IE80411B1 - Process for synthesizing 4-halo-5(hydroxymethyl)-imidazole compounds and certain novel 4-halo-5(hydroxymethyl) imidazole compounds - Google Patents

Process for synthesizing 4-halo-5(hydroxymethyl)-imidazole compounds and certain novel 4-halo-5(hydroxymethyl) imidazole compounds

Info

Publication number
IE80411B1
IE80411B1 IE940635A IE940635A IE80411B1 IE 80411 B1 IE80411 B1 IE 80411B1 IE 940635 A IE940635 A IE 940635A IE 940635 A IE940635 A IE 940635A IE 80411 B1 IE80411 B1 IE 80411B1
Authority
IE
Ireland
Prior art keywords
hydroxymethyl
imidazole
compound
bis
halo
Prior art date
Application number
IE940635A
Other versions
IE940635A1 (en
Inventor
Takayuki Murai
Tokuichi Saeki
Suzuko Satou
Shuzu Miura
Tomoko Takashige
Yuichi Ikeda
Naoki Kano
Original Assignee
Shikoku Chem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP94301080A external-priority patent/EP0611758B1/en
Application filed by Shikoku Chem filed Critical Shikoku Chem
Publication of IE940635A1 publication Critical patent/IE940635A1/en
Publication of IE80411B1 publication Critical patent/IE80411B1/en

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for preparing, on an industrial scale; 4-halo-5(hydroxymethyl) imidazole compounds that are useful as intermediates for medicines. A 4-halo-5(hydroxymethyl) imidazole compound is prepared by reacting a 4,5-bis(hydroxymethyl) imidazole compound with a halogenating agent such as an N-chlorosuccinimide, an N-bromosuccinimide or a chlorinated isocyanuric acid compound.

