inflammatory properties |
| BE858864A (en) * | 1977-09-20 | 1978-01-16 | Bago Sa Labor | NEW ESTERS OF PHENYL- AND PYRIDINE-3-CARBOXYLIC ACIDS AND PROCESS FOR THEIR PREPARATION |
-
1981
- 1981-01-27 JP JP56010715A patent/JPS5742680A/en active Pending
- 1981-02-03 IT IT19478/81A patent/IT1167704B/en active
- 1981-02-13 FR FR8103036A patent/FR2489328B1/en not_active Expired
- 1981-02-18 DE DE19813105908 patent/DE3105908A1/en active Granted
- 1981-02-27 GB GB8106211A patent/GB2086881B/en not_active Expired
- 1981-05-03 IE IE1069/81A patent/IE51324B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5742680A (en) | 1982-03-10 |
| FR2489328A1 (en) | 1982-03-05 |
| IE51324B1 (en) | 1986-12-10 |
| DE3105908C2 (en) | 1990-05-31 |
| IT8119478A1 (en) | 1982-08-03 |
| DE3105908A1 (en) | 1982-04-15 |
| GB2086881A (en) | 1982-05-19 |
| IT8119478A0 (en) | 1981-02-03 |
| IT1167704B (en) | 1987-05-13 |
| FR2489328B1 (en) | 1985-09-20 |
| GB2086881B (en) | 1984-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE811250L (en) | Imidazole derivatives | |
| GR3021014T3 (en) | 2-Substituted quinolines, process for their preparation as well as their use in medicaments | |
| IE45439L (en) | Penicillanic acid derivatives | |
| ES8305298A1 (en) | Analgesic and anti-inflammatory agents. | |
| IE45624L (en) | (pyrazol-1-yl)-phenylacetic acids. | |
| IE44339L (en) | Piperazine derivatives. | |
| AU1891683A (en) | Substituted 1-phenyl-isoquinoline anti-arrythmic agents | |
| IE811069L (en) | Esters of substituted benzoic acid | |
| SE8305917D0 (en) | INTERMEDIATES FOR USE IN THE PREPARATION OF HEXAHYDRO-GAMMA CARBOL COMPOUNDS | |
| IE44069L (en) | Noroxymorphones | |
| JPS56156273A (en) | Acetic derivative | |
| IE820310L (en) | 2-amino-3-(halobenzoyl)-methylphenylacetic acid and esters | |
| IE780279L (en) | Imidazole derivatives | |
| IE791087L (en) | Therapeutic cyclopentyl-aldehyde derivatives | |
| JPS52131544A (en) | Phenoxymalonic acid derivatives and herbicides containing them | |
| IE790650L (en) | Substituted n-iminomethylpiperidine | |
| ES481855A1 (en) | 6-Methoxy-2-acethylnaphthalene oximes | |
| IE820118L (en) | Anthranilic acid. | |
| SE8602492L (en) | INTERMEDIATE | |
| ES8300747A1 (en) | Indol acetic derivatives, process for producing the same and pharmaceutical compositions comprising the same. | |
| ES483463A1 (en) | 1-Methyl-4-piperidinol esters of 4-quinolinylamino benzoates and antiinflammatory and analgesic compositions and methods employing them | |
| ES8202002A1 (en) | Salts of the 3-hydroxy quinuclidine esters of a phenoxycarboxylic acid, a process for the preparation thereof, and related pharmaceutical compositions. | |
| IE812722L (en) | Naphthyridine derivatives | |
| GB1432578A (en) | Indol-7-ylacetic acids and esters thereof | |
| IE800960L (en) | Phenylthioethyl carboxylic acid hydrazides |