IE791455L - Medicinal formulation - Google Patents

Medicinal formulation

Info

Publication number
IE791455L
IE791455L IE791455A IE145579A IE791455L IE 791455 L IE791455 L IE 791455L IE 791455 A IE791455 A IE 791455A IE 145579 A IE145579 A IE 145579A IE 791455 L IE791455 L IE 791455L
Authority
IE
Ireland
Prior art keywords
sulfonamide
chloro
solubility
salt
surfactant
Prior art date
Application number
IE791455A
Other versions
IE48608B1 (en
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of IE791455L publication Critical patent/IE791455L/en
Publication of IE48608B1 publication Critical patent/IE48608B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

1. A stable liquid formulation containing 2,6-diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidine (trimethoprim) and a sulfonamide of the formula I see diagramm : EP0009559,P6,F1 in which R is 6-chloro-2-pyrazinyl or 6-chloro-3-pyridazinyl, or a salt thereof, in the quantity ratio of 1 : 1 to 1 : 20, preferably 1 : 4 to 1 : 5, with a total proportion of 15 to 25 per cent by weight being dissolved in a physiologically compatible, watermiscible solvent, a solubility-promoting agent and a surfactant, and a base in the case where the sulfonamide is not used as a salt, in which composition the solvent used is N-methylpyrrolidone, the surfactant used is bis-(2-ethylhexyl)-Na-sulfosuccinate or poly-oxyethylene-sorbitan monolaurate (polysorbatum 20), the solubility-promoting agent used is hydroxyethyltheophylline or polyvinylpyrrolidone K 25, and the base used is ethenolamine. [EP0009559A1]
IE1455/79A 1978-08-01 1979-08-08 Medicinal formulation IE48608B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH821778 1978-08-01

Publications (2)

Publication Number Publication Date
IE791455L true IE791455L (en) 1980-02-01
IE48608B1 IE48608B1 (en) 1985-03-20

Family

ID=4336949

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1455/79A IE48608B1 (en) 1978-08-01 1979-08-08 Medicinal formulation

Country Status (9)

Country Link
EP (1) EP0009559B1 (en)
JP (1) JPS5522693A (en)
AR (1) AR229570A1 (en)
AU (1) AU530816B2 (en)
CA (1) CA1134747A (en)
DE (1) DE2963584D1 (en)
DK (1) DK323579A (en)
IE (1) IE48608B1 (en)
ZA (1) ZA793928B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1099795B (en) * 1978-10-09 1985-09-28 Narxer S P A THERAPEUTIC COMPOSITION FOR THE TREATMENT OF INFECTIONS AND DISEASES OF FARM ANIMALS
JPS61181232U (en) * 1985-04-27 1986-11-12
HU212498B (en) * 1992-11-06 1996-07-29 Egyt Gyogyszervegyeszeti Gyar Process for producing water-soluble pharmaceutical compositions, containing sulfachlorpyridazin-sodium and trimethoprim
JP6186533B1 (en) * 2017-03-31 2017-08-23 ナガセ医薬品株式会社 Process for producing maxacalcitol-containing aqueous preparation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1028292B (en) * 1954-03-13 1958-04-17 Wuelfing J A Fa Process for the production of stable solutions of rutin
US3728452A (en) * 1971-01-20 1973-04-17 Abic Ltd Water-soluble composition comprising sulfadimidine and pyrimethamine
GB1538903A (en) * 1975-04-11 1979-01-24 Nelson Res & Dev Carrier for a topically applied physiologically active agent or cosmetic agent
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
IL49412A (en) * 1976-04-14 1979-03-12 Abic Ltd Water-soluble composition comprising sulfadimidine and pyrimethamine
DE2627706C2 (en) * 1976-06-21 1982-11-18 Saarstickstoff-Fatol Gmbh, 6685 Schiffweiler Process for the production of neutral, stable sulfonamide potentiator solutions that can be diluted with water to form clear solutions
DE2631780C3 (en) * 1976-07-15 1981-11-19 Basf Ag, 6700 Ludwigshafen Sulfonamide trimethoprim solutions
DE2631779A1 (en) * 1976-07-15 1978-01-19 Basf Ag Clear aqueous sulphonamide-trimethoprim solutions - contg. a water-soluble sulphonamide salt, trimethoprim and polyvinyl pyrrolidone of K-value 10-18

Also Published As

Publication number Publication date
DE2963584D1 (en) 1982-10-21
AU4939479A (en) 1980-02-07
CA1134747A (en) 1982-11-02
JPS5522693A (en) 1980-02-18
EP0009559B1 (en) 1982-08-25
AR229570A1 (en) 1983-09-30
AU530816B2 (en) 1983-07-28
ZA793928B (en) 1980-08-27
DK323579A (en) 1980-02-02
EP0009559A1 (en) 1980-04-16
IE48608B1 (en) 1985-03-20

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