Description

PROCESS FOR SYNTHESIZING 4-HALO-5 (HYDROXYMETHYL) IMIDAZOLE COMPOUNDS AND CERTAIN NOVEL 4-HALO-5(HYDROXYMETHYL) IMIDAZOLE COMPOUNDS * Background of The Invention * The present invention provides a process for producing 4- halo-5-(hydroxymethyl) imidazole compounds that are useful as intermediates of medicines such as hypotensive drugs and the like.
The 4-halo-5-(hydroxymethyl) imidazole compound can be converted upon oxidation with manganese dioxide or the like into a 4-halo-5-formylimidazole compound.
The 4-halo-5-(hydroxymethyl) imidazole compound has heretofore been synthesized by reacting a - (hydroxymethyl) imidazole compound which is a starting material with a halogenating agent such as an N-chlorosuccinimide to halogenate the position 4 of an imidazole ring. For instance, Japanese Patent Publication No. 64428/1988 (equivalent to EP-A-0 028 834) discloses a 4-chloro-5-(hydroxymethyl) imidazole compound synthesized by the above-mentioned method and having at the position 2 thereof an n-propyl group, an n-butyl group, a t-butyl group, a cyclopentyl group, an m-butoxyphenyl group, a p-methylphenyl group, a p-methoxyphenyl group and a p-chlorophenyl group, and Japanese Laid-Open Patent Publication No. 23868/1988 (equivalent to EP-A-0 253 310) discloses a 4-chloro-5-(hydroxymethyl) imidazole compound having an n-heptyl group and a methoxyethyl group at the position 2 thereof.
The 5-(hydroxymethyl) imidazole compound used as a * starting material in the above-mentioned method is prepared by a method of reacting an iminoester compound with a dihydroxyacetone in the liquid ammonia or by a method of reducing a 5-formylimidazole compound with a sodium borohydride. According to the former method, the starting material is handled with difficulty, the reaction apparatus becomes complex, the yield is low and the cost of production is high. The latter method, on the other hand, uses the 5-formyiimidazole compound which is an expensive starting material. In either case, therefore, synthesis of the 4-halo-5-(hydroxymethyl) imidazole compound by using the 5-(hydroxymethyl) imidazole compound as a starting material, is not practicable.
Summary of The Invention The object of the present invention is to provide a process which is capable of inexpensively mass-producing a 4-halo-5-(hydroxymethyl) imidazole compound by using a 4,5-bis(hydroxymethyl) imidazole compound that is easily obtained by the reaction of an imidazole compound as a starting material with a formaldehyde.
The present invention provides a process for producing a4-halo-5-(hydroxymethyl) imidazole compound of formula (I) X CH2OH H N NH V R wherein R is hydrogen, alkyl, aryl or aralkyl and X is halogen, which process comprises reacting a corresponding 4,5bis(hydroxymethyl) imidazole compound with a halogenating agent.
Detailed Description of Preferred Embodiment According to the present invention, a 4-naio-5-(hydroxymethyl) imidazole compound is obtained by dissolving a 4,5-bis(hydroxymethyl) imidazole compound in an organic solvent or in water, maintaining the solution at a temperature of 0 to 100” C and, preferably, at a temperature of 20 to 50’C, adding a halogenating agent to the solution to carry out the reaction for 1 to 24 hours and, preferably, for 2 to 5 hours, concentrating the reaction solution, and refining the concentrated product expressed by the following X CHzOH halogenating agent N NH m a customary manner.
The reaction can be formula, HOCH2 CH2OH N NH R R wherein R and X are as defined above.
In refining the 4-halo-5-(hydroxymethyl) imidazole compound according to the process of the present invention, when the 4-halo-5-(hydroxymethyl) imidazole compound which is the object compound is sparingly soluble or insoluble in water, the obtained reaction product is washed with water and is then recrystallized with a suitable solvent to obtain the object product in pure form and, conversely, when the object product is soluble in water, the obtained reaction product is subjected to the column chromatography and is then recrystallized with a suitable solvent to obtain the object product in pure form.
