IE51288B1 - Substituted pyrazinyl-1,2,4-oxadiazoles,processes for preparing the same and a pharmaceutical composition containing the same - Google Patents

Substituted pyrazinyl-1,2,4-oxadiazoles,processes for preparing the same and a pharmaceutical composition containing the same

Info

Publication number
IE51288B1
IE51288B1 IE1102/81A IE110281A IE51288B1 IE 51288 B1 IE51288 B1 IE 51288B1 IE 1102/81 A IE1102/81 A IE 1102/81A IE 110281 A IE110281 A IE 110281A IE 51288 B1 IE51288 B1 IE 51288B1
Authority
IE
Ireland
Prior art keywords
hydrogen
compound
methyl
formula
pharmaceutical composition
Prior art date
Application number
IE1102/81A
Other languages
English (en)
Other versions
IE811102L (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/151,494 external-priority patent/US4309540A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IE811102L publication Critical patent/IE811102L/xx
Publication of IE51288B1 publication Critical patent/IE51288B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IE1102/81A 1980-05-19 1981-05-18 Substituted pyrazinyl-1,2,4-oxadiazoles,processes for preparing the same and a pharmaceutical composition containing the same IE51288B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/151,494 US4309540A (en) 1980-05-19 1980-05-19 Substituted pyrazinyl-1,2,4-oxadiazoles
US06/244,509 US4362724A (en) 1980-05-19 1981-03-16 Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic

Publications (2)

Publication Number Publication Date
IE811102L IE811102L (en) 1981-11-19
IE51288B1 true IE51288B1 (en) 1986-11-26

Family

ID=26848697

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1102/81A IE51288B1 (en) 1980-05-19 1981-05-18 Substituted pyrazinyl-1,2,4-oxadiazoles,processes for preparing the same and a pharmaceutical composition containing the same

Country Status (12)

Country Link
US (1) US4362724A (enExample)
EP (1) EP0040422B1 (enExample)
AU (1) AU536493B2 (enExample)
DE (1) DE3161767D1 (enExample)
DK (1) DK214681A (enExample)
ES (1) ES8207528A1 (enExample)
FI (1) FI811421A7 (enExample)
GR (1) GR74903B (enExample)
IE (1) IE51288B1 (enExample)
NO (1) NO811667L (enExample)
NZ (1) NZ197055A (enExample)
PT (1) PT73016B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
KR20150095870A (ko) 2012-12-17 2015-08-21 패리온 사이언스 인코퍼레이티드 3,5-디아미노-6-클로로-n-(n-(4-페닐부틸)카르밤이미도일)피라진-2-카르복스아미드 화합물
EP3150585A1 (en) 2012-12-17 2017-04-05 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299931A (enExample) * 1962-10-30
MC641A1 (fr) * 1967-03-08 1967-12-05 Mauvernay Roland Yves Nouveaux composés chimiques et procédé pour leur préparation
US4196292A (en) * 1977-06-29 1980-04-01 Merck & Co., Inc. 6-Substituted amiloride derivatives
EP0009054A1 (en) * 1978-09-19 1980-04-02 Merck & Co. Inc. N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same

Also Published As

Publication number Publication date
PT73016A (en) 1981-06-01
EP0040422B1 (en) 1983-12-28
AU536493B2 (en) 1984-05-10
ES502282A0 (es) 1982-10-01
GR74903B (enExample) 1984-07-12
NO811667L (no) 1981-11-20
FI811421L (fi) 1981-11-20
DE3161767D1 (en) 1984-02-02
EP0040422A1 (en) 1981-11-25
FI811421A7 (fi) 1981-11-20
PT73016B (en) 1983-08-08
IE811102L (en) 1981-11-19
AU7018081A (en) 1981-11-26
ES8207528A1 (es) 1982-10-01
US4362724A (en) 1982-12-07
NZ197055A (en) 1984-07-31
DK214681A (da) 1981-11-20

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