In carrying out the process of the present invention, the halogenating agent may be added to the reaction system at one time or, preferably, in a divided manner or dropwiseiy. Moreover, the reaction temperature can be lowered and the reaction time can be shortened with a decrease in the molecular weight of the substituent at the position 2 of the starting 4,5-bis(hydroxymethyl) imidazole compound. Conversely, the reactivity decreases with an increase in the molecular weight of the substituent at the position 2 , making it necessary to raise the reaction temperature or to lengthen the reaction time.
The 4,5-bis(hydroxymethyl) imidazole compound used as the starting material for the process of the present invention can be prepared by reacting an imidazole compound with twice as much moles of a formaldehyde in an organic solvent such as alcohols or in water in the presence of an alkali catalyst such as sodium hydroxide. This reaction can be represented by the following formula, HOCH2 CH2OH N NH + 2HCHO V R NaOH -> N NH wherein R is as defined above.
Representative examples of the 4,5-bis(hydroxymethyl) imidazole compound that can be used for the process of the present invention include a 4,5-bis(hydroxymethyl) imidazole, a 2-methyi-4,5-bis(hydroxymethyl) imidazole, a 2-ethyl-4,5-bis(hydroxymethyl) imidazole, a 2-propyl-4,5-bis(hydroxymethyl) imidazole, a 2-isopropyl-4,5-bis(hydroxymethyl) imidazole, a 2-butyi-4,5-bis(hydroxymethyl) imidazole, a 2-pentyi-4,5-bis(hydroxymethyl) imidazole, a 2-hexyl-4,5-bis(hydroxymethyl) imidazole, a 2-heptyl-4,5-bis(hydroxymethyl) imidazole, a 2-octyl-4,5-bis(hydroxymethyl) imidazole, a 2-nonyl-4,5-bis(hydroxymethyl) imidazole, a 2-unaecyl-4,5-bis(hydroxymethyl) imidazole, a 2-heptadecyl-4,5-bis(hydroxymethyl·) imidazole, a 2-phenyl-4,5-bis(hydroxymethyl) imidazole, a 2-paratoluy1-4,5-bis(hydroxymethyl) imidazole, a 2-benzyl-4,5-bis(hydroxymethyl) imidazole, a 2-( 1-p’nenylethyi )-4,5-bis (hydroxymethyl) imidazole, and the like.
Representative examples of the halogenating agent used for the process of the present invention include N-halocarboxylic acid imides such as an N-chlorosuccinimide, an N-bromosuccinimide, etc.; N-halocarboxylic acid amides; halogenated isocyanuric acids such as a trichloroisocyanuric acid,a tribromoisocyanuric acid, a dichioroisocyanuric acid, a sodium dichloroisocyanurate, a potassium dicnloroisocyanurate, a calcium dichloroisocyanurate, a magnesium dichloroisocyanurate or hydrates thereof; chlorine, bromine; metal salts of alkali hypochlorite such as sodium hypochlorite, etc.; and alkaline earth metal salts of hypochlorous acid such as a·calcium hypocnloride, etc., which will be used in an amount of 0.5 to 1.5 equivalents and, preferably, in an amount of 0.8 to 1.2 equivalents per equivalent of the starting 4,5-bis(hydroxymethyl) imidazole compound.
When the halogenating agent is used in an amount of smaller than 0.5 equivalent per equivalent of the starting 4,5-bis(hydroxymethyl) imidazole compound, the unreacted starting material remains in large amounts. When the halogenating agent is used in an amount greater than 1.5 equivalents, on the other hand, the 4,5-dihaioimidazole compound is formed in large amounts, which is not desirable .
The solvent used for the process of the present invention may be water. It is, however, desired to use an organic solvent which dissolves the starting 4,55 bis(hydroxymethyl) imidazole compound but does not react with the halogenating agent such as N-chlorosuccinimide. Representative examples of the organic solvent include alcohols such as methanol, ethanol, etc., ethers such as tetrahydrofurane, 1,4-dioxane, etc.· and chlorinated hydrocarbons such as methylene chloride, chloroform, etc.
Among the 4-chloro-5-(hydroxymethyl) imidazole compounds synthesized by the process of the present invention, the following compounds are novel compounds which have not yet been prepared, i.e., a 2-methyl-4-chioro-5-(hydroxymethyl) imidazole, a 2-etnyl-4-chloro-5-(hydroxymethyl) imidazole, a 2-isopropyl-4-chloro-5-(hydroxymethyl) imidazole and a 2-undecyl-4-chloro-5-(hyaroxymethyl) imidazole. These 4-cnloro-5-(hydroxymethyl) imidazole compounds exhibit the I following properties. 2-Methyl-4-cnioro-5-(hydroxymethyl) imidazole : Cl CH2OH N NH V CHa Colorless powder, m.p., 166-167°C TLC (silica gel-acetone): Rf 0.42 IR(KBr): V3100, 1600, 1527, 1414, 1366, 1244, 1230, 1217, 1110, 1038, 1023, 1008, 784 cm'1 NMR(d4-methanol): S4.47(s,2H), 2.29(s,3H) MS: m/'e 146 (M+) 2-Ethy1-4-chloro-5-(hydroxymethyl) imidazole -Ία CHzOH Ν' NH 5 V C2H5 Colorless crystal, m.p., 134-136’C TLC (silica gel-acetone): Rf 0.6S IR(KBr): V3080, 1600, 1516, 1450, 1430, 13S2, 1355 10 1272, 1240, 1220, 1110, 1067, 1010, 960, 774, 710, 680 cm-1 NMR(04-methanol): 54.49(s,2H), 2.65(q,2H,J=8Hz), 1.25(t,3H,J=8Hz) MS: m/e 160(M+) 2-Isopropyl-4-chloro-5-(nydroxymethyl) imidazole Ci CH2OH N NH CH CH3 CH3 Colorless crystal, m.p., 170-176’C TLC (silica gel-acetonr): Rf 0.72 IR(KBr): V2980, 1600, 1514, 1450, 1395, 1366, 1327 1265, 1244, 1220, 1160, 1105, 1094, 1010, 767, 725 cm-1 N'MR(d4-methanol) : 54.48(s,2H), 2.95(m,lH), 1.27(d,6H,J=7Hz) MS: m/e 174(M+) 2-Unaecyl-4-chloro-5-(hydroxymethyl) imidazole 1323, 50 , 1305 , 840, Cl CH2OH N NH 5 V Cl 1H2 3 Colorless crystal, m.p., 103-114’C TLC (silica gel-ethyl acetate): Rf 0.56 IR(KBr): V3140, 3090, 2920, 2860, 1600, 1520, 1470, 1455 1425, 1234, 1110, 998, 850, 796, 712 cm1 NMR(d4-methanol): 54.47(s,2H), 2.61(t,2H,J=8Hz), 1.59(m,2H), 1.28(br.s, 16H), 0.89(t,3H,J=6Hz) MS: m/e 286(M-) Examples The invention will now be concretely described by way of Examples.
(Example 1) 1.45 Grams (10.9 mmol) of an N-chlorosuccinimide 20 was added to a solution consisting of 1.91 g (10.4 mmol) of a 2-butyl-4,5-bis(hydroxymethyl) imidazole, 100 ml of ethanol and 40 ml of 1,4-dioxane maintained at room temperature. The mixture was reacted for 18 hours with stirring and, then, the solvent was distilled off under reduced pressure. The resulting reaction product was washed with water and was recrystallized from acetonitrile to obtain a pale yellowish scale-like crystalline 2-butyl-4-chloro-5-(hydroxymethyl) imidazole in an amount of 1.00 g (yield, 51%).
Recrystallization was further effected with acetonitrile to obtain the milk-white crystalline compound in pure form.
The thus obtained 2-butyl-4-chloro-5-(hydroxymethyl) imidazole exhibited TLC and spectra as follows: Milk-white crystal, m.p., 141-147° C TLC (silica gel-acetone): Rf 0.73 IR(KBr): V2975, 1598, 1524, 1456, 1392, 1355, 1304, 1284, 1269, 1240, 1222, 1106, 1023, 860, 800, 726, 715 cm-1 NMR(04-methanol): S4.48(s,2H), 2.62(t,2K,J = 7Hz), 1.821.16(m,4H), 0.94(t,3H,J=6Hz) M5: m/e 188(M+) (Example 2) 3.86 Grams (28.9 mmol) of the N-chlorosuccinimide was added little by little to a solution consisting of 3*.S7 g (27.2 mmol) of a 2-methyi-4,5-bis(hydroxymethyl) imidazole and 50 ml of water maintained at room temperature with stirring over a period of about 40 minutes. The mixture was then stirred at the same temperature for 20 hours followed by the addition of sodium carbonate thereto to make the mixture alkaline. Water was then distilled off under reduced pressure. The resulting reaction mixture was extracted with ethanol, and the extract was evaporated to dryness under reduced pressure. The resulting solid product was then extracted with acetone and the extract was evaporated under reduced pressure to obtain a yellowish oily product. The oily product was then subjected to the column chromatography (silica gel-acetone) to obtain a yellowish brown crystalline 2-methyl-4-cnloro-5-(hydroxymethyl) imidazole in an amount of 2.4 g (yield, 60.2%). By using acetonitrile, the recrystallization was repeated two times to obtain a colorless powdery product in pure form. The TLC and spectra of this compound were the same as the properties exhibited by the above-mentioned 2-methyl-4-chloro-5(hydroxymethyl) imidazole.
(Example 3) 1.76 Grams (13.2 mmol) of the N-chiorosuccinimide was added little by little to a solution consisting of 2.06 g (13.2 mmol) of an ethyl-4,5-bis(hydroxymethyl) imidazole, 100 ml of ethanol and 40 ml of 1,4-dioxane maintained at room temperature with stirring over a period of about 11 minutes. The mixture was then stirred at the same temperature for three hours and for another 30 minutes at a temperature of 50“C. After the reaction, the solvent was distilled off under reduced pressure and the resulting yellowish oily product was subjected to the column chromatography (silica gel-acetone), and the obtained effluent was evaporated to dryness under reduced pressure. By using acetonitrile, the resulting solid product was recrystallized three times to obtain a colorless crystalline 2-ethyi-4-cnloro-5-(hydroxymethyl) imidazole in an amount of 0.82 g (yield, 39.0%). The TLC and spectra of this compound were the same as the properties exhibited by the above-mentioned 2-ethyl-4-c’nloro-5- (hydroxymethyl) imidazole .
(Example 4) 2.81 Grams (21 mmol) of the N-chlorosuccinimide was added little by little to a solution consisting of 3.47 g (20.4 mmol) of a 2-isopropyl-4,5bis(hydroxymethyl) imidazole and 220 ml of ethanol at a temperature of 40 to 45°C with stirring over a period of about 25 minutes. The mixture was stirred at the same temperature for two hours to effect the reaction, and then ethanol was distilled off under reduced pressure. The resulting reaction product was washed with water to obtain a pale yellowish powdery crystalline 2-isopropyl-4-cnloro-5-(hydroxymethyl) imidazole in an amount of 1.69 g (yield, 47.4%). By using acetonitrile, the recrystallization was effected twice to obtain a colorless crystalline product in pure form. The TLC and spectra of this compound were the same as the properties exhibited by the above-mentioned 2-isopropyl-4-chloro-5-(hydroxymethyl) imidazole.
(Example 5) 1.10 Grams (8.3 mmol) of the N-chlorosuccinimide was added little by little to a solution consisting of 2.15 g (7.6 mmol) of a 2-undecyl-4,55 bis (hydroxymethyl) imidazole and 200 ml of ethanol at a temperature of 40 to 45’C over a period of about 23 minutes. The mixture was stirred at the same temperature for two hours to effect the reaction and, then, ethanol was distilled off under reduced pressure.
The resulting reaction product was washed with water and was then recrystallized from acetone to obtain a' creamy-white fine crystalline 2-undecyl-4-chioro-5-(hydroxymethyl) imidazole in an amount of 1.16 g (yieid, 53.1%). By using acetonitrile, furthermore, the recrystallization was effected twice to obtain a colorless crystalline product in pure form. The TLC and spectra of this compound were the same as the properties exhibited the above-mentioned 2-undecyl-4-cnloro-5-(hydroxymethyl) imidazole .
(Example 6) 1.53 Grams (6.6 mmol) of trichioroisocyanuric acid was added little by little to a solution consisting of 2.03 g (13 mmol) of the 2-etnyi-4,5-bis(hydroxymethyl) imidazole, 100 ml of ethanol and 40 ml of 1,4-dioxane at room temperature with stirring over a period of about 10 minutes. The mixture was stirred at the same temperature for one hour, the solvent was distilled off under reduced pressure, the reaction product was extracted with ethanol, and the extract was evaporated to dryness under reduced pressure. The resulting solid product was then extracted with acetone, the extract was concentrated and was then subjected to the column chromatography (silica gel-acetone), and the effluent was further concentrated and was recrystallized from acetonitrile to obtain a 2-ethyi-4-cnloro-5-(hydroxymethyi) imidazole in an amount of 0.78 g (yield, 37.4%). The TLC and spectra were measured to be the same as those of Example 3.
(Example 7) 11.5 Grams (15 mmol) of an aqueous solution containing 9.7% of sodium hypochlorite was dropwiseiy added to a solution consisting of 2.53 g (16.2 mmol) of the 2-etny1-4,5-bis(hydroxymethyl) imidazole and 50 mi of water. After the dropwise addition has been finished, the mixture was stirred at room temperature for one hour, followed by neutralization by the addition of dry ice and further followed by evaporation to dryness under reduced pressure. The resulting solid was extracted with ethanol, the extract was evaporated under reduced pressure, and the resulting solid product was extracted with acetone. 1.48 Grams of the starting 2-ethyl-4,5-bis(hydroxymethyl) imidazole was recovered as an extraction residue, the extract was concentrated under reduced pressure, and was subjected to the column chromatography (silica gelacetone) to obtain a 2-ethyl-4-chioro-5-(hydroxymethyl) imidazole in an amount of 0.46 g (yield, 43.0% with respect to the starting material consumed). The TLC and spectra were measured to be the same as those of Example 3.
(Example 8) 26.3 Grams (15,6 mmol) of a 4.2% chlorinecarbon tetrachloride solution was dropwiseiy added to a solution consisting of 2.52 g (14.8 mmol) of the 2isopropyl-4,5-bis(hydroxymethyl) imidazole and 200 ml of ethanol maintaining a temperature of 40’C with stirring. After the dropwise addition has been finished, the stirring was continued at 40°C for one hour and, then, the solvent was distilled off under reduced pressure. After the residual brown oil was dissolved in water, sodium carbonate was added thereto to make the mixture alkaline. The mixture was evaporated again under reduced pressure.
The obtained resulting solid product was extracted with ethanol, the extract was evaporated under reduced pressure, and the resulting solid product was extracted with cold water. 0.71 Grams of the starting 2-isopropyi-4,5-bis(hydroxymethyl) imidazole was recovered as the extraction residue, and the extract after evaporate under reduced pressure was subjected to the column chromatography (silica gel-acetone) to obtain a 2-isopropyl-4-chloro-5-(hydroxymethyl) imidazole in an amount of 0.56 g (yield, 30.3% with respect to the starting material consumed). By using acetonitrile, the compound was further refined. The TLC and spectra of this compound were measured to be the same as those of Example 4 .
(Example 9) 2.4 Grams (10.9 mmol) of sodium dic'nloroisocyanurate was added to a solution consisting of 3.68 g (20 mmol) of the 2-butyl-4,o-bis(hydroxymethyl) imidazole, 40 ml of ethanol and 15 ml of dioxane maintained at a temperature of 40 to 45'C with stirring. The mixture was further stirred at a temperature of 40 to 60°C for two hours. The obtained reaction solution was cooled, filtered to separate impurities, the filtrate was concentrated under reduced pressure. The resulting residue product was washed with water, and was recrystallized twice from acetonitrile to obtain a pale yellowish crystalline 2-butyi-4-chloro-5-(hydroxymethyl) imidazole in an amount of 1.60 g (yield, 42.5%).
(Example 10) 2.56 Grams (10 mmol) of a sodium aichloroisocyanurate dihydrate was added to a solution consisting of 3.68 g (20 mmol) of the 2-butyl-4,5-bis(hydroxymethyl) imidazole, 40 ml of ethanol and 15 ml of dioxane maintained at a temperature of 40 to 45°C with stirring. The mixture was further stirred at a temperature of 50 to 60°C for three hours. The obtained reaction solution was cooled, filtered to separate impurities, the filtrate was concentrated under reduced pressure. The resulting residue product was washed with water and was recrystallized twice from acetonitrile to obtain a pale yellowish crystalline 2-butyl-4-cnloro-5(hydroxymethyl) imidazole in an amount of 1.90 g (yield, 50%) .
(Example 11) 3.56 Grams (20 mmol) of the N-bromosuccinimide was added to a solution consisting of 3.68 g (20.0 mmol) of the 2-butyl-4,5-bis(hydroxymethyl) imidazole, 40 ml of ethanol and 15 ml of dioxane maintained at a temperature of 45 to 50°C with stirring. The mixture was further reacted at the same temperature for 30 minutes with stirring, and then the solvent was distilled off under reduced pressure. The obtained reaction product was washed with water and was recrystallized from acetonitrile to obtain a pale yellowish scaie-like crystalline 2-butyl-4-bromo-5-(hydroxymethyl) imidazole in an amount of 2.36 g (yield, 51%).
(Example 12) 3.56 Grams (20 mmol) of the N-bromosuccinimide was added to a solution consisting of 4.36 g (20 mmol) of the 2-benzyl-4,5-bis(hydroxymethyl) imidazole, 80 mol of metnoxyethanol and 30 ml of dioxane maintained at a temperature of 45 to 50°C with stirring. The mixture was further reacted at the same temperature for 24 hours with stirring and, then, the solvent was distilled off under reduced pressure. The obtained reaction product was washed with water and was recrystallized from acetonitrile to obtain a 2-benzyl-4-bromo-5-(hydroxymethyl) imidazole in an amount of 2.1 g (yield, 39%).
(Example 13) 2.34 Grams (17.5 mmol) of the N-chlorosuccinimide was added to a solution consisting of 3.26 g (16 mmol) of the 2-pnenyl-4,5-bis(hydroxymethyl) imidazole, 24 mi of methoxyethanol and 37 ml of dioxane maintained at a temperature of 50°C with stirring. The mixture was then reacted at the same temperature for 24 hours with stirring, and the reaction solution was concentrated under reduced pressure. The obtained reaction product was washed with water and was recrystallized from propyl alcohol to obtain a 2-phenyi-4-chIoro-5-(hydroxymethyl) imidazole in an amount of 1.0 g (yield 30%).
The present invention simplifies the steps for preparing 4-halo-5-(hydroxymethyl) imidazole compounds that can be effectively used as intermediates for medicines, and uses the starting material which is relatively cheap and can be easily handled. Therefore, the present invention lends itself well for the production on an industrial scale.

Claims (12)

1. A process of producing (hydroxymethyl) imidazole compound a 4-halo-5of formula (I) CHzOH N NH (I) I R wherein R is hydrogen, alkyl, aryl or aralkyl and X is halogen, which process comprises reacting a corresponding 4,5bis(hydroxymethyl) imidazole compound with a halogenating agent.
2. A process according to claim 1 wherein the halogenating agent is an N-chlorosuccinimide.
3. A process according to claim 1 wherein the halogenating agent is a chlorinated isocyanuric acid compound.
4. A process according to claim 3 wherein the halogenating agent is a sodium dichloroisocyanurate.
5. A process according to claim 3 wherein the halogenating agent is trichloroisocyanuric acid. v
6. A process according to any one of the preceding claims for the production of a compound of formula (la) (Ia) wherein R is methyl, ethyl isopropyl or undecyl.
7. A process according to any one of the preceding claims, which comprises: reacting an imidazole compound of formula (II): Γ“λ N NH V (II) 10 wherein R is as defined in claim 1 or 6, with two equivalents of formaldehyde in an organic solvent or in water and in the presence of an alkali catalyst, to produce a 4,5-bis(hydroxymethyl)imidazole compound; and reacting the resulting 4,5-bis(hydroxymethyl) 15 imidazole compound with a halogenating agent.
8. A process according claim 1 of producing a compound of formula (I) given and defined therein, substantially as hereinbefore described and exemplified.
9. A compound of formula (I) given and defined 20 in claim 1, whenever produced by a process claimed in a preceding claim. F. R. KELLY & CO., AGENTS FOR THE APPLICANTS. -189. A process according to claim 1 of producing a compound given and defined therein, substantially as hereinbefore described and exemplified.
10. A compound of formula (I) given and defined in claim 1, whenever produced by a process claimed in a preceding claim.
11. A compound as claimed in claim 7, substantially as hereinbefore described and exemplified.
12. Use according to claim 8, substantially as hereinbefore described.
IE940635A 1993-09-22 1994-08-12 Process for synthesizing 4-halo-5(hydroxymethyl)-imidazole compounds and certain novel 4-halo-5(hydroxymethyl) imidazole compounds IE80411B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25907993 1993-09-22
EP94301080A EP0611758B1 (en) 1993-02-15 1994-02-15 Process for synthesizing 4-halo-5(hydroxymethyl) imidazole compounds and certain novel 4-halo-5(hydroxymethyl) imidazole compounds

Publications (2)

Publication Number Publication Date
IE940635A1 IE940635A1 (en) 1995-03-22
IE80411B1 true IE80411B1 (en) 1998-07-01

Family

ID=26136927

Family Applications (1)

Application Number Title Priority Date Filing Date
IE940635A IE80411B1 (en) 1993-09-22 1994-08-12 Process for synthesizing 4-halo-5(hydroxymethyl)-imidazole compounds and certain novel 4-halo-5(hydroxymethyl) imidazole compounds

Country Status (1)

Country Link
IE (1) IE80411B1 (en)

Also Published As

Publication number Publication date
IE940635A1 (en) 1995-03-22

Similar Documents

Publication Publication Date Title
HU223439B1 (en) A process for the preparation of tetraazamacrocycles
KR0176010B1 (en) Process for producing 1-amino-1,2,3-triazole
EP0611758B1 (en) Process for synthesizing 4-halo-5(hydroxymethyl) imidazole compounds and certain novel 4-halo-5(hydroxymethyl) imidazole compounds
KR20090066910A (en) Efficient prepartion of l-3-o-substituted-ascorbic acid
IE80411B1 (en) Process for synthesizing 4-halo-5(hydroxymethyl)-imidazole compounds and certain novel 4-halo-5(hydroxymethyl) imidazole compounds
KR100369274B1 (en) Improved process for producing 4-hydroxy-2-pyrrolidone
JP2849325B2 (en) Method for synthesizing 4-halo-5- (hydroxymethyl) imidazole compound
PL178167B1 (en) Method of obtaining dissymmetrically substituted triazines
HU196809B (en) Process for producing 7-oxo-4-thia-1-azabicyclo/3.2.0/-hept-2-ene derivatives
JP2595605B2 (en) Method for producing 2-substituted oxyimino-3-oxobutyric acid
US3427315A (en) Process for preparing purine derivatives
US5633387A (en) Process for producing 1-(2-chlorophenyl)-5(4H)-tetrazolinone
WO1998055445A1 (en) A process for the preparation of 1-bromoethyl acetate
EP0030475B1 (en) Process for producing solutions of aziridine-2-carboxylic acid salts
JP3499595B2 (en) Method for producing 2-cyanoimidazole compound
EP0468069B1 (en) Process for producing a 4,6-bis(difluoromethoxy)-2-alkylthiopyrimidine
SE435278B (en) 5-CYANO-1-LEGRE (C? 711? 71-? 714) ALKYL-PYRROL-2-ETHIC ACID, PREPARATION OF IT AND USE AS INTERMEDIATE IN THE PREPARATION OF THERAPEUTICALLY EFFECTIVE PYRROL DERIVATIVES
JP3159860B2 (en) Method for synthesizing 4,5-diformylimidazole compound and novel imidazole compound
CN111620829A (en) Synthesis method of 2-methyl-1, 2, 4-triazole-3-amine
US4897495A (en) Process for the preparation of pyrrolizine derivatives
CA1273345A (en) Process for the production of 3-phenyl-4- cyanopyrroles
JP2649122B2 (en) 4,5-Dihalogeno-6- (α-substituted ethyl) pyrimidine and process for producing the same
KR100234886B1 (en) Novel process for thr preparation of 3-alkoxy-4-piperidinone derivatives
KR100525358B1 (en) Method for the preparation of carboxyl benzotriazole alkyl ester
JP2770895B2 (en) 4,5-dihalogeno-6- (α-halogenoethyl) pyrimidine and process for producing the same

Legal Events

Date Code Title Description
MM4A Patent lapsed